17780-75-5
Chemical Structure
Clorgyline hydrochloride
- CAS No.: 17780-75-5
- Formula:C13H16Cl3NO
- Molecular Weight:308.63
IUPAC Name: N-(3-(2,4-dichlorophenoxy)propyl)-N-methylprop-2-yn-1-amine hydrochloride
InChIKey: BBAZDLONIUABKI-UHFFFAOYSA-N
SMILES: C#CCN(CCCOC1=CC=C(Cl)C=C1Cl)C.[H]Cl
Biological Activity:
Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research, structurally related to Pargyline (HY-A0091A). Clorgyline hydrochloride has little effect on the amounts of conjugated dopamine (DA) present in superfusate of slices from rat striatum. Clorgyline hydrochloride contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1][2][3].
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Clorgyline hydrochloride | 99.92% | Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research, structurally related to Pargyline (HY-A0091A). Clorgyline hydrochloride has little effect on the amounts of conjugated dopamine (DA) present in superfusate of slices from rat striatum. Clorgyline hydrochloride contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. |
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Clorgyline hydrochloride (Standard) | ≥98% | Clorgyline hydrochloride (Standard) is the analytical standard of Clorgyline hydrochloride. This product is intended for research and analytical applications. Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research, structurally related to Pargyline (HY-A0091A). Clorgyline hydrochloride has little effect on the amounts of conjugated dopamine (DA) present in superfusate of slices from rat striatum. Clorgyline hydrochloride contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. |
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- [1]. Murphy DL, et al. Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline). Journal of neural transmission. Supplementum 52: 39-48. [Content Brief]
- [2]. Guillem K, et al. Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats[J]. Eur J Neurosci. 2006 Dec;24(12):3532-40. [Content Brief]
- [3]. Tyce GM, et al. Conjugated dopamine in superfusates of slices of rat striatum[J]. J Neurochem. 1982 Nov;39(5):1333-9. [Content Brief]
