24269-96-3
Chemical Structure
GRK2 Inhibitor 1
- CAS No.: 24269-96-3
- Formula:C12H9NO6
- Molecular Weight:263.20
IUPAC Name: methyl (E)-5-(2-(5-nitrofuran-2-yl)vinyl)furan-2-carboxylate
InChIKey: YDJPHSNZGRVPCK-NSCUHMNNSA-N
SMILES: O=C(OC)C1=CC=C(O1)/C=C/C2=CC=C(O2)[N+]([O-])=O
Biological Activity: GRK2 Inhibitor 1 (methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate) is a dual GRK2/β-ARK1 inhibitor that induces dopamine (DA) inhibition reversal (DIR). GRK2 Inhibitor 1 can also block serotonin-induced or neurotensin-induced DIR reversal. Note: DIR refers to the phenomenon in which neurons in addiction-related brain pathways become less sensitive to DA inhibition when exposed to moderate concentrations of DA for a long time[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
GRK2 Inhibitor 1 | 98.06% | GRK2 Inhibitor 1 (methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate) is a dual GRK2/β-ARK1 inhibitor that induces dopamine (DA) inhibition reversal (DIR). GRK2 Inhibitor 1 can also block serotonin-induced or neurotensin-induced DIR reversal. Note: DIR refers to the phenomenon in which neurons in addiction-related brain pathways become less sensitive to DA inhibition when exposed to moderate concentrations of DA for a long time. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.67
HY-135470Nifurpirinol -
Similarity Score 0.64
HY-119669Furylfuramide -
Similarity Score 0.63
HY-122073Furalazine -
Similarity Score 0.62
HY-Z0539RMethyl 5-nitro-2-benzofurancarboxylate (Standard) -
Similarity Score 0.62
HY-170313GLUT-1-IN-4 -
Similarity Score 0.62
HY-19726NSC59984 -
Similarity Score 0.61
HY-B1436Nifuroxazide -
Similarity Score 0.61
HY-151514Antituberculosis agent-5 -
Similarity Score 0.61
HY-147328LCS3 -
Explore the MedChemAI to find more analogs
