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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
efavirenz
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "efavirenz" in MCE Product Catalog:
17
17 Cited Publications
Synonyms: DMP 266; EFV; L-743726
Synonyms: 8-OH-EFV
8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of (HY-10572). 8-Hydroxyefavirenz induces apoptosis via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. 8-Hydroxyefavirenz can be used in research of cancer . 8-Hydroxyefavirenz is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Synonyms: GSK2248761; FDV
Target:
Forschungsgebiete:
Fosdevirine (GSK2248761) is is a potent, selective, non-nucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus type 1 (HIV-1) replication with low nanomolar activity in vitro. Fosdevirine shows good activity against a broad range of HIV-1 strains, including efavirenz (HY-10572)-resistant clinical isolates .
Art. -Nr.: HY-10572S
CAS. Nr.: 1132642-95-5
Art. -Nr.: HY-131422S
CAS. Nr.: 1246812-30-5
Art. -Nr.: HY-10572R
CAS. Nr.: 154598-52-4
Synonyms: DMP 266 (Standard); EFV (Standard); L-743726 (Standard)
Category:
Art. -Nr.: HY-10572B
CAS. Nr.: 177530-93-7
Synonyms: (Rac)-DMP 266; (Rac)-EFV; (Rac)-L-743726
(Rac)-Efavirenz is the isomer of Efavirenz (HY-10572). Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .
Art. -Nr.: HY-10572A
CAS. Nr.: 154801-74-8
Synonyms: (R)-DMP 266; (R)-EFV; (R)-L-743726
Target:
Forschungsgebiete:
(R)-Efavirenz ((R)-DMP 266) is a non-nucleoside reverse transcriptase inhibitor that acts by non-competitive inhibition of the viral enzyme. (R)-Efavirenz can be metabolized by CYP2B6 to 8-hydroxyefavirenz in a highly stereoselective manner. (R)-Efavirenz is promising to be a useful probe for the CYP2B6 active site and catalytic mechanisms .
Art. -Nr.: HY-10572S1
CAS. Nr.: 1261394-62-0
Synonyms: DMP 266-13C6; EFV-13C6; L-743726-13C6
Art. -Nr.: HY-131422
CAS. Nr.: 205754-32-1
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Forschungsgebiete:
(Rac)-8-Hydroxy-efavirenz is a metabolite of Efavirenz (HY-10572), a non-nucleoside HIV-1 reverse transcriptase inhibitor .
Art. -Nr.: HY-123330
CAS. Nr.: 457635-65-3
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Forschungsgebiete:
GW695634 is an orally active prodrug of GW678248. GW695634 undergoes amidolysis in vivo to release the active ingredient GW678248, thereby inhibiting viral replication. GW678248 is a non-nucleoside reverse transcriptase inhibitor (NNRTi) with potent antiviral activity against Efavirenz (HY-10572)-resistant and Nevirapine (HY-10570)-resistant HIV and AIDS viruses .
Art. -Nr.: HY-10572BS1
CAS. Nr.: 2749807-27-8
Art. -Nr.: HY-10572BS
CAS. Nr.: 1246812-58-7
Art. -Nr.: HY-19869
CAS. Nr.: 878670-89-4
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Forschungsgebiete:
VRX-480773 is an efficient non-nucleoside reverse transcriptase inhibitor (NNRTI), used for HIV infection. VRX-480773 has high specificity for HIV-1, with an EC50 for wild-type HIV-1 being 0.14 nM. VRX-480773 does not inhibit HIV-2, HBV or HCV, and has no effect on human DNA polymerase α/β. VRX-480773 retains inhibitory activity against Efavirenz (HY-10572) resistant strains, with EC50s mostly < 1 nM. VRX-480773 can be used for research on AIDS .
Art. -Nr.: HY-134628S
CAS. Nr.: 1189859-26-4
Art. -Nr.: HY-W707595
Art. -Nr.: HY-10572BR
CAS. Nr.: 177530-93-7
Synonyms: (Rac)-DMP 266 (Standard); (Rac)-EFV (Standard); (Rac)-L-743726 (Standard)
(Rac)-Efavirenz (Standard) is the analytical standard of (Rac)-Efavirenz. This product is intended for research and analytical applications. (Rac)-Efavirenz is the isomer of Efavirenz (HY-10572). Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .
Art. -Nr.: HY-W023836
CAS. Nr.: 154598-53-5
Forschungsgebiete:
4-Chloro-2-(trifluoroacetyl)aniline (Compound 10), an analog of Efavirenz (HY-10572), is a Pregnane X receptor (PXR) ligand. 4-Chloro-2-(trifluoroacetyl)aniline has no PXR activation activity without induction of Cyp3a11 mRNA expression .
Art. -Nr.: HY-167690
CAS. Nr.: 1034474-19-5
Target:
Forschungsgebiete:
MK-6186 is a novel non-nucleoside reverse transcriptase inhibitor with sub-nanomolar activity against wild-type viruses and the two most common NNRTI-resistant RT mutants (K103N and Y181C). MK-6186 exhibits excellent antiviral activity against K103N and Y181C mutant viruses. When MK-6186 targets 12 common NNRTI-associated mutant viruses, only two relatively rare mutants (Y188L and V106I/Y188L) show high resistance, with FC values exceeding 100, while the FC values of the remaining viruses are all below 10. In addition, when MK-6186 faces 96 clinical virus isolates carrying NNRTI-resistant mutations, most (70%) viruses show more than 10-fold resistance to efavirenz (EFV), while only 29% of mutant viruses show more than 10-fold resistance to MK-6186 .
Art. -Nr.: HY-E72095
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Forschungsgebiete:
Human CYP2A6, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, which consists of human cytochrome P450 2A6, NADPH-P450 oxidoreductase (CPR) and cytochrome b5. Human CYP2A6 is a human cytochrome P450 subtype belonging to the CYP2 family, as well as a major metabolic enzyme. It is predominantly expressed in human liver and metabolizes a variety of active compounds including Coumarin (HY-N0709) and nicotine .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
