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Cat. No.: HY-10572BR

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(Rac)-Efavirenz (Standard)

(Synonyms: (Rac)-DMP 266 (Standard); (Rac)-EFV (Standard); (Rac)-L-743726 (Standard))

(Rac)-Efavirenz (Standard) is the analytical standard of (Rac)-Efavirenz. This product is intended for research and analytical applications. (Rac)-Efavirenz is the isomer of Efavirenz (HY-10572). Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture.

For research use only. We do not sell to patients.

CAS No.: 177530-93-7
Formula: C₁₄H₉ClF₃NO₂
Molecular Weight:315.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(Rac)-Efavirenz (Standard) Chemical Structure

CAS No.: 177530-93-7

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 177530-93-7
Molecular Weight 315.67
Formula C₁₄H₉ClF₃NO₂
SMILES

O=C1OC(C2=CC(Cl)=CC=C2N1)(C(F)(F)F)C#CC3CC3
Synonyms

(Rac)-DMP 266 (Standard); (Rac)-EFV (Standard); (Rac)-L-743726 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Grobler JA, et al. HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro. J Biol Chem. 2007 Mar 16;282(11):8005-10. [Content Brief]

[2]. Young SD, et al. L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother. 1995 Dec;39(12):2602-5. [Content Brief]

[3]. Held DM, et al. Differential susceptibility of HIV-1 reverse transcriptase to inhibition by RNA aptamers in enzymatic reactions monitoring specific steps during genome replication. J Biol Chem. 2006 Sep 1;281(35):25712-22. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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