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Results for "

ester hydrolysis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Carboxylesterase (CES) (5) 5-HT Receptor (8) Acyltransferase (2) ADC Linker (1) Adrenergic Receptor (5) Akt (3) Aldehyde Oxidase (AO) (1) Amino Acid Derivatives (4) Aminopeptidase (8) Amylases (6) Amyloid-β (1) Androgen Receptor (2) Angiotensin-converting Enzyme (ACE) (7) Antibiotic (24) Apoptosis (21) Arginase (1) ATP Synthase (4) Autophagy (3) Bacterial (54) Bcl-2 Family (3) BCRP (1) Beta-lactamase (9) Biochemical Assay Reagents (156) C-type Lectin-like Receptors (CTLRs) (1) Calcium Channel (4) Calmodulin (1) CaMK (1) Cannabinoid Receptor (4) Carboxypeptidase (6) Caspase (4) Cathepsin (4) CD73 (3) Ceramidase (1) Cholinesterase (ChE) (15) ClpP (2) COX (2) CXCR (1) DAGL (2) Dengue Virus (4) Deubiquitinase (1) Dipeptidyl Peptidase (3) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (11) Drug Derivative (17) Drug Intermediate (8) Drug Isomer (4) Drug Metabolite (34) EAAT (1) EGFR (3) Elastase (1) Endogenous Metabolite (100) Endonuclease (1) Endothelin Receptor (1) Environmental Pollutants (18) ERK (3) Estrogen Receptor/ERR (3) Eukaryotic Initiation Factor (eIF) (3) Exosomes (1) FAAH (3) FBPase (3) FGFR (1) Flavivirus (3) Fluorescent Dye (25) Fungal (4) Glutaminase (1) Glutathione Peroxidase (7) Glycosidase (50) HCV (1) HDAC (2) Hedgehog (1) Histone Demethylase (1) HIV (11) HIV Protease (4) HSP (1) IAP (1) IFNAR (1) iGluR (1) Influenza Virus (1) Insecticide (3) Integrin (1) Interleukin Related (6) Isotope-Labeled Compounds (18) Ligands for E3 Ligase (1) Lipase (10) LPL Receptor (1) mAChR (6) MAGL (6) mGluR (13) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) MMP (28) mRNA (1) NADPH Oxidase (1) Neprilysin (1) Neurokinin Receptor (2) NF-κB (5) NO Synthase (7) NOD-like Receptor (NLR) (1) NTPDase (5) Nucleoside Antimetabolite/Analog (2) Opioid Receptor (1) P-glycoprotein (1) P2Y Receptor (3) p38 MAPK (4) p97 (1) Parasite (15) PARP (1) Penicillin-binding protein (PBP) (2) Phosphatase (11) Phosphodiesterase (PDE) (35) Phospholipase (18) Photosensitizer (1) PKA (5) PKC (6) PKG (3) Polo-like Kinase (PLK) (1) Poly(ADP-ribose) Glycohydrolase (PARG) (3) Potassium Channel (2) PPAR (1) Prolyl Endopeptidase (PREP) (1) Prostaglandin Receptor (11) PROTACs (4) Protease Activated Receptor (PAR) (4) Proteasome (3) PSMA (2) Ras (1) Reactive Oxygen Species (ROS) (3) Reference Standards (42) Renin (1) ROCK (1) SARS-CoV (7) Ser/Thr Protease (5) STAT (1) STING (2) TGF-beta/Smad (1) TGF-β Receptor (1) Thrombin (1) Thyroid Hormone Receptor (1) TNF Receptor (4) Toll-like Receptor (TLR) (1) Topoisomerase (7) Transmembrane Glycoprotein (1) TRP Channel (1) Wnt (2) α-synuclein (1) β-glucuronidase (1)
By Research Areas:	Cancer (118) Cardiovascular Disease (40) Endocrinology (30) Infection (92) Inflammation/Immunology (89) Metabolic Disease (152) Neurological Disease (85)
Click Chemistry:	PROTAC Synthesis (2) Azide (3)
Oligonucleotides:	Nucleotide Analogs (1) Disintegrants (1) Emulsifiers (1) mRNA (1) Polymers (5)

740

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

GMP Molecules

Targets Recommended: CETP Carboxylesterase (CES) Hormone-Sensitive Lipase (HSL)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108666

ATPγS tetralithium salt 1 Publications Verification Adenosine-5'-O-3-thiotriphosphate tetralithium salt; Adenosine 5'-[γ-thio]triphosphate tetralithium salt	Eukaryotic Initiation Factor (eIF) P2Y Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology
ATPγS (tetralithium salt) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATPγS (tetralithium salt) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATPγS (tetralithium salt) is active in ATP hydrolysis .

HY-B2220

Cellulase	Endogenous Metabolite	Others
Cellulase is an enzyme catalyzing the hydrolysis of certain linkages in cellulose and other carbohydrates.

HY-Y0850E

Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) 3 Publications Verification PVA (Mw 30000-70000, 87-90% hydrolyzed); Poly(Ethenol) (Mw 30000-70000, 87-90% hydrolyzed)	Environmental Pollutants Biochemical Assay Reagents	Cardiovascular Disease Cancer
Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 30000-70000 and hydrolytic properties. The degree of hydrolysis refers to the degree to which the acetate groups in the original polyvinyl acetate are converted into hydroxyl groups during the hydrolysis process. Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) is the hydrolysis and removal of acetate groups after the polymerization of ethylene acetate. And polyvinyl alcohol is obtained. A degree of hydrolysis of 87-90% indicates that a large part of the acetate groups have been removed, resulting in a large number of hydroxyl groups in the PVA structure. Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipients .

HY-P2767

Urease, Jack bean 1 Publications Verification	Bacterial	Others
Urease, Jack bean is derived from jack bean and Catalyzes hydrolysis of urea to carbon dioxide and ammonia. Urease, Jack bean is useful in the determination of urea in body fluids.

HY-B1064

Clindamycin phosphate 4 Publications Verification Clindamycin 2-phosphate; U-28508	Bacterial Antibiotic Parasite	Infection Cancer
Clindamycin phosphate (Clindamycin 2-phosphate) is a broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin phosphate is the proagent of Clindamycin (HY-B1455) with no antimicrobial activity in vitro but can be rapidly converted in vivo to the active parent agent, Clindamycin, by phosphatase ester hydrolysis. Clindamycin phosphate can be used for researching acne and bacterial vaginosis . Clindamycin phosphate has no cytotoxicity. Combined with platelet rich fibrin (PRF), PRF-Clindamycin phosphate enhances antimicrobial properties .

HY-Y0850M

Polyvinyl alcohol (Mw 85000-124000, 87-89% hydrolyzed) 3 Publications Verification PVA (Mw 85000-124000, 87-89% hydrolyzed); Poly(Ethenol) (Mw 85000-124000, 87-89% hydrolyzed)	Environmental Pollutants Biochemical Assay Reagents	Others
Polyvinyl alcohol (Mw 85000-124000, 87-89% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 85000-124000 and hydrolytic properties. The degree of hydrolysis refers to the degree to which the acetate groups in the original polyvinyl acetate are converted into hydroxyl groups during the hydrolysis process. Polyvinyl alcohol (Mw 85000-124000, 87-89% hydrolyzed) is the hydrolysis and removal of acetate groups after the polymerization of ethylene acetate. And polyvinyl alcohol is obtained. A degree of hydrolysis of 87-89% indicates that a large part of the acetate groups have been removed, resulting in a large number of hydroxyl groups in the PVA structure. Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipient .

HY-P2972

Sulfatase, Helix pomatia	Endogenous Metabolite	Others
Sulfatase, Helix pomatia is an enzyme that catalyzes the hydrolysis of sulfate esters. Sulfatase, Helix pomatia participates in the metabolism of various substances .

HY-N6831

Xylohexaose 1 Publications Verification	Biochemical Assay Reagents	Others
Xylohexaose is a xylooligosaccharide composed of six xylose residues. Xylohexaose can be produced by hydrolysis of beechwood xylan by AfXynA. Xylohexaose serves as a substrate for the determination of xylan hydrolysis activity .

HY-150278

Peptone from casein	Biochemical Assay Reagents	Others
Peptone from casein is derived from casein hydrolysis, casein is hydrolyzed by pancreatic enzymes and refined into peptone.

HY-W040256

Acid phosphatase, wheat ACP	Endogenous Metabolite	Metabolic Disease Cancer
Acid phosphatase, wheat (ACP) is a hydrolase enzyme found in wheat. Acid phosphatase, wheat catalyses the hydrolysis of orthophosphate monoesters under acidic conditions .

HY-P2798

Cholinesterase, Horse serum EC 3.1.1.8; BCHE, Horse serum	Cholinesterase (ChE)	Neurological Disease
Cholinesterase, Horse serum infers to acetylcholinesterase (AChE) and butyryl cholinesterase (BChE). AChE and BChE catalyze the hydrolysis of 6-MAM to morphine .

HY-B2192

Amylase	Amylases	Metabolic Disease Cancer
Amylase is an enzyme produced by pancreas and salivary glands, catalyzing the hydrolysis of starch into sugars. Amylase are broadly classified into α, β, and γ subtypes .

HY-Y0850U4

PVA (Mw 145000, 99+% hydrolyzed, ~3300 polymerization) 1 Publications Verification Polyvinyl alcohol (Mw 145000, 99+% hydrolyzed, ~3300 polymerization); Poly(Ethenol) (Mw 145000, 99+% hydrolyzed, ~3300 polymerization)	Biochemical Assay Reagents	Others
PVA (Mw 145000, 99+% hydrolyzed, ~3300 polymerization) is a polyvinyl alcohol with molecular weight of 145000 with hydrolysis properties. PVA (Mw 145000, 99+% hydrolyzed, ~3300 polymerization) is obtained by polymerizing vinyl acetate followed by hydrolysis to remove acetate groups, yielding polyvinyl alcohol .

HY-Y0850U9

PVA (Mw 67000, 87-89% hydrolyzed, ~1400 polymerization) Polyvinyl alcohol (Mw 67000, 87-89% hydrolyzed, ~1400 polymerization); Poly(Ethenol) (Mw 67000, 87-89% hydrolyzed, ~1400 polymerization)	Biochemical Assay Reagents	Others
PVA (Mw 67000, 87-89% hydrolyzed, ~1400 polymerization) is a polyvinyl alcohol with a molecular weight of 67000 and hydrolytic properties. Degree of hydrolysis refers to the conversion rate of acetate groups in the original polyvinyl acetate to hydroxyl groups; PVA (Mw 67000, 87-89% hydrolyzed, ~1400 polymerization) is obtained by hydrolyzing and removing acetate groups after the polymerization of vinyl acetate. Polyvinyl alcohol with different degrees of hydrolysis can be used to form self-crosslinked cryogels and is applied as a biological adjuvant .

HY-142689

Carboxylesterase-IN-3	Carboxylesterase (CES) Wnt	Cancer
Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC₅₀ less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease .

HY-Y1422H

Lipase,Candida cylindracea (Immobilized)	Environmental Pollutants Biochemical Assay Reagents Lipase	Others
Lipase, Candida cylindracea (Immobilized) is an immobilized hydrolase and biocatalyst with relaxed positional and substrate specificity. Lipase, Candida cylindracea (Immobilized) can target primary and secondary ester bonds to completely hydrolyze triglycerides into fatty acids and glycerol, producing only trace amounts of monoglycerides. Lipase, Candida cylindracea (Immobilized) exhibits chain specificity, with a relatively fast hydrolysis rate for oleic acid and lauric acid chains, and the slowest hydrolysis rate for stearic acid chains. Lipase, Candida cylindracea (Immobilized) shows high catalytic activity toward long-chain triglycerides under the conditions of pH 8.0 and 37°C .

HY-P2893

Creatinase, Actinobacteria Creatine amidohydrolase	Endogenous Metabolite	Others
Creatinase, Actinobacteria (Creatine amidohydrolase) is a hydrolase that catalyzes the hydrolysis of creatine into sarcosine and urea, and plays an important role in the enzymatic determination of creatinine concentration .

HY-P2973

Aspergillopepsin I Aspergillus acid protease	Proteasome	Others
Aspergillopepsin I (Aspergillus acid protease) is a metal-containing aspartic protease that catalyzes the hydrolysis of peptide bonds in soybean 7S globulin, soybean 11S globulin and various proteins, with broad specificity. Aspergillopepsin I is intended for use in wine production, where it hydrolyzes haze-forming proteins into small peptides to prevent turbidity during storage. Aspergillopepsin I can be used in studies related to soybean protein hydrolysis and wine production .

HY-P2936

Sphingomyelin phosphodiesterase, Streptomyces sp.	Phospholipase	Cardiovascular Disease Infection
Sphingomyelin phosphodiesterase, Streptomyces sp. is a sphingomyelin phosphodiesterase derived from the genus Streptomyces, which cleaves the phosphodiester bond of sphingomyelin. Sphingomyelin phosphodiesterase, Streptomyces sp. catalyzes the hydrolysis of sphingomyelin in micelles, synthetic substrates, erythrocyte ghost membranes and liposomes, as well as the hydrolysis of the substrate HNP. In the presence of Mg ²⁺or Mn ²⁺, Sphingomyelin phosphodiesterase, Streptomyces sp. induces hemolysis of bovine erythrocytes through the hydrolysis of membrane sphingomyelin .

HY-W145498

D-(+)-Cellotetraose Cellotetraose	Drug Metabolite	Others
D-(+)-Cellotetraose (Cellotetraose) is a primary hydrolysis product of cellulose .

HY-137799

NOBA	Biochemical Assay Reagents	Others
NOBA is a synthetic chromogenic substrate that can be used to detect the enzyme activity of AplTX-II. NOBA can be used in the research of phospholipid hydrolysis .

HY-B1454

Clindamycin palmitate hydrochloride	Bacterial Antibiotic	Infection
Clindamycin palmitate hydrochloride is a hydrochloride salt of the ester of clindamycin and palmitic acid and it is an antibacterial agent. Clindamycin palmitate hydrochloride is inactive in vitro, rapid in vivo hydrolysis converts this compound to the antibacterially active clindamycin .

HY-P2812A

Phospholipase D, peanut	Endogenous Metabolite	Metabolic Disease
Phospholipase D, peanut is an important signaling enzyme in mammalian cells. Phospholipase D, peanut catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA) and choline .

HY-Y1766

2,3,4-Trimethoxybenzaldehyde 2,3,4-Trihydrooxy Benzaldehyde	Biochemical Assay Reagents	Others
2,3,4-Trimethoxybenzaldehyde (2,3,4-Trihydrooxy Benzaldehyde) can be used to study the effects on tubulin-dependent GTP hydrolysis .

HY-113441

4-Hydroxy-3-methoxyphenylglycol sulfate potassium MHPG sulfate potassium	Biochemical Assay Reagents	Others
4-Hydroxy-3-methoxyphenylglycol sulfate potassium is a biosynthesis product that releases Na₂SO₄ and free ethylene glycol on acidic hydrolysis .

HY-W209628

Methyl 2-acetoxybenzoate Methyl acetylsalicylate	Drug Intermediate	Inflammation/Immunology
Methyl 2-acetoxybenzoate (Methyl acetylsalicylate) is a safe and simple anti-inflammatory aspirin prodrug. Methyl 2-acetoxybenzoate (Methyl acetylsalicylate) can be chemical or enzymatically hydrolysed to methyl 2-hydroxy benzoate. Methyl 2-acetoxybenzoate (Methyl acetylsalicylate) can be used as analgesic agent in liniments and also inflammatory diseases research .

HY-150504

ERAP2-IN-1 1 Publications Verification	Aminopeptidase	Inflammation/Immunology
ERAP2-IN-1 (compound 61) is an uncompetitive ERAP2 inhibitor. ERAP2-IN-1 specifically inhibits the ERAP2 peptide hydrolysis activity, inhibiting Arg-AMC hydrolysis with an IC₅₀ of 27 μM and model peptide hydrolysis with an IC₅₀ of 44 μM .

HY-W14549

D-(+)-Cellotriose Cellotriose	Drug Intermediate	Others
D-(+)-Cellotriose (Cellotriose) is an oligosaccharide, it is an intermediate in the enzyme hydrolysis of cellulose .

HY-126488

H-Ser-His-OH	Endogenous Metabolite	Metabolic Disease
H-Ser-His-OH is a short peptide with hydrolysis cleavage activity, an endogenous metabolite .

HY-P2966

Protein-arginine deiminase	Endogenous Metabolite	Metabolic Disease
Protein-arginine deiminase is a unique family of enzymes that catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline .

HY-P3190

Arginase, Microorganism (immobilized) L-Arginine amidinase	Endogenous Metabolite	Metabolic Disease
Arginase, Microorganism immobilized (L-Arginine amidinase) is an enzyme of the urea cycle. Arginase catalyzes the hydrolysis of L-arginine to L-ornithine and urea .

HY-W007077

(2-Amino-5-bromophenyl)(pyridin-2-yl)methanone	Drug Metabolite	Neurological Disease
(2-Amino-5-bromophenyl)(pyridin-2-yl)methanone is a precursor in the synthesis of benzodiazepines and is also a hydrolysis product of Clonazepam.

HY-142688

Carboxylesterase-IN-2	Carboxylesterase (CES) Wnt	Cancer
Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC₅₀ less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease .

HY-Y0850U8

PVA (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization) Polyvinyl alcohol (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization); Poly(Ethenol) (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization)	Biochemical Assay Reagents	Others
PVA (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization) is a polyvinyl alcohol with molecular weight of 47000 with hydrolysis properties. Hydrolysis degree refers to the conversion rate of acetic acid group hydrolysis to hydroxyl group in the original polyvinyl acetate, PVA (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization). In addition, polyvinyl alcohol is obtained from polymerization of vinyl acetate to remove acetic acid group by hydrolysis. Polyvinyl alcohol with different degrees of hydrolysis can be self-crosslinked to form frozen gels and used as biological excipients .

HY-134361

ATP-γ-S tetrasodium	P2Y Receptor Eukaryotic Initiation Factor (eIF)	Neurological Disease Metabolic Disease Inflammation/Immunology
ATP-γ-S (tetrasodium) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATP-γ-S (tetrasodium) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATP-γ-S (tetrasodium) is active in ATP hydrolysis .

HY-W714675

Glucoiberin	Endogenous Metabolite	Cancer
Glucoiberin is a glucosinolate found in Brassica oleracea. Hydrolysis products of Glucoiberin exhibit anticancer activity .

HY-156752

Cyclosiversioside F 16,25-diacetate	Drug Metabolite	Others
Cyclosiversioside F 16,25-diacetate (Compound 6), a glycoside, is an alkaline hydrolysis product of Acetyl Derivative (Compound 2) .

HY-E70571

Glycylproline dipeptidyl aminopeptidase	Aminopeptidase	Metabolic Disease
Glycylproline dipeptidyl aminopeptidase is an enzyme that catalyzes the hydrolysis of N-terminal glycylproline from glycylprolyl-β-naphthylamide and glycylproline-β-nitroanilide .

HY-D0158

ZnAF-2 DA	Biochemical Assay Reagents	Others
ZnAF-2DAavailable for testing Zn(2+)fluorescence, as Zn(2+)Probe (after esterase hydrolysis).

HY-77195

Poloxime	Polo-like Kinase (PLK)	Cancer
Poloxime, a hydrolysis product of poloxin, is a non-ATP-competitive Plk1 inhibitor, with moderate Plk1 inhibitory activity.

HY-E70556

ADP-ribose pyrophosphatase	Biochemical Assay Reagents	Metabolic Disease
ADP-ribose pyrophosphatase is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose 5-phosphate .

HY-N12146

Spinosyn D 17-pseudoaglycone	Parasite	Infection
Spinosyn D 17-pseudoaglycone is a hydrolysis product of the minor insecticide component Spinosyn D (HY-125326) .

HY-E70409

Diacetinase, bacillus subtilis	Endogenous Metabolite	Metabolic Disease
Diacetinase, Bacillus subtilis is a member of the esterase family and is responsible for catalyzing the hydrolysis of diacetin. This enzyme is used in the measurement of lipase activity .

HY-B1064A

Clindamycin phosphate hydrochloride Clindamycin 2-phosphate hydrochloride; U-28508 hydrochloride	Bacterial Antibiotic Parasite	Infection Cancer
Clindamycin phosphate (Clindamycin 2-phosphate) hydrochloride is a broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin phosphate hydrochloride is the proagent of Clindamycin (HY-B1455) with no antimicrobial activity in vitro but can be rapidly converted in vivo to the active parent agent, Clindamycin, by phosphatase ester hydrolysis. Clindamycin phosphate hydrochloride can be used for researching acne and bacterial vaginosis .

HY-153398

Enpp-1-IN-17	Phosphodiesterase (PDE)	Infection Cancer
Enpp-1-IN-17 (example 274) is a potent ENPP1 inhibitor, with the inhibition constants (Ki values) toward cGAMP and ATP hydrolysis of 100 nM-1 μM and > 1 μM, respectively. The selectivity ratio for inhibition of cGAMP hydrolysis versus ATP hydrolysis is >6.4 .

HY-131995

O-Arachidonoyl glycidol	Cannabinoid Receptor	Metabolic Disease
O-Arachidonoyl glycidol (compound 1) is a 2-arachidonoylglycerol (2-AG) analog. O-Arachidonoyl glycidol inhibits cytosolic 2-oleoylglycerol (2-OG) hydrolysis with an IC₅₀ value of 4.5 µM. O-Arachidonoyl glycidol blocks 2-OG hydrolysis in membrane fractions and anandamide hydrolysis with IC₅₀s of 19, 12 µM, respectively .

HY-P2769

Agarase	Glycosidase	Metabolic Disease
Agarase is a glycosidase that catalyzes the hydrolysis of agar into oligosaccharides .

HY-W742940

O-Arachidonoyl glycidol-d5	Isotope-Labeled Compounds Cannabinoid Receptor	Metabolic Disease
O-Arachidonoyl glycidol-d₅ is the deuterium labeled O-Arachidonoyl glycidol (HY-131995). O-Arachidonoyl glycidol (compound 1) is a 2-arachidonoylglycerol (2-AG) analog. O-Arachidonoyl glycidol inhibits cytosolic 2-oleoylglycerol (2-OG) hydrolysis with an IC₅₀ value of 4.5 μM. O-Arachidonoyl glycidol blocks 2-OG hydrolysis in membrane fractions and anandamide hydrolysis with IC₅₀s of 19, 12 μM, respectively .

HY-19602

Cedefingol	Endogenous Metabolite	Cancer
Cedefingol is an antitumor compound with α-glucosidase inhibitory activity. Cedefingol was identified together with other compounds in fermented dark tea samples. The biotransformation of cedefingol is related to enzymatic hydrolysis, hydrolysis and biosynthesis. Cedefingol exhibited different bioactivities in samples with different fermentation times. The antioxidant properties of cedefingol showed certain activity in the DPPH model .

HY-E70017

Peptidase, microorganism Erepsin; Peptidase (IMPa)	Others	Others
Peptidase (IMPa) (Erepsin) is catalytically active enzyme that cleaves peptide bonds in proteins and peptides by hydrolysis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B2220

Cellulase	Structural Classification Natural Products Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Source Classification	Endogenous Metabolite
Cellulase is an enzyme catalyzing the hydrolysis of certain linkages in cellulose and other carbohydrates.

HY-113407A

D-Fructose-6-phosphate disodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite FBPase
D-Fructose 6-phosphate disodium is an endogenous metabolite. D-Fructose 6-phosphate disodium can be obtained by hydrolysis of Fructose-1,6-bisphosphatase (FBPase). D-Fructose-6-phosphate disodium is a sugar intermediate in the glycolysis pathway and the pentose phosphate pathway. D-Fructose-6-phosphate disodium can be used to detect glucosamine-6-phosphate synthase and TAL activities. D-Fructose 6-phosphate disodium can be used to study Lewy body dementia .

HY-P2818

Alkaline phosphatase, Bovine intestine 1 Publications Verification Apase	Structural Classification Natural Products Animals Classification of Application Fields Metabolic Disease Disease Research Fields Source Classification	Endogenous Metabolite Phosphatase Glutathione Peroxidase Bacterial
Alkaline phosphatase, Bovine intestine (Apase) is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Bovine intestine reduces myeloperoxidase activity and bacterial translocation. Alkaline phosphatase, Bovine intestine improves survival rate of mice infected with E. coli. Alkaline phosphatase, Bovine intestine improves TNBS-induced colon inflammation .

HY-B0442

Vardenafil 5 Publications Verification	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Phosphodiesterase (PDE) Endogenous Metabolite
Vardenafil is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC₅₀ of 0.7 nM. Vardenafil shows inhibitory towards PDE1, PDE6 with IC₅₀s of 180 nM, and 11 nM, while IC₅₀s are >1000 nM for PDE3 and PDE4 . Vardenafil competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels . Vardenafil can be used for the research of erectile dysfunction, hepatitis, diabetes ^[1]-[6].

HY-B2193

α-Amylase 2 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Source Classification	Environmental Pollutants Amylases
α-Amylase is a hydrolase enzyme that catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose.

HY-18252

Avanafil 1 Publications Verification TA1790	Cardiovascular Disease Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Phosphodiesterase (PDE) NO Synthase Endogenous Metabolite
Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC₅₀ values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis .

HY-129217

Naringinase 2 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Source Classification	Glycosidase
Naringinase, a hydrolytic enzymatic complex, possesses the activity of both α-L-rhamnosidase and β-D-glucosidase. Naringinase has wide occurrence in nature. Naringinase can be used in the biotransformation of steroids, antibiotics, and mainly on glycosides hydrolysis .

HY-B0442A

Vardenafil hydrochloride 5 Publications Verification	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Phosphodiesterase (PDE) Endogenous Metabolite
Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC₅₀ of 0.7 nM. Vardenafil hydrochloride shows inhibitory towards PDE1, PDE6 with IC₅₀s of 180 nM, and 11 nM, while IC₅₀s are >1000 nM for PDE3 and PDE4 . Vardenafil hydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels . Vardenafil hydrochloride can be used for the research of erectile dysfunction, hepatitis, diabetes ^[1]-[6].

HY-N3018

Isomaltose 6-O-α-D-Glucopyranosyl-D-glucose; D-Isomaltose	Structural Classification Human Gut Microbiota Metabolites Polysaccharides Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Source Classification	Endogenous Metabolite Parasite
Isomaltose (6-O-α-D-Glucopyranosyl-D-glucose) is a glucose disaccharide. Isomaltose induces G-CSF secretion via heat-induced oxidative polymerization of glucose groups into high-molecular-weight compounds. Isomaltose modulates cecal bacterial cluster structure in mice. Isomaltose exhibits low glycemic index, slow hydrolysis, and prebiotic properties. Isomaltose reduces in vivo Cryptosporidium parvum colonization in neonatal mice. Isomaltose can be used for the research of Cryptosporidium parvum infection .

HY-N6831

Xylohexaose 1 Publications Verification	Structural Classification Polysaccharides Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Saccharides Source Classification	Biochemical Assay Reagents
Xylohexaose is a xylooligosaccharide composed of six xylose residues. Xylohexaose can be produced by hydrolysis of beechwood xylan by AfXynA. Xylohexaose serves as a substrate for the determination of xylan hydrolysis activity .

HY-W040256

Acid phosphatase, wheat ACP	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Acid phosphatase, wheat (ACP) is a hydrolase enzyme found in wheat. Acid phosphatase, wheat catalyses the hydrolysis of orthophosphate monoesters under acidic conditions .

HY-B2192

Amylase	Natural Products Microorganisms other families Animals Classification of Application Fields Metabolic Disease Plants Disease Research Fields Source Classification	Amylases
Amylase is an enzyme produced by pancreas and salivary glands, catalyzing the hydrolysis of starch into sugars. Amylase are broadly classified into α, β, and γ subtypes .

HY-137824

4-Methylumbelliferyl-β-D-xylopyranoside 4-Methylumbelliferyl-β-D-xyloside	Structural Classification Animals Coumarins Phenylpropanoids Source Classification	Biochemical Assay Reagents
4-Methylumbelliferyl-β-D-xylopyranoside (4-Methylumbelliferyl-β-D-xyloside) is an enzymatically hydrolyzable β-D-xylopyranoside substrate. The enzymatic hydrolysis of 4-Methylumbelliferyl-β-D-xylopyranoside is mediated by the stereochemistry-retaining β-D-xylosidase GSXynB2 via a two-step catalytic process (xylosylation followed by dexylosidation). 4-Methylumbelliferyl-β-D-xylopyranoside serves as a substrate for the β-xylosidase of Trichoderma reesei QM 9414, and its enzymatic hydrolysis process is limited by the dexylosidation step.

HY-B0442B

Vardenafil hydrochloride trihydrate 5 Publications Verification	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Endogenous Metabolite Phosphodiesterase (PDE)
Vardenafil hydrochloride trihydrate is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC₅₀ of 0.7 nM. Vardenafil hydrochloride trihydrate shows inhibitory towards PDE1, PDE6 with IC₅₀s of 180 nM, and 11 nM, while IC₅₀s are >1000 nM for PDE3 and PDE4 . Vardenafil hydrochloride trihydrate competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels . Vardenafil hydrochloride trihydrate can be used for the research of erectile dysfunction, hepatitis, diabetes ^[1]-[6].

HY-N0757

8-O-Acetylharpagide 1 Publications Verification	Infection Structural Classification other families Iridoids Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Akt Bcl-2 Family Apoptosis Adrenergic Receptor
8-O-Acetylharpagide is an orally active iridoid glycoside compound. 8-O-Acetylharpagide exhibits anti-aging activity at low doses and anticancer activity at high doses. 8-O-Acetylharpagide induces late-stage apoptosis and necrosis-like death in cancer cells, and downregulates anti-apoptotic proteins such as Akt, p-Akt and Bcl-2. 8-O-Acetylharpagide is mainly metabolized in rats via demethylation, hydrolysis and glucuronidation, and its active metabolites downregulate the AKT/NF-κB/MMP9 signaling axis. 8-O-Acetylharpagide exerts vasoconstrictive effects by activating vascular α-adrenoceptor .

HY-N6667

Glucovanillin	Vanilla planifolia Classification of Application Fields Ketones, Aldehydes, Acids Orchidaceae Other Diseases Plants Disease Research Fields Source Classification	Lipase
Glucovanillin, found in vanilla, is a potential lipase inhibitor. Glucovanillin can be converted into vanillin through an enzyme-coupled process involving cell wall degradation and glucovanillin hydrolysis .

HY-N0872

Isosteviol (-)-Isosteviol; iso-Steviol	Structural Classification other families Classification of Application Fields Terpenoids Diterpenoids Plants Disease Research Fields Source Classification Cancer	Interleukin Related DNA/RNA Synthesis Reactive Oxygen Species (ROS) Topoisomerase
Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

HY-N6808

Rebaudioside B	Trifolium hybridum L. other families Classification of Application Fields Terpenoids Other Diseases Diterpenoids Plants Compositae Disease Research Fields Source Classification	Others
Rebaudioside B is the minor constituent isolated from the leaves of Stevia rebaudiana Bertoni. Rebaudioside B tastes about 150 times sweeter than sucrose. Rebaudioside B can hydrolysis to steviol .

HY-N6675

Gardenia yellow	Structural Classification Natural Products Neurological Disease Classification of Application Fields Lridaceae Plants Crocus sativus L. Disease Research Fields Source Classification Cancer	Amylases Glycosidase
Gardenia yellow is a competitive inhibitor of α-Amylase (HY-B2193) and α-glucosidase. Gardenia yellow can bind to the catalytic sites of α-Amylase and α-glucosidase, inhibit starch digestion, and significantly increase the contents of resistant starch and slowly digestible starch in starch-based systems. Gardenia yellow reduces the glycemic index and hydrolysis index. Gardenia yellow can be used in diabetes-related research .

HY-113407

D-Fructose-6-phosphate	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite FBPase
D-Fructose 6-phosphate is an endogenous metabolite. D-Fructose 6-phosphate can be obtained by hydrolysis of Fructose-1,6-bisphosphatase (FBPase). D-Fructose-6-phosphate is a sugar intermediate in the glycolysis pathway and the pentose phosphate pathway. D-Fructose-6-phosphate can be used to detect glucosamine-6-phosphate synthase and TAL activities. D-Fructose 6-phosphate can be used to study Lewy body dementia .

HY-N10455

24-Epicastasterone 2 Publications Verification 24-epi-Castasterone	Structural Classification Natural Products Microorganisms Classification of Application Fields Other Diseases Brassinolide Phytohormone Disease Research Fields Source Classification Agricultural Research	Drug Derivative
24-Epicastasterone (24-epi-Castasterone) is a bioactive brassinosteroid and a ligand of ABCB1 and ABCB19 in Arabidopsis thaliana. 24-Epicastasterone stimulates the ATPase activity of ABCB19 and the ATP hydrolysis activity of ABCB1, which drive the efflux of substances from plant cells. 24-Epicastasterone increases the activities of catalase and guaiacol peroxidase in the roots of wheat seedlings. 24-Epicastasterone alleviates heat-induced lipid peroxidation through a ROS-dependent mechanism and enhances the heat tolerance of common wheat seedlings .

HY-P2159

Dynorphin A (1-8)	Structural Classification Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Opioid Receptor Endogenous Metabolite
Dynorphin A (1-8) is a ligand with preference for the κ-opioid receptor, and its IC₅₀ value against human placental κ-opioid receptor is 330 nM. Dynorphin A (1-8) mediates neuroprotective effects by inhibiting oxidative stress, suppressing apoptosis, and competitively displacing the binding of κ partial agonists. Dynorphin A (1-8) is the dominant opioid peptide in human placental villi and tissue extracts; it undergoes rapid hydrolysis and can enter the central nervous system via intranasal administration. Dynorphin A (1-8) can be used in studies related to ischemic stroke .

HY-W010378

D-Asparagine H-D-Asn-OH	Structural Classification Classification of Application Fields Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
D-Asparagine (H-D-Asn-OH) acts as a competitive inhibitor of L-asparagine hydrolysis, with a K_i value of 0.24 mM. D-Asparagine serves as a nitrogen source for yeast strains. D-Asparagine is a good substrate for external yeast asparaginase but a poor substrate for internal yeast asparaginase .

HY-129099A

N-Desmethyltamoxifen hydrochloride	Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite
N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-N2512

1-Monomyristin 1 Publications Verification	Infection Structural Classification Serenoa repens Classification of Application Fields Palmae Plants Disease Research Fields Steroids	Environmental Pollutants Endogenous Metabolite FAAH Autophagy Bacterial Fungal
1-Monomyristin acts as an insecticide, enzyme inhibitor, antibacterial and antifungal agent, with an IC₅₀ of 18 μM against rat FAAH and an IC₅₀ of 32 μM against rat MAGL. 1-Monomyristin inhibits 2-oleoylglycerol hydrolysis via MAGL. 1-Monomyristin suppresses the growth of Staphylococcus aureus, Aggregatibacter actinomycetemcomitans and Candida albicans. 1-Monomyristin is lethal to brine shrimp . 1-Monomyristin exhibits marginal cytotoxicity against prostate cancer cells. 1-Monomyristin is applicable to research related to bacterial infections, fungal infections, renal cancer, prostate adenocarcinoma and pancreatic cancer .

HY-103249

Reutericyclin Reutericycline	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial
Reutericyclin (Reutericycline) is an orally active antibacterial and anti-obesity agent that selectively inhibits Gram-positive bacteria. By selectively dissipating transmembrane potential, Reutericyclin exerts non-lytic bactericidal or bacteriostatic activity against pathogens such as Clostridium difficile and Staphylococcus aureus, and rapidly kills vegetative cells and spores of Clostridium difficile. Reutericyclin possesses favorable properties including resistance to enzymatic hydrolysis, iron-chelating function, and poor absorption by colonic epithelium. Reutericyclin not only eradicates staphylococcal biofilms and inhibits drug-resistant strains, but also counteracts Risperidone (HY-11018)-induced weight gain by inducing changes in gut microbiota composition and restoring energy utilization efficiency. Reutericyclin can be used in research related to Clostridium difficile infection, Risperidone-induced weight gain, and staphylococcal superficial skin infections .

HY-W145498

D-(+)-Cellotetraose Cellotetraose	Structural Classification Polysaccharides Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Saccharides Source Classification	Drug Metabolite
D-(+)-Cellotetraose (Cellotetraose) is a primary hydrolysis product of cellulose .

HY-N3474

Isolicoflavonol	Flavonols Flavonoids other families Classification of Application Fields Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Carboxylesterase (CES)
Isolicoflavonol potently inhibits hCES2A (Human carboxylesterase 2)-mediated fluorescein diacetate hydrolysis in a reversible and mixed inhibition manner, with Ki values less than 1.0 μM .

HY-N10348

Progoitrin	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Glucosinolates Plants Brassica napus var. napobrassica (L.) Rchb. Brassicaceae Disease Research Fields Endocrinology Source Classification	Others Drug Derivative
Progoitrin is a sulfur-containing glucosinolate, as well as a naturally occurring orally active thioglycoside. Progoitrin acts as a hepatotoxin and antithyroid agent. Progoitrin is quantitatively converted to goitrin in vivo, including via a gastrointestinal hydrolysis pathway that does not require exogenous myrosinase, thereby blocking the organification of iodine in the thyroid gland and inhibiting the uptake and accumulation of radioactive iodine. Progoitrin can be used in studies related to Graves' disease .

HY-W14549

D-(+)-Cellotriose Cellotriose	Structural Classification Polysaccharides Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Saccharides Source Classification	Drug Intermediate
D-(+)-Cellotriose (Cellotriose) is an oligosaccharide, it is an intermediate in the enzyme hydrolysis of cellulose .

HY-126488

H-Ser-His-OH	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
H-Ser-His-OH is a short peptide with hydrolysis cleavage activity, an endogenous metabolite .

HY-129099

N-Desmethyltamoxifen	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite
N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-135000

Decarbamoylsaxitoxin DcSTX; DecarbamoylSTX	Structural Classification Natural Products Microorganisms Source Classification	Endogenous Metabolite Drug Metabolite
Decarbamoylsaxitoxin is a sodium channel inhibitor that blocks the influx of sodium ions through the membranes of excitable nerves and skeletal muscle cells, thereby preventing the formation of action potentials. Decarbamoylsaxitoxin is an acidic hydrolysis product of saxitoxin, and its toxic effects on mice are identical to those of saxitoxin. Decarbamoylsaxitoxin inhibits veratridine- and ouabain-induced swelling and lysis of mouse neuroblastoma cells by blocking Na ⁺ channels. Decarbamoylsaxitoxin can be used in studies related to paralytic shellfish poisoning .

HY-W714675

Glucoiberin	Structural Classification Iberis amara L. Plants Brassicaceae Saccharides Monosaccharides Source Classification	Endogenous Metabolite
Glucoiberin is a glucosinolate found in Brassica oleracea. Hydrolysis products of Glucoiberin exhibit anticancer activity .

HY-N6667R

Glucovanillin (Standard)	Structural Classification Vanilla planifolia Ketones, Aldehydes, Acids Orchidaceae Plants Source Classification	Reference Standards Lipase
Glucovanillin, found in vanilla, is a potential lipase inhibitor. Glucovanillin can be converted into vanillin through an enzyme-coupled process involving cell wall degradation and glucovanillin hydrolysis .

HY-N6730

Hydrolyzed Fumonisin B1 Aminopentol	Natural Products Microorganisms Source Classification	Apoptosis
Hydrolyzed Fumonisin B1 (Aminopentol) is the backbone and main hydrolysis product of the mycotoxin Fumonisin B1 (HY-N6719). Hydrolyzed Fumonisin B1 can weakly inhibit ceramide synthase .

HY-N8326

Maltononaose	Structural Classification Polysaccharides Microorganisms Saccharides Source Classification	Others
Maltononaose is a linear oligosaccharide consisting of 9 glucose units linked by alpha-1, 4-glucoside bonds. Maltononaose is used as a substrate to study the subsites affinity of glucoamylase. Maltononaose can be used to determine the activity of amylase and to optimize the process of starch hydrolysis .

HY-13906

Largazole (+)-Largazole	Structural Classification Natural Products Microorganisms Source Classification	HDAC
Largazole ((+)-Largazole) is a potent, selective, orally active and brain-penetrant class I HDAC inhibitor found in marine cyanobacteria. Largazole shows an IC₅₀ of 0.07 nM for HDAC2. Largazole releases its active form Largazole thiol (HY-170890) after hydrolysis. Largazole has a strong inhibitory effect on SF-268, SF-295 and SH-SY5Y cells, with IC₅₀ values of 62, 68 and 102 nM respectively Largazole can upregulate the tumor suppressor gene Pax6 to inhibit the proliferation, invasion and colony formation of glioblastoma cells. Largazole can significantly upregulated brain-derived neurotrophic factor BDNF, neuronal transcription factor Pax6, and μ-opioid receptor gene Oprm1. Largazole exerts antitumor and neuroprotective effects. Largazole can be used for researches of Glioblastoma and Alzheimer’s disease .

HY-N12146

Spinosyn D 17-pseudoaglycone	Natural Products Microorganisms Source Classification	Parasite
Spinosyn D 17-pseudoaglycone is a hydrolysis product of the minor insecticide component Spinosyn D (HY-125326) .

HY-N3921

Gancaonin I	Flavonoids Classification of Application Fields Leguminosae Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Isoflavones Source Classification Cancer	Carboxylesterase (CES)
Gancaonin I, an Isoflavone, exhibits moderate inhibition on human carboxylesterase 2 (hCES2A) with IC₅₀ of 1.72 μM. Gancaonin I inhibits hCES2A-mediated fluorescein diacetate (FD) hydrolysis .

HY-N2512R

1-Monomyristin (Standard)	Structural Classification Serenoa repens Palmae Plants Steroids	Reference Standards FAAH Bacterial Fungal Endogenous Metabolite Autophagy
1-Monomyristin, extracted from Serenoa repens, inhibits the hydrolysis of 2-oleoylglycerol (IC50=32 μM) and fatty acid amide hydrolase (FAAH) activity (IC50=18 μM). 1-Monomyristin shows antibacterial activity against Staphylococcus aureus and Aggregatibacter actinomycetemcomitans and also antifungal activity against Candida albicans .

HY-W747907

4-Pyridoxolactone β-Pyracin	Structural Classification Natural Products Endogenous metabolite Source Classification	Endogenous Metabolite
4-Pyridoxolactone (β-Pyracin) is a critical substrate in vitamin B6 degradation pathway I, primarily involved in the vitamin B6 metabolic process mediated by soil microorganisms. 4-Pyridoxolactone serves as the specific substrate for 4-pyridoxolactonase, undergoing a zinc-dependent lactone-ring hydrolysis reaction catalyzed by this enzyme to generate 4-pyridoxic acid (4PA) .

HY-165424

NIR-BG2	Alkaloids Other Alkaloids Cananga odorata Plants Annonaceae Indole Alkaloids Source Classification	Fluorescent Dye Glycosidase
NIR-BG2 is a near-infrared fluorescent probe targeting senescence-associated β-galactosidase (SA-β-Gal). NIR-BG2 is activated by SA-β-Gal and undergoes hydrolysis to release electrophilic quinone methide that covalently binds to surrounding proteins for in situ labeling, with a 16-fold enhancement of fluorescence signal at 709 nm . NIR-BG2 is promising for research of vivo imaging of cellular senescence .

HY-18252A

Avanafil dibenzenesulfonate TA1790 dibenzenesulfonate	Cardiovascular Disease Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Phosphodiesterase (PDE) NO Synthase Endogenous Metabolite
Avanafil (TA-1790) dibenzenesulfonate is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC₅₀ values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil dibenzenesulfonate activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil dibenzenesulfonate inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil dibenzenesulfonate can be used for the research of erectile dysfunction and osteoporosis .

HY-167885

SN-35210 free base	Flavonoids Labiatae Cynara scolymus L. Plants Source Classification	iGluR
SN-35210 free base, an ester analogue, is designed for rapid offset via esterase-mediated hydrolysis .

HY-N8246

2',3'-cUMP sodium Uridine-2', 3'-cyclic monophosphate sodium salt	Natural Products Microorganisms Source Classification	Others
2',3'-cUMP sodium (Uridine-2', 3'-cyclic monophosphate sodium salt) is a competitive inhibitor of dip-nitrophenyl diphosphate hydrolysis .

HY-N13105

Camelliagenin A 16-tiglate	Triterpenes Terpenoids Sapindaceae Plants Harpullia cupanioides Roxb. Source Classification	Others
Camelliagenin A 16-tiglate (compound 6) is a camellia saponin isolated from the acid hydrolysis product of Harpullia cupanioides Roxb root bark saponin .

HY-N6731

Hydrolyzed Fumonisin B2	Infection Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Others
Hydrolyzed Fumonisin B2 (HFB2) is a hydrolysis product of fumonisins (HF), which retains biological activity. Hydrolyzed Fumonisin B2 (HFB2) exhibits phytotoxicity .

HY-N15358

15:0-18:1 DG	Structural Classification Endogenous metabolite Lipid Source Classification	Drug Metabolite
15:0-18:1 DG is a type of diacylglycerol (DAG). 15:0-18:1 DG can be produced by hydrolysis of triacylglycerol (TAG) in butter fat. 15:0-18:1 DG is promising for research of obesity, cardiovascular diseases, and dietary interventions .

HY-N0872R

Isosteviol (Standard) (-)-Isosteviol (Standard); iso-Steviol (Standard)	Structural Classification other families Terpenoids Diterpenoids Plants Source Classification	Interleukin Related Reference Standards Reactive Oxygen Species (ROS) Topoisomerase
Isosteviol (Standard) is the analytical standard of Isosteviol. This product is intended for research and analytical applications. Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

Cat. No.	Product Name	Chemical Structure

HY-18569S

3-Indoleacetic acid-d5 2 Publications Verification
3-Indoleacetic acid-d₅ is the deuterium labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid-d₅ can be used as internal standard for assay of IAA releases by alkaline hydrolysis of ester and amide conjugates .

HY-B0593S

Ceftazidime-d5
Ceftazidime-d₅ (GR20263-d₅) is the deuterium labeled Ceftazidime (HY-B0593). Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .

HY-B0442AS

Vardenafil-d5 hydrochloride

Vardenafil-d₅ hydrochloride is deuterated labeled Vardenafil hydrochloride (HY-B0442A). Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC₅₀ of 0.7 nM. Vardenafil hydrochloride shows inhibitory towards PDE1, PDE6 with IC₅₀s of 180 nM, and 11 nM, while IC₅₀s are >1000 nM for PDE3 and PDE4 . Vardenafil hydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels . Vardenafil hydrochloride can be used for the research of erectile dysfunction, hepatitis, diabetes ^[1]-[6].

HY-12769S1

Mebeverine acid-d5 hydrochloride

Mebeverine acid-d₅ (Mebeverine metabolite Mebeverine acid-d₅) hydrochloride is deuterium labeled Mebeverine acid hydrochloride. Mebeverine acid hydrochloride is a secondary metabolite of the intestinal antispasmodic agent Mebeverine (HY-A0078). Mebeverine acid hydrochloride is generated by the hydrolysis of Mebeverine in the body and is considered a key circulating metabolite. Mebeverine acid hydrochloride is an important marker for oral Mebeverine.

HY-137522S

Zidovudine O-β-D-glucuronide-d3 sodium

Zidovudine O-β-D-glucuronide-d₃ sodium (3'-Azido-3'-deoxythymidine β-D-glucuronide-d₃ sodium) is a deuterium labeled Zidovudine O-β-D-glucuronide sodium (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .

HY-W742940

O-Arachidonoyl glycidol-d5

O-Arachidonoyl glycidol-d₅ is the deuterium labeled O-Arachidonoyl glycidol (HY-131995). O-Arachidonoyl glycidol (compound 1) is a 2-arachidonoylglycerol (2-AG) analog. O-Arachidonoyl glycidol inhibits cytosolic 2-oleoylglycerol (2-OG) hydrolysis with an IC₅₀ value of 4.5 μM. O-Arachidonoyl glycidol blocks 2-OG hydrolysis in membrane fractions and anandamide hydrolysis with IC₅₀s of 19, 12 μM, respectively .

HY-18253S

Udenafil-d7
Udenafil-d₇ is the deuterium labeled Udenafil. Udenafil (DA8159) is a potent, selective and orally active phosphodiesterase type 5 (PDE5) inhibitor. Udenafil also inhibits cGMP hydrolysis and can be used for erectile dysfunction research .

HY-12769S

Mebeverine acid-d5

Mebeverine acid-d₅ (Mebeverine metabolite Mebeverine acid-d₅) is the deuterium labeled Mebeverine Acid (HY-12769). Mebeverine acid is a secondary metabolite of the intestinal antispasmodic agent Mebeverine (HY-A0078). Mebeverine acid is generated by the hydrolysis of Mebeverine in the body and is considered a key circulating metabolite. Mebeverine acid is an important marker for oral Mebeverine.

HY-B0442S

Vardenafil-d5

Vardenafil-d₅ is deuterium labeled Vardenafil. Vardenafil is a selective, orally active, potent inhibitor of phosphodiesterase-5 (PDE5), with an IC₅₀ of 0.7 nM. Vardenafil shows selectivity over PDE1 (180 nM), PDE6 (11 nM), PDE2, PDE3, and PDE4 (>1000 nM). Vardenafil competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil can be used for the research of erectile dysfunction .

HY-146925S

15:0 Lyso PC-d5

15:0 Lyso PC-d₅ is deuterium labeled 15:0 Lyso PC (HY-W329357). 15:0 Lyso PC is a lysophosphatidylcholine (Lyso PC), a product of phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine (PC) and is involved in cell membrane remodeling and inflammatory signaling. 15:0 Lyso PC demonstrates significant lipid metabolism disturbances in the serum of patients with ischemic heart disease (IHD) and ischemic cardiomyopathy (ICM). 15:0 Lyso PC can be used as a lipid biomarker for cardiovascular disease.

HY-B0689S1

Indinavir-13C4,15N

Indinavir- ¹³C₄, ¹⁵N (MK-639 (free base)- ¹³C₄, ¹⁵N) is ¹³C and ¹⁵N labeled Indinavir. Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a K_i of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CL ^pro inhibitor .

HY-18252S3

Avanafil-13C5

Avanafil- ¹³C₅ (TA1790- ¹³C₅) is ¹³C labeled Avanafil. Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC₅₀ values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis .

HY-18252S1

Avanafil-13C5,15N,d2

Avanafil- ¹³C₅, ¹⁵N,d₂ is ¹⁵N and deuterated labeled Avanafil (HY-18252). Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC₅₀ values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis .

HY-B1120S

Temephos-d12

Temephos-d₁₂ is the deuterium labeled Temephos. Temephos (Temefos) is an orally active, blood-brain barrier-permeable organophosphate insecticide and AChE inhibitor. By irreversibly inhibiting AChE to induce cholinergic overactivation, Temephos effectively blocks larval development of Aedes aegypti (yellow fever mosquito) and Aedes albopictus (Asian tiger mosquito), and is commonly used in studies related to Dengue Virus, Zika Virus and other relevant pathogens. Temephos exhibits genotoxicity and neurodevelopmental toxicity, and may also cause liver injury, reproductive system abnormalities and cholinergic poisoning symptoms in mammals. Temephos tends to accumulate in adipose tissues and aquatic organisms, and is excreted via feces after metabolism through oxidation and hydrolysis. Note that CYP-mediated metabolic detoxification may reduce the actual larvicidal efficacy of Temephos against some mosquito species. Temephos can be used in research related to dengue fever, Zika virus disease, chikungunya and dracunculiasis .

HY-129934S

Latanoprost ethyl amide-d4

Latanoprost ethyl amide-d₄ (Lat-NEt-d₄) is deuterium labeled Latanoprost ethyl amide. Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides .

HY-W707394

NOBA-d15
NOBA-d₁₅ is the deuterium labeled NOBA (HY-137799). NOBA is a synthetic chromogenic substrate that can be used to detect the enzyme activity of AplTX-II. NOBA can be used in the research of phospholipid hydrolysis .

HY-12769S2

Mebeverine acid-d3

Mebeverine acid-d₃ (Mebeverine metabolite Mebeverine acid-d₃) is the deuterium labeled Mebeverine Acid (HY-12769). Mebeverine acid is a secondary metabolite of the intestinal antispasmodic agent Mebeverine (HY-A0078). Mebeverine acid is generated by the hydrolysis of Mebeverine in the body and is considered a key circulating metabolite. Mebeverine acid is an important marker for oral Mebeverine.

HY-W020576S

Rivastigmine metabolite-d6
Rivastigmine metabolite-d6 (NAP 226-90-d6) is a deuterated form of Rivastigmine metabolite. Rivastigmine metabolite (NAP 226-90) is a metabolite produced by the hydrolysis of Rivastigmine (HY-17368) . Rivastigmine metabolite serves as a surrogate marker to track the bioavailability, metabolic extent, and transdermal patch delivery rate of Rivastigmine .

HY-B0828S

Triazophos-d5

Triazophos-d₅ (Hostathion 40EC-d₅) is the deuterium labeled Triazophos(HY-B0828) . Triazophos, a non-systemic insecticide and acaricide that acts as an acetylcholinesterase (AChE) inhibitor, covalently and irreversibly binds to the acetylcholine binding site, thus blocking the hydrolysis of acetylcholine and leading to hyperexcitability; it is effective against a variety of soil insects and mites, including aphids, thrips, midges, beetles, Lepidoptera larvae, cutworms, and spider mites in crops such as ornamentals, cotton, rice, maize, soybeans, oil palms, olives, and coffee.

Targets Recommended: CETP Carboxylesterase (CES) Hormone-Sensitive Lipase (HSL)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70069GL

Endo S2, Streptococcus pyogenes (GMP Like)	Biochemical Assay Reagents	Infection
Endo S2, Streptococcus pyogenes (GMP Like) is Endo S2, Streptococcus pyogenes (HY-E70069) produced by using GMP like guidelines. Endo-β-N-acetylglucosaminidase (Endo S2) is a key enzyme involved in the processing of free oligosaccharides in the cytosol. Endo-β-N-acetylglucosaminidase catalyzes hydrolysis of N-linked oligosaccharides .

HY-107614G

1-Oleoyl lysophosphatidic acid sodium 1-Oleoyl-sn-glycero-3-phosphate sodium; 1-Oleoyl-LPA sodium	LPL Receptor ROCK TGF-beta/Smad TGF-β Receptor	Neurological Disease Cancer
1-Oleoyl lysophosphatidic acid sodium (GMP) is the GMP-grade form of 1-Oleoyl lysophosphatidic acid sodium (HY-107614). GMP-grade small molecules serve as auxiliary reagents in cell therapy. 1-Oleoyl lysophosphatidic acid sodium is a bioactive lipid signaling molecule. 1-Oleoyl lysophosphatidic acid sodium inhibits lysoPLD-catalyzed hydrolysis of lysophosphatidylcholine and FS-3. 1-Oleoyl lysophosphatidic acid sodium activates LPA₁ and LPA₂, thereby triggering calcium mobilization, NFATc1 translocation, Rho/ROCK activation, Smad2/3 phosphorylation and c-Fos expression. 1-Oleoyl lysophosphatidic acid sodium induces anxiety-like, depression-like and hypoactivity phenotypes, regulates osteoclast cytoskeleton and viability, reduces osteoclast bone resorptive activity, and drives mesenchymal stem cell differentiation into myofibroblast-like cells. 1-Oleoyl lysophosphatidic acid sodium stimulates the secretion of transforming growth factor-β1 and stromal cell-derived factor-1. 1-Oleoyl lysophosphatidic acid sodium is applicable to research related to anxiety, depression and ovarian cancer .

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