330808-88-3
Chemical Structure
Vardenafil hydrochloride trihydrate
- CAS No.: 330808-88-3
- Formula:C23H39ClN6O7S
- Molecular Weight:579.11
IUPAC Name: 2-(2-ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride trihydrate
InChIKey: FBCDRHDULQYRTB-UHFFFAOYSA-N
SMILES: O=C1N=C(C2=CC(S(=O)(N3CCN(CC)CC3)=O)=CC=C2OCC)NN4C1=C(C)N=C4CCC.Cl.O.O.O
Biological Activity: Vardenafil hydrochloride trihydrate is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil hydrochloride trihydrate shows inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM, while IC50s are >1000 nM for PDE3 and PDE4[1]. Vardenafil hydrochloride trihydrate competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels[2]. Vardenafil hydrochloride trihydrate can be used for the research of erectile dysfunction, hepatitis, diabetes[1]-[6].
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Vardenafil hydrochloride trihydrate | 99.58% | Vardenafil hydrochloride trihydrate is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil hydrochloride trihydrate shows inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM, while IC50s are >1000 nM for PDE3 and PDE4. Vardenafil hydrochloride trihydrate competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil hydrochloride trihydrate can be used for the research of erectile dysfunction, hepatitis, diabetes-. | ||||||||||||||||||||
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Vardenafil hydrochloride trihydrate (Standard) | ≥98% | Vardenafil (hydrochloride trihydrate) (Standard) is the analytical standard of Vardenafil (hydrochloride trihydrate). This product is intended for research and analytical applications. Vardenafil hydrochloride trihydrate is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil hydrochloride trihydrate shows inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM, while IC50s are >1000 nM for PDE3 and PDE4. Vardenafil hydrochloride trihydrate competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil hydrochloride trihydrate can be used for the research of erectile dysfunction, hepatitis, diabetes-. | ||||||||||||||||||||
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Similarity Score 0.97
HY-B0442CVardenafil dihydrochloride -
Similarity Score 0.90
HY-137300Hydroxy vardenafil -
Similarity Score 0.89
HY-W715511N-Desethyl-N-methyl vardenafil -
Similarity Score 0.85
HY-B0442ARVardenafil hydrochloride (Standard) -
Similarity Score 0.85
HY-133724Vardenafil N-oxide -
Similarity Score 0.85
HY-B0442Vardenafil -
Similarity Score 0.84
HY-129903N-Desethyl vardenafil -
Similarity Score 0.83
HY-142059PDE5-IN-4 -
Similarity Score 0.82
HY-W588234Pseudovardenafil -
Explore the MedChemAI to find more analogs
References
- [1]. Saenz de Tejada I, et al. The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil. Int J Impot Res. 2001;13(5):282-290. [Content Brief]
- [2]. Ashour AE, et al. Vardenafil dihydrochloride. Profiles Drug Subst Excip Relat Methodol. 2014;39:515-544. [Content Brief]
