Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
excitatory synaptic function
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "excitatory synaptic function" in MCE Product Catalog:
Category:
Human Gut Microbiota Metabolites Other Diseases Endogenous metabolite Disease Research Fields
Target:
Cat. No.: HY-156104
CAS No.: 2481744-33-4
Research Areas:
CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) targeting Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). Molecules such as PHOTAC can catalyze the ubiquitination and degradation of target proteins through the endogenous proteasome under specific wavelengths of light. CaMKIIα-PHOTAC reduces synaptic function under light conditions, and it attenuates the intensity of evoked field excitatory postsynaptic potentials in the mouse hippocampus in response to physiological stimuli. CaMKIIα-PHOTAC plays a critical role in maintaining long-term potentiation and memory capacity in subcellular dendritic domains .
Cat. No.: HY-175681
CAS No.: 1613270-82-8
Research Areas:
CaMKIIα ligand-1 is a photoactivatable CaMKIIα ligand that can be used for PROTAC synthesis. CaMKIIα ligand-1 serves as the target protein ligand for CaMKIIα-PHOTAC (HY-156104). CaMKIIα ligand-1 is applicable to research related to neurological diseases .
Cat. No.: HY-183101
CAS No.: 2163787-60-6
Target:
Research Areas:
AMPAR modulator-12 is a blood-brain barrier-permeable AMPAR positive allosteric modulator. AMPAR modulator-12 reduces NOX-1 expression, enhances AMPAR-mediated currents, promotes excitatory postsynaptic transmission and restores AMPAR function. AMPAR modulator-12 enhances excitatory and inhibitory synaptic transmission, reduces burst firing in the lateral habenula after withdrawal, and produces rapid and sustained antidepressant-like effects. AMPAR modulator-12 is applicable for the research of depression .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
