Search Result
Results for "
formyl
" in MedChemExpress (MCE) Product Catalog:
6
Biochemical Assay Reagents
6
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-P0224
-
|
fMLP; N-formyl-MLF
|
TNF Receptor
|
Inflammation/Immunology
|
|
N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR). N-Formyl-Met-Leu-Ph is reported to inhibit TNF-alpha secretion.
|
-
-
- HY-Y0051
-
|
2-Hydroxymethyl-5-furfural; 2-formyl-5-hydroxymethylfuran
|
Fungal
|
Others
|
|
5-Hydroxymethylfurfural (2-Hydroxymethyl-5-furfural), derived from Cornus officinalis, inhibits yeast growth and fermentation as stressors.
|
-
-
- HY-112169A
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
10-Formyltetrahydrofolic acid disodium is a form of tetrahydrofolic acid that acts as a donor of formyl groups in anabolism. 10-Formyltetrahydrofolic acid disodium can be used as a substrate for formyltransferase reactions and is involved in the biosynthesis of purines .
|
-
-
- HY-112169
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
10-Formyltetrahydrofolic acid is a form of tetrahydrofolic acid that acts as a donor of formyl groups in anabolism. 10-Formyltetrahydrofolic acid can be used as a substrate for formyltransferase reactions and is involved in the biosynthesis of purines .
|
-
-
- HY-172435
-
|
AGN-232411; AG-80308; AGN-411
|
Formyl Peptide Receptor (FPR)
|
Neurological Disease
|
|
Rezuforimod (AGN-232411; AG-80308) is an ophthalmic solution targeting the formyl peptide receptor (FPR) pathway. Rezuforimod exerts anti-inflammatory effects by targeting the formyl peptide receptor pathway. Administered topically, Rezuforimod significantly reduces the corneal conjunctival staining score and improves ocular discomfort symptoms, with no serious adverse events reported and favorable overall safety profile. Rezuforimod shows remarkable potential to serve as a novel therapeutic option for dry eye disease .
|
-
-
- HY-19574
-
-
-
- HY-P1795
-
|
|
Formyl Peptide Receptor (FPR)
|
Inflammation/Immunology
|
|
Boc-dPhe-Leu-dPhe-Leu-Phe (Boc-fLfLF) is a selective N-formyl peptide receptor1 (FPR1) antagonist. Boc-dPhe-Leu-dPhe-Leu-Phe inhibits fMIFL(HY-P0224)-induced NADPH oxidase activity. Boc-dPhe-Leu-dPhe-Leu-Phe can be used for the study of inflammation .
|
-
-
- HY-P10724
-
|
|
Formyl Peptide Receptor (FPR)
Bacterial
|
Infection
|
|
fMIFL is a formyl tetrapeptide derived from Staphylococcus aureus, and also an agonist of mouse formyl peptide receptor 1 (mFPR1). It exhibits nanomolar activity against mFPR1 and micromolar activity against mFPR2. fMIFL is applicable to studies related to bacterial infections .
|
-
-
- HY-129043
-
|
|
Drug Metabolite
|
Infection
|
|
3-Formyl rifamycin is an acid degradation product of the broad-spectrum antibiotic Rifampicin (HY-B0272). 3-Formyl rifamycin forms via acid hydrolysis of Rifampicin in an acidic environment .
|
-
-
- HY-P1117
-
MMK1
1 Publications Verification
|
Formyl Peptide Receptor (FPR)
Calcium Channel
|
Neurological Disease
Inflammation/Immunology
|
|
MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity .
|
-
-
- HY-137129
-
|
|
Dihydrofolate reductase (DHFR)
|
Cancer
|
|
10-Formyl-7,8-dihydrofolic acid is a biologically active folic acid and growth promoter. 10-Formyl-7,8-dihydrofolic acid serves as a substrate for aminoimidazolecarboxamide ribonucleotide transformylase and dihydrofolate reductase (DHFR) to support catalytic reactions (with detection wavelengths of 552 nm and 340 nm, respectively). 10-Formyl-7,8-dihydrofolic acid not only promotes the growth of leukemia cells, but also effectively reverses the growth inhibition induced by antifolate drugs under folate-deficient conditions. 10-Formyl-7,8-dihydrofolic acid can be used in the research of leukemia .
|
-
-
- HY-P10738
-
|
|
Formyl Peptide Receptor (FPR)
|
Infection
|
|
N-Formyl-MMYALF is a potent mitochondrial N-formyl peptide (mtFP) that has the activity of depleting calcium ions in the endoplasmic reticulum. N-Formyl-MMYALF can inhibit the FPR-1-mediated chemotactic response of polymorphonuclear leukocytes (PMNs) to bacterial peptides .
|
-
-
- HY-128113
-
-
-
- HY-135108
-
|
|
Neurokinin Receptor
|
Neurological Disease
|
|
QWF Peptide (Compound 4a) is a substance P antagonist with an IC50 of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC50 of 4.7 μM .
|
-
-
- HY-P1744
-
-
-
- HY-Y0051S
-
|
2-Hydroxymethyl-5-furfural-13C6; 2-formyl-5-hydroxymethylfuran-13C6
|
Isotope-Labeled Compounds
Fungal
|
Others
|
|
5-Hydroxymethylfurfural- 13C6 (2-Hydroxymethyl-5-furfural- 13C6; 2-Formyl-5-hydroxymethylfuran- 13C6) is a 13C labeled 5-Hydroxymethylfurfural (HY-Y0051). 5-Hydroxymethylfurfural (2-Hydroxymethyl-5-furfural), derived from Cornus officinalis, inhibits yeast growth and fermentation as stressors.
|
-
-
- HY-160596
-
|
5-formyl-deoxycytidine lithium
|
DNA/RNA Synthesis
|
Others
|
|
5-Formyl-dCTP (5-Formyl-deoxycytidine) lithium is a DCTPP1 substrate. 5-Formyl-dCTP lithium acts as a mutagen/epigenetic disruptor via DNA polymerase incorporation, mutagenic mispairings, and disturbed epigenetic programming. 5-Formyl-dCTP lithium can be used for research on genotoxicity .
|
-
-
- HY-W341499
-
|
|
Endogenous Metabolite
|
Others
|
|
5-Formyl-2'-deoxyuridine is a product formed when the 5-methyl group of thymine in DNA undergoes oxidation due to exposure to gamma radiation or certain chemical agents. Serving as a biomarker of oxidative DNA damage, 5-formyl-2'-deoxyuridine is employed in investigations of DNA damage and repair mechanisms. Additionally, 5-Formyl-2'-deoxyuridine can be used in studies involving chemically crosslinking with peptides derived from the RecA protein .
|
-
-
- HY-W130965
-
|
|
Influenza Virus
Akt
|
Infection
|
|
1-Formyl-beta-carboline is an alkaloid with inhibitory activity against Newcastle disease virus (NDV). 1-Formyl-beta-carboline can effectively inhibit different genotypes of NDV with IC50 values within 10 μM, and its inhibition rate is more than 90% at a concentration of 20 μM. 1-Formyl-beta-carboline mainly exerts its effects by inhibiting the adsorption and entry processes in the NDV life cycle. 1-Formyl-beta-carboline has been identified as a novel HN inhibitor that can directly interact with the NDV HN protein and affect the adsorption of NDV. 1-Formyl-beta-carboline also inhibits the entry of NDV by inhibiting the PI3K/Akt signaling pathway rather than the ERK pathway .
|
-
-
- HY-W024271
-
|
9-formyl-8-hydroxyjulolidine
|
Fluorescent Dye
|
Cardiovascular Disease
Neurological Disease
|
|
8-Hydroxyjulolidine-9-carboxaldehyde (9-Formyl-8-hydroxyjulolidine) is a highly selective fluorescent probe for hydrogen sulfide (S 2−) and silicate (SiO3 2−). 8-Hydroxyjulolidine-9-carboxaldehyde operates via a mechanism of blocking intramolecular charge transfer (ICT), exhibiting significant fluorescence enhancement in the presence of weak acid ions. 8-Hydroxyjulolidine-9-carboxaldehyde is promising for research of fluorescence imaging of hydrogen sulfide within living cells .
|
-
-
- HY-P1591
-
-
-
- HY-103473A
-
|
Boc-Met-Leu-Phe-OH TFA
|
Formyl Peptide Receptor (FPR)
|
Inflammation/Immunology
|
|
Boc-MLF (TFA) is a peptide, used as a specific formyl peptide receptor (FPR) antagonist, also inhibits the signaling through formyl peptide receptor like 1 (FPRL1) at higher concentrations .
|
-
-
- HY-103473
-
-
-
- HY-77049
-
|
4-formyl-1-tritylimidazole
|
Biochemical Assay Reagents
|
Others
|
|
1-Trityl-1H-imidazole-4-carbaldehyde is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
-
- HY-P1118
-
-
-
- HY-P2355
-
|
BOC2; Boc-Phe-dLeu-Phe-dLeu-Phe
|
Formyl Peptide Receptor (FPR)
|
Inflammation/Immunology
|
|
BOC-FlFlF (Boc-Phe-dLeu-Phe-dLeu-Phe) is a selective FPR1 antagonist. Boc-FlFlF has an apparent dissociation constant (KD) of 230 nM as determined by the intracellular calcium mobilization assay. Boc-FlFlF can be used for the study of inflammation .
|
-
-
- HY-Y0051R
-
|
2-Hydroxymethyl-5-furfural (Standard); 2-formyl-5-hydroxymethylfuran (Standard)
|
Reference Standards
Fungal
|
Others
|
|
5-Hydroxymethylfurfural (Standard) is the analytical standard of 5-Hydroxymethylfurfural. This product is intended for research and analytical applications. 5-Hydroxymethylfurfural (2-Hydroxymethyl-5-furfural), derived from Cornus officinalis, inhibits yeast growth and fermentation as stressors.
|
-
-
- HY-W141975
-
-
-
- HY-P1756
-
-
-
- HY-20794
-
|
|
Fluorescent Dye
|
Others
|
|
8-Hydroxyjulolidine is a chromophore moiety of a fluorescent probe for the detection of weak acid ions. 8-Hydroxyjulolidine can be used to synthesize the salicylaldehyde derivative 9-formyl-8-hydroxyjulolidine, which exhibits sensitive detection ability to pH changes of hydrogen sulfide and silicate in aqueous solution .
|
-
-
- HY-120571
-
|
|
Leukotriene Receptor
Lipoxygenase
|
Cancer
|
|
L-674573 is a quinoline leukotriene synthesis inhibitor, inhibiting Calcimycin (HY-N6687)- and N-Formyl-Met-Leu-Phe (HY-P0224)-induced leukotriene production with IC50s of 100 nM and 50 nM, respectively. L-674573 selectively inhibits Calcimycin- and N-Formyl-Met-Leu-Phe-induced 5-lipoxygenase translocation .
|
-
-
- HY-143207
-
-
-
- HY-20912
-
-
-
- HY-W010099
-
|
4-Hydroxy-5-formylbenzoic acid
|
MOFs
|
Others
|
|
3-Formyl-4-hydroxybenzoic acid (4-Hydroxy-5-formylbenzoic acid) is a metal-organic framework (MOF).
|
-
-
- HY-N8152
-
-
-
- HY-CE00369
-
-
-
- HY-W754546
-
|
|
Drug Metabolite
|
Cancer
|
|
2-Formyl sunitinib (1-CHO) is a metabolite of tyrosine kinase inhibitor Sunitinib (HY-10255A). 2-Formyl sunitinib can be used for the research of cancer .
|
-
-
- HY-W142169
-
|
formyl-L-histidine
|
Aminoacyl-tRNA Synthetase
|
Others
|
|
N-Formyl-L-histidine shows binding affinity to histidyl-tRNA synthetase with a Ki value of 4.6 μM. N-Formyl-L-histidine shows a competitive inhibition against L-histidine ammonia-lyase, inhibits urocanic acid formation from L-histidine with a Ki value of 4.26 mM .
|
-
-
- HY-I0591
-
-
-
- HY-180491
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2-(3-(Azidomethyl)-2-formyl-6-methylphenoxy)acetic acid (Compound C1-4) is an azide reagent. 2-(3-(Azidomethyl)-2-formyl-6-methylphenoxy)acetic acid can be used in studies of protein fixed-point azidation .
|
-
-
- HY-P10738A
-
|
|
Formyl Peptide Receptor (FPR)
|
Infection
|
|
N-Formyl-MMYALF TFA is a mitochondrial N-formyl peptide that has the activity of depleting calcium ions in the endoplasmic reticulum. N-Formyl-MMYALF TFA can inhibit the FPR-1-mediated chemotactic response of PMNs to bacterial peptides .
|
-
-
- HY-152714
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
5-Formyl-2’-O-methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .
|
-
-
- HY-N2220
-
|
|
Others
|
Inflammation/Immunology
|
|
6-Formyl-isoophiopogonanone A is a homoisoflavonoidal extracted from Ophiopogon japonicas, with antioxidant activity .
|
-
-
- HY-W056306
-
|
|
PROTAC Linkers
|
Cancer
|
|
tert-Butyl 6-formyl-2-azaspiro[3.3]heptane-2-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
|
-
![tert-Butyl 6-formyl-2-azaspiro[3.3]heptane-2-carboxylate](//file.medchemexpress.com/product_pic/hy-w056306.gif)
-
- HY-175881
-
|
|
ADC Linker
|
Cancer
|
|
3-Formyl-L-tyrosine-oxime-Val-Cit-PAPB is an ADC linker that can be used for the synthesis of the TUB-010 drug linker (HY-175884) .
|
-
-
- HY-P1591A
-
-
-
- HY-Z8644
-
|
N-formyl-N-deacetylcolchicine
|
Microtubule/Tubulin
Apoptosis
|
Cancer
|
|
N-Deacetyl-N-formylcolchicine (N-Formyl-N-deacetylcolchicine, Compound 11) is a selective inhibitor targeting the colchicine-binding site of tubulin. N-Deacetyl-N-formylcolchicine shows antiproliferative activity against various cancer cell lines with IC50 values of 32.61-100.28 nM. N-Deacetyl-N-formylcolchicine inhibits microtubule polymerization to block cell division, induces cancer cell apoptosis and suppresses migration. N-Deacetyl-N-formylcolchicine is promising for research of cancers such as lung cancer and various solid tumors .
|
-
-
- HY-P11491
-
|
|
Formyl Peptide Receptor (FPR)
Reactive Oxygen Species (ROS)
|
Inflammation/Immunology
|
|
Ac2-26 (mouse) is the N-terminal active peptide of Annexin A1 (AnxA1). Ac2-26 (mouse) regulates the inflammatory response by modulating the formyl peptide receptor (FPR) signaling pathway. Ac2-26 (mouse) can promote the release of chemokines and inhibit the production of ROS. Ac2-26 (mouse) can be used for the research of inflammation, such as rheumatoid arthritis .
|
-
-
- HY-129043R
-
|
|
Reference Standards
Drug Metabolite
|
Infection
|
|
3-Formyl rifamycin (Standard) is the analytical standard of 3-Formyl rifamycin (HY-129043). This product is intended for research and analytical applications. 3-Formyl rifamycin is an acid degradation product of the broad-spectrum antibiotic Rifampicin (HY-B0272). 3-Formyl rifamycin forms via acid hydrolysis of Rifampicin in an acidic environment .
|
-
-
- HY-151454S
-
-
- HY-134149
-
-
- HY-W700927
-
-
- HY-N3073
-
|
Picraline, 16-de(acetoxymethyl)-16-formyl-
|
COX
Lipoxygenase
|
Others
|
|
Picralinal (Picraline, 16-de(acetoxymethyl)-16-formyl-) is a Triterpenoids product that can be isolated from the whole plants of Scilla scilloides. .
|
-
- HY-79654
-
|
|
Drug Intermediate
|
Others
|
|
5-Chloro-4-formyl-3-methyl-1-phenylpyrazole is a drug intermediate for synthesis of various active compounds.
|
-
- HY-N13828
-
|
|
Bacterial
Interleukin Related
|
Infection
Inflammation/Immunology
|
|
1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole (Compound 19) is a carbazole alkaloid that can be isolated from Murraya koenigii. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole exhibits anti-inflammatory and antimicrobial activities. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole can inhibit the production of pro-inflammatory cytokines TNF-α and IL-6 . 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole has IC50 values of 10.9 μM and 95 μM for Bacillus cereus and Staphylococcus aureus, respectively. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole can be used in the research of inflammatory and infectious diseases .
|
-
- HY-N9355
-
|
|
Others
|
Others
|
|
(+)-N-Formylnorglaucine is an aporphine alkaloid isolated from the leaves of Unonopsis stipitata. (+)-N-Formylnorglaucine contains a formyl group linked to the heterocyclic nitrogen .
|
-
- HY-N9058
-
|
|
Others
|
Others
|
|
6-Formyl-1,2,9,10-tetramethoxy-6a,7-dehydroaporphine is a Alkaloids product that can be isolated from the aerial parts of Aconitum carmichaelii. .
|
-
- HY-W009215
-
|
L-Met-L-Ala-L-Ser
|
Amino Acid Derivatives
|
Others
|
|
H-Met-Ala-Ser-OH (L-Met-L-Ala-L-Ser) is a tripeptide. H-Met-Ala-Ser-OH can act as a formyl receptor .
|
-
- HY-N10880
-
|
|
Others
|
Others
|
|
2-((1R,2R)-2-Formyl-1,3,3-trimethylcyclohexyl)-4-hydroxy-5-isopropylbenzaldehyde is a natural product .
|
-
- HY-122309
-
|
|
Antibiotic
|
Infection
|
|
A-71497 is the 3-formyl derivative of the antibiotic Tosufloxacin (HY-B1802). A-71497 can produce high plasma levels of tosufloxacin upon both oral and subcutaneous administration to mice .
|
-
- HY-P1117A
-
|
|
Formyl Peptide Receptor (FPR)
Calcium Channel
|
Neurological Disease
Inflammation/Immunology
|
|
MMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity .
|
-
- HY-I0591R
-
-
- HY-137168
-
|
|
Bacterial
|
Infection
|
|
LAB 149202F is an acylanilide antimicrobial agent that also has inhibitory effects on strains that produce formyl and phosphate resistance .
|
-
- HY-P2355A
-
|
BOC2 TFA; Boc-Phe-dLeu-Phe-dLeu-Phe TFA
|
Formyl Peptide Receptor (FPR)
|
Inflammation/Immunology
|
|
BOC-FlFlF (TFA) (Boc-Phe-dLeu-Phe-dLeu-Phe (TFA)) is a selective FPR1 antagonist. BOC-FlFlF has an apparent dissociation constant (KD) of 230 nM as determined by the intracellular calcium mobilization assay. BOC-FlFlF can be used for the study of inflammation .
|
-
- HY-P1118A
-
-
- HY-W285163S
-
|
formyl Ciprofloxacin-d8
|
Isotope-Labeled Compounds
|
Others
|
|
1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d8 is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.
|
-
- HY-180687
-
-
- HY-W112341
-
|
4-formyl-3-hydroxynaphthalene-2-carboxylic acid
|
MOFs
|
Others
|
|
4-Formyl-3-hydroxy-2-naphthoic acid (4-Formyl-3-hydroxynaphthalene-2-carboxylic acid) is a metal-organic framework (MOF).
|
-
- HY-Z0449R
-
|
|
Reference Standards
|
|
|
5-Formyl-2-hydroxybenzoic acid (Standard) is the analytical standard of 5-Formyl-2-hydroxybenzoic acid. This product is intended for research and analytical applications.
|
-
- HY-180770
-
-
- HY-Z0779
-
-
- HY-178624
-
-
- HY-W588997
-
|
|
MOFs
|
Others
|
|
5-Formyl-1,3-benzenedicarboxylic acid is a metal-organic framework (MOF).
|
-
- HY-182117
-
-
- HY-W041446R
-
|
|
Reference Standards
|
|
|
4-Formyl-N-isopropylbenzamide (Standard) is the analytical standard of 4-Formyl-N-isopropylbenzamide. This product is intended for research and analytical applications.
|
-
- HY-N8019
-
|
|
Drug Derivative
|
Others
|
|
8-Formyl-5-O-methylophiopogonanone B is a natural product that can be found in Ophiopogon japonicus?(L. f.) Ker Gawl..
|
-
- HY-178594
-
-
- HY-W091144
-
|
|
Drug Intermediate
|
Others
|
|
3-Formyl-1-(phenylsulphonyl)-1H-indole is a drug intermediate for synthesis of various active compounds.
|
-
- HY-W456357
-
|
|
MOFs
|
Others
|
|
2-Formyl-[1,1'-biphenyl]-4,4'-dicarboxylic acid is a metal-organic framework (MOF).
|
-
![2-Formyl-[1,1'-biphenyl]-4,4'-dicarboxylic acid](//file.medchemexpress.com/product_pic/hy-w456357.gif)
- HY-W112178
-
|
Sodiumsalicylaldehyde-5-sulfonatemonohydrate
|
MOFs
|
Others
|
|
Sodium3-formyl-4-hydroxybenzenesulfonate (Sodiumsalicylaldehyde-5-sulfonatemonohydrate) is a metal-organic framework (MOF).
|
-
- HY-180659
-
-
- HY-N11533
-
|
|
Others
|
Others
|
|
6-Formyl-isoophiopogonanone B is a homoisoflavonoid, which can be isolated from Ophiopogon japonicus .
|
-
- HY-W748093
-
-
- HY-W078435
-
-
- HY-W285163
-
|
formyl Ciprofloxacin
|
Drug Intermediate
|
Others
|
|
Ciprofloxacin impurity 9 (Formyl Ciprofloxacin) is an impurity of Ciprofloxacin.
|
-
- HY-W586848
-
|
|
MOFs
|
Others
|
|
2'-Formyl-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid is a metal-organic framework (MOF).
|
-
![2'-Formyl-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid](//file.medchemexpress.com/product_pic/hy-w586848.gif)
- HY-W856187
-
|
|
MOFs
|
Others
|
|
4'-Formyl-3'-hydroxy[1,1'-biphenyl]-3,5-dicarboxylic acid is a metal-organic framework (MOF).
|
-
![4'-Formyl-3'-hydroxy[1,1'-biphenyl]-3,5-dicarboxylic acid](//file.medchemexpress.com/product_pic/hy-w856187.gif)
- HY-W125431
-
|
N-formyl Trimetazidine
|
Drug Intermediate
|
Others
|
|
Trimetazidine impurity 9 (N-Formyl Trimetazidine) is an impurity of Trimetazidine.
|
-
- HY-W056566
-
|
|
PROTAC Linkers
|
Cancer
|
|
tert-Butyl 2-formyl-6-azaspiro[3.4]octane-6-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
|
-
![tert-Butyl 2-formyl-6-azaspiro[3.4]octane-6-carboxylate](//file.medchemexpress.com/product_pic/hy-w056566.gif)
- HY-132519S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Delta-Tocopherol-5-formyl-chroman-5-carboxylic acid-d3 is the deuterium labeled Delta-Tocopherol-5-formyl-chroman-5-carboxylic acid .
|
-
- HY-W456490
-
|
|
MOFs
|
Others
|
|
3'-(tert-Butyl)-5'-formyl-4'-hydroxy-[1,1'-biphenyl]-3,5-dicarboxylic acid is a metal-organic framework (MOF).
|
-
![3'-(tert-Butyl)-5'-formyl-4'-hydroxy-[1,1'-biphenyl]-3,5-dicarboxylic acid](//file.medchemexpress.com/product_pic/hy-w456490.gif)
- HY-W042154R
-
|
|
Reference Standards
|
|
|
N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide (Standard) is the analytical standard of N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide. This product is intended for research and analytical applications.
|
-
- HY-W039891
-
-
- HY-W483854
-
|
N-(2-hydroxyphenyl)methanamide
|
Endogenous Metabolite
|
Metabolic Disease
|
|
N-Formyl-2-aminophenol (N-(2-hydroxyphenyl)methanamide) is a bacterial secondary metabolite that has been found in P. chrysogenum and has antioxidant activity .
|
-
- HY-W042234R
-
|
tert-Butyl(3R,5S)-6-oxo-3,5-O-iso-propylidene-3,5-dihydroxyhexanoate (Standard)
|
Reference Standards
|
|
|
tert-Butyl [(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate (Standard) is the analytical standard of tert-Butyl [(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate (HY-W042234). This product is intended for research and analytical applications.
|
-
![tert-Butyl [(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate (Standard)](//file.medchemexpress.com/product_pic/hy-w042234r.gif)
- HY-W725077S
-
|
Methyl N-(2,6-dimethylphenyl)-N-(formyl)-DL-alaninate-d9
|
Isotope-Labeled Compounds
|
Others
|
|
Benalaxyl metabolite F4-d9 (Methyl N-(2,6-dimethylphenyl)-N-(formyl)-DL-alaninate-d9) is deuterium labeled Methyl N-(2,6-dimethylphenyl)-N-formylalaninate .
|
-
- HY-Z0450R
-
|
|
Reference Standards
|
|
|
Methyl 5-formyl-2-hydroxybenzoate (Standard) is the analytical standard of Methyl 5-formyl-2-hydroxybenzoate. This product is intended for research and analytical applications.
|
-
- HY-P11704
-
|
|
Formyl Peptide Receptor (FPR)
Bacterial
|
Neurological Disease
|
|
f-MKKFRW is a selective mouse formyl peptide receptor 3 (Fpr3) activator and bacterial MgrB-derived peptide motif. f-MKKFRW activates Fpr3 to trigger downstream signaling and calcium responses in Fpr3-expressing cells. f-MKKFRW stimulates a subset of mouse vomeronasal sensory neurons in the accessory olfactory system to evoke calcium responses. f-MKKFRW drives innate avoidance behavior in mice via nasal contact .
|
-
- HY-P991864
-
|
MDX-124
|
Formyl Peptide Receptor (FPR)
|
Cancer
|
|
Annexuzlimab is a humanised IgG1 monoclonal antibody which specifically binds to ANXA1 disrupting its interaction with formyl peptide receptors 1 and 2 (FPR1/2). Annexuzlimab arrests cell cycle progression with cancer cells accumulating in the G1 phase. Annexuzlimab targets secreted ANXA1, preventing FPR1/2 activation and reducing cancer progression. Annexuzlimab can be used for the research of triple negative breast cancer, pancreatic cancer and osteosarcoma .
|
-
- HY-125871
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Neopatulin is a redox isomer and pivotal biogenetic precursor of the potent antibiotic patulin, which is produced by numerous fungal species. Neopatulin can be synthesized through Lewis acid-catalyzed aldol reaction or 2-formyl-1,3-dithiane with 2-(tert-butyldimethylsiloxy)-4-[(tert-butyldimethylsiloxy)-methyl]furan .
|
-
- HY-W784563
-
|
|
DNA/RNA Synthesis
Phosphoramidites
|
Others
|
|
(2R,3R,4R,5R)-5-(5-(1,3-Dioxan-2-yl)-4-(4-methoxybenzamido)-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) (R)-diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
|
-
- HY-N2100
-
|
|
Reactive Oxygen Species (ROS)
|
Metabolic Disease
|
|
6'-O-beta-D-Glucosylgentiopicroside is a secoiridoid isolated from the roots of G. straminea. 6'-O-beta-D-Glucosylgentiopicroside strongly suppresses N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation .
|
-
- HY-N3464
-
|
|
Phosphodiesterase (PDE)
|
Metabolic Disease
|
|
Isopedicin potently and concentration-dependently inhibits superoxide anion (O2 U?) production in formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP)-activated cells. Isopedicin increases cAMP formation and PKA activity in FMLP-activated cells by inhibiting phosphodiesterase (PDE) activity .
|
-
- HY-157253
-
|
|
Drug Metabolite
|
Metabolic Disease
|
|
13(S)-HODE is the lipoxygenase metabolite of Linoleic acid (HY-N0729). 13(S)-HODE modulates the platelet-activating factor, leukotriene B4, and formyl-Met-Leu-Phe-induced calcium influx in human polymorphonuclear leukocytes.
|
-
- HY-116730
-
|
|
Reactive Oxygen Species (ROS)
|
Others
|
|
CHS-111 is a benzyl indazole inhibitor of superoxide anion O 2- generation. CHS-111 inhibits the cell migration, and reduces the formyl-Met-Leu-Phe- but not phorbol ester-stimulated phospholipase D activity, with the IC50 of 3.9 μM .
|
-
- HY-176403
-
-
- HY-P1121A
-
|
|
Formyl Peptide Receptor (FPR)
|
Inflammation/Immunology
|
|
WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase .
|
-
- HY-156293
-
|
|
Formyl Peptide Receptor (FPR)
Apoptosis
|
Cancer
|
|
FPR1 antagonist 1 (compound 24a) is a formyl peptide receptor 1 (FPR1) antagonist with an IC50 of 25 nM. FPR1 antagonist 1 inhibits cell growth through a combined effect on cell proliferation and apoptosis and reduces cell migration, while inducing an increase in angiogenesis .
|
-
- HY-103472
-
FPR-A14
1 Publications Verification
|
Formyl Peptide Receptor (FPR)
|
Neurological Disease
|
|
FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca 2+ mobilization and chemotaxis with EC50s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation .
|
-
- HY-156294
-
|
|
Formyl Peptide Receptor (FPR)
Apoptosis
|
Cancer
|
|
FPR1 antagonist 2 (compound 25b) is a formyl peptide receptor 1 (FPR1) antagonist with an IC50 of 70 nM. FPR1 antagonist 2 inhibits cell growth through a combined effect on cell proliferation and apoptosis and reduces cell migration, while inducing an increase in angiogenesis .
|
-
- HY-131180
-
|
LAR-1219
|
Formyl Peptide Receptor (FPR)
|
Cardiovascular Disease
|
|
BMS-986235 (LAR-1219) is a selective, orally active formyl peptide receptor 2 (FPR2) agonist, with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 has potential for the prevention of heart failure .
|
-
- HY-124071
-
|
|
Formyl Peptide Receptor (FPR)
|
Inflammation/Immunology
|
|
ACT-389949 is a first-in-class, potent and selective and agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for the treatment of inflammatory disorders .
|
-
- HY-P1119
-
|
|
Formyl Peptide Receptor (FPR)
|
Neurological Disease
|
|
WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide .
|
-
- HY-184077
-
|
|
Indoleamine 2,3-Dioxygenase (IDO)
|
Infection
|
|
IDO1-IN-35 (Compound 16) is an inhibitor of the IDO1 mutant IDO1 F164A. IDO1-IN-35 inhibits the IDO1-mediated conversion of L-tryptophan to N-formyl-L-kynurenine. IDO1-IN-35 can be used in studies of viral and bacterial infections .
|
-
- HY-P1119A
-
|
|
Formyl Peptide Receptor (FPR)
|
Neurological Disease
|
|
WRW4 TFA, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 TFA specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide .
|
-
- HY-117971
-
|
|
CXCR
Formyl Peptide Receptor (FPR)
|
Others
|
|
BVT173187 is a selective inhibitor of the neutrophil formyl peptide receptor FPR1, with activity that inhibits FPR1 activation. BVT173187 inhibits FPR1 agonist-induced activation in neutrophils, reduces adhesion molecule mobilization and superoxide anion production, and has inhibitory activity on FPR1 similar to that of earlier described peptide antagonists, but also has effects on C5aR and CXCR signaling.
|
-
- HY-P5469
-
|
|
Formyl Peptide Receptor (FPR)
|
Others
|
|
WRW4-OH is a biological active peptide. (This peptide inhibits binding of one of formyl peptide receptor-like 1 (FPRL1) agonists WKYMVm to its specific receptor. FPRL1 is an important classical chemoattractant receptor that is expressed in phagocytic cells in the peripheral blood and brain. Activation of FPRL1 is closely related to inflammatory responses in the host defense mechanism and neurodegenerative disorders.)
|
-
- HY-32813
-
|
3-Iodopyridin-2-amine
|
Biochemical Assay Reagents
|
Others
|
|
2-Amino-3-iodopyridine (3-Iodopyridin-2-amine) can be coupled with formyl derivatives under a copper-catalyzed indole synthesis method, and then constructed azide analogs through copper-mediated conjugated adducts things. The nucleophilicity of 2-Amino-3-iodopyridine is lower than that of the corresponding aniline used in the synthesis of indole, a potential obstacle for future synthesis .
|
-
- HY-110246
-
|
|
Formyl Peptide Receptor (FPR)
|
Inflammation/Immunology
|
|
Quin C1 is a highly specific and potent agonist for formyl peptide receptor 2 (FPR2/ALX). Quin-C1 significantly reduces the neutrophil and lymphocyte counts in BALF, diminishes expression of TNF-α, IL-1β, KC, and TGF-β1, and decreases collagen deposition in lung tissue. Quin C1 has the potential for the research of lung injury .
|
-
- HY-103472R
-
|
|
Reference Standards
Formyl Peptide Receptor (FPR)
|
Neurological Disease
|
|
FPR-A14 (Standard) is the analytical standard of FPR-A14 (HY-103472). This product is intended for research and analytical applications. FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca2+ mobilization and chemotaxis with EC50s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation .
|
-
- HY-101283
-
HCH6-1
5 Publications Verification
|
Formyl Peptide Receptor (FPR)
|
Inflammation/Immunology
|
|
HCH6-1 is a potent and competitive dipeptide antagonist of Formyl peptide receptor 1 (FPR1). HCH6-1 inhibits chemotaxis, superoxide anion generation, and elastase release in human neutrophils specifically activated by fMLF (an FPR1 agonist). HCH6-1 has protective effects against acute lung injury (ALI) in vivo and can be used for the research of FPR1-involved inflammatory lung diseases .
|
-
- HY-P1122
-
|
|
Formyl Peptide Receptor (FPR)
|
Infection
Inflammation/Immunology
|
|
Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952). Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.
|
-
- HY-146196
-
|
|
Bacterial
|
Infection
|
|
Anticandidal agent-1 (compound c2) is a potent and broad-spectrum anticandidal agent. Anticandidal agent-1 shows anticandidal activity against C. albicans and C. glabrata, with MIC50 values of 8.65 and 13.51 μg/mL, respectively. Anticandidal agent-1 inhibits biofilm by blocking hyphal elongation and filamentation .
|
-
- HY-N2071
-
-
- HY-130675
-
|
(±)15-hydroxyeicosapentaenoic acid; 15-OHEPA
|
Lipoxygenase
Bacterial
|
Metabolic Disease
|
|
(±)15-HEPE is a racemic mixture of the monohydroxy fatty acids 15(R)-HEPE and 15(S)-HEPE (HY-130675A). (±)15-HEPE is active against P. acnes and S. aureus (MICs = 128 and 512 mg/L, respectively). It inhibits aggregation of isolated rat neutrophils induced by the formyl peptide receptor agonist fMLP (IC50 = 4.7 µM). Bronchoalveolar lavage fluid (BALF) levels of (±)15-HEPE are increased in patients with allergic asthma or COVID-19.
|
-
- HY-P1120
-
|
WKYMVm-amide; W-Peptide
|
Formyl Peptide Receptor (FPR)
PERK
Apoptosis
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
WKYMVm is a selective formylpeptide receptor 2 (FPR2) agonist. WKYMVm has a powerful anti-inflammatory effect that can reduce lung injury and spinal cord injury. WKYMVm ameliorates obesity by regulating lipid metabolism and leptin signaling. WKYMVm is involved in the regulation of immune cells by activating FPRs. WKYMVm can promote the chemotactic migration of immune cells and inhibit the apoptosis of phagocytes. In addition, WKYMVm may play a favorable or unfavorable role in tumors, depending on the type of tumor .
|
-
- HY-N2071R
-
|
(+)-Cedrol (Standard); α-Cedrol (Standard)
|
Reference Standards
Cytochrome P450
Fungal
Apoptosis
Caspase
|
Infection
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Cedrol (Standard) is the analytical standard of Cedrol. This product is intended for research and analytical applications. Cedrol is a potent competitive inhibitor of cytochrome P-450(CYP) enzyme. Cedrol plays an anticancer role by inducing cell cycle arrest and Caspase-dependent apoptosis. Cedrol acts as a neutrophil agonist that can desensitize cells to subsequent stimulation of N-formyl peptides. Cedrol prevents neuropathic pain caused by chronic contractile injury by inhibiting oxidative stress and inflammation. In addition, Cedrol has antibacterial, hair loss prevention and anti-anxiety properties.
|
-
- HY-103286
-
|
|
Bombesin Receptor
|
Cancer
|
|
PD176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells.
|
-
- HY-W002251
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Benzo[b]thiophene-3-carbaldehyde is a 3-formyl-substituted benzo[b]thiophene derivative that acts as an oxidizable substrate to convert to benzo[b]thiophene-3-carboxylic acid under liquid-phase conditions. Compared with analogs such as benzaldehyde and thiophene-2-carbaldehyde, Benzo[b]thiophene-3-carbaldehyde has lower oxidation difficulty, and can significantly increase the reaction rate in the presence of initiators (such as Na +Br - or DBA). Benzo[b]thiophene-3-carbaldehyde also serves as a key starting material for the synthesis of compounds including heteroaryl chalcones .
|
-
![Benzo[b]thiophene-3-carbaldehyde](//file.medchemexpress.com/product_pic/hy-w002251.gif)
- HY-101283R
-
|
|
Formyl Peptide Receptor (FPR)
Reference Standards
|
Inflammation/Immunology
|
|
HCH6-1 (Standard) is the analytical standard of HCH6-1 (HY-101283). This product is intended for research and analytical applications. HCH6-1 is a potent and competitive dipeptide antagonist of Formyl peptide receptor 1 (FPR1). HCH6-1 inhibits chemotaxis, superoxide anion generation, and elastase release in human neutrophils specifically activated by fMLF (an FPR1 agonist). HCH6-1 has protective effects against acute lung injury (ALI) in vivo and can be used for the research of FPR1-involved inflammatory lung diseases .
|
-
- HY-103286R
-
|
|
Reference Standards
Bombesin Receptor
|
Cancer
|
|
PD176252 (Standard) is the analytical standard of PD176252 (HY-103286). This product is intended for research and analytical applications. PD176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells.
|
-
- HY-P3318
-
|
L-BOC2
|
Leukotriene Receptor
|
Inflammation/Immunology
|
|
Boc-Phe-Leu-Phe-Leu-Phe (Boc-FLFLF) is a N-formyl peptide receptors (FPR) inhibitor. Boc-Phe-Leu-Phe-Leu-Phe abolishes the FMLP-induced release of peptide leukotrienes. Boc-Phe-Leu-Phe-Leu-Phe inhibits the sprouting of human umbilical vein endothelial cell (HUVEC) spheroids mediated by proliferative diabetic retinopathy (PDR) vitreous and vascular endothelial growth factor (VEGF) respectively in a three-dimensional fibrin gel. Boc-Phe-Leu-Phe-Leu-Phe inhibits the anti-inflammatory and antifibrotic effects of Ac2-26 (HY-P1098). Boc-Phe-Leu-Phe-Leu-Phe can be used for the study of immunology .
|
-
- HY-178144
-
|
|
Formyl Peptide Receptor (FPR)
Calcium Channel
Interleukin Related
NO Synthase
|
Neurological Disease
Inflammation/Immunology
|
|
FPR2 agonist 5 is a selective Formyl Peptide Receptor 2 (FPR2) agonist. FPR2 agonist 5 induces Ca 2+ mobilization in FPR2-HL60 transfected cells with an EC50 of 1.2 μM and causes FPR2 desensitization with an IC50 of 0.32 μM. FPR2 agonist 5 exerts neuroprotective effects by mitigating LDH release, NO production, IL-1β, IL-6, IL-33, and IL-10 levels in LPS (HY-D1056)-induced mouse primary microglial cells. FPR2 agonist 5 can be used for the study of neuroinflammatory-related diseases .
|
-
- HY-181822
-
|
|
Formyl Peptide Receptor (FPR)
Arrestin
PKA
Interleukin Related
|
Cardiovascular Disease
|
|
BMS-986331 is an orally active selective N-Formyl Peptide Receptor 2 (FPR2) agonist with an EC50 of 0.5 nM in humans and 1 nM in rats. BMS-986331 activates Gαi2, GαoA, Gα12, Gα13 signaling pathways, recruits β-arrestin1 and β-arrestin2, and inhibits downstream cAMP. BMS-986331 induces the expression and release of the pro-resolution cytokine IL-10. BMS-986331 improves cardiac structure and function in a rat model of heart failure induced by permanent coronary artery occlusion. BMS-986331 can be used for the research of heart failure .
|
-
- HY-P4744
-
|
|
Formyl Peptide Receptor (FPR)
Bacterial
|
Infection
Cancer
|
|
LL-37 amide is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens (ED99=8.5-8.7 μg/mL). LL-37 amide exerts its bactericidal effect by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It can also regulate inflammatory responses (inhibiting the release of factors such as TNF-α) and promote angiogenesis. Amidation modification reduces its sensitivity to serum inhibition and improves its stability. LL-37 amide possesses key activities in bactericidal action, immunomodulation, and wound healing, and is mainly used in research on infection-related diseases such as periodontal disease and deep tissue injuries (pressure ulcers), and wound healing .
|
-
- HY-P4744A
-
|
|
Formyl Peptide Receptor (FPR)
Bacterial
|
Infection
Cancer
|
|
LL-37 amide TFA is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens (ED99=8.5-8.7 μg/mL). LL-37 amide TFA exerts its bactericidal effect by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It can also regulate inflammatory responses (inhibiting the release of factors such as TNF-α) and promote angiogenesis. Amidation modification reduces its sensitivity to serum inhibition and improves its stability. LL-37 amide TFA possesses key activities in bactericidal action, immunomodulation, and wound healing, and is mainly used in research on infection-related diseases such as periodontal disease and deep tissue injuries (pressure ulcers), and wound healing .
|
-
- HY-173591
-
|
|
Formyl Peptide Receptor (FPR)
Apoptosis
|
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
|
|
T0080 is a central nervous system-penetrant FPR1 inhibitor. By functionally blocking the FPR1 signaling pathway, T0080 effectively reduces neutrophil infiltration into ischemic brain tissue and maintains the integrity of the blood-brain barrier. T0080 alleviates tPA-associated hemorrhagic transformation, inhibits demyelination responses and the expression of NOX2. T0080 also possesses anti-apoptotic (apoptosis) and anti-inflammatory properties, thereby protecting myelin and reducing neurological deficits. T0080 is widely used in studies related to ischemic stroke complicated by hemorrhagic transformation after tPA thrombolysis, as well as multiple sclerosis .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-W002251
-
|
|
Biochemical Assay Reagents
|
|
Benzo[b]thiophene-3-carbaldehyde is a 3-formyl-substituted benzo[b]thiophene derivative that acts as an oxidizable substrate to convert to benzo[b]thiophene-3-carboxylic acid under liquid-phase conditions. Compared with analogs such as benzaldehyde and thiophene-2-carbaldehyde, Benzo[b]thiophene-3-carbaldehyde has lower oxidation difficulty, and can significantly increase the reaction rate in the presence of initiators (such as Na +Br - or DBA). Benzo[b]thiophene-3-carbaldehyde also serves as a key starting material for the synthesis of compounds including heteroaryl chalcones .
|
-
- HY-77049
-
|
4-formyl-1-tritylimidazole
|
Biochemical Assay Reagents
|
|
1-Trityl-1H-imidazole-4-carbaldehyde is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-32813
-
|
3-Iodopyridin-2-amine
|
Biochemical Assay Reagents
|
|
2-Amino-3-iodopyridine (3-Iodopyridin-2-amine) can be coupled with formyl derivatives under a copper-catalyzed indole synthesis method, and then constructed azide analogs through copper-mediated conjugated adducts things. The nucleophilicity of 2-Amino-3-iodopyridine is lower than that of the corresponding aniline used in the synthesis of indole, a potential obstacle for future synthesis .
|
-
- HY-20912
-
-
- HY-W078435
-
-
- HY-W039891
-
|
|
Biochemical Assay Reagents
|
|
β-D-Glucopyranosiduronic acid,2-formyl-4-nitrophenyl,methyl ester,2,3,4-triacetate can be used in glycobiology research.
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P0224
-
|
fMLP; N-formyl-MLF
|
TNF Receptor
|
Inflammation/Immunology
|
|
N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR). N-Formyl-Met-Leu-Ph is reported to inhibit TNF-alpha secretion.
|
-
- HY-P1122
-
|
|
Formyl Peptide Receptor (FPR)
|
Infection
Inflammation/Immunology
|
|
Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952). Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.
|
-
- HY-P1119
-
|
|
Formyl Peptide Receptor (FPR)
|
Neurological Disease
|
|
WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide .
|
-
- HY-P1120
-
|
WKYMVm-amide; W-Peptide
|
Formyl Peptide Receptor (FPR)
PERK
Apoptosis
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
WKYMVm is a selective formylpeptide receptor 2 (FPR2) agonist. WKYMVm has a powerful anti-inflammatory effect that can reduce lung injury and spinal cord injury. WKYMVm ameliorates obesity by regulating lipid metabolism and leptin signaling. WKYMVm is involved in the regulation of immune cells by activating FPRs. WKYMVm can promote the chemotactic migration of immune cells and inhibit the apoptosis of phagocytes. In addition, WKYMVm may play a favorable or unfavorable role in tumors, depending on the type of tumor .
|
-
- HY-P4744
-
|
|
Formyl Peptide Receptor (FPR)
Bacterial
|
Infection
Cancer
|
|
LL-37 amide is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens (ED99=8.5-8.7 μg/mL). LL-37 amide exerts its bactericidal effect by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It can also regulate inflammatory responses (inhibiting the release of factors such as TNF-α) and promote angiogenesis. Amidation modification reduces its sensitivity to serum inhibition and improves its stability. LL-37 amide possesses key activities in bactericidal action, immunomodulation, and wound healing, and is mainly used in research on infection-related diseases such as periodontal disease and deep tissue injuries (pressure ulcers), and wound healing .
|
-
- HY-P1795
-
|
|
Formyl Peptide Receptor (FPR)
|
Inflammation/Immunology
|
|
Boc-dPhe-Leu-dPhe-Leu-Phe (Boc-fLfLF) is a selective N-formyl peptide receptor1 (FPR1) antagonist. Boc-dPhe-Leu-dPhe-Leu-Phe inhibits fMIFL(HY-P0224)-induced NADPH oxidase activity. Boc-dPhe-Leu-dPhe-Leu-Phe can be used for the study of inflammation .
|
-
- HY-P10724
-
|
|
Formyl Peptide Receptor (FPR)
Bacterial
|
Infection
|
|
fMIFL is a formyl tetrapeptide derived from Staphylococcus aureus, and also an agonist of mouse formyl peptide receptor 1 (mFPR1). It exhibits nanomolar activity against mFPR1 and micromolar activity against mFPR2. fMIFL is applicable to studies related to bacterial infections .
|
-
- HY-P1117
-
MMK1
1 Publications Verification
|
Formyl Peptide Receptor (FPR)
Calcium Channel
|
Neurological Disease
Inflammation/Immunology
|
|
MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity .
|
-
- HY-P10738
-
|
|
Formyl Peptide Receptor (FPR)
|
Infection
|
|
N-Formyl-MMYALF is a potent mitochondrial N-formyl peptide (mtFP) that has the activity of depleting calcium ions in the endoplasmic reticulum. N-Formyl-MMYALF can inhibit the FPR-1-mediated chemotactic response of polymorphonuclear leukocytes (PMNs) to bacterial peptides .
|
-
- HY-135108
-
|
|
Neurokinin Receptor
|
Neurological Disease
|
|
QWF Peptide (Compound 4a) is a substance P antagonist with an IC50 of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC50 of 4.7 μM .
|
-
- HY-P1744
-
-
- HY-P4744A
-
|
|
Formyl Peptide Receptor (FPR)
Bacterial
|
Infection
Cancer
|
|
LL-37 amide TFA is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens (ED99=8.5-8.7 μg/mL). LL-37 amide TFA exerts its bactericidal effect by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It can also regulate inflammatory responses (inhibiting the release of factors such as TNF-α) and promote angiogenesis. Amidation modification reduces its sensitivity to serum inhibition and improves its stability. LL-37 amide TFA possesses key activities in bactericidal action, immunomodulation, and wound healing, and is mainly used in research on infection-related diseases such as periodontal disease and deep tissue injuries (pressure ulcers), and wound healing .
|
-
- HY-P1591
-
-
- HY-103473
-
-
- HY-P1118
-
-
- HY-P2355
-
|
BOC2; Boc-Phe-dLeu-Phe-dLeu-Phe
|
Formyl Peptide Receptor (FPR)
|
Inflammation/Immunology
|
|
BOC-FlFlF (Boc-Phe-dLeu-Phe-dLeu-Phe) is a selective FPR1 antagonist. Boc-FlFlF has an apparent dissociation constant (KD) of 230 nM as determined by the intracellular calcium mobilization assay. Boc-FlFlF can be used for the study of inflammation .
|
-
- HY-P1121A
-
|
|
Formyl Peptide Receptor (FPR)
|
Inflammation/Immunology
|
|
WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase .
|
-
- HY-P3318
-
|
L-BOC2
|
Leukotriene Receptor
|
Inflammation/Immunology
|
|
Boc-Phe-Leu-Phe-Leu-Phe (Boc-FLFLF) is a N-formyl peptide receptors (FPR) inhibitor. Boc-Phe-Leu-Phe-Leu-Phe abolishes the FMLP-induced release of peptide leukotrienes. Boc-Phe-Leu-Phe-Leu-Phe inhibits the sprouting of human umbilical vein endothelial cell (HUVEC) spheroids mediated by proliferative diabetic retinopathy (PDR) vitreous and vascular endothelial growth factor (VEGF) respectively in a three-dimensional fibrin gel. Boc-Phe-Leu-Phe-Leu-Phe inhibits the anti-inflammatory and antifibrotic effects of Ac2-26 (HY-P1098). Boc-Phe-Leu-Phe-Leu-Phe can be used for the study of immunology .
|
-
- HY-W141975
-
-
- HY-P1756
-
-
- HY-W142169
-
|
formyl-L-histidine
|
Aminoacyl-tRNA Synthetase
|
Others
|
|
N-Formyl-L-histidine shows binding affinity to histidyl-tRNA synthetase with a Ki value of 4.6 μM. N-Formyl-L-histidine shows a competitive inhibition against L-histidine ammonia-lyase, inhibits urocanic acid formation from L-histidine with a Ki value of 4.26 mM .
|
-
- HY-I0591
-
-
- HY-P10738A
-
|
|
Formyl Peptide Receptor (FPR)
|
Infection
|
|
N-Formyl-MMYALF TFA is a mitochondrial N-formyl peptide that has the activity of depleting calcium ions in the endoplasmic reticulum. N-Formyl-MMYALF TFA can inhibit the FPR-1-mediated chemotactic response of PMNs to bacterial peptides .
|
-
- HY-P1591A
-
-
- HY-P11491
-
|
|
Formyl Peptide Receptor (FPR)
Reactive Oxygen Species (ROS)
|
Inflammation/Immunology
|
|
Ac2-26 (mouse) is the N-terminal active peptide of Annexin A1 (AnxA1). Ac2-26 (mouse) regulates the inflammatory response by modulating the formyl peptide receptor (FPR) signaling pathway. Ac2-26 (mouse) can promote the release of chemokines and inhibit the production of ROS. Ac2-26 (mouse) can be used for the research of inflammation, such as rheumatoid arthritis .
|
-
- HY-W009215
-
|
L-Met-L-Ala-L-Ser
|
Amino Acid Derivatives
|
Others
|
|
H-Met-Ala-Ser-OH (L-Met-L-Ala-L-Ser) is a tripeptide. H-Met-Ala-Ser-OH can act as a formyl receptor .
|
-
- HY-P1117A
-
|
|
Formyl Peptide Receptor (FPR)
Calcium Channel
|
Neurological Disease
Inflammation/Immunology
|
|
MMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity .
|
-
- HY-I0591R
-
-
- HY-P2355A
-
|
BOC2 TFA; Boc-Phe-dLeu-Phe-dLeu-Phe TFA
|
Formyl Peptide Receptor (FPR)
|
Inflammation/Immunology
|
|
BOC-FlFlF (TFA) (Boc-Phe-dLeu-Phe-dLeu-Phe (TFA)) is a selective FPR1 antagonist. BOC-FlFlF has an apparent dissociation constant (KD) of 230 nM as determined by the intracellular calcium mobilization assay. BOC-FlFlF can be used for the study of inflammation .
|
-
- HY-P1118A
-
-
- HY-P1119A
-
|
|
Formyl Peptide Receptor (FPR)
|
Neurological Disease
|
|
WRW4 TFA, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 TFA specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide .
|
-
- HY-P5469
-
|
|
Formyl Peptide Receptor (FPR)
|
Others
|
|
WRW4-OH is a biological active peptide. (This peptide inhibits binding of one of formyl peptide receptor-like 1 (FPRL1) agonists WKYMVm to its specific receptor. FPRL1 is an important classical chemoattractant receptor that is expressed in phagocytic cells in the peripheral blood and brain. Activation of FPRL1 is closely related to inflammatory responses in the host defense mechanism and neurodegenerative disorders.)
|
-
- HY-P11704
-
|
|
Formyl Peptide Receptor (FPR)
Bacterial
|
Neurological Disease
|
|
f-MKKFRW is a selective mouse formyl peptide receptor 3 (Fpr3) activator and bacterial MgrB-derived peptide motif. f-MKKFRW activates Fpr3 to trigger downstream signaling and calcium responses in Fpr3-expressing cells. f-MKKFRW stimulates a subset of mouse vomeronasal sensory neurons in the accessory olfactory system to evoke calcium responses. f-MKKFRW drives innate avoidance behavior in mice via nasal contact .
|
| Cat. No. |
Product Name |
Target |
Research Area |
Image |
-
- HY-P991864
-
|
MDX-124
|
Formyl Peptide Receptor (FPR)
|
Cancer
|
|
Annexuzlimab is a humanised IgG1 monoclonal antibody which specifically binds to ANXA1 disrupting its interaction with formyl peptide receptors 1 and 2 (FPR1/2). Annexuzlimab arrests cell cycle progression with cancer cells accumulating in the G1 phase. Annexuzlimab targets secreted ANXA1, preventing FPR1/2 activation and reducing cancer progression. Annexuzlimab can be used for the research of triple negative breast cancer, pancreatic cancer and osteosarcoma .
|
-
(5)
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-Y0051S
-
|
|
|
5-Hydroxymethylfurfural- 13C6 (2-Hydroxymethyl-5-furfural- 13C6; 2-Formyl-5-hydroxymethylfuran- 13C6) is a 13C labeled 5-Hydroxymethylfurfural (HY-Y0051). 5-Hydroxymethylfurfural (2-Hydroxymethyl-5-furfural), derived from Cornus officinalis, inhibits yeast growth and fermentation as stressors.
|
-
-
- HY-151454S
-
|
|
|
N-Formyl palbociclib-d8 is the deuterium-labeled N-Formyl palbociclib.
|
-
-
- HY-W700927
-
|
|
|
N-Formyl-L-leucine-d3 (N-Formyl-S-leucine-d3) is deuterium labeled N-Formyl-L-leucine. N-Formyl-L-leucine is a leucine derivative .
|
-
-
- HY-W285163S
-
|
|
|
1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d8 is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.
|
-
-
- HY-132519S
-
|
|
|
Delta-Tocopherol-5-formyl-chroman-5-carboxylic acid-d3 is the deuterium labeled Delta-Tocopherol-5-formyl-chroman-5-carboxylic acid .
|
-
-
- HY-W725077S
-
|
|
|
Benalaxyl metabolite F4-d9 (Methyl N-(2,6-dimethylphenyl)-N-(formyl)-DL-alaninate-d9) is deuterium labeled Methyl N-(2,6-dimethylphenyl)-N-formylalaninate .
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-180491
-
|
|
|
Azide
|
|
2-(3-(Azidomethyl)-2-formyl-6-methylphenoxy)acetic acid (Compound C1-4) is an azide reagent. 2-(3-(Azidomethyl)-2-formyl-6-methylphenoxy)acetic acid can be used in studies of protein fixed-point azidation .
|
| Cat. No. |
Product Name |
|
Classification |
-
- HY-W341499
-
|
|
|
Nucleoside Analogs
Uridine
|
|
5-Formyl-2'-deoxyuridine is a product formed when the 5-methyl group of thymine in DNA undergoes oxidation due to exposure to gamma radiation or certain chemical agents. Serving as a biomarker of oxidative DNA damage, 5-formyl-2'-deoxyuridine is employed in investigations of DNA damage and repair mechanisms. Additionally, 5-Formyl-2'-deoxyuridine can be used in studies involving chemically crosslinking with peptides derived from the RecA protein .
|
-
- HY-152714
-
|
|
|
Nucleoside Analogs
Cytidine
|
|
5-Formyl-2’-O-methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .
|
-
- HY-178624
-
-
- HY-182117
-
|
|
|
Phosphoramidites
Cytosine
|
|
5-Formyl dC III CE phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
|
-
- HY-178594
-
-
- HY-W748093
-
|
|
|
Phosphoramidites
Cytosine
|
|
5-Formyl-dC-CE phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
|
-
- HY-W784563
-
|
|
|
Phosphoramidites
Cytosine
|
|
(2R,3R,4R,5R)-5-(5-(1,3-Dioxan-2-yl)-4-(4-methoxybenzamido)-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) (R)-diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
|
Your information is safe with us. * Required Fields.
Inquiry Information
- Product Name:
- Cat. No.:
- Quantity:
- MCE Japan Authorized Agent:
![tert-Butyl 6-formyl-2-azaspiro[3.3]heptane-2-carboxylate](http://file.medchemexpress.com/product_pic/hy-w056306.gif)
![2-Formyl-[1,1'-biphenyl]-4,4'-dicarboxylic acid](http://file.medchemexpress.com/product_pic/hy-w456357.gif)
![2'-Formyl-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid](http://file.medchemexpress.com/product_pic/hy-w586848.gif)
![4'-Formyl-3'-hydroxy[1,1'-biphenyl]-3,5-dicarboxylic acid](http://file.medchemexpress.com/product_pic/hy-w856187.gif)
![tert-Butyl 2-formyl-6-azaspiro[3.4]octane-6-carboxylate](http://file.medchemexpress.com/product_pic/hy-w056566.gif)
![3'-(tert-Butyl)-5'-formyl-4'-hydroxy-[1,1'-biphenyl]-3,5-dicarboxylic acid](http://file.medchemexpress.com/product_pic/hy-w456490.gif)
![tert-Butyl [(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate (Standard)](http://file.medchemexpress.com/product_pic/hy-w042234r.gif)
![Benzo[b]thiophene-3-carbaldehyde](http://file.medchemexpress.com/product_pic/hy-w002251.gif)
