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Boc-MLF TFA (Synonyms: Boc-Met-Leu-Phe-OH (TFA))

Cat. No.: HY-103473A
Handling Instructions

Boc-MLF (TFA) is a peptide, used as a specific formyl peptide receptor (FPR) antagonist, also inhibits the signaling through formyl peptide receptor like 1 (FPRL1) at higher concentrations.

For research use only. We do not sell to patients.

Boc-MLF TFA Chemical Structure

Boc-MLF TFA Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 137 In-stock
Estimated Time of Arrival: December 31
1 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Boc-MLF (TFA) is a peptide, used as a specific formyl peptide receptor (FPR) antagonist, also inhibits the signaling through formyl peptide receptor like 1 (FPRL1) at higher concentrations[1].

IC50 & Target

FPR/FPRL1[1]

In Vitro

Boc-MLF inhibits superoxide production induced by FPR agonist fMLF, with an EC50 of 630 nM in neutrophils[1].
Boc-MLF (25 μM) blocks FPRL1-agonist serum amyloid A (SAA) induced calcium response[1].

Molecular Weight

623.68

Formula

C₂₇H₄₀F₃N₃O₈S

SMILES

O=C(O)[[email protected]](CC1=CC=CC=C1)NC([[email protected]](CC(C)C)NC([[email protected]](CCSC)NC(OC(C)(C)C)=O)=O)=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (240.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6034 mL 8.0169 mL 16.0339 mL
5 mM 0.3207 mL 1.6034 mL 3.2068 mL
10 mM 0.1603 mL 0.8017 mL 1.6034 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.01 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.01 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.01 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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Boc-MLF TFA
Cat. No.:
HY-103473A
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