67247-12-5
Chemical Structure
Boc-MLF
Synonym(s): Boc-Met-Leu-Phe-OH
- CAS No.: 67247-12-5
- Formula:C25H39N3O6S
- Molecular Weight:509.66
IUPAC Name: (tert-butoxycarbonyl)-L-methionyl-L-leucyl-L-phenylalanine
InChIKey: GYBXWOPENJVQKE-UFYCRDLUSA-N
SMILES: O=C(O)[C@H](CC1=CC=CC=C1)NC([C@H](CC(C)C)NC([C@H](CCSC)NC(OC(C)(C)C)=O)=O)=O
Biological Activity: Boc-MLF (Boc-Met-Leu-Phe-OH) is a competitive FPR1 antagonist. Boc-MLF inhibits fMLF-induced neutrophil activation through FPR. Boc-MLF inhibits receptor-induced inflammation and cell migration. Boc-MLF inhibits amniotic epithelial-mesenchymal transition. Boc-MLF reduces pro-inflammatory cytokine levels. Boc-MLF increases collagen expression in fetal membranes. Boc-MLF reverses fetal membrane epithelial cell collapse, increases villi, and reduces mucus attachment. Boc-MLF can be used in research on premature rupture of fetal membranes[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Boc-MLF | 99.36% | Boc-MLF (Boc-Met-Leu-Phe-OH) is a competitive FPR1 antagonist. Boc-MLF inhibits fMLF-induced neutrophil activation through FPR. Boc-MLF inhibits receptor-induced inflammation and cell migration. Boc-MLF inhibits amniotic epithelial-mesenchymal transition. Boc-MLF reduces pro-inflammatory cytokine levels. Boc-MLF increases collagen expression in fetal membranes. Boc-MLF reverses fetal membrane epithelial cell collapse, increases villi, and reduces mucus attachment. Boc-MLF can be used in research on premature rupture of fetal membranes. | ||||||||||||||||||||
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References
- [1]. Stenfeldt AL, et al. Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation. 2007 Dec;30(6):224-9. [Content Brief]
- [2]. Huang XM, et al. FPR1 Antagonist (BOC-MLF) Inhibits Amniotic Epithelial-mesenchymal Transition. Current medical science. 2024 Feb;44(1):187-194.
