5 Results for "

human 80S ribosome

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "human 80S ribosome" in MCE Product Catalog:

2
Cephaeline
Cephaeline
0 Images
2 Cited Publications
Cat. No.: HY-N4118
CAS No.: 483-17-0
Synonyms: (-)-Cephaeline; NSC 32944 free base
Category:  

Infection Alkaloids other families Monophenols Phenols Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Reactive Oxygen Species (ROS) SARS-CoV Ferroptosis MDM-2/p53 Keap1-Nrf2 Glutathione Peroxidase Flavivirus

Cephaeline ((-)-Cephaeline; NSC 32944) is a ferroptosis inducer, with broad-spectrum anticancer and antiviral activities. Cephaeline induces ferroptosis (Ferroptosis) by upregulating p53, inhibiting NRF2, activating ULK3, downregulating the expressions of SLC7A11 and GPX4 in a p53-dependent manner, reducing GSH and mitochondrial membrane potential, and increasing lipid peroxidation and iron accumulation. Cephaeline inhibits cancer cell proliferation, migration and tumor growth. Cephaeline inhibits Ebola virus (EBOV) VLP entry and infection, with IC50 values of 3.27 μM and 22.18 μM respectively; it also inhibits Zika virus (ZIKV) NS5 RdRp activity (IC50 = 976 nM), and binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RdRp and N protein, with Kd values of 8.9 μM and 53.8 μM respectively. Cephaeline can be used in studies related to breast cancer, lung cancer, COVID-19, EBOV and ZIKV infections .
loading...
    loading...
View All Sizes
R-IMPP
R-IMPP
0 Images
Cat. No.: HY-101354
CAS No.: 2133832-83-2
Purity:  98.76%
Synonyms: PF-00932239
Target:  

PCSK9 Ras MEK ERK NF-κB LDLR

R-IMPP (PF-00932239) is a PCSK9 translation inhibitor and a selective 80S ribosome binder. R-IMPP inhibits the KRAS/MEK/ERK signaling cascade. R-IMPP reduces LPS-induced nuclear translocation of NFkB P65. R-IMPP increases LDL-R levels in cells, promotes LDL-C uptake, and does not alter the secretion of transferrin or albumin. R-IMPP inhibits the growth of colorectal cancer (CRC) cells, organoids and xenografts carrying APC/KRAS mutations, as well as the number and burden of spontaneous mouse tumors. R-IMPP can be used in research related to colorectal cancer with APC/KRAS mutations, hepatic ischemia-reperfusion injury and hypercholesterolemia .
loading...
    loading...
View All Sizes
Cephaeline hydrochloride
Cephaeline hydrochloride
0 Images
Cat. No.: HY-N2076
CAS No.: 3738-70-3
Synonyms: (-)-Cephaeline hydrochloride; NSC 32944 monohydrochloride
Category:  

Infection Alkaloids other families Monophenols Phenols Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Reactive Oxygen Species (ROS) SARS-CoV Ferroptosis MDM-2/p53 Keap1-Nrf2 Glutathione Peroxidase Flavivirus

Cephaeline hydrochloride ((-)-Cephaeline (hydrochloride); NSC 32944 (monohydrochloride)) is a ferroptosis inducer, with broad-spectrum anticancer and antiviral activities. Cephaeline hydrochloride induces Ferroptosis by upregulating p53, inhibiting NRF2, activating ULK3, downregulating the expressions of SLC7A11 and GPX4 in a p53-dependent manner, reducing GSH and mitochondrial membrane potential, and increasing lipid peroxidation and iron accumulation. Cephaeline hydrochloride inhibits cancer cell proliferation, migration and tumor growth. Cephaeline hydrochloride inhibits Ebola virus (EBOV) VLP entry and infection, with IC50 values of 3.27 μM and 22.18 μM respectively; it also inhibits Zika virus (ZIKV) NS5 RdRp activity (IC50 = 976 nM), and binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RdRp and N protein, with Kd values of 8.9 μM and 53.8 μM respectively. Cephaeline hydrochloride can be used in studies related to breast cancer, lung cancer, COVID-19, EBOV and ZIKV infections .
loading...
    loading...
View All Sizes
Cephaeline dihydrobromide
Cephaeline dihydrobromide
0 Images
Cat. No.: HY-N4118A
CAS No.: 6014-81-9
Synonyms: (-)-Cephaeline dihydrobromide; NSC 32944 dihydrobromide
Category:  

Alkaloids other families Monophenols Phenols Plants Isoquinoline Alkaloids

Target:  

Reactive Oxygen Species (ROS) SARS-CoV Ferroptosis MDM-2/p53 Keap1-Nrf2 Glutathione Peroxidase Flavivirus

Cephaeline dihydrobromide ((-)-Cephaeline dihydrobromide; NSC 32944 dihydrobromide) is a ferroptosis inducer, with broad-spectrum anticancer and antiviral activities. Cephaeline dihydrobromide induces ferroptosis (Ferroptosis) by upregulating p53, inhibiting NRF2, activating ULK3, downregulating the expressions of SLC7A11 and GPX4 in a p53-dependent manner, reducing GSH and mitochondrial membrane potential, and increasing lipid peroxidation and iron accumulation. Cephaeline dihydrobromide inhibits cancer cell proliferation, migration and tumor growth. Cephaeline dihydrobromide inhibits Ebola virus (EBOV) VLP entry and infection, with IC50 values of 3.27 μM and 22.18 μM respectively; it also inhibits Zika virus (ZIKV) NS5 RdRp activity (IC50 = 976 nM), and binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RdRp and N protein, with Kd values of 8.9 μM and 53.8 μM respectively. Cephaeline dihydrobromide can be used in studies related to breast cancer, lung cancer, COVID-19, EBOV and ZIKV infections .
loading...
    loading...
View All Sizes
R-IMPP hydrochloride
R-IMPP hydrochloride
0 Images
Cat. No.: HY-101354A
CAS No.: 2173005-10-0
Synonyms: PF-00932239 hydrochloride
Target:  

PCSK9 Ras MEK ERK NF-κB LDLR

Research Areas:  

Metabolic Disease Inflammation/Immunology Cancer

R-IMPP hydrochloride (PF-00932239 hydrochloride) is a PCSK9 translation inhibitor and a selective 80S ribosome binder. R-IMPP hydrochloride inhibits the KRAS/MEK/ERK signaling cascade. R-IMPP hydrochloride reduces LPS-induced nuclear translocation of NFkB P65. R-IMPP hydrochloride increases LDL-R levels in cells, promotes LDL-C uptake, and does not alter the secretion of transferrin or albumin. R-IMPP hydrochloride inhibits the growth of colorectal cancer (CRC) cells, organoids and xenografts carrying APC/KRAS mutations, as well as the number and burden of spontaneous mouse tumors. R-IMPP hydrochloride can be used in research related to colorectal cancer with APC/KRAS mutations, hepatic ischemia-reperfusion injury and hypercholesterolemia .
loading...
    loading...
View All Sizes
Assay Types