51 Results for "

human patients

" in MedChemExpress (MCE) Product Catalog:
Products (51)

51 Results for "human patients" in MCE Product Catalog:

14
14 Cited Publications
Cat. No.: HY-B0539
CAS No.: 100643-71-8
Synonyms: Sch34117
Desloratadine (Sch34117) is an orally active and selective H1 receptor antagonist (Ki=0.9 nM) with anti-inflammatory and anti-allergic activities. Desloratadine inhibits the release of histamine and LTC4 from human basophils and targets the regulatory signals of IL-4 and IL-13 production in basophils. Desloratadine significantly alleviates SAR symptoms in patients with concurrent asthma and can be used in the study of seasonal allergic rhinitis and chronic idiopathic urticaria .
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1
1 Cited Publications
Cat. No.: HY-B0708
CAS No.: 1743-60-8
Synonyms: 1,3,5(10)-Estratriene-3,17β-diol 17-acetate
β-Estradiol 17-acetate (1,3,5(10)-Estratriene-3,17β-diol 17-acetate) is a long-acting endogenous estrogen precursor and also a cell viability and proliferation enhancer. β-Estradiol 17-acetate promotes the adhesion and proliferation of freshly isolated and revived female-derived human brain microvascular endothelial cells, and reverses the decreased viability of revived male-derived human brain microvascular endothelial cells. β-Estradiol 17-acetate exerts the microvascular protective effect of estrogen, enabling non-tumor human brain microvascular endothelial cells to be cultured in vitro for 2 months after cryopreservation. β-Estradiol 17-acetate is biotransformed into β-estradiol via hydrolase action in the in vitro skin of humans, hairless dogs, rats and hairless mice .
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Cat. No.: HY-126995
CAS No.: 13042-33-6
Purity:  99.86%
Glycohyodeoxycholic acid is a glycine-conjugated bile acid and also a metabolite of Hyodeoxycholic acid (HY-N0169). The serum level of Glycohyodeoxycholic acid is negatively correlated with the severity of non-alcoholic fatty liver disease. Glycohyodeoxycholic acid can be used in research related to non-alcoholic fatty liver disease .
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Cat. No.: HY-141606
CAS No.: 1375258-01-7
Purity:  99.36%
Synonyms: BAY 94-9343
Anetumab ravtansine (BAY 94-9343) is a selective and highly potent antibody-drug conjugate (ADC) to target maytansinoid tubulin. Anetumab ravtansine consists of a human anti-mesothelin antibody conjugated to the maytansinoid tubulin inhibitor DM4. Anetumab ravtansine shows antitumor efficacy correlated with the amount of mesothelin expressed in patient-derived xenograft tumor models .
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Cat. No.: HY-P99268
CAS No.: 1334296-12-6
Synonyms: SAR 256212; MM 121

Target:  

EGFR Apoptosis

Research Areas:  

Cancer

Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models .
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Cat. No.: HY-P99505
CAS No.: 2226654-05-1
Synonyms: COR-001; MEDI-5117; MEDI-5117; NN-6018; WBP-216
Ziltivekimab (COR-001) is a fully human monoclonal antibody and also an IL-6 inhibitor. Ziltivekimab significantly reduces inflammatory biomarkers and Lipoprotein (a) in chronic kidney disease patients with systemic inflammation. Ziltivekimab does not increase pro-atherosclerotic lipid levels. Ziltivekimab is used in studies related to atherosclerotic thrombotic diseases and chronic kidney disease .
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Cat. No.: HY-P99152
CAS No.: 140608-64-6
Synonyms: Muromanab-CD3

Research Areas:  

Inflammation/Immunology Cancer

Muromonab (Muromonab-CD3; OKT3) is a mouse monoclonal antibody targeting the CD3 antigen. Muromonab specifically binds to the CD3 antigen on the surface of human and higher primate T cells. Muromonab blocks the function of T cell receptors to recognize foreign antigens and inhibits T cell-mediated immune responses, including cell-mediated lymphocyte lysis and T cell proliferation responses. Muromonab can be used to study acute kidney, liver, heart and combined kidney-pancreas transplant rejection, and can also be used to study graft-versus-host disease in bone marrow transplant patients .
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Cat. No.: HY-131516
CAS No.: 77591-18-5
Purity:  96.8%
Target:  

Drug Derivative

Research Areas:  

Metabolic Disease

Tiopronin-cysteine disulfide is a soluble disulfide metabolite/derivative of Tiopronin (HY-B0373) formed by reaction of Tiopronin with cystine. Tiopronin-cysteine disulfide reduces cystine crystal formation in cystinuria. Tiopronin-cysteine disulfide can be used for the research of cystinuria .
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Cat. No.: HY-156437
CAS No.: 2225902-98-5
Purity:  99.73%
Target:  

Apoptosis NEKs Mitosis Akt

Research Areas:  

Cancer

NBI-961 is a NEK2 catalytic inhibitor with human NEK2 IC50 ~12-fold lower than FLT3. NBI-961 induces proteasomal degradation of NEK2. NBI-961 induces G2/mitosis arrest, apoptosis, and compromises viability in DLBCL cells and patient-derived cells. NBI-961 sensitizes DLBCL cells to doxorubicin and vincristine, and suppresses DLBCL tumor growth in mice. NBI-961 can be used for the research of diffuse large b cell lymphoma .
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Cat. No.: HY-P99806
CAS No.: 499212-74-7
Synonyms: ACA-11; CLN-IgG; CLNH-11

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Pritumumab is a natural human IgG1kappa mAb originally isolated from a regional draining lymph node of a patient with cervical carcinoma. Pritumumab recognizes vimentin expressing on the cell surface of the malignant tumor. Pritumumab can be used for glioblastoma research .
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Cat. No.: HY-P4882A
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

(Pyr3)-Amyloid β-Protein (3-42) TFA is the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. (Pyr3)-Amyloid β-Protein (3-42) TFA is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits .
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Cat. No.: HY-N0821
CAS No.: 63492-69-3
Synonyms: Griffonin
Lithospermoside (Griffonin) is an orally active Na +/K +-ATPase inhibitor and hypoglycemic agent. Lithospermoside increases intracellular sodium levels in normal and sickle red blood cells. Lithospermoside reduces fasting blood glucose levels, improves glucose tolerance, and prevents weight loss in diabetic mice. Lithospermoside can be used in the research of sickle cell disease and diabetes .
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Cat. No.: HY-113043
CAS No.: 13382-27-9
Galactonic acid is a metabolite of Galactose. Galactose is converted into Galactonic acid in vivo. Galactonic acid can be used in galactosemia research .
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Cat. No.: HY-129912A
CAS No.: 178244-42-3
Purity:  ≥98.0%
N1,N8-Diacetylspermidine hydrochloride is a polyamines in the human urine . N1,N8-Diacetylspermidine hydrochloride is useful as prognostic indicators after treatment and during follow-up examination of cancer patients .
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Cat. No.: HY-P990953
CAS No.: 2640279-10-1
Synonyms: Gen1047

Target:  

CD3

Research Areas:  

Cancer

Zubotamig (Gen1047) is an CD3E/VTCN1-targeting Ig(G1 -κ_G1 -λ2) type chimeric human antibody. The recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001). Zubotamig induces T-cell mediated cytotoxicity of B7H4-positive tumor cells, triggers T-cell activation, and induces cytokine release from T cells in the presence of B7H4-expressing tumor cells. Zubotamig demonstrates antitumor activity in mouse patient-derived xenograft (PDX) models. Zubotamig can be used for the research of solid cancers (including breast, ovarian and lung cancer) .
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Cat. No.: HY-P990947
CAS No.: 2868265-50-1
Synonyms: AZD9592 Antibody

Target:  

ADC Antibodies EGFR

Research Areas:  

Cancer

Tilatamig (AZD9592 Antibody) is a human antibody of the Ig (G1-κ_G1-λ2) subtype that targets EGFR/MET. Tilatamig conjugates with the Top1 inhibitor AZ14170133 (HY-145399) to form the antibody-drug conjugate (ADC) Tilatamig samrotecan (HY-171124) (AZD9592). Tilatamig accurately targets NSCLC models including EGFR-mutant, EGFR-wildtype, and EGFR tyrosine kinase inhibitor-treated ones, and its activity correlates with high expression of EGFR, c-MET and SLFN11. Tilatamig is available for in vivo anti-tumor studies in patient-derived xenograft models of non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) .
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Cat. No.: HY-113406
CAS No.: 6418-78-6
Synonyms: DL-Hexanoylcarnitine
(±)-Hexanoylcarnitine exists in human urine and plasma. (±)-Hexanoylcarnitine can be used as a plasma detection indicator in patients with methylmalonic aciduria, propionic acidemia, and medium-chain acyl-CoA dehydrogenase deficiency .
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Cat. No.: HY-121660
CAS No.: 23597-82-2
Purity:  98.96%
Target:  

Drug Derivative

Research Areas:  

Cardiovascular Disease

Hexyl nicotinate is a lipid-soluble nicotinic acid ester and cutaneous vasodilator. Hexyl nicotinate induces localized cutaneous vasodilation and increases blood flow. Hexyl nicotinate can be used for the research of Raynaud's phenomenon .
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Cat. No.: HY-113086
CAS No.: 16711-66-3
Synonyms: 16:1(9Z) CE; 16:1(9Z) Cholesterol ester; Cholesterol Palmitoleate
Target:  

Endogenous Metabolite

Research Areas:  

Cardiovascular Disease

CE(16:1(9Z)) (16:1(9Z) CE) is a cholesterol ester. Plasma levels of cholesteryl palmitoleate are increased in ApoE -/- mice exposed to cigarette smoke and in pediatric patients with biliary atresia. Cholesteryl palmitoleate has been used as a standard for the identification of cholesterol esters in human meibomian gland secretions.
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Cat. No.: HY-P4882
CAS No.: 183449-57-2
Target:  

Amyloid-β Tau Protein

Research Areas:  

Neurological Disease

(Pyr3)-Amyloid β-Protein (3-42) is an N-terminally truncated pyroglutamylated β-amyloid peptide. (Pyr3)-Amyloid β-Protein (3-42) forms stable β-sheet structures across different pH values, co-oligomerizes with Aβ1-42 to form cytotoxic oligomers, induces tau-dependent cytotoxicity and neuronal loss, inhibits hippocampal LTP, and exhibits stronger protease resistance. (Pyr3)-Amyloid β-Protein (3-42) exists in the brain tissues of human Alzheimer's disease patients, correlates with the pathogenesis of Alzheimer's disease, and follows a unique, faster oligomerization pathway. (Pyr3)-Amyloid β-Protein (3-42) can be used in Alzheimer's disease-related research .
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