63492-69-3
Chemical Structure
Lithospermoside
Synonym(s): Griffonin
- CAS No.: 63492-69-3
- Formula:C14H19NO8
- Molecular Weight:329.30
IUPAC Name: (Z)-2-((4R,5S,6S)-4,5-dihydroxy-6-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)cyclohex-2-en-1-ylidene)acetonitrile
InChIKey: WIIDBJNWXCWLKF-VVAXPEBGSA-N
SMILES: O[C@@H]1[C@@](/C(C=C[C@H]1O)=C\C#N)([H])O[C@@H]([C@@H]([C@@H](O)[C@@H]2O)O)O[C@@H]2CO
Biological Activity: Lithospermoside (Griffonin) is an orally active Na+/K+-ATPase inhibitor and hypoglycemic agent. Lithospermoside increases intracellular sodium levels in normal and sickle red blood cells. Lithospermoside reduces fasting blood glucose levels, improves glucose tolerance, and prevents weight loss in diabetic mice. Lithospermoside can be used in the research of sickle cell disease and diabetes[1][2].
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Lithospermoside | 99.48% | Lithospermoside (Griffonin) is an orally active Na+/K+-ATPase inhibitor and hypoglycemic agent. Lithospermoside increases intracellular sodium levels in normal and sickle red blood cells. Lithospermoside reduces fasting blood glucose levels, improves glucose tolerance, and prevents weight loss in diabetic mice. Lithospermoside can be used in the research of sickle cell disease and diabetes. | ||||||||||||||||||||
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Lithospermoside (Standard) | ≥98% | Lithospermoside (Griffonin) (Standard) is the analytical standard of Lithospermoside (HY-N0821). This product is intended for research and analytical applications. Lithospermoside is an orally active Na+/K+-ATPase inhibitor and hypoglycemic agent. Lithospermoside increases intracellular sodium levels in normal and sickle red blood cells. Lithospermoside reduces fasting blood glucose levels, improves glucose tolerance, and prevents weight loss in diabetic mice. Lithospermoside can be used in the research of sickle cell disease and diabetes. | ||||||||||||||||||||
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- [1]. Larmie ET, et al. The in vitro effects of griffonin and ouabain on erythrocyte sodium content obtained from normal subjects and sickle cell patients. Planta medica. 1991 Apr;57(2):116-8. [Content Brief]
- [2]. Saldanha LL, et al. Hypoglycemic active principles from the leaves of Bauhinia holophylla: Comprehensive phytochemical characterization and in vivo activity profile. PloS one. 2021;16(9):e0258016. [Content Brief]
