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Results for "

hydroxylase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dopamine β-hydroxylase (21) HIF/HIF Prolyl-Hydroxylase (65) Tryptophan Hydroxylase (27) Tyrosine Hydroxylase (11) 11β-HSD (4) 5 alpha Reductase (1) 5-HT Receptor (6) ADC Payload (1) Adrenergic Receptor (6) Akt (3) Amino Acid Derivatives (1) AMPK (1) Androgen Receptor (1) Antibiotic (4) Apoptosis (12) Aryl Hydrocarbon Receptor (1) ATF6 (1) Autophagy (8) Bacterial (8) Bcl-2 Family (1) BCRP (2) Biochemical Assay Reagents (12) Calcium Channel (3) Cannabinoid Receptor (1) Caspase (2) CFTR (5) Collagen (2) COMT (1) COX (3) Cyclic GMP-AMP Synthase (3) Cytochrome P450 (50) DNA Methyltransferase (1) DNA/RNA Synthesis (1) Dopamine Receptor (7) Drug Derivative (4) Drug Intermediate (3) Drug Metabolite (3) EGFR (2) Endogenous Metabolite (30) Environmental Pollutants (5) ERK (5) Estrogen Receptor/ERR (1) Farnesyl Transferase (1) Ferroptosis (3) Fluorescent Dye (1) Fungal (8) FXR (1) GABA Receptor (5) GSK-3 (1) Herbicide (7) Histamine Receptor (1) Histone Demethylase (5) IGF-1R (2) Imidazoline Receptor (3) Influenza Virus (2) Insecticide (1) Interleukin Related (3) Isotope-Labeled Compounds (10) KMO (2) Liposome (1) MDM-2/p53 (1) Mineralocorticoid Receptor (3) Mitochondrial Metabolism (6) MMP (5) MOFs (1) Monoamine Oxidase (8) mTOR (5) nAChR (3) NF-κB (4) NO Synthase (4) Notch (1) Nuclear Hormone Receptor 4A/NR4A (3) OAT (2) Opioid Receptor (3) P-glycoprotein (2) p38 MAPK (2) Parasite (3) PARP (1) Phosphatase (1) Phosphodiesterase (PDE) (2) Phospholipase (1) Phytohormone (2) PI3K (2) PKA (3) PKC (2) PPAR (2) Prostaglandin Receptor (1) RAR/RXR (3) Reactive Oxygen Species (ROS) (4) Reference Standards (41) REV-ERB (1) Reverse Transcriptase (2) ROS Kinase (2) Somatostatin Receptor (1) Squalene Monooxygenase (1) Telomerase (2) TGF-beta/Smad (2) TGF-β Receptor (1) Thyroid Hormone Receptor (2) TNF Receptor (1) Transferrin Receptor (1) VD/VDR (1) Wnt (1) α-synuclein (1) β-catenin (1)
By Research Areas:	Cancer (87) Cardiovascular Disease (63) Endocrinology (14) Infection (30) Inflammation/Immunology (39) Metabolic Disease (75) Neurological Disease (65)
Click Chemistry:	Alkynes (6)
Oligonucleotides:	Pegylated Lipids (1)

302

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Tryptophan Hydroxylase Tyrosine Hydroxylase Dopamine β-hydroxylase HIF/HIF Prolyl-Hydroxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-A0124A

Sapropterin dihydrochloride 2 Publications Verification (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride	Endogenous Metabolite	Infection Metabolic Disease Inflammation/Immunology
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE) .

HY-15849

LP-533401 5 Publications Verification	Tryptophan Hydroxylase	Cardiovascular Disease Metabolic Disease
LP-533401 is a *Tryptophan hydroxylase* 1** inhibitor that regulates serotonin production in the gut.

HY-12347

Ro 61-8048 5 Publications Verification	KMO	Neurological Disease
Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, with an IC₅₀ of 37 nM. Ro 61-8048 provokes a significant increase of extracellular kynurenic acid concentrations .

HY-15468

IOX2 15+ Cited Publications	HIF/HIF Prolyl-Hydroxylase	Cancer
IOX2, a chemical probe, is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC₅₀ of 22 nM. IOX2 regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production. IOX2 can be used in the study of thrombotic diseases .

HY-121172

1,4-DPCA 1 Publications Verification	HIF/HIF Prolyl-Hydroxylase	Cancer
1,4-DPCA, a potent *prolyl-4-hydroxylase* inhibitor, is a collagen hydroxylation inhibitor in human foreskin fibroblasts with an IC₅₀ of 2.4 µM. 1,4-DPCA inhibits prolyl-4-hydroxylases α isoforms stabilizes HIF-1α protein. 1,4-DPCA also inhibits factor inhibiting HIF (FIH) with an IC₅₀ of 60 μM .

HY-33549

α-Methyl-p-tyrosine 2 Publications Verification	Tyrosine Hydroxylase	Neurological Disease Cancer
α-Methyl-p-tyrosine is a competitive inhibitor of tyrosine hydroxylase, which converts tyrosine into DOPA. α-Methyl-p-tyrosine is also an orally active inhibitor of catecholamine synthesis, inhibiting the hydroxylation of tyrosine into DOPA. α-Methyl-p-tyrosine can be used in research related to epilepsy, glaucoma, cancer, and other related diseases .

HY-109123

Soticlestat TAK-935; OV935	Cytochrome P450	Neurological Disease
Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active *cholesterol 24-hydroxylase* (CH24H)** inhibitor. Soticlestat has the potential for epilepsy syndromes research .

HY-103227

Desidustat 2 Publications Verification ZYAN1	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
Desidustat is an orally active HIF hydroxylase inhibitor. Desidustat can be used for the research of various disorders including anemia of different types and conditions associated with ischemia/hypoxia .

HY-103068

Diethyl-pythiDC 4 Publications Verification	MMP	Cancer
Diethyl-pythiDC is an inhibitor of collagen prolyl 4-hydroxylases (CP4Hs).

HY-15849A

LP-533401 hydrochloride 5 Publications Verification	Tryptophan Hydroxylase	Cardiovascular Disease Metabolic Disease
LP-533401 hydrochloride is a *tryptophan hydroxylase* 1** inhibitor that regulates serotonin production in the gut.

HY-W019599

4-Chloro-L-phenylalanine L-PCPA	5-HT Receptor Tryptophan Hydroxylase	Neurological Disease
4-Chloro-L-phenylalanine (L-PCPA) is a tryptophan hydroxylase inhibitor targeting TPH1 and TPH2, with the activity of blocking serotonin biosynthesis. 4-Chloro-L-phenylalanine reduces the levels of serotonin and its metabolites in the brain without impairing the survival of serotonergic neurons. 4-Chloro-L-phenylalanine enhances anhedonic, depression-like and anxiety-like behaviors in mice with depleted noradrenergic and dopaminergic neurons. 4-Chloro-L-phenylalanine acts as a decarboxylation substrate for aromatic L-amino acid decarboxylase from Bacillus atrophaeus. 4-Chloro-L-phenylalanine can be used in studies related to Parkinson's disease .

HY-15641

FG-2216 5+ Cited Publications IOX3; YM311	HIF/HIF Prolyl-Hydroxylase	Metabolic Disease
FG-2216 (IOX3) is a potent and orally active inhibitor of *HIF prolyl hydroxylase-2 (PHD2), with an IC₅₀* of 3.9 μM. FG-2216 induces robust erythropoietin and modest fetal hemoglobin in vivo .

HY-W008452

H-Tyr(3-I)-OH 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .

HY-B0237

Aminoglutethimide DL-Aminoglutethimide	Cytochrome P450	Neurological Disease Endocrinology Cancer
Aminoglutethimide (DL-Aminoglutethimide) is an orally active anticonvulsant with various endocrine-related side effects. Aminoglutethimide blocks multiple steroid hormone synthesis pathways by inhibiting several cytochrome P-450-dependent hydroxylases, such as aromatase, cholesterol side-chain cleavage enzyme, *11-hydroxylase, and 18-hydroxylase, with IC₅₀* values of 0.3, 3.5, 120, and 20 μM, respectively. Aminoglutethimide reduces cortisol levels. Aminoglutethimide can be used in research on Cushing's syndrome, breast cancer, and other conditions .

HY-N1477

Dencichine Dencichin; ODAP	HIF/HIF Prolyl-Hydroxylase	Neurological Disease
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit *HIF-prolyl hydroxylase-2 (PHD-2)* activity.

HY-B0873

Uniconazole	Environmental Pollutants Cytochrome P450 ROS Kinase	Others
Uniconazole, a plant growth retardant, is a potent inhibitor of abscisic acid (ABA) catabolism with an IC₅₀ of 68 nM against ABA 8’-hydroxylase. Uniconazole is a potent competitive inhibitor of CYP707A3 activity with a K_i of 8 nM. Uniconazole evidently inhibits gibberellin biosynthesis, and brassinosteroid biosynthesis is also inhibited to some extent .

HY-13289A

Nepicastat hydrochloride 3 Publications Verification SYN-117 hydrochloride; RS-25560-197 hydrochloride	Dopamine β-hydroxylase	Cardiovascular Disease
Nepicastat hydrochloride (SYN-117 hydrochloride) is a selective, potent, and orally active inhibitor of *dopamine-beta-hydroxylase. Nepicastat hydrochloride produces concentration-dependent inhibition of bovine (IC₅₀=8.5 nM) and human (IC₅₀=9 nM) dopamine-beta-hydroxylase*. Nepicastat hydrochloride can cross the blood-brain barrier (BBB) .

HY-13055A

Telotristat ethyl 4 Publications Verification LX1032; LX1606	Tryptophan Hydroxylase	Neurological Disease Cancer
Telotristat ethyl (LX1032) is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.

HY-13055B

Telotristat LP-778902	Tryptophan Hydroxylase	Neurological Disease Cancer
Telotristat (LP-778902) is a potent tryptophan hydroxylase inhibitor with an in vivo IC₅₀ of 0.028 μM.

HY-13055

Telotristat etiprate 4 Publications Verification LX1606 Hippurate	Tryptophan Hydroxylase	Neurological Disease Cancer
Telotristat etiprate (LX1606 Hippurate) is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.

HY-23460

p-Ethynylphenylalanine 1 Publications Verification 4-Ethynyl-L-phenylalanine	Tryptophan Hydroxylase	Neurological Disease
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of *tryptophan hydroxylase* (TPH), with a K_i** of 32.6 μM . p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W013407

α-Methyltyrosine methyl ester hydrochloride 1 Publications Verification	Tyrosine Hydroxylase Thyroid Hormone Receptor	Neurological Disease
α-Methyltyrosine methyl ester hydrochloride is an orally active and competitive tyrosine hydroxylase inhibitor. α-Methyltyrosine methyl ester hydrochloride can inhibit the conversion of tyrosine to dopamine. α-Methyltyrosine methyl ester hydrochloride causes kidney damage and urethral calculi in rats. α-Methyltyrosine methyl ester hydrochloride can be used as a tool for sympathetic nervous system research .

HY-44809

Izilendustat	HIF/HIF Prolyl-Hydroxylase Bacterial	Cardiovascular Disease Infection Inflammation/Immunology
Izilendustat is a potent prolyl hydroxylase inhibitor. Izilendustat competitively inhibits HIFPH2 activity, blocks HIF-1α degradation, stabilizes HIF-1α and HIF-2α proteins, and upregulates downstream target gene expression. Izilendustat can reduce intestinal inflammation and damage, enhance the ability of phagocytes to clear pathogens, and improve ischemia-related pathological phenotypes. Izilendustat can be used for the research of inflammatory bowel disease, ischemic vascular disease and anemia .

HY-13041

LX-1031 1 Publications Verification	Tryptophan Hydroxylase	Neurological Disease
LX-1031 is a potent, orally available *tryptophan 5-hydroxylase* (TPH)** inhibitor that reduces serotonin (5-HT) synthesis peripherally.

HY-41404

Piperonylic acid 2H-1,3-benzodioxole-5-carboxylic acid	Cytochrome P450 Interleukin Related EGFR IGF-1R	Infection Others Cancer
Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase. Piperonylic acid has anticancer, antioxidant and antibacterial activities .

HY-15183

*Collagen proline hydroxylase* inhibitor**	Collagen	Cancer
Collagen proline hydroxylase inhibitor is a collagen proline hydroxylase inhibitor, which can be used as an anti-fibrotic agent .

HY-129079A

TFMB-(S)-2-HG 2 Publications Verification	DNA Methyltransferase Wnt β-catenin	Endocrinology Cancer
TFMB-(S)-2-HG is a potent TET2 inhibitor. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG downregulates Wnt3a, β-catenin (intranuclear) protein expression. TFMB-(S)-2-HG inhibits osteogenic differentiation of cells. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML) .

HY-23460A

p-Ethynylphenylalanine hydrochloride 1 Publications Verification 4-Ethynyl-L-phenylalanine hydrochloride	Tryptophan Hydroxylase	Neurological Disease
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of *tryptophan hydroxylase* (TPH), with a K_i** of 32.6 μM . p-Ethynylphenylalanine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N2560

Senecionine Senecionan-11,16-dione, 12-hydroxy-; Aureine; Senecionin	Others	Metabolic Disease
Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid could be isolated from Senecio vulgaris. Senecionine decreases the activities of glutathione S-transferase, aminopyrine demethylase and arylhydrocarbon hydroxylase (AHH) .

HY-149597

*Lysyl hydroxylase* 2-IN-1**	Monoamine Oxidase	Cancer
Lysyl hydroxylase 2-IN-1 (compound 12) is a selective *lysyl hydroxylase* 2 (LH2) Inhibitor with an IC₅₀** of ~300 nM. Lysyl hydroxylase 2-IN-1 demonstrates selectivity for LH2 over LH1 and LH3 .

HY-W677684

Nurr1 agonist 2	Nuclear Hormone Receptor 4A/NR4A	Others
Nurr1 agonist 2 (Compound 7) is a Nurr1 agonist (EC₅₀: 0.07 μM). Nurr1 agonist 2 binds to the recombinant Nurr1 ligand binding domain (LBD) with a K_d value of 0.14 μM. Nurr1 agonist 2 increases the Nurr1-regulated genes tyrosine hydroxylase (TH) and vesicular amino acid transporter 2 (VMAT2) mRNA expression .

HY-10505

Orteronel 2 Publications Verification TAK-700	Cytochrome P450	Cancer
Orteronel (TAK-700) is a highly selective inhibitor of human 17,20-lyase (CYP17) with IC₅₀ of 38 nM, and exhibits >1000-fold selectivity over other CYPs such as 11-hydroxylase and CYP3A4 .

HY-W071686

6-Methyltetrahydropterin dihydrochloride	Biochemical Assay Reagents	Others
6-Methyltetrahydropterin (dihydrochloride) is a biochemical detection reagent that can be used in tyrosine hydroxylase activity assay .

HY-W092533

6-Fluorotryptophan	Tryptophan Hydroxylase	Neurological Disease
6-Fluorotryptophan, a competitive inhibitor of tryptophan hydroxylase, produced a transient disruption of sleep in rats chronically implanted with EEG recording electrodes .

HY-A0124AR

Sapropterin dihydrochloride (Standard) (6R)-BH4 dihydrochloride (Standard); (6R)-Tetrahydro-L-biopterin dihydrochloride (Standard)	Endogenous Metabolite Reference Standards	Infection Metabolic Disease Inflammation/Immunology
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride (Standard) is the analytical standard of Sapropterin dihydrochloride (HY-A0124A) . This product is intended for research and analytical applications. Sapropterin dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE) .

HY-103070

PythiDC	MMP	Inflammation/Immunology
PythiDC is a selective collagen prolyl 4-hydroxylase (CP4H1) inhibitor with an IC₅₀ value of 4.0 μM. PythiDC can be used as a CP4H probe and also can be used for the development of a new class of antifibrotic and antimetastatic agents .

HY-116893

Diethyl bipy55'DC	HIF/HIF Prolyl-Hydroxylase MOFs	Cancer
Diethyl bipy55'DC is an inhibitor of collagen proline 4-hydroxylases (CP4Hs) with antifibrotic and anti-metastatic activities. Diethyl bipy55'DC can inhibit CP4H activity in cultured cells at concentrations that do not cause iron deficiency .

HY-144309

*Cholesterol 24-hydroxylase-IN-1*	Cytochrome P450	Neurological Disease
Cholesterol 24-hydroxylase-IN-1 (compound 17) is a potent, orally active, and highly selective cholesterol 24-hydroxylase (CH24H or CYP46A1) inhibitor (IC₅₀=8.5 nM). Cholesterol 24-hydroxylase-IN-1 can cross blood-brain barrier .

HY-123468

HA-1004	Cyclic GMP-AMP Synthase PKA ERK Tyrosine Hydroxylase Calcium Channel	Cardiovascular Disease Metabolic Disease
HA-1004 is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 is an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models .

HY-157014

TPT-004	Tryptophan Hydroxylase	Cancer
TPT-004 is a selective and oraly active *tryptophan hydroxylases* (TPH) inhibitor with IC₅₀**s of 77 nM and 16 nM for TPH1 and TPH2, repsectively. TPT-004 exhibits exceptional selectivity for TPH1 compared with other members of the AAAH family. TPT-004 shows efficacy peripheral serotonin attenuation and colorectal tumor growth in mice^[1][2].

HY-137391

2-Bromoestradiol	Estrogen Receptor/ERR	Metabolic Disease
2-Bromoestradiol is a estrogen 2-hydroxylase inhibitor. 2-Bromoestradiol decreases irreversible binding of radiolabeled estradiol metabolite(s) to microsomal proteins .

HY-119351

BNS	HIF/HIF Prolyl-Hydroxylase	Others
BNS is a cell penetrant, potent and selective PHD2 (prolyl-hydroxylase 2) inhibitor .

HY-112441

*Prolyl Hydroxylase* inhibitor 1**	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
Prolyl Hydroxylase inhibitor 1 (Compound 15i) is an orally active hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitor with an IC₅₀ of 62.23 nM . Antianemia agent .

HY-125796

U-14624	Dopamine β-hydroxylase	Neurological Disease
U-14624 is a potent and orally active dopamine beta-hydroxylase inhibitor. U-14624 suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes .

HY-129502

Fibrostatin C P-23924C	HIF/HIF Prolyl-Hydroxylase	Others
Fibrostatin C (P-23924C) is an orally active prolyl hydroxylase inhibitor that also inhibits collagen biosynthesis. Fibrostatin C also increases the number of cytoplasmic granules immunoreactive with antibodies to collagen I or III. Fibrostatin C inhibits the secretion of type I collagen in Tenon's capsule fibroblasts. Fibrostatin C is promising for research of the wound fibrotic response in the wound of glaucoma filtering surgery .

HY-E70279

Phytanoyl-CoA Phytanoyl-Coenzyme A	Biochemical Assay Reagents	Metabolic Disease
Phytanoyl-CoA is a coenzyme A derivative of phytanic acid that can serve as a substrate to be catalyzed by phytanoyl-CoA 2-hydroxylase (PAHX) into 2-hydroxyphytanoyl-CoA .

HY-13289

Nepicastat SYN117; RS-25560-197	Dopamine β-hydroxylase	Cardiovascular Disease
Nepicastat (SYN117) is a selective, potent, and orally active inhibitor of *dopamine-beta-hydroxylase. Nepicastat (SYN117) produces concentration-dependent inhibition of bovine (IC₅₀=8.5 nM) and human (IC₅₀=9 nM) dopamine-beta-hydroxylase*. Nepicastat (SYN117) can cross the blood-brain barrier (BBB) .

HY-N3550

Catalponol	Others	Cancer
Catalponol is a naphthoquinone derivative. Catalponol enhances dopamine biosynthesis by inducing tyrosine hydroxylase activity. Catalponol also increases the levels of cAMP and tyrosine hydroxylase phosphorylation in PC12 cells .

HY-141625

TRC160334	HIF/HIF Prolyl-Hydroxylase	Others
TRC160334 is a hypoxia-inducible factor (HIF) hydroxylase inhibitor. TRC160334 can be used for the research of ischemia/reperfusion injury .

HY-15641R

FG-2216 (Standard) IOX3 (Standard); YM311 (Standard)	HIF/HIF Prolyl-Hydroxylase Reference Standards	Metabolic Disease
FG-2216 (Standard) is the analytical standard of FG-2216. This product is intended for research and analytical applications. FG-2216 (IOX3) is a potent and orally active inhibitor of HIF prolyl hydroxylase-2 (PHD2), with an IC50 of 3.9 μM. FG-2216 induces robust erythropoietin and modest fetal hemoglobin in vivo .

Cat. No.	Product Name

HY-L173

Anti-Ovarian Cancer Compound Library

2,817 compounds

Ovarian cancer is the most common cause of death in female genital malignancies, with the highest mortality rate in female genital malignancies. It is characterized by difficulty in detection in the early stage of the disease, high recurrence rate and poor prognosis. In fact, ovarian cancer includes many pathologic types. It is usually divided into epithelial ovarian cancer, malignant germ cell tumors and sex cord stromal tumors, of which epithelial ovarian cancer is the most dominant form. Clinical treatment of ovarian cancer prioritizes surgery combined with paclitaxel chemotherapy. However, due to the spread and drug resistance of tumor cells, the recurrence of ovarian cancer is high. In this case, combined with traditional methods, the development of new therapeutic agents can help to improve the treatment effect of ovarian cancer.

MCE designs a unique collection of 2,817 compounds with definite or potential anti-ovarian cancer activity, which mainly targeting the main targets of ovarian cancer such as PARP, ATM/ATR, VEGFR and HIF/HIF Prolyl-Hydroxylase, etc. It is an essential tool for development and research of anti-ovarian compounds.

HY-L045

Oxygen Sensing Compound Library

4,029 compounds

Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.

HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O₂ concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.

MCE offers a unique collection of 4,029 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

Cat. No.	Product Name	Type

HY-172723

DSPE-PEG2000-T7

Biochemical Assay Reagents

DSPE-PEG2000-T7 is a PEGylated compound composed of DSPE and peptideT7. T7 (HAIYPRH) specifically binds to TfR. DSPE-PEG2000-T7 can be used to prepare T7-modified liposomes, where liposomes modified with both T7 and DA7R peptides can effectively co-deliver Doxorubicin (HY-15142A) and Vincristine (HY-N0488A) to gliomas. DSPE-PEG2000-T7 can also be used to prepare nanomodulators that mediate the co-delivery of tyrosine hydroxylase mRNA and interferon gene stimulator antagonists for synergistic intervention in Parkinson's disease .

HY-W014018

2,5-Diphenyloxazole PPO; DPO; POP	Biochemical Assay Reagents
2,5-Diphenyloxazole (PPO; DPO; POP) is a fluorescent dye, as well as a substrate and metabolite precursor of cytochrome P-450 (cytochrome P-448/P₁-450). 2,5-Diphenyloxazole serves as a scintillator .

HY-W071686

6-Methyltetrahydropterin dihydrochloride	Biochemical Assay Reagents
6-Methyltetrahydropterin (dihydrochloride) is a biochemical detection reagent that can be used in tyrosine hydroxylase activity assay .

Cat. No.	Product Name	Target	Research Area

HY-17365

Octreotide acetate 15+ Cited Publications SMS 201-995 acetate	Somatostatin Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently.

HY-125586

β-Amanitin	DNA/RNA Synthesis ADC Payload	Cancer
β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs) .

HY-W019599

4-Chloro-L-phenylalanine L-PCPA	5-HT Receptor Tryptophan Hydroxylase	Neurological Disease
4-Chloro-L-phenylalanine (L-PCPA) is a tryptophan hydroxylase inhibitor targeting TPH1 and TPH2, with the activity of blocking serotonin biosynthesis. 4-Chloro-L-phenylalanine reduces the levels of serotonin and its metabolites in the brain without impairing the survival of serotonergic neurons. 4-Chloro-L-phenylalanine enhances anhedonic, depression-like and anxiety-like behaviors in mice with depleted noradrenergic and dopaminergic neurons. 4-Chloro-L-phenylalanine acts as a decarboxylation substrate for aromatic L-amino acid decarboxylase from Bacillus atrophaeus. 4-Chloro-L-phenylalanine can be used in studies related to Parkinson's disease .

HY-105055

Didemnin B	Peptides	Cancer
Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer .

HY-W013407

α-Methyltyrosine methyl ester hydrochloride 1 Publications Verification	Tyrosine Hydroxylase Thyroid Hormone Receptor	Neurological Disease
α-Methyltyrosine methyl ester hydrochloride is an orally active and competitive tyrosine hydroxylase inhibitor. α-Methyltyrosine methyl ester hydrochloride can inhibit the conversion of tyrosine to dopamine. α-Methyltyrosine methyl ester hydrochloride causes kidney damage and urethral calculi in rats. α-Methyltyrosine methyl ester hydrochloride can be used as a tool for sympathetic nervous system research .

HY-P10447

Plipastatin A1 Fengycin IX; SNA-60-367-3	Phospholipase Fungal	Infection
Plipastatin A1 (Fengycin IX; SNA-60-367-3) is a lipopeptide with phospholipase A2 inhibitory activity. Plipastatin A1 inhibits conidial germination of Botrytis cinerea in vitro and reduces the incidence of gray mold on tomato leaves. Plipastatin A1 is applicable to research related to gray mold ^[1][2].

HY-P4755

*N-((RS)-2-Hydroxy-propyl)-Val-Leu-anilide*	Peptides	Others
N-((RS)-2-Hydroxy-propyl)-Val-Leu-anilide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P3100

Orfamide A	Parasite	Infection
Orfamide A is a major metabolite of insecticidal biosurfactant in Pseudomonas sp. F6 and has aphidicidal activity. Orfamide A can be used for aphid control in organic agriculture. Orfamide A exhibits dose-dependent mortality against aphids with an LC₅₀ value of 34.5 μg/mL .

HY-125357

Ternatin	Peptides	Metabolic Disease
Ternatin (compound 2) is a cyclic heptapeptides that can be isolated from mushroom Coliorus versicolor. Ternatin inhibits fat-accumulation with an IC₅₀ of 0.027 μM in 3T3-L1 adipocytes .

HY-158104

LPPM-8	ATF6	Others
LPPM-8 is a ligand of Med25 and an inhibitor of Med25 protein-protein interactions (PPIs). LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a). LPPM-8 can be used for studying Med25 and Mediator complex biology .

HY-P4817

Human PTH-(1-31)	Thyroid Hormone Receptor	Metabolic Disease
Human PTH-(1-31) is the 1-31 fragment of human PTH. Human PTH-(1-31) stimulates the release of cAMP and also is a weaker stimulator of the 25-hydroxyvitamin D-1α-hydroxylase. Human PTH-(1-31) induces bone formation without inducing bone resorption. Human PTH-(1-31) has the potential for the research of osteoporosis .

HY-P11783

Surfactin C2	Fungal	Infection
Surfactin C2 is a lipopeptide produced by Bacillus subtilis A18 with antifungal activity. Surfactin C2 acts against Heterobasidion annosum and Heterobasidion parviporum. Surfactin C2 exerts its activity mainly through membrane‑active effects to disrupt fungal cell structures and inhibit mycelial growth. Surfactin C2 can be used for the research of butt rot and root rot of conifers .

HY-P2209

Nummularine B Daechuine S27; N-Demethylamphibine H	Parasite Phosphodiesterase (PDE)	Infection
Nummularine B (Daechuine S27; N-Demethylamphibine H) is an anti-parasite agent. Nummularine B inhibits calmodulin-dependent phosphodiesterase activity with an IC₅₀ of 16.8 μM. Nummularine B inhibits the growth of Plasmodium and Leishmania donovani in vitro. Nummularine B inhibits the calmodulin-dependent activity of actomyosin Ca ²⁺-ATPase. Nummularine B is applicable to research related to malaria and visceral leishmaniasis .

HY-P4948

Coumarin-Phalloidin	Biochemical Assay Reagents	Others
Coumarin-phalloidin is a kind of phalloidin labeled with Coumarin (HY-N0709). Coumarin-phalloidin is a new type of actin probe that can be used for triple immunofluorescence microscopic observation of the cell skeleton .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0124A

Sapropterin dihydrochloride 2 Publications Verification (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride	Cardiovascular Disease Classification of Application Fields Disease Research Fields	Endogenous Metabolite
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE) .

HY-N0453

Hypericin 5+ Cited Publications	Quinones Structural Classification Classification of Application Fields Anthraquinones Guttiferae Hyperlcurn perforatum L. Plants Disease Research Fields Source Classification Cancer	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), *dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450*). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-B1232

Metyrapone Maximum Cited Publications 11 Publications Verification Su-4885	Alkaloids Classification of Application Fields Pyridine Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Endocrinology Source Classification Cancer	Endogenous Metabolite Cytochrome P450 Autophagy
Metyrapone (Su-4885) is a potent and orally active *11β-hydroxylase* inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone can be used for researching Cushing's syndrome and depression .

HY-107383

Tetrahydrobiopterin 3 Publications Verification (Rac)-Sapropterin	Alkaloids Classification of Application Fields Other Alkaloids Disease markers Endogenous metabolite Inflammation/Immunology Disease Research Fields Cardiovascular System Disorder Source Classification	NO Synthase Endogenous Metabolite
Tetrahydrobiopterin ((Rac)-Sapropterin) is a cofactor of the *aromatic amino acid hydroxylases* enzymes and also acts as an essential cofactor for all nitric oxide synthase** (NOS) isoforms.

HY-113342

7-Ketocholesterol 5 Publications Verification	Triterpenes Terpenoids Endogenous metabolite Source Classification	Endogenous Metabolite p38 MAPK
7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis) .

HY-101392

Harmane 1 Publications Verification	Alkaloids other families Pyridine Alkaloids Plants Indole Alkaloids Source Classification	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀ = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-113038B

α-Hydroxyglutaric acid 2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid	Immune System Disorder Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification Cancer	Histone Demethylase Endogenous Metabolite
α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-N7204

4-Hydroxyderricin 1 Publications Verification	Chalcones Monophenols Flavonoids Phenols Umbelliferae Plants Ondetia linearis Benth.	Monoamine Oxidase Dopamine β-hydroxylase Apoptosis
4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is an orally active, potent selective MAO-B (Monoamine oxidase inhibitors) inhibitor with an IC₅₀ of 3.43 μM. 4-Hydroxyderricin also mildly inhibits dopamine β (DBH)-hydroxylase activity. 4-Hydroxyderricin has antidepressant activity, anti-allergic, anti-diabetic, anti-oxidant, and antitumor effects. 4-Hydroxyderricin promotes apoptosis and cell cycle arrest through regulating PI3K/AKT/mTOR pathway in hepatocellular cells. 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation . 4-Hydroxyderricin is promising for research of inflammatory diseases .

HY-W592871

*10-Hydroxy-2-decenoic acid* 10-HDA; Queen Bee Acid	Animals Ketones, Aldehydes, Acids Source Classification	mTOR Apoptosis ERK MDM-2/p53 GSK-3 AMPK Interleukin Related TNF Receptor Caspase NF-κB Bacterial Fungal
10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence .

HY-112234

L-Sepiapterin 1 Publications Verification Sepiapterin	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
L-Sepiapterin (Sepiapterin), is a phenylalanine hydroxylase activator, is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70 ^S6K-dependent VEGFR-2 expression. L-Sepiapterin can be used for the study of hyperphenylalaninemia .

HY-128483

Fusaric acid	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor
Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β₁/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .

HY-W017113

2-Mercaptobenzothiazole 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite
2-Mercaptobenzothiazole is an activator of the aryl hydrocarbon receptor (AhR) , inhibiting thyroid hormone synthesis and dopamine beta-hydroxylase activity . 2-Mercaptobenzothiazole promotes bladder cancer cell invasion by altering the conformation of the AhR ligand binding domain (LBD), activating AhR transcription, and upregulating the mRNA and protein expression of target genes CYP1A1 and CYP1B1 . 2-Mercaptobenzothiazole inhibits thyroid peroxidase (TPO) with an IC₅₀ value of 11.5 μM, induces histological changes such as follicular cell hypertrophy in Xenopus laevis tadpoles, delaying metamorphosis . 2-Mercaptobenzothiazole increases chromosomal aberrations and sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells, and enhances carcinogenicity in F344/N rats . 2-Mercaptobenzothiazole inhibits norepinephrine synthesis in mice and completely blocks the conversion of exogenous dopamine to norepinephrine in rat cardiomyocytes .

HY-W008226

Phloracetophenone 2,4,6-trihydroxyacetophenone; 1-(2,4,6-Trihydroxyphenyl)ethanone	Infection other families Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Source Classification Curcuma comosa Roxb. Zingiberaceae	Cytochrome P450 Bacterial Antibiotic
Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity . Phloracetophenone stimulats bile secretion mediated through Mrp2 .

HY-114464

11-Beta-hydroxyandrostenedione 4-Androsten-11β-ol-3,17-dione	Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Endogenous Metabolite 11β-HSD
11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism .

HY-W008452

H-Tyr(3-I)-OH 1 Publications Verification	Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Phenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .

HY-N1477

Dencichine Dencichin; ODAP	Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Amino acids Plants Araliaceae Source Classification	HIF/HIF Prolyl-Hydroxylase
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit *HIF-prolyl hydroxylase-2 (PHD-2)* activity.

HY-113038A

α-Hydroxyglutaric acid disodium 2-Hydroxyglutarate disodium; 2-Hydroxyglutaric acid disodium; 2-Hydroxypentanedioic acid disodium	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Histone Demethylase Endogenous Metabolite
α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-105055

Didemnin B	Natural Products Animals Classification of Application Fields Marine natural products Other marine organisms Disease Research Fields Source Classification Cancer	Others
Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer .

HY-W016409

Ethyl 3,4-dihydroxybenzoate 1 Publications Verification Protocatechuic acid ethyl ester	Arachis hypogaea L. Classification of Application Fields Leguminosae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Source Classification	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) NO Synthase Autophagy Apoptosis
Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive *prolyl hydroxylase* (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor (HIF) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB** pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema .

HY-41404

Piperonylic acid 2H-1,3-benzodioxole-5-carboxylic acid	Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Piperaceae Plants Disease Research Fields Piper nigrum Linn. Source Classification	Cytochrome P450 Interleukin Related EGFR IGF-1R
Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase. Piperonylic acid has anticancer, antioxidant and antibacterial activities .

HY-113423

Tetrahydro-11-deoxycortisol Tetrahydrodeoxycortisol	Infection Classification of Application Fields Disease markers Other Diseases Endogenous metabolite Disease Research Fields Steroids Cancer Source Classification	Endogenous Metabolite
Tetrahydro-11-deoxycortisol (Tetrahydrodeoxycortisol) is an endogenous metabolite present in Urine that can be used for the research of 11 Beta Hydroxylase Deficiency .

HY-B0927

Hydrastine (-)-β-Hydrastine; (1R,9S)-β-Hydrastine	Alkaloids Piperidine Alkaloids Classification of Application Fields Ranunculaceae Other Diseases Plants Disease Research Fields	Tyrosine Hydroxylase Dopamine Receptor OAT
Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) is a selective competitive inhibitor of *tyrosine hydroxylase* (TH), inhibiting dopamine biosynthesis (IC₅₀=20.7 μM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 (IC₅₀=6.6 μM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis** when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage .

HY-N2560

Senecionine Senecionan-11,16-dione, 12-hydroxy-; Aureine; Senecionin	Pterogyne nitens Tul. Alkaloids Structural Classification Pyrrole Alkaloids Erinacea anthyllis Link Classification of Application Fields Metabolic Disease Plants Compositae Disease Research Fields Source Classification	Others
Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid could be isolated from Senecio vulgaris. Senecionine decreases the activities of glutathione S-transferase, aminopyrine demethylase and arylhydrocarbon hydroxylase (AHH) .

HY-N2589

Isosaponarin	Flavonoids Vaccaria segetalis (Neck.) Garcke Classification of Application Fields Flavones Other Diseases Phenols Polyphenols Plants Disease Research Fields Caryophyllaceae Source Classification	TGF-β Receptor Collagen
Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin is a P4HA2 enzymatic agonist. Isosaponarin increases collagen synthesis via up-regulated TGF-β type II receptor (TβR-II) and *prolyl 4-hydroxylase* (P4H)** proteins production, promoting skin health and wound healing. Isosaponarin-rich plants exhibit strong antimicrobial, antioxidant, anti-hyaluronidase, antiplatelet, anti-atopic dermatitis, and anti-tumor effects .

HY-N4205

Tetrahydropiperine	Alkaloids Piperidine Alkaloids Classification of Application Fields Piperaceae Plants Disease Research Fields Piper nigrum Linn. Source Classification Cancer	Cytochrome P450
Tetrahydropiperine is an orally effective, selective inhibitor of NF-κB and MAPKs<、b>, and an activator of the PI3K/Akt/mTOR<、b> pathway. Tetrahydropiperine reduces the production of pro-inflammatory cytokines such as TNF-α, IL-6, and nitric oxide (NO) by inhibiting the nuclear translocation of NF-κB and the phosphorylation of MAPKs such as ERK, JNK, and p38. At the same time, Tetrahydropiperine inhibits excessive autophagy by activating the PI3K/Akt/mTOR pathway, protecting neurons from oxidative damage. Tetrahydropiperine has anti-inflammatory, anti-apoptotic, and neuroprotective effects, and is mainly used in the study of inflammatory diseases (such as endotoxemia, arthritis) and neurological diseases such as ischemic stroke .

HY-101392A

Harmane hydrochloride 1 Publications Verification	Apocynaceae Alkaloids Other Alkaloids Plants Rauwolfia canescens Source Classification	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane hydrochloride is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane hydrochloride inhibits the I1 imidazoline receptor (IC₅₀ = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane hydrochloride inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane hydrochloride can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-N0453R

Hypericin (Standard) 5+ Cited Publications	Natural Products Classification of Application Fields Guttiferae Phenols Hyperlcurn perforatum L. Plants Disease Research Fields Source Classification Cancer	Reference Standards Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase
Hypericin (Standard) is the analytical standard of Hypericin. This product is intended for research and analytical applications. Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), *dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450*). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-N7512

Asimilobine	Infection Alkaloids Monophenols Classification of Application Fields Phenols Nelumbo nucifera Gaertn. Plants Isoquinoline Alkaloids Nymphaeaceae Disease Research Fields Source Classification	Dopamine Receptor 5-HT Receptor Parasite
Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity .

HY-129502

Fibrostatin C P-23924C	Natural Products Microorganisms Source Classification	HIF/HIF Prolyl-Hydroxylase
Fibrostatin C (P-23924C) is an orally active prolyl hydroxylase inhibitor that also inhibits collagen biosynthesis. Fibrostatin C also increases the number of cytoplasmic granules immunoreactive with antibodies to collagen I or III. Fibrostatin C inhibits the secretion of type I collagen in Tenon's capsule fibroblasts. Fibrostatin C is promising for research of the wound fibrotic response in the wound of glaucoma filtering surgery .

HY-N3550

Catalponol	Other Terpenoids Catalpa ovata G. Don Classification of Application Fields Terpenoids Bignoniaceae Plants Disease Research Fields Source Classification Cancer	Others
Catalponol is a naphthoquinone derivative. Catalponol enhances dopamine biosynthesis by inducing tyrosine hydroxylase activity. Catalponol also increases the levels of cAMP and tyrosine hydroxylase phosphorylation in PC12 cells .

HY-N6030

(Rac)-Dencichine (Rac)-Dencichin; (Rac)-ODAP	other families Classification of Application Fields Other Diseases Amino acids Plants Disease Research Fields Source Classification	HIF/HIF Prolyl-Hydroxylase
(Rac)-Dencichine ((Rac)-Dencichin) is the racemate of Dencichin. Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity .

HY-N3769

Dipterocarpol	Infection Triterpenes Microorganisms Classification of Application Fields Terpenoids Inflammation/Immunology Disease Research Fields	Others
Dipterocarpol is a dammarane-type triterpenoid. Dipterocarpol is substrate of the bacterial steroid-hydroxylase CYP106A2 .

HY-N11706

β-Cedrene (+)-β-Cedrene	Structural Classification Terpenoids Sesquiterpenes Erythrina arborescensRoxb. Plants Compositae Source Classification	Fungal
β-Cedrene ((+)-β-Cedrene) is a sesquiterpene compound that can be isolated from Centaurea kotschyi var. kotschyi and Centaurea kotschyi var. decumbens, exhibiting antibacterial, anti-inflammatory, antispasmodic, tonic, diuretic, sedative, insecticidal, and antifungal activities. β-Cedrene is also a potent competitive inhibitor of the CYP2B6-mediatedbupropion hydroxylase, with a K_i value of 1.6 μM .

HY-N7454

Anhydroerythromycin A	Infection Structural Classification Macrolide Antibiotics Classification of Application Fields Antibiotics Antibacterial Disease Research Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite Bacterial
Anhydroerythromycin A is a degradation product of the macrolide antibiotic erythromycin. Anhydroerythromycin A is formed via degradation of erythromycin in acidic aqueous solutions in vitro as well as in vivo. Anhydroerythromycin A is active against S. aureus and B. cereus in vitro (MICs = 12.5 and 6.25 μg/ml, respectively). Anhydroerythromycin A also inhibits steroid 6β-hydroxylase activity associated with the cytochrome P450 (CYP) isoform CYP3A in human liver microsomes.

HY-145751

*7α-Hydroxy-DHEA* 7α-Hydroxydehydroepiandrosterone; 3β,7α-Dihydroxy-Δ5-androsten-17-one	Endogenous metabolite Steroids Source Classification	Cytochrome P450 Mitochondrial Metabolism
7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of DHEA (HY-14650), catalyzed by intracellular steroid 7α-hydroxylases such as P450 2A1. 7α-Hydroxy-DHEA exhibits biological activity comparable to DHEA but does not convert into compounds with androgenic or estrogenic activity. It induces the activity of thermogenic enzymes such as mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, enhancing heat production and reducing food utilization efficiency. As a more efficient and safer metabolite compared to DHEA, 7α-Hydroxy-DHEA holds potential for studies in the fields of obesity, metabolic diseases, and adrenal carcinoma .

HY-W592871R

*10-Hydroxy-2-decenoic acid (Standard)* 10-HDA (Standard); Queen Bee Acid (Standard)	Structural Classification Animals Ketones, Aldehydes, Acids Source Classification	Reference Standards mTOR
10-Hydroxy-2-decenoic acid (Standard) is an analytical standard for 10-Hydroxy-2-decenoic acid (HY-W592871). This product is intended for research and analytical applications.10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence .

HY-N2560R

Senecionine (Standard) Senecionan-11,16-dione, 12-hydroxy- (Standard); Aureine (Standard); Senecionin (Standard)	Pterogyne nitens Tul. Alkaloids Structural Classification Pyrrole Alkaloids Erinacea anthyllis Link Plants Compositae Source Classification	Reference Standards Others
Senecionine (Standard) is the analytical standard of Senecionine. This product is intended for research and analytical applications. Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid could be isolated from Senecio vulgaris. Senecionine decreases the activities of glutathione S-transferase, aminopyrine demethylase and arylhydrocarbon hydroxylase (AHH) .

HY-N4205R

Tetrahydropiperine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Piperaceae Plants Piper nigrum Linn. Source Classification	Reference Standards Cytochrome P450
Tetrahydropiperine (Standard) is the analytical standard of Tetrahydropiperine. This product is intended for research and analytical applications. Tetrahydropiperine, a cyclohexyl analogue of piperine, is the first natural aryl pentanamide from Piper longum . Tetrahydropiperine (compound 14) inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50=23 µM) .

HY-N14330

Fibrostatin A	Quinones Microorganisms Naphthalene Quinones Source Classification	HIF/HIF Prolyl-Hydroxylase
Fibrostatin A is a proline hydroxylase inhibitor found in Strptomyces catenulae .

HY-N12475

Solavetivone	Structural Classification Terpenoids Sesquiterpenes Solanum virginianum Linnaeus Solanaceae Plants Source Classification	Fungal Cytochrome P450
Solavetivone is a Sesquiterpenoid phytoalexin and Antifungal agent. Solavetivone is isolated from stress-challenged potato plants. Solavetivone is hydroxylated by sesquiterpenoid phytoalexin hydroxylase (SPH/CYP76A2L). Solavetivone helps solanaceous plants defend against pathogens, damages plant cells after pathogen threat, and inhibits mycelial growth of Rhizoctonia solani. Solavetivone is applicable to studies related to Rhizoctonia solani infection .

HY-N15013

7-Deoxyloganin	Structural Classification Caprifoliaceae Iridoids Lonicera japonica Thunb. Terpenoids Plants Source Classification	Biochemical Assay Reagents
7-Deoxyloganin serves as a biosynthetic precursor of Loganin (HY-N0512). 7-Deoxyloganin undergoes hydroxylation catalyzed by 7-deoxyloganin 7-hydroxylase, a cytochrome P450-dependent monooxygenase, to produce Loganin .

HY-41404R

Piperonylic acid (Standard) 2H-1,3-benzodioxole-5-carboxylic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Piperaceae Plants Piper nigrum Linn. Source Classification	Cytochrome P450 Interleukin Related EGFR IGF-1R Reference Standards
Piperonylic acid (Standard) is the analytical standard of Piperonylic acid. This product is intended for research and analytical applications. Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase. Piperonylic acid has anticancer, antioxidant and antibacterial activities .

HY-116158

Oosponol	Monophenols Microorganisms Phenols Source Classification	Dopamine β-hydroxylase Fungal
Oosponol is a dopamine beta-hydroxylase inhibitor exhibiting hypotensive effects.Oospongol has strong antifungal activity against many antagonistic fungi .

HY-N7538

Dealanylalahopcin	Microorganisms Ketones, Aldehydes, Acids Source Classification	Bacterial
Dealanylalahopcin is an antimicrobial agent that can be isolated from the culture filtrate of Streptomyces leucoderma subsp. ochraceus. Dealanylalahopcin can also be synthesized by enzymatic hydrolysis of alahopcin by microbial α-amino acid ester hydrolases. Dealanylalahopcin has weak antimicrobial activity against Gram-positive and Gram-negative bacteria and exhibits moderate inhibition of collagen prolyl hydroxylase .

HY-N3548

Catalpalactone	Natural Products Catalpa ovata G. Don Plants Bignoniaceae Source Classification	NF-κB
Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities .

HY-B1232A

Metyrapone Tartrate Su-4885 Tartrate	Alkaloids Neurological Disease Classification of Application Fields Pyridine Alkaloids Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Endogenous Metabolite Cytochrome P450 Autophagy mTOR
Metyrapone (Su-4885) Tartrate is a potent and orally active *11β-hydroxylase* inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone Tartrate inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone Tartrate increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone Tartrate can be used for researching Cushing's syndrome and depression .

HY-113342R

7-Ketocholesterol (Standard)	Triterpenes Structural Classification Terpenoids Endogenous metabolite Source Classification	Endogenous Metabolite p38 MAPK Reference Standards
7-Ketocholesterol (Standard) is the analytical standard of 7-Ketocholesterol. This product is intended for research and analytical applications. 7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis) .

HY-B1232R

Metyrapone (Standard) Su-4885 (Standard)	Structural Classification Alkaloids Pyridine Alkaloids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Cytochrome P450 Autophagy
Metyrapone (Standard) is the analytical standard of Metyrapone. This product is intended for research and analytical applications. Metyrapone (Su-4885) is a potent and orally active *11β-hydroxylase* inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone can be used for researching Cushing's syndrome and depression .

HY-B0927R

Hydrastine (Standard) (-)-β-Hydrastine (Standard); (1R,9S)-β-Hydrastine (Standard)	Structural Classification Alkaloids Piperidine Alkaloids Ranunculaceae Plants	Reference Standards Tyrosine Hydroxylase Dopamine Receptor OAT
Hydrastine (Standard) is the analytical standard of Hydrastine (HY-B0927). This product is intended for research and analytical applications. Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) is a selective competitive inhibitor of *tyrosine hydroxylase* (TH), inhibiting dopamine biosynthesis (IC₅₀=20.7 μM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 (IC₅₀=6.6 μM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis** when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage .

HY-128483R

Fusaric acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor Reference Standards
Fusaric acid (Standard) is the analytical standard of Fusaric acid (HY-128483). This product is intended for research and analytical applications. Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β₁/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .

Species:	Human (20) Mouse (4)
Tag:	SUMO (3) His (27) Strep (1) Tag Free (5) Flag (1)
Source:	HEK293 (3) E. coli Cell-free (1) P. pastoris (1) Sf9 insect cells (4) E. coli (23)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73566

	*Tryptophan Hydroxylase* 1/TPH-1 Protein, Human (His)** TPH; TPH-1; TPRH; Tryptophan 5-hydroxylase 1; Tryptophan hydroxylase 1	Human	E. coli
	The tryptophan hydroxylase 1 (TPH-1) protein is key to serotonin biosynthesis, catalyzing the rate-limiting step: the oxidation of L-tryptophan to 5-hydroxy-L-tryptophan. This enzyme activity is critical for the synthesis of serotonin, a neurotransmitter that affects mood, sleep, and appetite. Tryptophan Hydroxylase 1/TPH-1 Protein, Human (His) is the recombinant human-derived Tryptophan Hydroxylase 1/TPH-1 protein, expressed by E. coli , with N-His labeled tag.

HY-P77565

	ASPH Protein, Mouse (His) Aspartate beta-hydroxylase; ASP beta-hydroxylase; Asph; Bah	Mouse	E. coli
	ASPH proteins exhibit enzymatic specificity by selectively hydroxylating aspartate (Asp) or asparagine (Asn) residues within specific epidermal growth factor-like (EGF) domains of the protein. This site-specific hydroxylation regulates post-translational modifications of EGF-containing proteins, potentially affecting their conformation, stability, or interactions. ASPH Protein, Mouse (His) is the recombinant mouse-derived ASPH protein, expressed by E. coli , with N-His labeled tag.

HY-P76874

	*Dopamine beta-Hydroxylase* Protein, Human (HEK293, His)** Dopamine beta-hydroxylase; DBH; DOPBHY	Human	HEK293
	Dopamine beta-hydroxylase protein is an essential enzyme involved in the regulation of neurotransmitters. Its main function is to catalyze the hydroxylation of dopamine, converting it into norepinephrine (also known as norepinephrine). Dopamine beta-Hydroxylase Protein, Human (HEK293, His) is the recombinant human-derived Dopamine beta-Hydroxylase protein, expressed by HEK293 , with N-His labeled tag.

HY-P706012

	EGLN1 Protein, Human (His) Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2); Prolyl hydroxylase domain-containing protein 2 (PHD2); SM-20; C1orf12; PNAS-118; PNAS-137	Human	E. coli

HY-P71375

	TPH2 Protein, Human (His) Tryptophan 5-hydroxylase 2; Neuronal Tryptophan hydroxylase; Tryptophan 5-Monooxygenase 2; TPH2; NTPH	Human	E. coli
	TPH2 Protein, an isozyme of tryptophan hydroxylase, is a member of the pterin-dependent aromatic acid hydroxylase family. TPH2 is selectively expressed only in the serotonergic neurons of the raphe nuclei and is a rate-limiting enzyme in the brain serotonin synthesis pathway. TPH2 plays a more prominent role in the 5-HT synthesis in the brain. Moreover, it is a key factor in maintaining normal serotonin transfer in the central nervous system. TPH2 Protein, Human (His) is the recombinant human-derived TPH2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P703327

	EGLN1 Protein, Human (246a.a, His) C1orf12; PNAS-118; PNAS-137; Egl nine homolog 1; Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2); Prolyl hydroxylase domain-containing protein 2 (PHD2)	Human	E. coli
	EGLN1 Protein, Human (246a.a, His) is the recombinant human-derived EGLN1, expressed by E. coli , with His labeled tag.

HY-P72092

	ASPH Protein, Human (His-SUMO) ASPH; BAHAspartyl/asparaginyl beta-hydroxylase; EC 1.14.11.16; Aspartate beta-hydroxylase; ASP beta-hydroxylase; Peptide-aspartate beta-dioxygenase	Human	E. coli
	ASPH protein phosphorylates SPRTN, facilitating its chromatin recruitment and decreasing replication stress. ASPH activates the G2/M checkpoint by phosphorylating and inhibiting PABIR1/FAM122A, leading to serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity. ASPH Protein, Human (His-SUMO) is the recombinant human-derived ASPH protein, expressed by E. coli, with N-6*His, N-SUMO labeled tag.

HY-P702161

	*Hyoscyamine 6 beta-hydroxylase* Protein, Hyoscyamus niger** H6H; Hyoscyamine 6-dioxygenase; Hyoscyamine 6-beta-hydroxylase	Others	E. coli
	Hyoscyamine 6 beta-hydroxylase Protein, Hyoscyamus niger is the recombinant Hyoscyamine 6 beta-hydroxylase protein, expressed by E. coli, with tag free.

HY-P702105

	Phytanoyl-CoA dioxygenase Protein, Actinophytocola oryzae Ectoine hydroxylase	Others	E. coli
	Phytyl-CoA dioxygenase (PHYH) is an enzyme involved in the alpha-oxidation of phytanic acid, a branched-chain fatty acid. PHYH catalyzes the conversion of phytyl-CoA to 2-hydroxyphytyl-CoA, initiating the degradation pathway. Phytanoyl-CoA dioxygenase Protein, Actinophytocola oryzae is the recombinant Phytanoyl-CoA dioxygenase protein, expressed by E. coli , with tag free.

HY-P72184

	EPHX1 Protein, Human (His-SUMO) EPHX 1; EPHX; Ephx1; EPOX; Epoxide hydratase; Epoxide hydrolase 1; Epoxide hydrolase 1 microsomal xenobiotic; ; Epoxide hydroxylase 1; Epoxide hydroxylase 1 microsomal xenobiotic; ; HYEP_HUMAN; HYL1; MEH; Microsomal epoxide hydrolase	Human	E. coli
	The EPHX1 protein is an important biotransformation enzyme that hydrolyzes aromatic hydrocarbons and aliphatic epoxides by catalyzing the transaddition of water. This makes the epoxide less reactive and more water-soluble. EPHX1 Protein, Human (His-SUMO) is the recombinant human-derived EPHX1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P702106

	Phytanoyl-CoA dioxygenase Protein, Actinophytocola oryzae (His) Ectoine hydroxylase	Others	E. coli
	Phytyl-CoA dioxygenase (PHYH) is an enzyme involved in the alpha-oxidation of phytanic acid, a branched-chain fatty acid. PHYH catalyzes the conversion of phytyl-CoA to 2-hydroxyphytyl-CoA, initiating the degradation pathway. Phytanoyl-CoA dioxygenase Protein, Actinophytocola oryzae (His) is the recombinant Phytanoyl-CoA dioxygenase protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702798

	CYP7A1 Protein, Human (His) Cytochrome P450 7A1; 24-hydroxycholesterol 7-alpha-hydroxylase; CYPVII; Cholesterol 7-alpha-hydroxylase	Human	E. coli
	CYP7A1 Protein, Human (His) is the recombinant human-derived CYP7A1, expressed by E. coli , with N-6*His labeled tag.

HY-P704040

	KMO Protein, Human (His) dJ317G22.1; kmo; KMO_HUMAN; Kynurenine 3 hydroxylase; Kynurenine 3 monooxygenase (kynurenine 3 hydroxylase); Kynurenine 3 monooxygenase; Kynurenine 3-hydroxylase; Kynurenine 3-monooxygenase; RP1-317G22.1	Human	E. coli
	KMO Protein, Human (His) is the recombinant human-derived KMO protein, expressed by E. coli, with N-10*His tag.

HY-P73733

	PAH Protein, Human (D415N, sf9, His) 1 Publications Verification Phenylalanine-4-hydroxylase; PAH	Human	Sf9 insect cells
	PAH protein is a key enzyme involved in amino acid metabolism. Its main function is to catalyze the hydroxylation of L-phenylalanine and convert it into L-tyrosine. PAH Protein, Human (D415N, sf9, His) is the recombinant human-derived PAH protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P702162

	ido Protein, Bacillus thuringiensis ido; L-isoleucine-4-hydroxylase; L-isoleucine dioxygenase; IDO	Others	E. coli
	IDO Protein, an enzyme, is involved in the conversion of tryptophan to kynurenine. Dysregulation of IDO Protein has been associated with immune suppression and tumor development. Targeting IDO Protein may present potential therapeutic approaches in cancer by modulating tryptophan metabolism, restoring immune responses, and inhibiting tumor growth. ido Protein, Bacillus thuringiensis is the recombinant ido protein, expressed by E. coli , with tag free.

HY-P701979

	kshB Protein, Mycobacterium tuberculosis hmp; 3-ketosteroid-9-alpha-monooxygenase; ferredoxin reductase component; 3-ketosteroid-9-alpha-hydroxylase; ferredoxin reductase component; KSH; Androsta-1; 4-diene-3; 17-dione 9-alpha-hydroxylase; Rieske-type oxygenase; RO	Others	E. coli
	The kshB protein significantly degrades cholesterol by catalyzing the introduction of the 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD), resulting in the 9OHADD intermediate. It is spontaneously converted to HSA through the cleavage of the B ring and aromatization of the A ring. kshB Protein, Mycobacterium tuberculosis is the recombinant kshB protein, expressed by E. coli , with tag free.

HY-P702163

	ido Protein, Bacillus thuringiensis (FLAG, His) ido; L-isoleucine-4-hydroxylase; L-isoleucine dioxygenase; IDO	Others	E. coli
	IDO Protein, an enzyme, is involved in the conversion of tryptophan to kynurenine. Dysregulation of IDO Protein has been associated with immune suppression and tumor development. Targeting IDO Protein may present potential therapeutic approaches in cancer by modulating tryptophan metabolism, restoring immune responses, and inhibiting tumor growth. ido Protein, Bacillus thuringiensis (FLAG, His) is the recombinant ido protein, expressed by E. coli , with N-6*His, N-Flag labeled tag.

HY-P701623

	KDM8 Protein, Human KDM8; Bifunctional peptidase and arginyl-hydroxylase JMJD5; JmjC domain-containing protein 5; Jumonji C domain-containing protein 5; L-arginine (3R)-hydroxylase KDM8	Human	E. coli
	The KDM8 protein is a multifunctional enzyme that acts as an endopeptidase and 2-oxoglutarate-dependent monooxygenase. As an endopeptidase, it cleaves histone tails at methylated arginine or lysine residues, producing "tailless nucleosomes" that facilitate transcription elongation. KDM8 Protein, Human is the recombinant human-derived KDM8 protein, expressed by E. coli , with tag free.

HY-P701980

	kshB Protein, Mycobacterium tuberculosis (His) hmp; 3-ketosteroid-9-alpha-monooxygenase; ferredoxin reductase component; 3-ketosteroid-9-alpha-hydroxylase; ferredoxin reductase component; KSH; Androsta-1; 4-diene-3; 17-dione 9-alpha-hydroxylase; Rieske-type oxygenase; RO	Others	E. coli
	The kshB protein significantly degrades cholesterol by catalyzing the introduction of the 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD), resulting in the 9OHADD intermediate. It is spontaneously converted to HSA through the cleavage of the B ring and aromatization of the A ring. kshB Protein, Mycobacterium tuberculosis (His) is the recombinant kshB protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701624

	KDM8 Protein, Human (His) KDM8; Bifunctional peptidase and arginyl-hydroxylase JMJD5; JmjC domain-containing protein 5; Jumonji C domain-containing protein 5; L-arginine (3R)-hydroxylase KDM8	Human	E. coli
	The KDM8 protein is a multifunctional enzyme that acts as an endopeptidase and 2-oxoglutarate-dependent monooxygenase. As an endopeptidase, it cleaves histone tails at methylated arginine or lysine residues, producing "tailless nucleosomes" that facilitate transcription elongation. KDM8 Protein, Human (His) is the recombinant human-derived KDM8 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P73564

	*Tyrosine Hydroxylase* Protein, Human (sf9, His)** DYT14; TH; TYH dystonia 14; TYH; Tyrosine 3-monooxygenase	Human	Sf9 insect cells
	Tyrosine hydroxylase is a key enzyme in the biosynthesis of catecholamines, catalyzing the conversion of L-tyrosine into L-dopa, which is the rate-limiting step in the synthesis of dopamine, norepinephrine, and epinephrine. Tyrosine is hydroxylated using tetrahydrobiopterin and oxygen. Tyrosine Hydroxylase Protein, Human (sf9, His) is the recombinant human-derived Tyrosine Hydroxylase protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P73563A

	*Tyrosine Hydroxylase* Protein, Mouse (sf9, His)** DYT14; TH; TYH dystonia 14; TYH; Tyrosine 3-monooxygenase	Mouse	Sf9 insect cells
	Tyrosine hydroxylase protein is a key catalyst in the biosynthesis of catecholamines, including dopamine, norepinephrine, and epinephrine, and oversees the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa) , which is the critical and rate-limiting step pathway in synthesis.Tyrosine Hydroxylase Protein, Mouse (sf9, His) is the recombinant mouse-derived Tyrosine Hydroxylase protein, expressed by sf9 insect cells , with N-His labeled tag.

HY-P73563

	*Tyrosine Hydroxylase* Protein, Mouse (sf9, His, solution)** DYT14; TH; TYH dystonia 14; TYH; Tyrosine 3-monooxygenase	Mouse	Sf9 insect cells
	Tyrosine hydroxylase protein is a key catalyst in the biosynthesis of catecholamines, including dopamine, norepinephrine, and epinephrine, and oversees the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa) , which is the critical and rate-limiting step pathway in synthesis.Tyrosine Hydroxylase Protein, Mouse (sf9, His) is the recombinant mouse-derived Tyrosine Hydroxylase protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P705481

	CH25H Protein, Mouse (Cell-Free, His) Cholesterol 25-hydroxylase; Cholesterol 25-monooxygenase (m25OH); Ch25h	Mouse	E. coli Cell-free

HY-P703426

	kshA Protein, Mycobacterium tuberculosis (His, Strep) 3-ketosteroid-9-alpha-monooxygenase, oxygenase component; 3-ketosteroid-9-alpha-hydroxylase, oxygenase component; KSH; Androsta-1,4-diene-3,17-dione 9-alpha-hydroxylase; 1.14.15.30; Rieske-type oxygenase; RO; kshA; Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); Oxidoreductase;	Others	E. coli
	kshA Protein, Mycobacterium tuberculosis (His, Strep) is the recombinant kshA, expressed by E. coli , with Strep, His labeled tag. ,

HY-P71728

	CYP21A2 Protein, Human (P.pastoris, His) CYP21; 21 OHase; CYP21A2; Steroid 21 monooxygenase; Steroid 21-hydroxylase	Human	P. pastoris
	CYP21A2 Protein, a cytochrome P450 monooxygenase, crucially hydroxylates progesterone and 17alpha-hydroxyprogesterone at C-21, yielding vital intermediates for mineralocorticoid and glucocorticoid biosynthesis in adrenal steroidogenesis. This enzymatic process involves molecular oxygen, with NADPH providing essential electrons via cytochrome P450 reductase (CPR). CYP21A2 plays a pivotal role in regulating adrenal cortex hormone production. CYP21A2 Protein, Human (P.pastoris, His) is the recombinant human-derived CYP21A2 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P71917

	P4HB Protein, Human (His) 1 Publications Verification Cellular thyroid hormone binding protein; Cellular thyroid hormone-binding protein; Collagen prolyl 4 hydroxylase beta; Disulphide Isomerase; DSI; EC 5.3.4.1; ER protein 59; ERBA2L; ERp59; GIT; P4HB; P4Hbeta; p55; PDI; PDIA1; PDIA1_HUMAN; PDIR; PHDB; PO4DB; PO4HB; PROHB; Protocollagen hydroxylase; Thbp;	Human	E. coli
	The P4HB protein is a multifunctional entity that catalyzes disulfide bonding processes at the cell surface and within cells. As a reductase, it modifies outer surface proteins and participates in the formation of disulfide bonds in nascent proteins. P4HB Protein, Human (His) is the recombinant human-derived P4HB protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70096

	COQ7 Protein, Human (HEK293, His) rHu5-demethoxyubiquinone hydroxylase, mitochondrial/COQ7, His; Ubiquinone Biosynthesis Protein COQ7 Homolog; Coenzyme Q Biosynthesis Protein 7 Homolog; Timing Protein Clk-1 Homolog; COQ7	Human	HEK293
	The COQ7 protein is a key enzyme in lipid A biosynthesis and catalyzes a key hydrolysis step involving UDP-3-O-myristoyl-N-acetylglucosamine. This activity leads to the formation of UDP-3-O-myristoylglucosamine and acetate, which is a decisive point in lipid A synthesis. COQ7 Protein, Human (HEK293, His) is the recombinant human-derived COQ7 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71087

	P4HB Protein, Human (HEK293, His) Protein Disulfide-Isomerase; PDI; Cellular Thyroid Hormone-Binding Protein; Prolyl 4-hydroxylase Subunit Beta; p55; P4HB; ERBA2L; PDI; PDIA1; PO4DB	Human	HEK293
	The P4HB protein is a multifunctional entity that catalyzes disulfide bonding processes at the cell surface and within cells. As a reductase, it modifies outer surface proteins and participates in the formation of disulfide bonds in nascent proteins. P4HB Protein, Human (HEK293, His) is the recombinant human-derived P4HB protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71203

	PHS Protein, Human (His) Pterin-4-Alpha-Carbinolamine Dehydratase; PHS; 4-Alpha-Hydroxy-Tetrahydropterin Dehydratase; Dimerization Cofactor of Hepatocyte Nuclear Factor 1-Alpha; DCoH; Dimerization Cofactor of HNF1; Phenylalanine hydroxylase-Stimulating Protein; Pterin Carbinolamine Dehy	Human	E. coli
	PHS protein is crucial in tetrahydrobiopterin biosynthesis and has the dual function of hindering the formation of 7-pterin and promoting quinone-BH2. It also acts as a coactivator of HNF1A-dependent transcription, affecting HNF1A dimerization and enhancing its activity. PHS Protein, Human (His) is the recombinant human-derived PHS protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72163

	CYP11B2 Protein, Human (His-SUMO) ALDOS; Aldosterone synthase; Aldosterone-synthesizing enzyme; C11B2_HUMAN; CYP11B2; CYPXIB2; Cytochrome P-450Aldo; Cytochrome P-450C18; Cytochrome P450 11B2; Cytochrome P450 11B2; mitochondrial; mitochondrial; P-450Aldo; P-450C18; Steroid 18-hydroxylase	Human	E. coli
	CYP11B2 Protein, a cytochrome P450 monooxygenase, synthesizes aldosterone, pivotal for salt and water balance, impacting blood pressure and cardiovascular health. Mechanistically, it orchestrates three oxidative reactions, forming aldosterone, utilizing molecular oxygen and a mitochondrial transfer system. Additionally, CYP11B2 may be involved in the androgen metabolic pathway, expanding its physiological roles. CYP11B2 Protein, Human (His-SUMO) is the recombinant human-derived CYP11B2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P72164

	CYP21A2 Protein, Human (His) CYP21; 21 OHase; 21-OHase; CA21H ; CAH1; CP21A_HUMAN; CPS1; CYP21A 2; CYP21A2; CYP21B; Cytochrome P-450c21; Cytochrome P450 21; Cytochrome P450 C21B; Cytochrome P450 XXI; Cytochrome P450; family 21; subfamily A; polypeptide 2; Cytochrome P450; subfamily XXIA steroid 21 hydroxylase;	Human	E. coli
	CYP21A2 Protein, a cytochrome P450 monooxygenase, crucially hydroxylates progesterone and 17alpha-hydroxyprogesterone at C-21, yielding vital intermediates for mineralocorticoid and glucocorticoid biosynthesis in adrenal steroidogenesis. This enzymatic process involves molecular oxygen, with NADPH providing essential electrons via cytochrome P450 reductase (CPR). CYP21A2 plays a pivotal role in regulating adrenal cortex hormone production. CYP21A2 Protein, Human (His) is the recombinant human-derived CYP21A2 protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-70013S

Abiraterone-d4
Abiraterone-d₄ is the deuterium labeled Abiraterone. Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, which inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17 with IC50s of 2.5 nM and 15 nM, respectively.

HY-113038AS

α-Hydroxyglutaric acid-13C5 disodium
α-Hydroxyglutaric acid- ¹³C₅ (sodium) is the ¹³C labeled α-Hydroxyglutaric acid sodium . α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-114464S1

11-Beta-hydroxyandrostenedione-d7
11-Beta-hydroxyandrostenedione-d₇ is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor

HY-113038AS1

α-Hydroxyglutaric acid-d4 disodium

α-Hydroxyglutaric acid-d₄ (disodium) is the deuterium labeled α-Hydroxyglutaric acid disodium . α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-13426S

Roxadustat-d5
Roxadustat-d₅ is deuterium labeled Roxadustat. Roxadustat is an oral hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin .

HY-144856S1

Sapropterin-d3
Sapropterin-d₃ ((6R)-BH4-d₃) is deuterium labeled Sapropterin. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) .

HY-B0859S1

MCPA-d3

MCPA-d₃ is the deuterium labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds .

HY-101277S1

Vadadustat-13C6
Vadadustat- ¹³C₆ (PG-1016548- ¹³C₆) is ¹³C labeled Vadadustat. Vadadustat (PG-1016548) is a titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor . Vadadustat is an erythropoiesis-stimulating agent and has the potential for anemia treatment in chronic kidney disease in vivo .

HY-114464S

11-Beta-hydroxyandrostenedione-d4
11-Beta-hydroxyandrostenedione-d₄ is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor .

HY-W015007S

Metyrosine-13C9,15N,d7
Metyrosine- ¹³C₉, ¹⁵N,d₇ is the deuterium, ¹³C-, and 15-labeled Metyrosine. Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity . Metyrosine is a very effective agent for blood pressure control .

HY-W008452S

H-Tyr(3-I)-OH-13C6
H-Tyr(3-I)-OH- ¹³C₆ is the ¹³C-labeled H-Tyr(3-I)-OH. H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .

HY-W713900

MCPA-d3-1

MCPA-d₃-1 is the deuterium labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds .

HY-W704805

Sodium 2-hydroxypentanedioate-2,3,3-d3

Sodium 2-hydroxypentanedioate-2,3,3-d₃ is the deuterium labeled α-Hydroxyglutaric acid disodium (HY-113038A). α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-B0859S

MCPA-13C8

MCPA- ¹³C₈ is the ¹³C-labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds .

HY-W777360

Harman-13C2,15N

Harman- ¹³C₂, ¹⁵N is ¹³C and ¹⁵N labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-W778057

Ethyl 3,4-Dihydroxybenzoate-13C3

Ethyl 3,4-Dihydroxybenzoate- ¹³C₃ (Protocatechuic acid ethyl ester- ¹³C₃) is the ¹³C-labeled Ethyl 3,4-dihydroxybenzoate (HY-W016409). Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive prolyl hydroxylase (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor (HIF) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema .

HY-W700834

Harman-d3

Harman-d₃ is deuterium labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

Host:	Mouse (11) Rabbit (15)
Reactivity:	Human (25) Bovine (1) Rat (15) Mouse (14) Dog (1) Golden hamster (1)
Application:	IHC-P (13) ICC/IF (11) IF-Tissue (3) IP (4) IHC-F (1) WB (24) FC (8) ELISA (4)
Isotype:	IgG (15) IgG1 (7)
Conjugation:	Non-conjugated (26)
Clonality:	Polyclonal (1) Monoclonal (22) Recombinant (12)
Modification:	Unmodified (23)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83004

	*Tryptophan 5 Hydroxylase* 1 Antibody (YA2749)** TPH1; MGC119994; TPRH; TRPH; Tryptophan 5-hydroxylase 1; Tryptophan hydroxylase	WB, IHC-P, IP	Human, Mouse, Rat
	Tryptophan 5 Hydroxylase 1 Antibody (YA2749) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Tryptophan 5 Hydroxylase 1.

HY-P85701

	*Tyrosine Hydroxylase* Antibody (YA5393)** 1 Publications Verification Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH;	WB, ICC/IF, ELISA	Human, Mouse, Rat
	Tyrosine Hydroxylase Antibody (YA5393) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Tyrosine Hydroxylase.

HY-P86075

	*Tyrosine Hydroxylase* Antibody (YA5767)** Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Tyrosine Hydroxylase Antibody (YA5767) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Tyrosine Hydroxylase.

HY-P80362

	*Tyrosine Hydroxylase* Antibody (YA023)** 2 Publications Verification	WB, IHC-P, ICC/IF, FC, IF-Tissue	Human, Mouse, Rat
	Tyrosine Hydroxylase Antibody (YA023) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Tyrosine Hydroxylase.

HY-P87117

	TPH2 Antibody (YA6810) MGC138871 antibody; ADHD7 antibody; FLJ37295 antibody; MGC138872 antibody; Neuronal tryptophan hydroxylase antibody; NTPH antibody; TPH 2 antibody; Tph2 antibody; TPH2_HUMAN antibody; Tryptophan 5-hydroxylase 2 antibody; MGC138871 antibody; ADHD7 antibody; FLJ37295 antibody; MGC138872 antibody; Neuronal tryptophan hydroxylase antibody; NTPH antibody; TPH 2 antibody; Tph2 antibody; TPH2_HUMAN antibody; Tryptophan 5-hydroxylase 2 antibody; Tryptophan 5-monooxygenase 2 antibody; Tryptophan hydroxylase 2 antibody;	WB, IHC-P, IHC-F, IP	Mouse, Rat
	TPH2 Antibody (YA6810) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TPH2.

HY-P86857

	*Dopamine beta Hydroxylase* Antibody (YA6550)** dbh antibody; DBM antibody; Dopamine beta hydroxylase antibody; Dopamine beta monooxygenase antibody; Dopamine beta-hydroxylase (dopamine beta-monooxygenase) antibody; Dopamine beta-monooxygenase antibody; DOPO_HUMAN antibody; OTTHUMP00000022501 antibody; Soluble dopamine beta-hydroxylase antibody;	WB	Human
	Dopamine beta Hydroxylase Antibody (YA6550) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dopamine beta Hydroxylase.

HY-P82418

	Cytochrome P450 27A1 Antibody (YA2163) CYP27A1; CYP27; Sterol 26-hydroxylase; mitochondrial; 5-beta-cholestane-3-alpha; 7-alpha; 12-alpha-triol 27-hydroxylase; Cytochrome P-450C27/25; Cytochrome P450 27; Sterol 27-hydroxylase; Vitamin D(3) 25-hydroxylase	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Cytochrome P450 27A1 Antibody (YA2163) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 27A1.

HY-P88144

	P4HA3 Antibody (YA7828) 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase); alpha III subunit; alpha polypeptide III; C-P4H alpha III; collagen prolyl 4-hydroxylase alpha(III); procollagen-proline; prolyl 4-hydroxylase	IHC-P	Human, Mouse, Rat
	P4HA3 Antibody (YA7828) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to P4HA3.

HY-P87578

	PHD1 Antibody (YA7262) DKFZp434E026 antibody; Egl nine homolog 2 antibody; EGLN 2 antibody; EIT 6 antibody; Estrogen-induced tag 6 antibody; HIF P4H 1 antibody; HIF prolyl hydroxylase 1 antibody; HIF-PH1 antibody; HIF-prolyl hydroxylase 1 antibody; HIFPH 1 antibody; HPH-3 antibody; HPH3 antibody; Hypoxia-inducible factor prolyl hydroxylase 1 antibody; P4H1 antibody; PHD 1 antibody; prolyl hydroxylase domain containing protein 1 antibody	WB, IHC-P, ICC/IF, FC, IF-Tissue	Human, Mouse, Rat
	PHD1 Antibody (YA7262) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PHD1.

HY-P88144A

	P4HA3 Antibody (YA7828)(PBS only) 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase); alpha III subunit; alpha polypeptide III; C-P4H alpha III; collagen prolyl 4-hydroxylase alpha(III); procollagen-proline; prolyl 4-hydroxylase	IHC-P	Human, Mouse, Rat
	P4HA3 Antibody (YA7828) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to P4HA3.

HY-P83980

	*Tyrosine Hydroxylase* Antibody (YA3677)** TYH; DYT14; DYT5b	WB, IHC-P, FC, ELISA	Human, Rat
	Tyrosine Hydroxylase Antibody (YA3677) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Tyrosine Hydroxylase.

HY-P83980A

	*Tyrosine Hydroxylase* Antibody (YA3677)(PBS only)** TYH; DYT14; DYT5b	WB, IHC-P, FC, ELISA	Human, Rat
	Tyrosine Hydroxylase Antibody (YA3677) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Tyrosine Hydroxylase.

HY-P82376

	Cytochrome P450 24A1 Antibody (YA2121) CYP24A1; CYP24; 1; 25-dihydroxyvitamin D(3) 24-hydroxylase; mitochondrial; 24-OHase; Vitamin D(3) 24-hydroxylase; Cytochrome P450 24A1; Cytochrome P450-CC24	WB	Human
	Cytochrome P450 24A1 Antibody (YA2121) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 24A1.

HY-P81319

	JMJD6 Antibody (YA1064) JMJD6; KIAA0585; PTDSR; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-diox	WB, ICC/IF	Human
	JMJD6 Antibody (YA1064) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to JMJD6.

HY-P85461

	JMJD6 Antibody (YA5153) JMJD6; KIAA0585; PTDSR; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-diox	WB, ICC/IF	Human, Mouse, Rat, Bovine, Dog
	JMJD6 Antibody (YA5153) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to JMJD6.

HY-P81319A

	JMJD6 Antibody (YA1064)(PBS only) JMJD6; KIAA0585; PTDSR; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-diox	WB, ICC/IF	Human
	JMJD6 Antibody (YA1064) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to JMJD6.

HY-P86297

	DOHH Antibody (YA5989) DOHH; HLRC1; Deoxyhypusine hydroxylase ; hDOHH; Deoxyhypusine dioxygenase; Deoxyhypusine monooxygenase; HEAT-like repeat-containing protein 1;	WB, IP	Human
	DOHH Antibody (YA5989) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DOHH.

HY-P81069

	CYP7A1 Antibody CYP7A1; CYP7; Cholesterol 7-alpha-monooxygenase; CYPVII; Cholesterol 7-alpha-hydroxylase; Cytochrome P450 7A1	WB	Human, Mouse
	CYP7A1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to CYP7A1.

HY-P85425

	CYP7A1 Antibody (YA5117) CYP7A1; CYP7; Cholesterol 7-alpha-monooxygenase; CYPVII; Cholesterol 7-alpha-hydroxylase; Cytochrome P450 7A1	WB	Human, Golden hamster
	CYP7A1 Antibody (YA5117) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CYP7A1.

HY-P81244

	CYP2E1 Antibody (YA9212) CYP2E1; CYP2E; Cytochrome P450 2E1; 4-nitrophenol 2-hydroxylase; CYPIIE1; Cytochrome P450-J	WB, IHC-P, IF-Tissue	Human, Mouse, Rat
	CYP2E1 Antibody (YA9212) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CYP2E1.

HY-P86780

	Aldehyde Oxidase Antibody (YA6473) Aldehyde oxidase 1 antibody; AO antibody; AOH1 antibody; AOX 1 antibody; azaheterocycle hydroxylase antibody; EC 1.2.3.1 antibody;	WB, IHC-P, FC	Human, Mouse, Rat
	Aldehyde Oxidase Antibody (YA6473) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aldehyde Oxidase.

HY-P82557

	Cytochrome P450 2E1 Antibody (YA2302) CYP2E1; CYP2E; Cytochrome P450 2E1; 4-nitrophenol 2-hydroxylase; CYPIIE1; Cytochrome P450-J	WB	Human, Mouse, Rat
	Cytochrome P450 2E1 Antibody (YA2302) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 2E1.

HY-P83639

	Cytochrome P450 2D6 Antibody (YA3384) CYP2D6; CYP2DL1; Cytochrome P450 2D6; CYPIID6; Cytochrome P450-DB1; Debrisoquine 4-hydroxylase	WB, IHC-P, ICC/IF, FC	Human
	Cytochrome P450 2D6 Antibody (YA3384) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 2D6.

HY-P85566

	Cytochrome P450 17A1 Antibody (YA5258) 20 lyase; CP17A_HUMAN; CPT7; CYP17; CYP17A1; CYPXVII; Cytochrome P450 17A1; Cytochrome P450 family 17; Cytochrome P450 family 17 subfamily A polypeptide 1; Cytochrome p450 subfamily XVII; steroid 17 alpha hydroxylase; adrenal hyperplasia; Cytochrome p450 XVIIA1; Cytochrome P450-C17; Cytochrome P450c17; OTTHUMP00000020382; P450 C17; P450c17; S17AH; Steroid 17 alpha hydroxylase/17,20 lyase; Steroid 17 alpha monooxygenase; Steroid 17-alpha-hydroxylase/17; Steroid 17-alpha-monooxygenase.	WB	Human
	Cytochrome P450 17A1 Antibody (YA5258) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Cytochrome P450 17A1.

HY-P85485

	JMJD6(N-term) Antibody (YA5177) Apoptotic cell clearance receptor; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; JMJD 6; JMJD6; JMJD6_HUMAN; Jumonji domain containing 6; Jumonji domain-containing protein 6; KIAA0585; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-dioxygenase JMJD6; Phosphatidylserine receptor; Protein PTDSR; PSR; PTDSR 1; PTDSR; PTDSR1.	WB, ICC/IF	Human
	JMJD6(N-term) Antibody (YA5177) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to JMJD6(N-term).

HY-P81245

	Cytochrome P450 1A2 Antibody (YA3505) Cytochrome P450 1A2; cytochrome P450, family 1, subfamily a, polypeptide 2; Cytochrome P450 family 1 polypeptide 2; Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2; Cyp1a2; CYPD45; P-450d; RATCYPD45; CP12; CP 12; P3-450; Aryl hydrocarbon hydroxylase; Dioxin inducable P3 45; Flavoprotein linked monooxygenase; Microsomal monooxygenase; P450 4; P450 form 4; P450 P3; P450(PA); Xenobiotic monooxygenase; P450 1A2.	WB, ICC/IF, FC	Human
	Cytochrome P450 1A2 Antibody (YA3505) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 1A2.

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Cat. No.	Product Name		Classification

HY-106203

Crinecerfont SSR-125543		Alkynes
Crinecerfont (SSR-125543) is an orally effective corticotropin-releasing factor receptor type-1 (CRF1 receptor) antagonist. Crinecerfont blocks CRF1 receptor signaling to reduce adrenocorticotropic hormone secretion. Crinecerfont improves hypothalamic-pituitary-adrenal axis negative feedback sensitivity in chronically stressed mice. Crinecerfont can be used for the research of chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency . Crinecerfont is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-101016

17-ODYA 1 Publications Verification		Alkynes
17-ODYA is a CYP450 ω-hydroxylase inhibitor. 17-ODYA is also a potent inhibitor (IC₅₀<100 nM) of the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids by rat renal cortical microsomes incubated with arachidonic acid. 17-ODYA completely attenuates the isoproterenol (ISO)-induced apoptosis, and necrosis in cultured cardiomyocytes . 17-ODYA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-23460

p-Ethynylphenylalanine 1 Publications Verification 4-Ethynyl-L-phenylalanine		Alkynes
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of *tryptophan hydroxylase* (TPH), with a K_i** of 32.6 μM . p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-106203A

Crinecerfont hydrochloride SSR-125543 hydrochloride		Alkynes
Crinecerfont (SSR-125543) hydrochloride is an orally effective corticotropin-releasing factor receptor type-1 (CRF1 receptor) antagonist. Crinecerfont hydrochloride blocks CRF1 receptor signaling to reduce adrenocorticotropic hormone secretion. Crinecerfont hydrochloride improves hypothalamic-pituitary-adrenal axis negative feedback sensitivity in chronically stressed mice. Crinecerfont hydrochloride can be used for the research of chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency . Crinecerfont hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-23460A

p-Ethynylphenylalanine hydrochloride 1 Publications Verification 4-Ethynyl-L-phenylalanine hydrochloride		Alkynes
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of *tryptophan hydroxylase* (TPH), with a K_i** of 32.6 μM . p-Ethynylphenylalanine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-106203B

(R)-Crinecerfont (R)-SSR-125543		Alkynes
(R)-Crinecerfont is the R-enantiomer of Crinecerfont (HY-106203). Crinecerfont (SSR-125543) is an orally effective corticotropin-releasing factor receptor type-1 (CRF1 receptor) antagonist. Crinecerfont blocks CRF1 receptor signaling to reduce adrenocorticotropic hormone secretion. Crinecerfont improves hypothalamic-pituitary-adrenal axis negative feedback sensitivity in chronically stressed mice. Crinecerfont can be used for the research of chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency . Crinecerfont is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-172723

DSPE-PEG2000-T7		Pegylated Lipids
DSPE-PEG2000-T7 is a PEGylated compound composed of DSPE and peptideT7. T7 (HAIYPRH) specifically binds to TfR. DSPE-PEG2000-T7 can be used to prepare T7-modified liposomes, where liposomes modified with both T7 and DA7R peptides can effectively co-deliver Doxorubicin (HY-15142A) and Vincristine (HY-N0488A) to gliomas. DSPE-PEG2000-T7 can also be used to prepare nanomodulators that mediate the co-delivery of tyrosine hydroxylase mRNA and interferon gene stimulator antagonists for synergistic intervention in Parkinson's disease .

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hydroxylase

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