1154097-71-8
1154097-71-8
Chemical Structure
IOX4
- CAS. Nr.: 1154097-71-8
- Formula:C15H16N6O3
- Molecular Weight:328.33
IUPAC Name: tert-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate
InChIKey: HWQQDVNGHZIALS-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(N2NC=C(N3N=NC=C3)C2=O)N=C1)OC(C)(C)C
Biological Activity: IOX4 is a selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor with an IC50 value of 1.6 nM, induces HIFα in cells and in wildtype mice with marked induction in the brain tissue. IOX4 competes with and displaces 2-oxoglutarate (2OG) at the active site of PHD2[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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IOX4 | 99.96% | IOX4 is a selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor with an IC50 value of 1.6 nM, induces HIFα in cells and in wildtype mice with marked induction in the brain tissue. IOX4 competes with and displaces 2-oxoglutarate (2OG) at the active site of PHD2. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.55
HY-12654RMolidustat (Standard) -
Similarity Score 0.51
HY-W1865056-(3,5-Dimethyl-1h-pyrazol-1-yl)pyridine-3-carboxylic acid -
Similarity Score 0.50
HY-W1127101,1'-Pyridine-2,6-diylbis(1H-pyrazole-3-carboxylicacid) -
Similarity Score 0.50
HY-W1126022,6-Di(1H-pyrazol-1-yl)isonicotinic acid -
Similarity Score 0.48
HY-W6745102,6-Bis(4-Methyl-1H-pyrazol-1-yl)pyridine -
Similarity Score 0.48
HY-W6738432,6-Bis(3-Methyl-1H-pyrazol-1-yl)pyridine -
Similarity Score 0.48
HY-136682N19-0881 -
Similarity Score 0.48
HY-1372391,4-DPCA ethyl ester -
Similarity Score 0.48
HY-168708AH2-14c -
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