1154097-71-8
1154097-71-8
Chemical Structure
IOX4
- CAS No.: 1154097-71-8
- Formula:C15H16N6O3
- Molecular Weight:328.33
IUPAC Name: tert-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate
InChIKey: HWQQDVNGHZIALS-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(N2NC=C(N3N=NC=C3)C2=O)N=C1)OC(C)(C)C
Biological Activity: IOX4 is a selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor with an IC50 value of 1.6 nM, induces HIFα in cells and in wildtype mice with marked induction in the brain tissue. IOX4 competes with and displaces 2-oxoglutarate (2OG) at the active site of PHD2[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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IOX4 | 99.96% | IOX4 is a selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor with an IC50 value of 1.6 nM, induces HIFα in cells and in wildtype mice with marked induction in the brain tissue. IOX4 competes with and displaces 2-oxoglutarate (2OG) at the active site of PHD2. | ||||||||||||||||||||
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References
Keywords
