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Results for "

imaging agents

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (1) ADC Linker (1) Adenosine Receptor (4) Amino Acid Derivatives (2) Amino acid Transporter (1) Aminopeptidase (2) Amyloid-β (2) Antibiotic (1) Apoptosis (9) ASCT (1) Autophagy (3) Bacterial (9) Biochemical Assay Reagents (52) c-Met/HGFR (1) Carbonic Anhydrase (1) CD22 (1) CD38 (1) COX (1) CXCR (1) Cytochrome P450 (1) DNA-PK (1) Dopamine Receptor (1) Drug Derivative (2) Drug Intermediate (6) EGFR (2) Endogenous Metabolite (1) Environmental Pollutants (3) FAP (5) Ferroptosis (1) Fluorescent Dye (36) Folate Receptor (FR) (1) Formyl Peptide Receptor (FPR) (1) Galectin (1) GLUT (1) Glycoprotein VI (1) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (1) Histone Demethylase (1) HSP (1) Integrin (1) Isotope-Labeled Compounds (3) LDLR (1) Ligands for Target Protein for PROTAC (1) Liposome (5) Mitophagy (3) Monoamine Transporter (1) Mucin (1) OAT (1) Organoid (1) PARP (3) PD-1/PD-L1 (2) Phosphatase (1) PSMA (9) Pyroptosis (1) Radionuclide-Drug Conjugates (RDCs) (15) Reactive Oxygen Species (ROS) (3) Reference Standards (14) SHP1 (1) SOD (1) Somatostatin Receptor (3) STAT (1) Synaptic Vesicle Proteins (1) Tau Protein (1) TNF Receptor (1)
By Research Areas:	Cancer (103) Cardiovascular Disease (7) Endocrinology (2) Infection (11) Inflammation/Immunology (18) Metabolic Disease (5) Neurological Disease (11)
Click Chemistry:	Labeling and Fluorescence Imaging (2) DBCO (2) Azide (4) BCN (1) Tetrazine (1) Alkynes (1)
Oligonucleotides:	Fluorescent Lipids (1) Pegylated Lipids (1) Aptamers (1)

178

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128890

DOTA-NHS-ester 1 Publications Verification	ADC Linker	Cancer
DOTA-NHS-ester is a linker for affibody molecules and is applied in small animals PET, SPECT, and CT. DOTA-NHS-ester can be used to label radiotherapeutic agents or imaging probes for the detection of tumors .

HY-B0594

Iohexol 5 Publications Verification	Autophagy Mitophagy	Cancer
Iohexol is a non-ionic, water-soluble contrast agent used as a reference marker for the determination of glomerular filtration rate (GFR) at the level of renal function. Iohexol can be used for contrast in myelography, computerized tomography (cisternography, ventriculography) and MicroCT imaging .

HY-D1041

ICG NHS ester ICG-OSu	Fluorescent Dye	Cancer
ICG NHS ester (ICG-OSu) is a near-infrared fluorescent agent ICG derivative. ICG NHS ester is amine-reactive and has been widely used to design in vivo imaging probes .

HY-136886

IR-820 2 Publications Verification New Indocyanine Green	Fluorescent Dye	Cancer
IR-820 (New Indocyanine Green) is an infrared blood pool contrast agent. IR-820 also is normally used as a laser and near-infrared dye to detect and quantify diseased tissue in live animals .

HY-W034551

DOTA-tri(t-butyl ester)	Radionuclide-Drug Conjugates (RDCs)	Others Cancer
DOTA-tri(t-butyl ester) belongs to the DOTA class of chelating agents. DOTA-tri(t-butyl ester) is a key raw material for synthesizing nanospherical magnetic resonance imaging (MRI) contrast agents, which are used in MR angiography and tumor angiogenesis imaging .

HY-139579

Pafolacianine 1 Publications Verification OTL 38	Fluorescent Dye	Cancer
Pafolacianine (OTL 38) is a fluorescent imaging agent made of near-infrared dye used in detecting tumor lesions during surgical procedures. Pafolacianine excites at 774 to 775 nm and emits at 794 to 796 nm .

HY-145746

Sulfo-Cy5 azide	Fluorescent Dye PD-1/PD-L1	Inflammation/Immunology Cancer
Sulfo-Cy5 azide is a near-infrared fluorescent probe with favorable click chemistry reactivity. Sulfo-Cy5 azide enables fluorescence imaging, tissue and cellular visualization of PD-L1 in tumors, and site-specific modification of anti-PD-L1 antibodies. Sulfo-Cy5 azide has been employed for RNA labeling and imaging. Sulfo-Cy5 azide can be conjugated to targeting agents for fluorescence imaging in atherosclerosis and breast cancer models (Ex/Em = 645/670 nm) .

HY-134797

p-SCN-Bn-deferoxamine 1 Publications Verification	Radionuclide-Drug Conjugates (RDCs)	Cancer
P-SCN-Bn-deferoxamine is a bifunctional chelating agent that can link radioactive metal nuclides (such as Zr-89) and biological targeting molecules (such as antibodies). P-SCN-Bn-deferoxamine can be used for the research of immune PET imaging .

HY-W012634

Benzothiazole	Environmental Pollutants Bacterial	Infection Metabolic Disease Inflammation/Immunology Cancer
Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral. Furthermore, Benzothiazole nucleus can function as an efficacious β-amyloid imaging agent ^[1][2][3][4].

HY-B0926A

Sodium diatrizoate Diatrizoic acid sodium salt; Sodium amidotrizoate	Apoptosis	Inflammation/Immunology
Sodium diatrizoate (Diatrizoic acid sodium salt) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Sodium diatrizoate induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium .

HY-B0926

Diatrizoic acid Diatrizoate; Amidotrizoic acid	Apoptosis	Inflammation/Immunology
Diatrizoic acid (Diatrizoate) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Diatrizoic acid induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium .

HY-P99289

Epratuzumab Antibody hLL 2; AMG-412	CD22	Inflammation/Immunology Cancer
Epratuzumab (Antibody hLL 2) is an anti-CD22 IgG1 monoclonal antibody. Epratuzumab is also a tumor-imaging agent and an immunomodulatory agent. Epratuzumab can induce CD22 phosphorylation. Epratuzumab has been used to research non-Hodgkin’s lymphomas (NHL) and certain autoimmune diseases .

HY-B1292

Iodipamide 1 Publications Verification Adipiodone	Biochemical Assay Reagents	Inflammation/Immunology
Iodipamide (Adipiodone) is an ionic iodinated contrast agent. Iodipamide is used for diagnostic imaging to visualize the bile ducts and gallbladder during X-ray examinations .

HY-D1716

S0456	Fluorescent Dye Drug Intermediate	Cancer
S0456 is a raw material that plays a crucial role in the construction of the folate receptor-targeted near-infrared dye OTL 38 (HY-139579). S0456 is connected to the modified folic acid to form OTL 38, endowing OTL 38 with good optical properties, high affinity, and specificity. S0456 can be used in the research of tumor optical imaging agents .

HY-D0077

2',7'-Difluorofluorescein Oregon green 488	Fluorescent Dye	Others
2',7'-Difluorofluorescein (Oregon green 488) is a fluorescein derivative and a pH-sensitive fluorescent probe (pK_a ~4.7). Upon excitation at 488 nm, 2',7'-Difluorofluorescein exhibits pH-sensitive fluorescence intensity through the formation of dianions, while its pH sensitivity decreases under excitation at 450 nm, allowing its use in ratiometric pH analysis. 2',7'-Difluorofluorescein can be used for the quantitative analysis of pH values in the range of 2-7 in submicron aerosol particles. 2',7'-Difluorofluorescein undergoes buffer-mediated and buffer-free excited-state proton transfer between different protonated forms, and its cationic form undergoes rapid excited-state deprotonation. 2',7'-Difluorofluorescein is resistant to photodegradation, maintains stable absorption and fluorescence properties within the physiological pH range, and serves as a fluorescent protein label, a component of Ca ²⁺ indicators, a fluorescent imaging agent, and an anisotropy probe .

HY-117756

Piflufolastat DCFPYL	PSMA	Cancer
Piflufolastat (DCFPYL) can be used for the preparation of piflufolastat F 18 (DCFPyL F-18). Piflufolastat F-18 (DCFPyL F-18) is an ¹⁸F-labeled imaging agent. Piflufolastat F-18 can be used for positron emission tomography (PET) targeting prostate-specific membrane antigen (PSMA). Piflufolastat can be used for imaging of prostate cancer .

HY-106594A

Prussian blue insoluble Iron(III) ferrocyanide; Milori blue	Environmental Pollutants Bacterial	Infection Cancer
Prussian blue soluble is a good adsorbent to be used as antidotes for poisoning with cesium or thallium ions. Prussian blue soluble has anticancerous and antibacterial properties. Prussian blue soluble can be used as a contrast agent in photoacoustic and magnetic resonance imaging (MRI) .

HY-129650

Florbetapir 1 Publications Verification AV-45; Flobetapir	Biochemical Assay Reagents	Others
Flobetapir (AV-45) may be a well-tolerated imaging agent. Flobetapir synthesizes Florbetapir (18F) that is a PET scanning radiopharmaceutical compound containing the radionuclide fluorine-18 .

HY-47176

QTZ	Fluorescent Dye	Others
QTZ is a bioluminescence agent for in vivo imaging. QTZ has red-shifted emission and yields very little background. QTZ is a coelenterazine analog with the 4-quinolinyl substitution at the C8 position of the imidazopyrazinone core .

HY-D1443

BSB (trans,trans)-1-Bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene	Amyloid-β	Others
BSB is a Congo red-derived fluorescent probe. BSB binds not only to extracellular amyloid β protein, but also many intracellular lesions composed of abnormal tau and synuclein proteins. BSB acts as a prototype imaging agent for Alzheimer's disease .

HY-120115

PARPi-FL Olaparib-bodipy FL	PARP Fluorescent Dye	Cancer
PARPi-FL (Olaparib-bodipy FL) is a small-molecule fluorescent inhibitor of PARP1 that can specifically bind to PARP1. PARPi-FL can be used as a fluorescent imaging agent for tumor detection, diagnosis, and surgical guidance .

HY-147287

Glu-urea-Glu-NHS ester	PSMA Drug Intermediate	Cancer
Glu-urea-Glu-NHS ester is an activated N-hydroxysuccinamide (NHS) ester of Glu-urea-Glu. Glu-urea-Glu-NHS ester can be used for synthesis of small-molecule prostate-specific membrane antigen (PSMA) inhibitors, imaging agents (such as PSMAi-PEG conjugates), and targeted drug delivery vehicles .

HY-B0594S

Iohexol-d5	Isotope-Labeled Compounds Autophagy Mitophagy	Cancer
Iohexol-d₅ is deuterium labeled Iohexol. Iohexol is a radiographic contrast agent and can be applied for myelography, computerized tomography?(cisternography, ventriculography) and MicroCT imaging in vivo .

HY-D2335

SERTlight	Fluorescent Dye	Neurological Disease
SERTlight is a fluorescent agent that can specifically label serotonergic neuronal cell bodies, dendrites, and axonal projections as fluorescent substrates of the serotonin transporter (SERT). SERTlight is orthogonal to various genetically encoded sensors in terms of optics, pharmacology, and operation, enabling multiple imaging. SERTlight allows the use of GRAB_5HT sensors to label distal 5HT axonal projections and simultaneously image the release of endogenous 5HT, providing a new multifunctional molecular tool for studying serotonergic systems .

HY-DY1072

ICG NHS ester (solution) ICG-OSu (solution)	Fluorescent Dye	Cancer
ICG NHS ester (ICG-OSu) (solution) is a near-infrared fluorescent agent ICG derivative. ICG NHS ester is amine-reactive and has been widely used to design in vivo imaging probes . Solvent and concentration: DMSO: 10 mM

HY-P1043

NGR peptide 1 Publications Verification	Aminopeptidase	Cancer
NGR peptide containing the Asn-Gly-Arg (NGR) motif. NGR peptide binds to APN/CD13. NGR peptide is directly conjugated to imaging agents that can be used for tumor imaging .

HY-126369

Exametazime HM-PAO	Biochemical Assay Reagents	Others
Exametazime (HM-PAO) is a lipophilic agent used for the preparation of brain imaging radiopharmaceuticals. ⁹⁹Tcm-Exametazime is an effective in vitro leukocyte labeling agent .

HY-136201

Sodium Glucoheptonate	Biochemical Assay Reagents	Cancer
Sodium Glucoheptonate is used as a kit for radio-labeling with Tc-99m. Tc-99m glucoheptonate is kidney- and brain-imaging agent, and can be used in brain-tumor detection .

HY-106594B

Prussian blue soluble Pigment blue 27	Bacterial	Infection Cancer
Prussian blue soluble is a good adsorbent to be used as antidotes for poisoning with cesium or thallium ions. Prussian blue soluble has anticancerous and antibacterial properties. Prussian blue soluble can be used as a contrast agent in photoacoustic and magnetic resonance imaging (MRI) .

HY-P10557

DAG peptide	Biochemical Assay Reagents	Neurological Disease
DAG peptide is a cyclic peptide. DAG peptide selectively recognizes a subset of astrocytes that are activated in Alzheimer's disease (AD) starting at an early stage of the disease. DAG peptide can be used as a tool to enhance the delivery of therapeutics and imaging agents to sites of vascular changes and astrogliosis in diseases associated with neuroinflammation .

HY-139579A

Pafolacianine tetrasodium OTL 38 tetrasodium	Fluorescent Dye	Cancer
Pafolacianine tetrasodium (OTL 38 tetrasodium) is a fluorescent imaging agent made of near-infrared dye used in detecting tumor lesions during surgical procedures. Pafolacianine tetrasodium excites at 774 to 775 nm and emits at 794 to 796 nm .

HY-B0594R

Iohexol (Standard)	Reference Standards Autophagy Mitophagy	Cancer
Iohexol (Standard) is the analytical standard of Iohexol. This product is intended for research and analytical applications. Iohexol is a non-ionic, water-soluble contrast agent used as a reference marker for the determination of glomerular filtration rate (GFR) at the level of renal function. Iohexol can be used for contrast in myelography, computerized tomography (cisternography, ventriculography) and MicroCT imaging .

HY-D1423

Dibromobimane	Fluorescent Dye	Others
Dibromobimane is a thiol-selective fluorescent imaging agent. Dibromobimane is used to crosslink cysteine- and homocysteine-containing peptides .

HY-177459

DOTA-2P(FAPI)2	FAP	Cancer
DOTA-2P(FAPI)2 is a dimeric FAP (fibroblast activation protein) that can be used as a PET imaging agent and a tracer for tumor therapy .

HY-P10364

Ubiquicidin(29-41) UBI(29-41)	Bacterial Antibiotic	Infection Inflammation/Immunology
Ubiquicidin (29-41) (UBI (29-41)) is an Antimicrobial peptide and infection-localizing agent. Ubiquicidin (29-41) acts as an infection-specific imaging agent and infection-targeting agent. Ubiquicidin (29-41) serves as an antibiotic efficacy monitoring agent, and its aggregation level in infections induced by Staphylococcus aureus is higher than that in infections induced by Escherichia coli .

HY-109513

Ioxilan 1 Publications Verification	Biochemical Assay Reagents	Others
Ioxilan is a low-osmolar, nonionic and tri-iodinated diagnostic contrast agent. Ioxilan is also an X-ray contrast agent for excretory urography and contrast enhanced computed tomographic (CECT) imaging of the head and body. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs .

HY-D1450

IR-1048 S01448	Fluorescent Dye	Cancer
IR-1048 is a nitroreductase (NTR)-responsive near-infrared fluorescence (NIR)/photoacoustic (PA) imaging probe and photothermal agent. IR-1048 is coupled with a nitroimidazole group to form IR-1048-MZ. IR-1048-MZ is catalytically reduced by NTR in a hypoxic environment, restoring strong near-infrared absorption and fluorescence emission (NIR II window), while activating the photothermal effect. IR-1048 relies on NTR-mediated electron transfer to relieve intramolecular fluorescence quenching, achieving specific imaging and photothermal ablation of tumor hypoxic areas. IR-1048 is mainly used for high-contrast NIR II/photoacoustic imaging and photothermal therapy research and tumor diagnosis of the tumor hypoxic microenvironment .

HY-P11236

Cronexitide lanocianine LS301	Biochemical Assay Reagents	Others
Cronexitide lanocianine is a diagnostic imaging agent.

HY-145385

Coelenteramide	Fluorescent Dye	Others
Coelenteramide is a oxidative product of Coelenterazine (HY-18743). Coelenteramide can form a complex with apoAequorin/Ca ²⁺, which is known as blue fluorescent protein (BFP) and shows continuous weak luminescence with Coelenterazine like a luciferase. Coelenteramide can be used as an imaging agent .

HY-P1043A

NGR peptide Trifluoroacetate 1 Publications Verification	Aminopeptidase	Cancer
NGR peptide Trifluoroacetatecontaining the Asn-Gly-Arg (NGR) motif. NGR peptide Trifluoroacetate binds to APN/CD13. NGR peptide Trifluoroacetate is directly conjugated to imaging agents that can be used for tumor imaging .

HY-169732

Gadoquatrane	Biochemical Assay Reagents	Others
Gadoquatrane is a highly stable gadolinium-based MRI contrast agent that enhances soft tissue imaging by altering the local magnetic field, with low permeability and high biological safety .

HY-172205

CHL2310	Cytochrome P450	Cancer
CHL2310 is the inhibitor for CYP46A1 with an IC₅₀ of 0.11 nM, and a K_d of 0.37 nM. CHL2310 can cross blood-brain barrier. CHL2310 can be used as a PET imaging agent, when labeled with radioactive ¹⁸F .

HY-P10590

Talogreptide mesaroxetan	Fluorescent Dye	Cancer
Talogreptide mesaroxetan is a diagnostic imaging agent, with antineoplastic effect .

HY-129040

m-Iodobenzylguanidine 1 Publications Verification MIBG; Iobenguane	Monoamine Transporter	Neurological Disease Endocrinology Cancer
m-Iodobenzylguanidine (Iobenguane) is a ligand with high affinity against norepinephrine transporter (NET). m-Iodobenzylguanidine is used as an imaging agent in the diagnostic imaging and radionuclide studies of neuroendocrine tumors, such as neuroblastoma, pheochromocytoma and carcinoid tumor .

HY-136213

Endoplasmic reticulum dye 1	Fluorescent Dye	Others
Endoplasmic reticulum dye 1 is a promising live cell imaging agent for the detection of exocytotic events at the plasma membrane. Endoplasmic reticulum dye 1 shows low cytotoxicity, resistance to photobleaching , which is ideal for imaging either short- or long-time courses .

HY-180450

Caloxetate trisodium	Biochemical Assay Reagents	Cancer
Gadoxetate disodium is a liver-specific magnetic resonance imaging (MRI) contrast agent, can be used for detecting and identifying liver tumors .

HY-P10012

Pendetide GYK-DTPA	Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs)	Cancer
Pendetide is a chelating agent, can be conjugated with Indium (111In) Capromab for further diagnostic use. Capromab pendetide is a FDA-approved imaging agent for the detection of soft tissue metastases in prostate carcinoma . Pendetide can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-P11310

PSMA-1-SMCC	PSMA	Cancer
PSMA-1-SMCC is a selective binding agent targeting Prostate-Specific Membrane Antigen (PSMA). PSMA-1-SMCC is promising for research of targeted imaging for prostate cancer .

HY-107943

Tyropanoate sodium NSC 107434 sodium	Biochemical Assay Reagents	Others
Tyropanoate (NSC 107434) sodium is an orally active contrast agent for the gallbladder. Tyropanoate sodium is absorbed through the intestines and secreted by the liver into the bile. Tyropanoate sodium then concentrates in the gallbladder to form an image that is not transparent to X-rays, enabling visualization of the gallbladder .

HY-106586

Ioxaglic acid P-286	Biochemical Assay Reagents	Others
Ioxaglic acid (P-286) is negatively charged contrast agent, is useful as an inverse indicator for glycosaminoglycan (GAG) used in computed tomography (CT). Ioxaglic acid can be used for imaging of human osteoarthritic cartilage via quantitative assessment of glycosaminoglycan content .

Cat. No.	Product Name

HY-L105S

Peptide Compound Library

0 compounds

Peptides, composed of amino acids, serve as crucial building blocks for proteins and have gained significant attention in drug development over the past decade. The advancements in production, modification, and analytical technologies have led to a surge in the potential applications of peptides in medicine. Peptides offer a number of advantages over small molecule drugs, including: greater target specificity and efficacy, more predictable metabolic profiles, easier delivery to where they are needed in the body, and fewer side effects. Peptides are increasingly appearing in all branches of medicine as components of innovative drugs, imaging agents, diagnostic agents, and other complex drugs such as peptide-drug conjugates. To date, more than 80 peptide drugs have been approved to treat a variety of diseases, including microbial infections, obesity, anti-diabetes, and cancer, as well as to develop cell targeting platforms and improve cell penetration properties.

MCE designs a unique collection of 0 peptide compounds. HY-L105S is a peptide compound library that can be provided with solution form based on HY-L105, and can be applied to peptides-based drug development.

Cat. No.	Product Name	Type

HY-D1041

ICG NHS ester ICG-OSu	Fluorescent Dye
ICG NHS ester (ICG-OSu) is a near-infrared fluorescent agent ICG derivative. ICG NHS ester is amine-reactive and has been widely used to design in vivo imaging probes .

HY-136886

IR-820 2 Publications Verification New Indocyanine Green	Fluorescent Dye
IR-820 (New Indocyanine Green) is an infrared blood pool contrast agent. IR-820 also is normally used as a laser and near-infrared dye to detect and quantify diseased tissue in live animals .

HY-D1063

IR-780

Maximum Cited Publications

6 Publications Verification

Fluorescent Dye

IR-780 is a near-infrared fluorescent probe for in vivo imaging of tumor cells. IR-780 is transported into tumor cells via OATPs and ABCB10, with uptake dependent on glycolytic activity and plasma membrane potential. IR-780 preferentially accumulates in tumor cell mitochondria, including those of drug-resistant cancer cells, without chemical conjugation. IR-780 generates reactive oxygen species (ROS), induces hyperthermia and apoptosis, inhibits tumor growth and recurrence, and modulates HSP70 expression upon ultrasound or 808 nm laser exposure. IR-780 acts as a sonosensitizer, photodynamic and photothermal agent, and drug delivery carrier, with low acute imaging-dose toxicity and rapid vital organ clearance. IR-780 can be used for the research of cancer, such as breast cancer, lung cancer, and non-small cell lung cancer (NSCLC) .

HY-139579

Pafolacianine 1 Publications Verification OTL 38	Fluorescent Dye
Pafolacianine (OTL 38) is a fluorescent imaging agent made of near-infrared dye used in detecting tumor lesions during surgical procedures. Pafolacianine excites at 774 to 775 nm and emits at 794 to 796 nm .

HY-145746

Sulfo-Cy5 azide

Fluorescent Dye

Sulfo-Cy5 azide is a near-infrared fluorescent probe with favorable click chemistry reactivity. Sulfo-Cy5 azide enables fluorescence imaging, tissue and cellular visualization of PD-L1 in tumors, and site-specific modification of anti-PD-L1 antibodies. Sulfo-Cy5 azide has been employed for RNA labeling and imaging. Sulfo-Cy5 azide can be conjugated to targeting agents for fluorescence imaging in atherosclerosis and breast cancer models (Ex/Em = 645/670 nm) .

HY-D1716

S0456	Fluorescent Dye
S0456 is a raw material that plays a crucial role in the construction of the folate receptor-targeted near-infrared dye OTL 38 (HY-139579). S0456 is connected to the modified folic acid to form OTL 38, endowing OTL 38 with good optical properties, high affinity, and specificity. S0456 can be used in the research of tumor optical imaging agents .

HY-D1443

BSB (trans,trans)-1-Bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene	Fluorescent Dye
BSB is a Congo red-derived fluorescent probe. BSB binds not only to extracellular amyloid β protein, but also many intracellular lesions composed of abnormal tau and synuclein proteins. BSB acts as a prototype imaging agent for Alzheimer's disease .

HY-D2335

SERTlight

Fluorescent Dye

SERTlight is a fluorescent agent that can specifically label serotonergic neuronal cell bodies, dendrites, and axonal projections as fluorescent substrates of the serotonin transporter (SERT). SERTlight is orthogonal to various genetically encoded sensors in terms of optics, pharmacology, and operation, enabling multiple imaging. SERTlight allows the use of GRAB_5HT sensors to label distal 5HT axonal projections and simultaneously image the release of endogenous 5HT, providing a new multifunctional molecular tool for studying serotonergic systems .

HY-DY1072

ICG NHS ester (solution) ICG-OSu (solution)	Fluorescent Dye
ICG NHS ester (ICG-OSu) (solution) is a near-infrared fluorescent agent ICG derivative. ICG NHS ester is amine-reactive and has been widely used to design in vivo imaging probes . Solvent and concentration: DMSO: 10 mM

HY-106594B

Prussian blue soluble Pigment blue 27	Fluorescent Dye
Prussian blue soluble is a good adsorbent to be used as antidotes for poisoning with cesium or thallium ions. Prussian blue soluble has anticancerous and antibacterial properties. Prussian blue soluble can be used as a contrast agent in photoacoustic and magnetic resonance imaging (MRI) .

HY-D2062

ATTO 740 NHS ester

Fluorescent Dye

ATTO 740 NHS ester is a near-infrared fluorescent dye and a multimodal fluorescence/photoacoustic contrast agent with excellent near-infrared emission properties and extremely high photostability. The photoacoustic signal of ATTO 740 NHS ester shows no significant decrease after continuous irradiation with a 750 nm laser for 30 min, making it suitable for in vivo fluorescence imaging and photoacoustic contrast imaging. When conjugated with the cystine knot peptide R01, ATTO 740 NHS ester enables precise detection of integrin αvβ6-positive cells and tumors in nude mouse xenograft models .

HY-D1423

Dibromobimane	Fluorescent Dye
Dibromobimane is a thiol-selective fluorescent imaging agent. Dibromobimane is used to crosslink cysteine- and homocysteine-containing peptides .

HY-128536

KMG-104AM

Fluorescent Dye

KMG-104AM is a Mg ²⁺fluorescent probe. KMG-104AM is a membrane-permeable ester-modified derivative of KMG-104, which serves as a reporter and imaging agent. KMG-104AM can track the increase in intracellular free magnesium ion concentration induced by mitochondrial uncoupling. KMG-104AM enables visualization of the three-dimensional distribution of intracellular magnesium ion concentration. KMG-104AM is applicable to research related to the functions of intracellular magnesium ions .

HY-145385

Coelenteramide	Fluorescent Dye
Coelenteramide is a oxidative product of Coelenterazine (HY-18743). Coelenteramide can form a complex with apoAequorin/Ca ²⁺, which is known as blue fluorescent protein (BFP) and shows continuous weak luminescence with Coelenterazine like a luciferase. Coelenteramide can be used as an imaging agent .

HY-136213

Endoplasmic reticulum dye 1	Fluorescent Dye
Endoplasmic reticulum dye 1 is a promising live cell imaging agent for the detection of exocytotic events at the plasma membrane. Endoplasmic reticulum dye 1 shows low cytotoxicity, resistance to photobleaching , which is ideal for imaging either short- or long-time courses .

HY-D1274

Sulfo-cyanine3 azide

Fluorescent Dye

Sulfo-cyanine3 azide is an azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). Sulfo-cyanine3 azide can be involved in synthesis of fused tricyclic heterocycles, produces immunostimulatory agents . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D1274A

Sulfo-cyanine3 azide sodium

Fluorescent Dye

Sulfo-cyanine3 azide sodium a water-soluble azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). Sulfo-cyanine3 azide sodium can be involved in synthesis of fused tricyclic heterocycles, produces immunostimulatory agents . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D2378

Abenacianine	Fluorescent Dye
Abenacianine is a diagnostic imaging agent .

HY-D1274B

Sulfo-cyanine3 azide TEA

Fluorescent Dye

Sulfo-cyanine3 azide TEA is an azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). Sulfo-cyanine3 azide TEA can be involved in synthesis of fused tricyclic heterocycles, produces immunostimulatory agents . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D3353

PSMA-SulfoCy7

Fluorescent Dye

PSMA-SulfoCy7 is a high-affinity imaging agent targeting PSMA/GCPII (with a K_i of 18.1 nM for human PSMA). PSMA-SulfoCy7 regulates PSMA-dependent NAAG hydrolysis. PSMA-SulfoCy7 exhibits excellent in vivo imaging capability, enabling clear visualization of PSMA-expressing tumors in xenograft models, with no obvious toxicity even at a dose of 87.9 mg/kg. PSMA-SulfoCy7 is widely used in prostate cancer-related studies .

HY-D3199

NIR‐fluorescent glucose	Fluorescent Dye
NIR-fluorescent glucose is a functional glucose-based fluorescent imaging agent. Conjugated with the nitrobenzoselenadiazole-based SCOTfluor (compound 9), NIR-fluorescent glucose acts as a substrate for GLUT4 and GLUT2 transporters. NIR-fluorescent glucose enables the visualization of glucose uptake in live cells and in vivo .

HY-D3352

EMI-137 AGSCYCSGPPRFECWCYETEGT-Cy5	Fluorescent Dye
EMI-137 (AGSCYCSGPPRFECWCYETEGT-Cy5) is a fluorescent imaging agent targeting the c-Met receptor. EMI-137 specifically binds to the extracellular domain of the c-Met receptor and is used for fluorescent visualization of c-Met-expressing cells and tissues. EMI-137 can be applied to research related to colorectal cancer .

HY-106594BR

Prussian blue soluble (Standard)

Pigment blue 27 (Standard)

Fluorescent Dye

Prussian blue soluble (Standard) is the analytical standard of Prussian blue soluble (HY-106594B). This product is intended for research and analytical applications. Prussian blue soluble is a good adsorbent to be used as antidotes for poisoning with cesium or thallium ions. Prussian blue soluble has anticancerous and antibacterial properties. Prussian blue soluble can be used as a contrast agent in photoacoustic and magnetic resonance imaging (MRI) .

HY-D3411

Rhobo6

Fluorescent Dye

Rhobo6 is a glycan-binding, fluorescence turn-on imaging agent with a K_d of 53 µM for glycans containing 1,2- and 1,3-diols. Rhobo6 reversibly binds target glycans to trigger fluorescence turn-on and spectral red shift and enables wash-free live ECM visualization. Rhobo6 resists photobleaching, penetrates full tissue cross-sections, and supports non-perturbative ECM labeling. Rhobo6 can be used for fluorescent labeling in ECM (Ex/Em = 488/575 nm) .

HY-D3405

BO-TAP-3

Fluorescent Dye

BO-TAP-3 is an orange fluorescent carbocyanine monomer dye, and it is also a cell impermeable nucleic acid staining agent. When there is no nucleic acid present, BO-TAP-3 shows a non-fluorescent state. However, when it binds to double-stranded DNA, it exhibits multiple fluorescence enhancement effects. BO-TAP-3 can be used for cell nucleus and cytoplasm imaging, bacterial and sperm labeling, and can also be applied in nucleic acid detection and amplification research. It can also be used as a temperature sensor (Ex/Em = 564/600 nM).

HY-172754

ICAAc

Fluorescent Dye

ICAAc is a solvatochromic fluorophore with reduced basicity. ICAAc demonstrates significant solvatochromic behavior across solvents of varying polarity, with a large dipole moment difference and low quantum yield in water, making it a tunable solvatochromic fluorophore. ICAAc enables pH sensing via UV-vis/fluorescence detection and in microenvironments including sodium lauryl sulfate micelle Stern layers. ICAAc acts as a supravital cell stain for epifluorescence imaging of live cancer cells .

Cat. No.	Product Name	Type

HY-W053583

Tetraxetan

1 Publications Verification

DOTA

Biochemical Assay Reagents

Tetraxetan (DOTA) is a macrocyclic chelating agent. Tetraxetan can form stable coordination complexes with a variety of metal ions (e.g., ⁶⁸Ga, ¹¹¹In, ¹⁷⁷Lu). Tetraxetan can be conjugated with targeting molecules (e.g., RGD peptide, folic acid) to enable the complex to target specific biomolecules or cells. Tetraxetan can be used for imaging studies of tumors, including melanoma and folate receptor-positive tumors (e.g., cervical cancer) .

HY-W011696

Oleylamine, 80-90%

cis-1-Amino-9-octadecene, 80-90%

Biochemical Assay Reagents

Oleylamine, 80-90% (cis-1-Amino-9-octadecene, 80-90%) is a multifunctional reagent used for metal ion coordination and nanoparticle surface modification, and acts as a solvent, surfactant and reducing agent in the synthesis of metal oxide nanoparticles. Oleylamine, 80-90% regulates nanoparticle morphology, magnetization intensity and water proton relaxation rate via thiol-ene "click" reaction, and enhances the colloidal stability of nanoparticles in organic reagents. Oleylamine, 80-90% is mainly used in research and applications in fields such as nanomaterial synthesis, biomedical imaging (MRI contrast agents, fluorescent probes), cancer cell targeting and drug delivery .

HY-W250149

Chlorophosphonazo III

Biochemical Assay Reagents

Chlorophosphonazo III is a cell membrane-permeable contrast agent and spectrophotometric reagent. Chlorophosphonazo III forms stable 1:1 complexes with intracellular calcium, magnesium, uranium, titanium, zirconium, thorium, scandium, equivalent actinides and protactinium. Chlorophosphonazo III generates photoacoustic signals correlated with Ca ²⁺ concentrations, which is applicable for imaging 3D tumor cell cultures and tumor spheroids. Chlorophosphonazo III exhibits no cytotoxicity, can be used for spectrophotometric detection of target ions, and the absorbance of its complexes remains stable for up to one week within the pH range of 2.2 to 7.0 .

HY-158067

Deferoxamine-DBCO

DFO-DBCO

Biochemical Assay Reagents

Deferoxamine-DBCO is a bifunctional chelating agent. Deferoxamine-DBCO efficiently chelates with radioactive metals (such as ⁸⁹Zr) through the DFO structure to achieve radiolabeling. Deferoxamine-DBCO undergoes a metal-free Huisgen cycloaddition reaction with azide-containing biomolecules (such as siRNA, monoclonal antibodies) under bioorthogonal conditions through the DBCO structure to achieve targeted coupling. Deferoxamine-DBCO has efficient metal chelating ability and specific bioorthogonal reaction activity. Deferoxamine-DBCO can be used for targeted radioactive imaging studies of tumors .

HY-NP163A

Wheat germ agglutinin-AF488

WGA-AF488

Biochemical Assay Reagents

Wheat germ agglutinin-AF488 (WGA-AF488) is a cell membrane-specific staining agent prepared by conjugating wheat germ agglutinin with the Alexa Fluor 488 (HY-D1304) fluorescent dye, and it binds to cell surface glycoproteins with high affinity. Wheat germ agglutinin-AF488 is applied in fluorescence microscopy and confocal imaging techniques, and it can clearly label the membrane structures of various cells including breast cancer cells, enabling high-resolution visual observation. Wheat germ agglutinin-AF488 is used in studies of breast cancer and triple-negative breast cancer to observe cell morphology and membrane dynamic changes .

HY-B1684

Mebrofenin SQ 26962	Biochemical Assay Reagents
Mebrofenin (SQ 26962) is a type of iminodiacetic acid (IDA). Mebrofenin is available as a ready to use the kit for radio-labeling with Tc-99m. Tc-99m Mebrofenin, a diagnostic agent, is used for hepatobiliary imaging. Tc-99m Mebrofenin is the radiopharmaceutical of choice for the evaluation of hepatic function .

HY-W053583R

Tetraxetan (Standard)

DOTA (Standard)

Biochemical Assay Reagents

Tetraxetan (Standard) is the analytical standard of Tetraxetan (HY-W053583). This product is intended for research and analytical applications. Tetraxetan (DOTA) is a macrocyclic chelating agent. Tetraxetan can form stable coordination complexes with a variety of metal ions (e.g., ⁶⁸Ga, ¹¹¹In, ¹⁷⁷Lu). Tetraxetan can be conjugated with targeting molecules (e.g., RGD peptide, folic acid) to enable the complex to target specific biomolecules or cells. Tetraxetan can be used for imaging studies of tumors, including melanoma and folate receptor-positive tumors (e.g., cervical cancer) .

HY-173384

DSPE-DOTA sodium 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N- tetraazacyclododecane-N-tetraacetic acid, sodium salt	Biochemical Assay Reagents
DSPE-DOTA sodium (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N- tetraazacyclododecane-N-tetraacetic acid, sodium salt) is a chelating lipid used as a key contrast agent in magnetic resonance imaging (MRI). DSPE-DOTA sodium can be used for imaging detection of tumors, neurological and inflammatory diseases .

HY-173383

DOPE-DOTA sodium 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N- tetraazacyclododecane-N-tetraacetic acid, sodium salt	Biochemical Assay Reagents
DOPE-DOTA sodium is a chelated lipid that serves as a key contrast agent in magnetic resonance imaging (MRI). DOPE-DOTA sodium can be used for cancer, blood-brain barrier disruption, abnormalities such as aneurysms or plaque buildup, inflammation in arthritis, and liver function and lesions study

HY-W440919

DSPE-PEG2000-Rhodamine	Biochemical Assay Reagents
DSPE-PEG2000-Rhodamine is a dye functionalized phospholipid. The amphiphilic polymer can form lipid bilayer in water and be used to encapsulate therapeutic agents, such as liposomal anticancer drug or mRNA vaccine. Rhodamine has maximum absorption at 570 nm and emission around 595 nm and can be easily traced using an imaging technique.

HY-B1684R

Mebrofenin (Standard)

SQ 26962 (Standard)

Biochemical Assay Reagents

Mebrofenin (Standard) is the analytical standard of Mebrofenin. This product is intended for research and analytical applications. Mebrofenin (SQ 26962) is a type of iminodiacetic acid (IDA). Mebrofenin is available as a ready to use the kit for radio-labeling with Tc-99m. Tc-99m Mebrofenin, a diagnostic agent, is used for hepatobiliary imaging. Tc-99m Mebrofenin is the radiopharmaceutical of choice for the evaluation of hepatic function .

HY-182092

DSPE-PEG1000-Asp6	Biochemical Assay Reagents
DSPE-PEG1000-Asp6 is a PEG compound which composed of DSPE and a Asp6 peptide. DSPE-PEG1000-Asp6 achieves bone-targeted delivery of drugs or imaging agents by binding to bone tissue with the Asp6 peptide through high affinity .

HY-182092A

DSPE-PEG5000-Asp6	Biochemical Assay Reagents
DSPE-PEG5000-Asp6 is a PEG compound which composed of DSPE and a Asp6 peptide. DSPE-PEG5000-Asp6 achieves bone-targeted delivery of drugs or imaging agents by binding to bone tissue with the Asp6 peptide through high affinity .

HY-182092C

DSPE-PEG3400-Asp6	Biochemical Assay Reagents
DSPE-PEG3400-Asp6 is a PEG compound which composed of DSPE and a Asp6 peptide. DSPE-PEG3400-Asp6 achieves bone-targeted delivery of drugs or imaging agents by binding to bone tissue with the Asp6 peptide through high affinity .

HY-182092B

DSPE-PEG2000-Asp6	Biochemical Assay Reagents
DSPE-PEG2000-Asp6 is a PEG compound which composed of DSPE and a Asp6 peptide. DSPE-PEG2000-Asp6 achieves bone-targeted delivery of drugs or imaging agents by binding to bone tissue with the Asp6 peptide through high affinity .

Cat. No.	Product Name	Target	Research Area

HY-P4116

pH-Low Insertion Peptide pHLIP	Peptides	Metabolic Disease Cancer
pH-Low Insertion Peptide (pHLIP) is a short, pH-responsive peptide capable of inserting across a cell membrane to form a transmembrane helix at acidic pH. pH-Low Insertion Peptide targets the acidic tumor microenvironment for tumors at early and metastatic stages with high specificity, used as a specific ligand. pH-Low Insertion Peptide successfully modify polylysine polymers to have the pH-responsive capability. pH-Low Insertion Peptide-based targeting of cancer presents an opportunity to monitor metabolic changes, and to selectively deliver imaging and therapeutic agents to tumors .

HY-P5362

NODAGA-LM3	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Neurological Disease Cancer
NODAGA-LM3 is a ligand that can cross the blood-brain barrier and targets somatostatin receptor SSTR2 with high affinity (IC₅₀ = 1.3 nM). NODAGA-LM3 does not trigger the internalization of SSTR2 and can inhibit agonist-induced internalization processes. NODAGA-LM3 shows low uptake in normal tissues such as the liver and spleen, but high uptake in the lungs and blood pool. ⁶⁸Ga-labeled NODAGA-LM3 can serve as a PET imaging agent for well-differentiated neuroendocrine tumors, and is applied in studies related to small cell lung cancer and well-differentiated neuroendocrine tumors .

HY-P1043

NGR peptide 1 Publications Verification	Aminopeptidase	Cancer
NGR peptide containing the Asn-Gly-Arg (NGR) motif. NGR peptide binds to APN/CD13. NGR peptide is directly conjugated to imaging agents that can be used for tumor imaging .

HY-P10557

DAG peptide	Biochemical Assay Reagents	Neurological Disease
DAG peptide is a cyclic peptide. DAG peptide selectively recognizes a subset of astrocytes that are activated in Alzheimer's disease (AD) starting at an early stage of the disease. DAG peptide can be used as a tool to enhance the delivery of therapeutics and imaging agents to sites of vascular changes and astrogliosis in diseases associated with neuroinflammation .

HY-P10369

Betiatide	Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs)	Cardiovascular Disease Inflammation/Immunology
Betiatide, as a chelating agent for Technetium-99m ( ^99mTc), is used to prepare ^99mTc-MAG3 (mercaptoacetyltriglycine), a radiopharmaceutical for renal function imaging. Betiatide is used for the diagnosis of congenital and acquired abnormalities, renal failure, urinary tract obstructions, and calculi . Betiatide can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-P10792

HER2-targeted peptide H6F	EGFR	Cancer
HER2-targeted peptide H6F is a HER2 targeting peptide that binds to HER2 to target breast cancer cells, with the amino acid sequence YLFFVFER. The HER2-targeted peptide H6F can be conjugated with the bifunctional chelating agent hydrazinonicotinamide (HYNIC) for radiolabeling with 99mTc. Single-photon emission computed tomography (SPECT) imaging shows that the labeled HER2-targeted peptide H6F specifically accumulates in HER2-positive MDA-MBA-453 tumor-bearing mice models. The HER2-targeted peptide H6F can be used for tumor molecular imaging studies .

HY-P10913

HYNIC-UBI29-41	Bacterial	Infection
HYNIC-UBI29-41 is composed of a bifunctional chelator HYNIC and an antimicrobial peptide UBI 29-41 (HY-P10364) (HY-P10364). HYNIC-UBI29-41 retains the antibacterial properties of UBI 29-41, and exhibits good affinity to Gram-positive and Gram-negative bacteria. HYNIC-UBI29-41 can be used as an imaging agent for bacterial infection detection in mouse models, when labeled with the radioactive element technetium (99mTc) .

HY-P10364

Ubiquicidin(29-41) UBI(29-41)	Bacterial Antibiotic	Infection Inflammation/Immunology
Ubiquicidin (29-41) (UBI (29-41)) is an Antimicrobial peptide and infection-localizing agent. Ubiquicidin (29-41) acts as an infection-specific imaging agent and infection-targeting agent. Ubiquicidin (29-41) serves as an antibiotic efficacy monitoring agent, and its aggregation level in infections induced by Staphylococcus aureus is higher than that in infections induced by Escherichia coli .

HY-P11430

UBI (31-38)	Biochemical Assay Reagents	Infection
UBI (31-38) is a Ubiquicidin-derived octapeptide and anti-bacterial agent. UBI (31-38) selectively interacts with anionic phospholipid membranes and restricts lipid lateral motion. UBI (31-38) induces anionic vesicle aggregation via electrostatic repulsion screening, and undergoes conformational changes in membrane-mimicking environments. UBI (31-38) can be used for the research of infection imaging probes .

HY-P4116A

pH-Low Insertion Peptide TFA pHLIP TFA	Peptides	Metabolic Disease Cancer
pH-Low Insertion Peptide TFA (pHLIP TFA) is a short, pH-responsive peptide capable of inserting across a cell membrane to form a transmembrane helix at acidic pH. pH-Low Insertion Peptide TFA targets the acidic tumor microenvironment for tumors at early and metastatic stages with high specificity, used as a specific ligand. pH-Low Insertion Peptide TFA successfully modifys polylysine polymers to have the pH-responsive capability. pH-Low Insertion Peptide TFA -based targeting of cancer presents an opportunity to monitor metabolic changes and to selectively deliver imaging and therapeutic agents to tumors .

HY-P11236

Cronexitide lanocianine LS301	Biochemical Assay Reagents	Others
Cronexitide lanocianine is a diagnostic imaging agent.

HY-P11277

Pocuvotide satetraxetan	Peptides	Cancer
Pocuvotide satetraxetan is an anticancer agent. Pocuvotide satetraxetan labeled with ¹⁷⁷Lu can be used for imaging diagnosis .

HY-P1043A

NGR peptide Trifluoroacetate 1 Publications Verification	Aminopeptidase	Cancer
NGR peptide Trifluoroacetatecontaining the Asn-Gly-Arg (NGR) motif. NGR peptide Trifluoroacetate binds to APN/CD13. NGR peptide Trifluoroacetate is directly conjugated to imaging agents that can be used for tumor imaging .

HY-P10590

Talogreptide mesaroxetan	Fluorescent Dye	Cancer
Talogreptide mesaroxetan is a diagnostic imaging agent, with antineoplastic effect .

HY-P10012

Pendetide GYK-DTPA	Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs)	Cancer
Pendetide is a chelating agent, can be conjugated with Indium (111In) Capromab for further diagnostic use. Capromab pendetide is a FDA-approved imaging agent for the detection of soft tissue metastases in prostate carcinoma . Pendetide can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-P11310

PSMA-1-SMCC	PSMA	Cancer
PSMA-1-SMCC is a selective binding agent targeting Prostate-Specific Membrane Antigen (PSMA). PSMA-1-SMCC is promising for research of targeted imaging for prostate cancer .

HY-P10913A

HYNIC-UBI29-41 TFA	Bacterial	Infection
HYNIC-UBI29-41 TFA is composed of a bifunctional chelator HYNIC and an antimicrobial peptide UBI 29-41 (HY-P10364). HYNIC-UBI29-41 TFA retains the antibacterial properties of UBI 29-41, and exhibits good affinity to Gram-positive and Gram-negative bacteria. HYNIC-UBI29-41 TFA can be used as an imaging agent for bacterial infection detection in mouse models, when labeled with the radioactive element technetium (99mTc) .

HY-P5362A

NODAGA-LM3 TFA	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Cancer
NODAGA-LM3 TFA is a ligand that can cross the blood-brain barrier and targets somatostatin receptor SSTR2 with high affinity (IC₅₀ = 1.3 nM). NODAGA-LM3 TFA does not trigger the internalization of SSTR2 and can inhibit agonist-induced internalization processes. NODAGA-LM3 TFA shows low uptake in normal tissues such as the liver and spleen, but high uptake in the lungs and blood pool. ⁶⁸Ga-labeled NODAGA-LM3 TFA can serve as a PET imaging agent for well-differentiated neuroendocrine tumors, and is applied in studies related to small cell lung cancer and well-differentiated neuroendocrine tumors .

HY-159526

Adarulatide tetraxetan DOTA-AE105	Biochemical Assay Reagents	Others
Copper adarulatidum tetraxetanum (Copper adarulatide tetraxetan) is a diagnostic imaging agent .

HY-P10157

ARF(1-22)	Biochemical Assay Reagents	Others
ARF(1-22) is potentially capable of intracellular penetration to deliver small molecules, proteins, imaging agents, and pharmaceutical nanocarriers .

HY-P10911

IETP2	LDLR	Others
IETP2 targets low-density lipoprotein receptor-related protein 1 (LRP1) with a K_D of 738 nM and can be used for drug- and imaging agents delivery across the blood-labyrinth barrier (BLB) .

HY-181696

EC0652	PSMA	Cancer
EC0652 is a PSMA imaging agent with SPECT imaging capability. EC0652 can be used for the research of metastatic castration-resistant prostate cancer .

HY-P11591

PDI2 PSMA-DOTA-PEI2	Radionuclide-Drug Conjugates (RDCs) PSMA	Cancer
PDI2 (PSMA-DOTA-PEI2) is a prostate-specific membrane antigen (PSMA) ligand that acts as a tumor retention agent, renal uptake reducer, imaging agent and antitumor agent, applicable in SPECT diagnostic imaging and radiotheranostics. PDI2 specifically binds to PSMA on prostate cancer cells, enters cells via clathrin-dependent endocytosis, and exhibits higher tumor retention rate and lower renal uptake level. PDI2 is applicable in research related to prostate cancer and castration-resistant metastatic prostate cancer .

HY-P11739

ZD2 peptide	Biochemical Assay Reagents	Cancer
ZD2 peptide is an EDB-FN-binding peptide with a K_d value of 11 μM. ZD2 peptide binds specifically to the EDB protein fragment of extradomain B fibronectin, a tumor microenvironment biomarker. ZD2 peptide can be conjugated to imaging agents. ZD2 peptide can be used for the research of cancer .

HY-P11718

cFLFLF	Formyl Peptide Receptor (FPR) Radionuclide-Drug Conjugates (RDCs)	Inflammation/Immunology
cFLFLF is a FPR-specific peptide. cFLFLF is sequentially conjugated with a bifunctional polyethylene glycol moiety (PEG, 3.4 kD) and a DOTA through a lysine (K) spacer and finally labeled with ⁶⁴Cu-CuCl₂ to form cFLFLFKPEG- ⁶⁴Cu. cFLFLFKPEG- ⁶⁴Cu is a neutrophil-specific PET imaging agent .

HY-P11613

DOTA-WC8	EGFR	Cancer
DOTA-WC8 is a HER2-targeting peptide probe with a K_D of 61.20 nM. ⁶⁸Ga-labeled DOTA-WC8 serves as a PET imaging agent for the specific identification of HER2-positive breast cancer. DOTA-WC8 is applicable to breast cancer-related research .

HY-P11618

10P3Me	Glycoprotein VI	Cancer
10P3Me is a Glypican-3 (GPC3)-targeting probe with a K_a of 93.8 nM for the human target. 10P3Me exhibits high binding affinity to GPC3, targets GPC3-positive cells, and serves as an agent for PET imaging. 10P3Me selectively accumulates in GPC3-positive tumor tissues, including subcutaneous xenograft models and orthotopic HepG2-LUC liver cancer models, to achieve precise localization of lesions .

HY-P11655

NOTA-TATE	Somatostatin Receptor	Neurological Disease
NOTA-TATE is a somatostatin receptor 2 (SSTR2) binder. NOTA-TATE binds to SSTR2 to enable targeting of SSTR2-positive tumour cells for PET imaging. NOTA-TATE can be used for the research of neuroendocrine tumours .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99289

Epratuzumab Antibody hLL 2; AMG-412	CD22	Inflammation/Immunology Cancer
Epratuzumab (Antibody hLL 2) is an anti-CD22 IgG1 monoclonal antibody. Epratuzumab is also a tumor-imaging agent and an immunomodulatory agent. Epratuzumab can induce CD22 phosphorylation. Epratuzumab has been used to research non-Hodgkin’s lymphomas (NHL) and certain autoimmune diseases .

HY-P992339

cT84.66	Radionuclide-Drug Conjugates (RDCs)	Cancer
cT84.66 is a highly efficient tumor-targeting agent against carcinoembryonic antigen (CEA). cT84.66 engages in bivalent binding with CEA via variable region antigen-binding sites, enabling precise targeting of CEA-producing tumor cells for delivery of therapeutic radiation. cT84.66 exhibits high tumor uptake rate, rapid clearance rate, and excellent tumor-to-blood ratio. With dual functions as an imaging agent and an antibody-directed radiotherapy agent, cT84.66 is widely used in studies of colorectal cancer and metastatic CEA-positive malignancies .

HY-P992340

CTB006	Radionuclide-Drug Conjugates (RDCs) TNF Receptor	Cancer
CTB006 is a monoclonal antibody targeting a humanized chimeric recombinant anti-DR5. CTB006 specifically binds to and activates DR5, thereby inducing tumor cell apoptosis, inhibiting tumor growth and reducing tumor drug resistance. ¹⁷⁷Lu-radiolabeled CTB006 can deliver targeted radiotherapy to tumor cells; while ⁸⁹Zr- or ¹⁷⁷Lu-labeled CTB006 can serve as a PET/CT imaging agent for detecting DR5 expression levels in preclinical tumor models and screening cancers with DR5 overexpression. CTB006 can be applied to research related to gastrointestinal cancer, colorectal cancer and other solid tumors .

HY-P992449

REGN2878 PRLR ADC antibody	ADC Antibody	Cancer
REGN2878 (PRLR ADC antibody) is a monoclonal antibody targeting the prolactin receptor (PRLR) and can block prolactin‑mediated activation of PRLR. REGN2878 exhibits an equilibrium dissociation constant (K_D) of 1.05 nM and an IC₅₀ of 0.344 nM for human PRLR. REGN2878 can be rapidly internalized and degraded in lysosomes by PRLR‑positive tumor cells, showing antigen‑specific binding and targeted enrichment properties. REGN2878 derivatives can be used as an immunoPET agent for antigen‑specific imaging of PRLR‑related tumors, and can also serve as a component of ADCs to exert anti‑tumor activity in breast cancer xenograft models. REGN2878 can be used in the research of breast cancer and prostate cancer. Isotype Comparison HY-P99001 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W012634

Benzothiazole	Source Classification	Environmental Pollutants Bacterial
Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral. Furthermore, Benzothiazole nucleus can function as an efficacious β-amyloid imaging agent ^[1][2][3][4].

HY-N15866

DOPE-DOTA (Gd) ammonium	Lipid	Biochemical Assay Reagents
DOPE-DOTA (Gd) ammonium is a lipid in which DOPE is attached to a gadolinium complex via the DOTA chelating agent. DOPE-DOTA (Gd) ammonium is a key contrast agent in magnetic resonance imaging (MRI).

HY-W012634R

Benzothiazole (Standard)	Microorganisms Source Classification	Reference Standards Bacterial
Benzothiazole (Standard) is the analytical standard of Benzothiazole. This product is intended for research and analytical applications. Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral. Furthermore, Benzothiazole nucleus can function as an efficacious β-amyloid imaging agent .

HY-W009310R

9-cis-Retinal (Standard)	Structural Classification Terpenoids Diterpenoids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Organoid
Mebrofenin (Standard) is the analytical standard of Mebrofenin. This product is intended for research and analytical applications. Mebrofenin (SQ 26962) is a type of iminodiacetic acid (IDA). Mebrofenin is available as a ready to use the kit for radio-labeling with Tc-99m. Tc-99m Mebrofenin, a diagnostic agent, is used for hepatobiliary imaging. Tc-99m Mebrofenin is the radiopharmaceutical of choice for the evaluation of hepatic function .

Cat. No.	Product Name	Chemical Structure

HY-B0594S

Iohexol-d5
Iohexol-d₅ is deuterium labeled Iohexol. Iohexol is a radiographic contrast agent and can be applied for myelography, computerized tomography?(cisternography, ventriculography) and MicroCT imaging in vivo .

HY-B0926S

Diatrizoic acid-d6
Diatrizoic acid-d₆ (Diatrizoate-d₆; Amidotrizoic acid-d₆) is the deuterium labeled Diatrizoic acid (HY-B0926). Diatrizoic acid (Diatrizoate) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Diatrizoic acid induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium .

HY-A0168S

Regadenoson-d3

Regadenoson-d₃ is the deuterium labeled Regadenoson. Regadenoson (CVT-3146) is a potent and selective A2A adenosine receptor agonist, with K_is of 290 and 1120 nM for rat and pig adenosine A2A receptor, respectively. Regadenoson is selective for the adenosine A2A receptor over adenosine A1 and A2B receptors, and shows 13-fold selectivity over the human adenosine A1 receptor. Regadenoson is a vasodilator stress agent has shifted the landscape of vasodilator myocardial perfusion imaging. Regadenoson increases blood-brain barrier (BBB) permeability in rodents .

Cat. No.	Product Name		Classification

HY-145746

Sulfo-Cy5 azide		Azide Labeling and Fluorescence Imaging
Sulfo-Cy5 azide is a near-infrared fluorescent probe with favorable click chemistry reactivity. Sulfo-Cy5 azide enables fluorescence imaging, tissue and cellular visualization of PD-L1 in tumors, and site-specific modification of anti-PD-L1 antibodies. Sulfo-Cy5 azide has been employed for RNA labeling and imaging. Sulfo-Cy5 azide can be conjugated to targeting agents for fluorescence imaging in atherosclerosis and breast cancer models (Ex/Em = 645/670 nm) .

HY-158067

Deferoxamine-DBCO DFO-DBCO		DBCO
Deferoxamine-DBCO is a bifunctional chelating agent. Deferoxamine-DBCO efficiently chelates with radioactive metals (such as ⁸⁹Zr) through the DFO structure to achieve radiolabeling. Deferoxamine-DBCO undergoes a metal-free Huisgen cycloaddition reaction with azide-containing biomolecules (such as siRNA, monoclonal antibodies) under bioorthogonal conditions through the DBCO structure to achieve targeted coupling. Deferoxamine-DBCO has efficient metal chelating ability and specific bioorthogonal reaction activity. Deferoxamine-DBCO can be used for targeted radioactive imaging studies of tumors .

HY-D1274

Sulfo-cyanine3 azide		Azide
Sulfo-cyanine3 azide is an azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). Sulfo-cyanine3 azide can be involved in synthesis of fused tricyclic heterocycles, produces immunostimulatory agents . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D1274A

Sulfo-cyanine3 azide sodium		Azide Labeling and Fluorescence Imaging
Sulfo-cyanine3 azide sodium a water-soluble azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). Sulfo-cyanine3 azide sodium can be involved in synthesis of fused tricyclic heterocycles, produces immunostimulatory agents . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-164766

ICG-DBCO-1-Maltotriose		DBCO
ICG-DBCO-1-Maltotriose is a specific imaging agent for detecting bacterial infections. ICG-DBCO-1-Maltotriose is composed of the fluorescent dye Indocyanine green (ICG) (HY-D0711) and a maltotriose sugar .

HY-170749

DFO-BCN		BCN
DFO-BCN is a drug intermediate, that can be used for synthesis of PET/CT imaging agent DFO-CPC634 through click chemistry .

HY-D1274B

Sulfo-cyanine3 azide TEA		Azide
Sulfo-cyanine3 azide TEA is an azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). Sulfo-cyanine3 azide TEA can be involved in synthesis of fused tricyclic heterocycles, produces immunostimulatory agents . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-183740

NAIA N-Acryloylindole-alkyne		Alkynes
NAIA (N-Acryloylindole-alkyne) is a cysteine-reactive probe. NAIA can be used as an imaging agent, proteome profiling agent, and covalent ligand screening tool .

HY-W422109

4-(6-Methyl-1,2,4,5-tetrazin-3-yl)benzoic acid		Tetrazine
4-(6-Methyl-1,2,4,5-tetrazin-3-yl) benzoic acid is an asymmetric tetrazine derivative and a bioorthogonal reaction partner. 4-(6-Methyl-1,2,4,5-tetrazin-3-yl) benzoic acid can be conjugated with Bevacizumab (HY-P9906) via EDC/NHS activation while retaining the VEGF-binding affinity of the antibody, thus constructing a targeting agent for pretargeted immuno-PET/NIRF imaging .

Cat. No.	Product Name		Classification

HY-160062

S2.2 aptamer sodium		Aptamers
S2.2 aptamer sodium is a nucleic acid-based MUC1-binding aptamer with high affinity and low toxicity. Upon binding to its target, S2.2 aptamer sodium undergoes a conformational switch and restores fluorescence signal, serving as a targeted imaging agent for MUC1-positive cancer cells. S2.2 aptamer sodium enables targeted delivery to breast cancer cells with overexpressed MUC1. When formulated as the S2.2-PEG-MZF molecular probe, S2.2 aptamer sodium possesses the functions of T2 signal inhibition, magnetic field-induced hyperthermia and targeted magnetic resonance molecular imaging. In the S2.2-PEG-MZF/DOX nanoliposome, S2.2 aptamer sodium supports targeted thermochemotherapy, effectively inhibiting cancer cell proliferation and invasion as well as inducing apoptosis, and is widely used in studies related to breast cancer .

HY-W440919

DSPE-PEG2000-Rhodamine		Pegylated Lipids Fluorescent Lipids
DSPE-PEG2000-Rhodamine is a dye functionalized phospholipid. The amphiphilic polymer can form lipid bilayer in water and be used to encapsulate therapeutic agents, such as liposomal anticancer drug or mRNA vaccine. Rhodamine has maximum absorption at 570 nm and emission around 595 nm and can be easily traced using an imaging technique.

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