1628423-76-6
Chemical Structure
Pafolacianine
Synonym(s): OTL 38
- CAS No.: 1628423-76-6
- Formula:C61H67N9O17S4
- Molecular Weight:1326.49
IUPAC Name: 2-((Z)-2-((Z)-2-(4-((S)-2-(4-(((2-amino-4-oxo-4,8-dihydropteridin-6-yl)methyl)amino)benzamido)-2-carboxyethyl)phenoxy)-3-(2-((Z)-3,3-dimethyl-5-sulfo-1-(4-sulfobutyl)indolin-2-ylidene)ethylidene)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfobutyl)-3H-indol-1-ium-5-sulfonate
InChIKey: PDXNSXLPXJFETD-DYVQZXGMSA-N
SMILES: O=S(CCCCN1C2=CC=C(S(=O)(O)=O)C=C2C(C)(/C1=C/C=C3C(OC4=CC=C(C=C4)C[C@@H](C(O)=O)NC(C5=CC=C(C=C5)NCC(N=C67)=CNC6=NC(N)=NC7=O)=O)=C(CCC\3)/C=C\C8=[N+](C9=CC=C(S(=O)([O-])=O)C=C9C8(C)C)CCCCS(=O)(O)=O)C)(O)=O
Biological Activity: Pafolacianine (OTL 38) is a fluorescent imaging agent made of near-infrared dye used in detecting tumor lesions during surgical procedures. Pafolacianine excites at 774 to 775 nm and emits at 794 to 796 nm[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pafolacianine | 98.70% | Pafolacianine (OTL 38) is a fluorescent imaging agent made of near-infrared dye used in detecting tumor lesions during surgical procedures. Pafolacianine excites at 774 to 775 nm and emits at 794 to 796 nm. | ||||||||||||||||||||
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References
- [1]. Jane J Keating, et, al. Intraoperative near-infrared fluorescence imaging targeting folate receptors identifies lung cancer in a large-animal model. Cancer. 2017 May 15;123(6):1051-1060. [Content Brief]
- [2]. Gul Z, et al. Pafolacianine, the magic wand of intraoperative imaging of folate-receptor positive ovarian cancer. Ann Transl Med. 2023 Oct 25;11(11):394. [Content Brief]
