1102 Results for "

insulin-

" in MedChemExpress (MCE) Product Catalog:
Products (1102)

1102 Results for "insulin-" in MCE Product Catalog:

199
Metformin hydrochloride
Metformin hydrochloride
0 Images
199 Publications Verification
Cat. No.: HY-17471A
CAS No.: 1115-70-4
Synonyms: 1,1-Dimethylbiguanide hydrochloride
Target:  

AMPK Autophagy Mitophagy Apoptosis mTOR

Research Areas:  

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .
199
Metformin
Metformin
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199 Publications Verification
Cat. No.: HY-B0627
CAS No.: 657-24-9
Synonyms: 1,1-Dimethylbiguanide
Target:  

AMPK Autophagy Mitophagy Apoptosis mTOR

Research Areas:  

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .
92
Insulin (human)
Insulin (human)
0 Images
92 Cited Publications
Cat. No.: HY-P0035
CAS No.: 11061-68-0
Target:  

Insulin Receptor

Research Areas:  

Metabolic Disease Endocrinology

Insulin (human) is a polypeptide hormone that regulates the level of glucose. Insulin (human) can be used for the diabetes mellitus .
92
Insulin solution (human)
Insulin solution (human)
0 Images
92 Cited Publications
Cat. No.: HY-P0035A
CAS No.: 11061-68-0
Target:  

Insulin Receptor

Research Areas:  

Metabolic Disease

Insulin solution (human) is a polypeptide hormone that regulates the level of glucose. Insulin solution (human) can be used for the diabetes mellitus .
51
Linsitinib
Linsitinib
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51 Cited Publications
Cat. No.: HY-10191
CAS No.: 867160-71-2
Purity:  99.87%
Synonyms: OSI-906
Target:  

IGF-1R Insulin Receptor

Research Areas:  

Endocrinology Cancer

Linsitinib (OSI-906) is a potent, selective and orally bioavailable dual inhibitor of the IGF-1 receptor and insulin receptor (IR) with IC50s of 35 and 75 nM, respectively .
41
Semaglutide
Semaglutide
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41 Cited Publications
Cat. No.: HY-114118
CAS No.: 910463-68-2
Purity:  99.84%
Target:  

GLP Receptor Insulin Receptor α-synuclein Apoptosis p38 MAPK Autophagy Bcl-2 Family

Research Areas:  

Neurological Disease Metabolic Disease Cancer

Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .
41
Semaglutide acetate
Semaglutide acetate
0 Images
41 Cited Publications
Cat. No.: HY-114118B
CAS No.: 1997361-85-9
Purity:  99.92%
Target:  

GLP Receptor Insulin Receptor α-synuclein Apoptosis p38 MAPK Autophagy Bcl-2 Family

Research Areas:  

Neurological Disease Metabolic Disease Cancer

Semaglutide acetate is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide acetate promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide acetate also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide acetate has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide acetate can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .
41
Semaglutide TFA
Semaglutide TFA
0 Images
41 Cited Publications
Cat. No.: HY-114118A
Purity:  99.92%
Target:  

GLP Receptor Insulin Receptor α-synuclein Apoptosis p38 MAPK Autophagy Bcl-2 Family

Research Areas:  

Neurological Disease Metabolic Disease Cancer

Semaglutide TFA is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide TFA promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide TFA also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide TFA has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide TFA can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .
40
Liraglutide TFA
Liraglutide TFA
0 Images
40 Cited Publications
Cat. No.: HY-P0014B
Target:  

GLP Receptor

Research Areas:  

Metabolic Disease

Liraglutide (TFA) is an agonist of glucagon-like peptide 1 receptor (GLP-1). Liraglutide (TFA) can activate GLP-1, leading to the release of insulin in the presence of increased glucose concentration. Liraglutide (TFA) also reduces glucagon secretion in a glucose-dependent manner. Liraglutide (TFA) can be studied in research on type 2 diabetes .
30
Picropodophyllin
Picropodophyllin
0 Images
30 Cited Publications
Cat. No.: HY-15494
CAS No.: 477-47-4
Purity:  99.85%
Synonyms: AXL1717; Picropodophyllotoxin; PPP
Category:  

Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Endocrinology

Target:  

IGF-1R Apoptosis

Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.
29
NCT-503
NCT-503
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29 Cited Publications
Cat. No.: HY-101966
CAS No.: 1916571-90-8
Purity:  99.69%
Target:  

Phosphoglycerate Dehydrogenase (PHGDH)

Research Areas:  

Metabolic Disease Cancer

NCT-503 is a blood-brain barrier-permeable, non-competitive PHGDH inhibitor with an IC50 of 2.5 μM against human PHGDH. NCT-503 reduces glucose-derived serine production and the incorporation of one-carbon units into nucleotides without decreasing PHGDH protein expression. NCT-503 prevents high selenium-induced insulin resistance in mice by regulating blood glucose and insulin levels and improving glucose tolerance, and also inhibits the growth of tumors overexpressing PHGDH. NCT-503 can be used in research related to insulin resistance and breast cancer .
25
Insulin Protein, Human (P.pastoris)
Insulin Protein, Human (P.pastoris)
0 Images
25 Cited Publications
Cat. No.: HY-P73243
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: insulin; INS; IDDM; ILPR; IRDN; MODY10
Species:  
Human
Source:  
P. pastoris
19
Adenosine 5'-monophosphate disodium
Adenosine 5'-monophosphate disodium
0 Images
19 Cited Publications
Cat. No.: HY-W011012
CAS No.: 4578-31-8
Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .
16
Octreotide acetate
Octreotide acetate
0 Images
16 Cited Publications
Cat. No.: HY-17365
CAS No.: 79517-01-4
Synonyms: SMS 201-995 acetate
Target:  

Somatostatin Receptor

Research Areas:  

Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer

Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently.
13
Insulin(cattle)
Insulin(cattle)
0 Images
13 Cited Publications
Cat. No.: HY-P1156
CAS No.: 11070-73-8
Target:  

Insulin Receptor

Research Areas:  

Metabolic Disease Endocrinology

Insulin cattle is a two-chain polypeptide hormone produced in vivo in the pancreatic β cells. Insulin cattle has often been used as growth supplement in culturing cells.
13
NVP-AEW541
NVP-AEW541
0 Images
13 Cited Publications
Cat. No.: HY-50866
CAS No.: 475489-16-8
Synonyms: AEW541
Target:  

IGF-1R Insulin Receptor Autophagy

Research Areas:  

Endocrinology Cancer

NVP-AEW541 (AEW541 ) is an orally active inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with an IC50 value of 0.15 μM. NVP-AEW541 also inhibits InsR, IC50 with a value of 0.14 μM. NVP-AEW541 has antitumor activity .
13
D-Mannitol
D-Mannitol
0 Images
13 Cited Publications
Cat. No.: HY-N0378
CAS No.: 69-65-8
Synonyms: Mannitol; Mannite
Category:  

Natural Products other families Metabolic Disease Plants Endogenous metabolite Disease Research Fields Sweeteners Food Research

Target:  

Environmental Pollutants Endogenous Metabolite Apoptosis PGC-1α PKA Adrenergic Receptor

D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells . D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed .
13
D-Mannitol (Standard)
D-Mannitol (Standard)
0 Images
13 Cited Publications
Cat. No.: HY-N0378R
CAS No.: 69-65-8
Synonyms: Mannitol(Standard); Mannite (Standard)
Category:  

Natural Products other families Microorganisms Metabolic Disease Plants Endogenous metabolite Disease Research Fields Sweeteners Food Research

Target:  

Reference Standards Endogenous Metabolite Apoptosis PGC-1α Adrenergic Receptor PKA

D-Mannitol (Standard) is the analytical standard of D-Mannitol (HY-N0378). This product is intended for research and analytical applications. D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells . D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed .
12
L-Cysteine hydrochloride hydrate
L-Cysteine hydrochloride hydrate
0 Images
12 Cited Publications
Cat. No.: HY-W016715
CAS No.: 7048-04-6
Category:  

Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite NF-κB Insulin Receptor

L-Cysteine hydrochloride hydrate is an orally active and essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride hydrate regulates CBS/H2S pathway, inhibits NF-κB activation and insulin and ghrelin secretion. L-Cysteine hydrochloride hydrate reduces blood sugar, vascular inflammation markers and appetite. L-Cysteine hydrochloride hydrate induces kidney damage. L-Cysteine hydrochloride hydrate can be used in the study of neurological diseases and diabetes .
11
Acarbose
Acarbose
0 Images
11 Cited Publications
Cat. No.: HY-B0089
CAS No.: 56180-94-0
Synonyms: BAY g 5421
Category:  

Polysaccharides Microorganisms Anti-aging Metabolic Disease Disease Research Fields Saccharides

Target:  

Glycosidase

Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .
Assay Types