475489-16-8
475489-16-8
Chemical Structure
NVP-AEW541
Synonym(s): AEW541
- CAS No.: 475489-16-8
- Formula:C27H29N5O
- Molecular Weight:439.55
IUPAC Name: 7-((1s,3s)-3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
InChIKey: AECDBHGVIIRMOI-GRGXKFILSA-N
SMILES: NC1=C2C(N([C@@H]3C[C@@H](C3)CN4CCC4)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1
Biological Activity: NVP-AEW541 (AEW541 ) is an orally active inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with an IC50 value of 0.15 μM. NVP-AEW541 also inhibits InsR, IC50 with a value of 0.14 μM. NVP-AEW541 has antitumor activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NVP-AEW541 | 99.71% | NVP-AEW541 (AEW541 ) is an orally active inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with an IC50 value of 0.15 μM. NVP-AEW541 also inhibits InsR, IC50 with a value of 0.14 μM. NVP-AEW541 has antitumor activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.98
HY-50866BNVP-AEW541 dihydrochloride -
Similarity Score 0.96
HY-10252Acis-NVP-ADW742 -
Similarity Score 0.96
HY-10252RNVP-ADW742 (Standard) -
Similarity Score 0.65
HY-108318RK-24466 -
Similarity Score 0.64
HY-118105RK-20448 -
Similarity Score 0.64
HY-15764GA 419259 (GMP) -
Similarity Score 0.64
HY-401475Protein kinase inhibitor 9 -
Similarity Score 0.63
HY-15764AA 419259 trihydrochloride -
Similarity Score 0.59
HY-126425NCGC00262650 -
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