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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
331 Results for "
kinase-3
" in MedChemExpress (MCE) Product Catalog:
Products (331)
331 Results for "kinase-3" in MCE Product Catalog:
22
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Target:
Research Areas:
GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM. GSK-843 can be used for the research of inflammation .
6
9-ING-41 (Elraglusib) is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic agents [3] .
4
4 Cited Publications
Target:
Research Areas:
HS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC50 of 20.8 nM .
4
Category:
Alkaloids Rutaceae Quinoline Alkaloids Plants Skimmia reevesiana Fort. Disease Research Fields Inflammation/Immunology
Target:
3
Target:
Research Areas:
1-Azakenpaullone (1-Akp) is a highly selective and ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β), with an IC50 value of 18 nM .
2
2 Cited Publications
Cat. No.: HY-P70178
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FLT3; CD135 Antigen; Fms Related Receptor Tyrosine kinase 3; FLK-2; CD135; Growth Factor Receptor Tyrosine kinase Type III; STK1; Receptor Protein-Tyrosine kinase; FLK2; Fms-Related Tyrosine kinase 3; Fms-Like Tyrosine kinase 3; Fetal Liver kinase 2; Rece
2
2
2 Cited Publications
Cat. No.: HY-P81190
Synonyms: p-PERK(Thr980); PERK(Phospho Thr980); PERK(Phospho T980); mo(Thr980)/hu (Thr982)/rat (Thr974); HRI; HsPEK; Pancreatic eIF2-alpha kinase; PEK; PRKR like endoplasmic reticulum kinase; WRS; DKFZp781H1925; EC 2.7.11.1; EIF2AK3; Eukaryotic translation initiation factor 2 alpha kinase 3; Heme regulated EIF2 alpha kinase.
1
1 Cited Publications
Cat. No.: HY-P7111
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FLT3LG; IMD125; Fms Related Receptor Tyrosine kinase 3 Ligand; FLG3L; Fms-Related Tyrosine kinase 3 Ligand; FLT3L; Fms Related Tyrosine kinase 3 Ligand; Flt3L; Flt3 Ligand; FL; SL Cytokine
1
1 Cited Publications
Cat. No.: HY-P70563
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FLT3LG; IMD125; Fms Related Receptor Tyrosine kinase 3 Ligand; FLG3L; Fms-Related Tyrosine kinase 3 Ligand; FLT3L; Fms Related Tyrosine kinase 3 Ligand; Flt3L; Flt3 Ligand; FL; SL Cytokine
1
1 Cited Publications
Cat. No.: HY-P701821
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: STK3; Serine/Threonine-Protein kinase Krs-1; Serine/Threonine kinase 3; MST-2; MST2; Serine/Threonine kinase 3 (STE20 Homolog, Yeast); KRS1; Non-Specific Serine/Threonine Protein kinase; Mammalian STE20-Like Protein kinase 2; Epididymis Secretory Sperm Bi
Species:
Source:
1
1 Cited Publications
Cat. No.: HY-P75236
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EPHB2; Ephrin Type-B Receptor 2 Variant; Prev. EPHT3; Protein-Tyrosine kinase HEK5; Prev. DRT; Elk-Related Tyrosine kinase; Prev. ERK; ELK-Related Tyrosine kinase; Tyrosine-Protein kinase Receptor EPH-3; Eph Tyrosine kinase 3; Ephrin Type-B Receptor 2; EP
1
1 Cited Publications
Synonyms: 7-Bromoindirubin-3-Oxime
Research Areas:
7BIO (7-Bromoindirubin-3-Oxime) is the derivate of indirubin. 7BIO (7-Bromoindirubin-3-Oxime) has inhibitory effects against cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3β (GSK3β). 7BIO (7-Bromoindirubin-3-Oxime) inhibits Aβ oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, activation of astrocytes and microglia, and attenuates Aβ oligomer-induced cognitive impairments in mice [1].
1
Target:
Research Areas:
GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 0.9 nM, and inhibits kinase activity with an IC50 of 0.3 nM .
1
1 Cited Publications
GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β), with an IC50 of 6.6 μM. GSK-3β inhibitor 3 can be used for the research of acute promyelocytic leukemia .
1
1 Cited Publications
Target:
Research Areas:
LMTK3-IN-1 (compound C28) is an ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM)，that acts by degrading LMTK3 via the ubiquitin-proteasome pathway. LMTK3-IN-1 shows anticancer activity in a variety of cancer cell lines and in vivo BC mouse models. LMTK3-IN-1 induces apoptosis in BC cell lines at 10-20 μM .
Synonyms: CGP52421
3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412 .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
