916440-85-2
Chemical Structure
7BIO
Synonym(s): 7-Bromoindirubin-3-Oxime
- CAS No.: 916440-85-2
- Formula:C16H10BrN3O2
- Molecular Weight:356.17
IUPAC Name: (2Z,3E)-7'-bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one
InChIKey: VJTWDKLJCDHHRX-FQJRYBMTSA-N
SMILES: O/N=C1C2=CC=CC=C2NC\1=C3C(NC4=C(C=CC=C4/3)Br)=O
Biological Activity: 7BIO (7-Bromoindirubin-3-Oxime) is the derivate of indirubin. 7BIO (7-Bromoindirubin-3-Oxime) has inhibitory effects against cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3β (GSK3β). 7BIO (7-Bromoindirubin-3-Oxime) inhibits Aβ oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, activation of astrocytes and microglia, and attenuates Aβ oligomer-induced cognitive impairments in mice[1].
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7BIO | 99.20% | 7BIO (7-Bromoindirubin-3-Oxime) is the derivate of indirubin. 7BIO (7-Bromoindirubin-3-Oxime) has inhibitory effects against cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3β (GSK3β). 7BIO (7-Bromoindirubin-3-Oxime) inhibits Aβ oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, activation of astrocytes and microglia, and attenuates Aβ oligomer-induced cognitive impairments in mice. | ||||||||||||||||||||
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Keywords
