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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
lactam derivative
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "lactam derivative" in MCE Product Catalog:
2
2 Cited Publications
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Nitrocefin is a highly activated, chromogenic cephalosporin derivative. Nitrocefin is a chromogenic β-lactamase substrate. Nitrocefin undergoes a distinctive color change from yellow to red as the amide bond in the β-lactam ring is hydrolyzed by β-lactamase. Nitrocefin is used in competitive inhibition studies in developmental work on β-lactamase-resistant antibiotics .
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1 Cited Publications
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GW779439X is a pyrazolopyridazine identified in an inhibitor of the S. aureus PASTA kinase Stk1. GW779439X potentiates the activity of β-lactam antibiotics against various MRSA and MSSA isolates, some even crossing the breakpoint from resistant to sensitive. GW779439X is an AURKA inhibitor and induces apoptosis by the caspases 3/7 pathway . MRSA:methicillin-resistant S. aureus; MSSA: methicillin-sensitive S. aureus
Cat. No.: HY-P1209A
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Cat. No.: HY-W011792
CAS No.: 20880-92-6
Synonyms: 2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose
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Diacetone-β-D-fructose (2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose) is a chiral carbohydrate derivative and a precursor for β-lactam synthesis .
Cat. No.: HY-P1209
CAS No.: 944111-22-2
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Cat. No.: HY-W013376
CAS No.: 841-77-0
Synonyms: 1-(Diphenylmethyl)piperazine; 1-Benzhydrylpiperazine
Norcyclizine is a piperazine compound that can be used for the synthesis of antimicrobial agents. 1-Benzhydrylpiperazine derivatives have been found to enhance the antibacterial activity of β-lactam antibiotics (Oxacillin, HY-B0925A) against Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA). This enhancement is likely achieved by inhibiting the allosteric site of PBP2a. Additionally, 1-Benzhydrylpiperazine can also serve as a pharmacological scaffold for the synthesis of anticancer agents .
Cat. No.: HY-149327
CAS No.: 2864443-47-8
HCT-116-IN-1, a γ-lactam-fused pyridone derivative, has anticancer activity and displayed high cytotoxicity against HCT116 cells with an IC50 of 5.59 μM .
Cat. No.: HY-W011792R
CAS No.: 20880-92-6
Synonyms: 2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose (Standard)
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Diacetone-β-D-fructose (2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose) (Standard) is the analytical standard of Diacetone-β-D-fructose (HY-W011792). This product is intended for research and analytical applications. Diacetone-β-D-fructose is a chiral carbohydrate derivative and a precursor for β-lactam synthesis .
Cat. No.: HY-W766041
Synonyms: 2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose-d12
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Diacetone-β-D-fructose-d12 (2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose-d12) is the d12-labeled Diacetone-β-D-fructose (HY-W011792). Diacetone-β-D-fructose is a chiral carbohydrate derivative and a precursor for β-lactam synthesis .
Cat. No.: HY-150766
CAS No.: 2232877-85-7
KPC-2-IN-1, boronic acid derivative, is a potent KPC-2 inhibitor with Ki of 0.032 μM. KPC-2-IN-1 enhances the activity of cefotaxime in KPC-2 expressing E. coli. KPC-2-IN-1 exhibits well tolerated in human HEK-293 cells, which can be used for the study of E. coli resistance to β-lactam antibiotics .
Cat. No.: HY-103645R
CAS No.: 551919-98-3
GW779439X (Standard) is the analytical standard of GW779439X (HY-103645). This product is intended for research and analytical applications. GW779439X is a pyrazolopyridazine identified in an inhibitor of the S. aureus PASTA kinase Stk1. GW779439X potentiates the activity of β-lactam antibiotics against various MRSA and MSSA isolates, some even crossing the breakpoint from resistant to sensitive. GW779439X is an AURKA inhibitor and induces apoptosis by the caspases 3/7 pathway . MRSA:methicillin-resistant S. aureus; MSSA: methicillin-sensitive S. aureus
Cat. No.: HY-W754216
Synonyms: 2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose-13C6
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Diacetone-β-D-fructose- 13C6 (2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose- 13C6) is the 13C6-labeled Diacetone-β-D-fructose (HY-W011792). Diacetone-β-D-fructose is a chiral carbohydrate derivative and a precursor for β-lactam synthesis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
