841-77-0
Chemical Structure
Norcyclizine
Synonym(s): 1-(Diphenylmethyl)piperazine; 1-Benzhydrylpiperazine
- CAS No.: 841-77-0
- Formula:C17H20N2
- Molecular Weight:252.35
IUPAC Name: 1-benzhydrylpiperazine
InChIKey: NWVNXDKZIQLBNM-UHFFFAOYSA-N
SMILES: C1(C(N2CCNCC2)C3=CC=CC=C3)=CC=CC=C1
Biological Activity: Norcyclizine is a piperazine compound that can be used for the synthesis of antimicrobial agents. 1-Benzhydrylpiperazine derivatives have been found to enhance the antibacterial activity of β-lactam antibiotics (Oxacillin, HY-B0925A) against Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA). This enhancement is likely achieved by inhibiting the allosteric site of PBP2a. Additionally, 1-Benzhydrylpiperazine can also serve as a pharmacological scaffold for the synthesis of anticancer agents[1][2].
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Norcyclizine | Norcyclizine is a piperazine compound that can be used for the synthesis of antimicrobial agents. 1-Benzhydrylpiperazine derivatives have been found to enhance the antibacterial activity of β-lactam antibiotics (Oxacillin, HY-B0925A) against Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA). This enhancement is likely achieved by inhibiting the allosteric site of PBP2a. Additionally, 1-Benzhydrylpiperazine can also serve as a pharmacological scaffold for the synthesis of anticancer agents. | |||||||||||||||||||||
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Norcyclizine-d8 | Norcyclizine-d8 is the deuterium labeled Norcyclizine. | |||||||||||||||||||||
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- [1]. Witek K, et al. Chalcogen-Varied Imidazolone Derivatives as Antibiotic Resistance Breakers in Staphylococcus aureus Strains. Antibiotics (Basel). 2023 Nov 11;12(11):1618. [Content Brief]
- [2]. Ananda Kumar CS et al. Synthesis and in vitro antiproliferative activity of novel 1-benzhydrylpiperazine derivatives against human cancer cell lines. Eur J Med Chem. 2009 Mar;44(3):1223-9. [Content Brief]
Keywords
