179 Results for "

lambda

" in MedChemExpress (MCE) Product Catalog:
Products (179)

179 Results for "lambda" in MCE Product Catalog:

5
5 Cited Publications
Cat. No.: HY-P9952
CAS No.: 356547-88-1
Synonyms: LymphoStat B

Target:  

TNF Receptor CD20

Research Areas:  

Inflammation/Immunology Cancer

Belimumab (LymphoStat B) is a humanized IgG1λ monoclonal antibody against B-lymphocyte stimulator (BLyS) protein. Belimumab antagonizes BLyS activity in autoimmune diseases and B-lymphocyte malignancies. Belimumab can be used for systemic lupus erythematosus (SLE) research . The component ratio of this product is Active ingredient: Excipients = 1:1.0-1:1.2.
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4
4 Cited Publications
Cat. No.: HY-B0836
CAS No.: 91465-08-6
λ-Cyhalothrin is a high efficiency, broad-spectrum type II synthetic pyrethroid insecticide containing α-cyano group. λ-Cyhalothrin is used to control a wide range of pests in a variety of applications. λ-Cyhalothrin is a neurotoxin that targets sodium channels in the membranes of neurons in the central nervous system .
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4
4 Cited Publications
Cat. No.: HY-P2377
CAS No.: 219137-85-6
Target:  

Fluorescent Dye

Research Areas:  

Others

Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm .
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3
3 Cited Publications
Cat. No.: HY-W015490
CAS No.: 130-15-4
1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-κB and monoamine oxidase (MAO-A/B), with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B (Ki=1.4 μM) and a non-competitive inhibitor of MAO-A (Ki=7.7 μM). 1,4-Naphthoquinone inhibits DNA polymerase pol α, β, γ, δ, ε, λ with IC50 ranging from 5.57-128 μM. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione (GSH), inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-κB nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models .
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2
2 Cited Publications
Cat. No.: HY-N9470
CAS No.: 9064-57-7
λ-Carrageenan is a seaweed polysaccharide which has been generally used as proinflammatory agent in the basic research. λ-Carrageenan is a potent antitumor agent .
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2
2 Cited Publications
Cat. No.: HY-P99992
Human IgG1 lambda1, Isotype Control, a human-derived antibody, is an isotype control for human IgG1λ1 antibody. Human IgG1 lambda1, Isotype Control can be used in the research of diabetes and pancreatic cancer .
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2
2 Cited Publications
Cat. No.: HY-P7026
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuIFN-λ1/IL-29; IL-29; IFN-lambda-1; Cytokine Zcyto21; Interleukin-29
Species:  
Source:  
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2
2 Cited Publications
Cat. No.: HY-P74851
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Interferon lambda-3; IFN-lambda-3; IL-28B; IL-28C; ZCYTO22
Species:  
Source:  
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2
2 Cited Publications
Cat. No.: HY-P990672

Target:  

FGFR

Research Areas:  

Inflammation/Immunology

U3-1784 is a humanized antibody expressed in CHO that targets FGFR4/CD334. U3-1784 is equipped with a huIgG1 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for U3-1784 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
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1
1 Cited Publications
Cat. No.: HY-P990006
CAS No.: 2750005-84-4
Synonyms: TEV-48574; SAR-447189; TEV-574

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

Duvakitug (TEV-48574) is a humanized IgG1-λ2 monoclonal antibody targeting to TNFSF15/TL1A. Duvakitug' main expression system is CHOK1SV cells endogenously expressing glutamine synthetase (GS). Duvakitug can be used in the study of Crohn's Disease (CD) .
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1
1 Cited Publications
Cat. No.: HY-P99039
CAS No.: 1803176-05-7
Synonyms: MEDI9447

Target:  

CD73

Research Areas:  

Cancer

Oleclumab (MEDI9447) is a human IgG1λ monoclonal antibody targeting CD73 and inhibits the exonuclease activity of the extracellular enzyme CD73. Oleclumab can adjust the composition of bone marrow and lymphoid infiltrating leukocyte populations in the tumor microenvironment and has anti-tumor activity .
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1
1 Cited Publications
Cat. No.: HY-P99103
CAS No.: 2578319-11-4
Synonyms: LY-3853113; LY-COV1404

Target:  

SARS-CoV

Research Areas:  

Infection

Bebtelovimab a human IgG1-λ2 antibody targeting to SARS-CoV-2, especially COVID-19 ((the IC50 value for SARS-CoV-2/MT020880.1 virus is 9-22.1 ng/mL)). Bebtelovimab potently neutralizes SARS-CoV-2 variants, and inhibits COVID-19 with mild-to-moderate efficacy .
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1
1 Cited Publications
Cat. No.: HY-P99730
CAS No.: 2227490-52-8
Synonyms: TAK-079

Target:  

CD38 Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Mezagitamab (TAK-079) is a IgG1λ anti-CD38 monoclonal antibody. Mezagitamab depletes tumor cells expressing CD38 through antibody and complement dependent cytotoxicity. Mezagitamab has potential application in relapsed/refractory multiple myeloma (RRMM) and idiopathic thrombocytopenic purpura (ITP) .
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1
1 Cited Publications
Cat. No.: HY-P990675

Target:  

VEGFR

Research Areas:  

Inflammation/Immunology

VGX-100 is a humanized antibody expressed in CHO cells, targeting VEGFC. VGX-100 is composed of huIgG1 heavy chains and huλ light chains, with a predicted molecular weight (MW) of 143.6 kDa. The isotype control for VGX-100 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
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1
1 Cited Publications
Cat. No.: HY-P99588
CAS No.: 705287-60-1
Synonyms: MYO-029

Target:  

TGF-β Receptor

Research Areas:  

Metabolic Disease

Stamulumab (MYO-029) is a recombinant human IgG1λ antibody that binds to myostatin and neutralizes its activity by preventing binding to its endogenous high-affinity receptor ActRIIB. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia in SCID mice. Stamulumab has the potential for Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) research .
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1
1 Cited Publications
Cat. No.: HY-P72243
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IFN-alpha14; IFN14_HUMAN; IFNA14; Interferon alpha 14; Interferon alpha H; Interferon alpha-14; Interferon alpha-H; Interferon lambda-2-H; Interferon lambda2H ; LeIF H; LeIFH; MGC125756; MGC125757
Species:  
Source:  
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1
1 Cited Publications
Cat. No.: HY-P76401
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Interferon alpha-14; Interferon alpha-H; LeIF H; Interferon lambda-2-H; IFNA14
Species:  
Source:  
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1
1 Cited Publications
Cat. No.: HY-N7694
CAS No.: 97871-44-8
Isotoosendanin is an orally active TGFβR1 inhibitor and abrogating its kinase activity (IC50 = 6732 nM). Isotoosendanin inhibits the JAK/STAT3 signaling pathway by directly targeting SHP-2, enhancing its stability, and reducing its ubiquitination. Isotoosendanin inhibits TGF-β-induced reduces the migration, invasion, and metastasis in triple-negative breast cancer (TNBC) cells. Isotoosendanin exhibits anti-tumor efficacy in TNBC xenograft models and A549 xenograft tumors. Isotoosendanin exhibits significant anti-inflammatory effects in acetic acid-induced vascular permeability and λ-carrageenan-induced hind paw edema tests. Isotoosendanin can be used for the study of non-small cell lung cancer (NSCLC), TNBC and inflammation .
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Cat. No.: HY-P99366A
CAS No.: 1572943-04-4
Synonyms: AMG 157 (anti-TSLP); MEDI 19929 (anti-TSLP); Tezepelumab-ekko (anti-TSLP)

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Tezepelumab (anti-TSLP) is human monoclonal antibody (IgG2λ) that binds specifically to TSLP, blocking it from interacting with its heterodimeric receptor. Tezepelumab can be used for the research of severe, uncontrolled asthma .
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Cat. No.: HY-P990096

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Human IgG1 lambda2, Isotype Control is a human monoclonal antibody that is the isotype control of human IgG1λ antibody. Isotype control antibodies can help remove non-specific signals from experimental results and assess the accuracy and reliability of the experiment .
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