1. Anti-infection Membrane Transporter/Ion Channel
  2. Parasite Sodium Channel
  3. λ-Cyhalothrin

λ-Cyhalothrin is a high efficiency, broad-spectrum type II synthetic pyrethroid insecticide containing α-cyano group. λ-Cyhalothrin is used to control a wide range of pests in a variety of applications. λ-Cyhalothrin is a neurotoxin that targets sodium channels in the membranes of neurons in the central nervous system.

For research use only. We do not sell to patients.

λ-Cyhalothrin Chemical Structure

λ-Cyhalothrin Chemical Structure

CAS No. : 91465-08-6

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Customer Review

Based on 2 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

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Description

λ-Cyhalothrin is a high efficiency, broad-spectrum type II synthetic pyrethroid insecticide containing α-cyano group. λ-Cyhalothrin is used to control a wide range of pests in a variety of applications. λ-Cyhalothrin is a neurotoxin that targets sodium channels in the membranes of neurons in the central nervous system[1].

In Vitro

The mechanism of λ-Cyhalothrin toxicity produces delay in sodium channel inactivation, which leads to persistent depolarization of the nerve membrane. λ-Cyhalothrin produces membrane depolarization, calcium ion infl ux, and neurotransmitter release from rat brain synaptosomes[1].
λ-Cyhalothrin possesses estrogenic properties and has an ability to function as a xenoestrogen promoting human breast carcinoma cell proliferation in vitro[1].
λ-Cyhalothrin has found multiple uses in pest (fleas, cockroaches, flies, and ants) control[1].
λ-Cyhalothrin is highly effective against the malaria transmitting species of Anopheles[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The effect of λ-Cyhalothrin (i.p.) on memory, movement activity, and co-ordination in mice exposed to bilateral clamping of the carotid arteries (BCCA) is investigated. Neither memory nor movement co-ordination are impaired by BCCA or λ-Cyhalothrin. Exploratory locomotor activity is significantly reduced in the BCCA/LCH group. Spontaneous movement activity is significantly reduced in the BCCA/λ-Cyhalothrin group . Exposure to λ-Cyhalothrin coexisting with BCCA decreases motor activity in the mice in 2 subsequent 30-min[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

449.85

Formula

C23H19ClF3NO3

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H]1C(C)(C)[C@@H]1/C=C(Cl)/C(F)(F)F)O[C@@H](C#N)C2=CC=CC(OC3=CC=CC=C3)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (74.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2230 mL 11.1148 mL 22.2296 mL
5 mM 0.4446 mL 2.2230 mL 4.4459 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (5.56 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2230 mL 11.1148 mL 22.2296 mL 55.5741 mL
5 mM 0.4446 mL 2.2230 mL 4.4459 mL 11.1148 mL
10 mM 0.2223 mL 1.1115 mL 2.2230 mL 5.5574 mL
15 mM 0.1482 mL 0.7410 mL 1.4820 mL 3.7049 mL
20 mM 0.1111 mL 0.5557 mL 1.1115 mL 2.7787 mL
25 mM 0.0889 mL 0.4446 mL 0.8892 mL 2.2230 mL
30 mM 0.0741 mL 0.3705 mL 0.7410 mL 1.8525 mL
40 mM 0.0556 mL 0.2779 mL 0.5557 mL 1.3894 mL
50 mM 0.0445 mL 0.2223 mL 0.4446 mL 1.1115 mL
60 mM 0.0370 mL 0.1852 mL 0.3705 mL 0.9262 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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λ-Cyhalothrin
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