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  4. γ-Cyhalothrin

γ-Cyhalothrin is an orally active, blood-brain barrier permeable Type II synthetic pyrethroid insecticide. γ-Cyhalothrin is the insecticidally active enantiomer of λ-Cyhalothrin (HY-B0836). γ-Cyhalothrin disrupts voltage-gated sodium channels, induces salivation and reduces spontaneous activity in rats. γ-Cyhalothrin exerts toxic effects on aquatic invertebrates and fish, triggers community-level effects in aquatic ecosystems, and inhibits host-seeking Ixodes scapularis nymphs in residential lawn ecotones. γ-Cyhalothrin is applicable to insecticidal-related research.

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γ-Cyhalothrin

γ-Cyhalothrin Chemical Structure

CAS No. : 76703-62-3

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γ-Cyhalothrin Related Antibodies

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Description

γ-Cyhalothrin is an orally active, blood-brain barrier permeable Type II synthetic pyrethroid insecticide. γ-Cyhalothrin is the insecticidally active enantiomer of λ-Cyhalothrin (HY-B0836). γ-Cyhalothrin disrupts voltage-gated sodium channels, induces salivation and reduces spontaneous activity in rats. γ-Cyhalothrin exerts toxic effects on aquatic invertebrates and fish, triggers community-level effects in aquatic ecosystems, and inhibits host-seeking Ixodes scapularis nymphs in residential lawn ecotones. γ-Cyhalothrin is applicable to insecticidal-related research[1][2][3].

In Vitro

Gamma-cyhalothrin exhibits a median HC5 value of 0.47 ng/L for invertebrates, a median HC5 value of 23.7 ng/L for fish, and a no-observed-effect concentration at the community level (NOECcommunity) of 5 ng/L[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

γ-Cyhalothrin Related Antibodies
In Vivo

γ-Cyhalothrin (0.05% formulation, 362 g/92.9 m2; single application) reduces the number of host-seeking Ixodes scapularis nymphs in residential lawn ecotone plots by 89-97.6% for up to 4 weeks post-treatment[2].
γ-Cyhalothrin (0.0938-4 mg/kg; p.o.; single administration) dose-dependently reduces spontaneous activity and induces salivation in male Long-Evans rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: nymphal stage[2]
Dosage: 0.05% γ-Cyhalothrin, 362 g/92.9 m2 (equivalent to 292.5 mg active ingredient per 150 m2 plot)
Administration: topical application; single dose
Result: Reduced nymphal Ixodes scapularis density by 97.7% in Eau Claire County and 97.4% in Sauk County at 1 week postapplication.
Reduced density by 91.5% in Eau Claire County at 3 weeks and 89.5% at 4 weeks postapplication.
Reduced density by 90.9% in Sauk County at 2 weeks and 97.6% at 3 weeks postapplication.
Limited treated homes with at least one nymphal tick posttreatment to a range of 4.2% (Eau Claire County, week 1) to 29.2% (Eau Claire County, week 3), compared to 50-81.5% of placebo homes.
Lowered the odds of detecting a nymphal tick in treated plots to 0.04 times that of placebo plots at week 1 and 0.09 times that of placebo plots at week 3, after adjusting for plot characteristics and study area.
Animal Model: Long-Evans (male, 63-67 days old, 331.1-361.7 g)[3]
Dosage: 0.0938 mg/kg, 0.188 mg/kg, 0.375 mg/kg, 0.75 mg/kg, 1.5 mg/kg, 3 mg/kg; additional pilot doses: 0.3 mg/kg, 1 mg/kg, 2 mg/kg, 4 mg/kg
Administration: p.o.; single dose
Result: Produced statistically significant decreases in locomotor activity counts relative to controls at doses ≥0.75 mg/kg.
Achieved an ED50 of 1.29 mg/kg for reducing locomotor activity.
Reached a benchmark dose (BMD) of 0.256 mg/kg for a 1 standard deviation decrease in activity.
Induced salivation at 13% incidence with 0.75 mg/kg, 17% incidence with 1 mg/kg, 69% incidence with 1.5 mg/kg, 92% incidence with 2 mg/kg, and 100% incidence with 3 mg/kg and 4 mg/kg.
Associated a 50% decrease in locomotor activity with a plasma concentration of 486.1 ng/mL and a brain concentration of 13.37 ng/g.
Showed a strong positive linear correlation between brain and plasma concentrations, with both tissue levels correlating significantly with decreases in locomotor activity counts.
Molecular Weight

449.85

Formula

C23H19ClF3NO3
CAS No.
SMILES

C(=C(/C(F)(F)F)\Cl)\[C@H]1[C@@H](C(O[C@H](C#N)C2=CC(OC3=CC=CC=C3)=CC=C2)=O)C1(C)C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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γ-Cyhalothrin Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

γ-Cyhalothrin76703-62-3ParasiteinsecticideIxodes scapularisLong-EvansratInhibitorinhibitorinhibit

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