158 Results for "

loading

" in MedChemExpress (MCE) Product Catalog:
Products (158)

158 Results for "loading" in MCE Product Catalog:

34
Paquinimod
Paquinimod
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34 Cited Publications
Cat. No.: HY-100442
CAS No.: 248282-01-1
Purity:  99.90%
Synonyms: ABR-215757; ABR 25757
Target:  

SARS-CoV

Research Areas:  

Metabolic Disease Inflammation/Immunology

Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .
16
TPE-MI
TPE-MI
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16 Cited Publications
Cat. No.: HY-143218
CAS No.: 1245606-71-6
Purity:  98.05%
Synonyms: Tetraphenylethene maleimide
TPE-MI (Tetraphenylethene maleimide) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm). TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasites Plasmodium falciparum .
3
Thiethylperazine
Thiethylperazine
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3 Cited Publications
Cat. No.: HY-B1794
CAS No.: 1420-55-9
Target:  

Dopamine Receptor Histamine Receptor Bacterial Amyloid-β

Research Areas:  

Infection Neurological Disease

Thiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects .
3
Thiethylperazine dimaleate
Thiethylperazine dimaleate
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3 Cited Publications
Cat. No.: HY-B1794A
CAS No.: 1179-69-7
Target:  

Dopamine Receptor Histamine Receptor Bacterial Amyloid-β

Research Areas:  

Infection Neurological Disease

Thiethylperazine dimaleate, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine dimaleate is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine dimaleate has anti-emetic, antipsychotic and antimicrobial effects .
3
SDS-PAGE Sample Loading Buffer (4×)
SDS-PAGE Sample Loading Buffer (4×)
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3 Cited Publications
Cat. No.: HY-K1100

SDS-PAGE Sample Loading Buffer (4×) is appropriate for loading protein samples on SDS-PAGE. The 1 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

3
Ezurpimtrostat
Ezurpimtrostat
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3 Cited Publications
Cat. No.: HY-137978
CAS No.: 1914148-72-3
Synonyms: GNS561
Target:  

SARS-CoV IFNAR Autophagy Apoptosis

Research Areas:  

Infection Metabolic Disease Inflammation/Immunology Cancer

Ezurpimtrostat (GNS561) is an orally active PPT1 inhibitor, autophagy inhibitor, immunomodulator, anti-inflammatory agent, and anticancer agent. Ezurpimtrostat inhibits PPT1, dysregulates lysosomal function, redistributes mTOR, and induces apoptosis. Ezurpimtrostat reduces IFN‑α, CRP, immune complex deposition, and SARS‑CoV‑2 viral load. Ezurpimtrostat can be used for the study of systemic lupus erythematosus, SARS‑CoV‑2, hepatocellular carcinoma, fibrosis, and related disorders .
3
Ezurpimtrostat hydrochloride
Ezurpimtrostat hydrochloride
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3 Cited Publications
Cat. No.: HY-137978A
CAS No.: 1914148-73-4
Purity:  99.29%
Synonyms: GNS561 hydrochloride
Target:  

SARS-CoV IFNAR Autophagy Apoptosis

Research Areas:  

Metabolic Disease Inflammation/Immunology Cancer

Ezurpimtrostat hydrochloride (GNS561 hydrochloride) is an orally active PPT1 inhibitor, autophagy inhibitor, immunomodulator, anti-inflammatory agent, and anticancer agent. Ezurpimtrostat hydrochloride inhibits PPT1, dysregulates lysosomal function, redistributes mTOR, and induces apoptosis. Ezurpimtrostat hydrochloride reduces IFN‑α, CRP, immune complex deposition, and SARS‑CoV‑2 viral load. Ezurpimtrostat hydrochloride can be used for the study of systemic lupus erythematosus, SARS‑CoV‑2, hepatocellular carcinoma, fibrosis, and related disorders .
2
Casirivimab
Casirivimab
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2 Cited Publications
Cat. No.: HY-P99341
CAS No.: 2415933-42-3
Synonyms: REGN10933

Target:  

SARS-CoV

Research Areas:  

Infection

Casirivimab (REGN10933) is a human monoclonal antibody that targets the SARS-CoV-2 virus, which causes COVID-19. Casirivimab is ineffective against COVID-19 variants. Casirivimab can be used in combination with Imdevimab (HY-P99342), which alters the lung response of K18-hACE2 mice to the SARS-CoV-2 δ variant, effectively reducing viral load and improving symptoms .
2
EDTA-AM
EDTA-AM
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2 Cited Publications
Cat. No.: HY-D1746
CAS No.: 162303-59-5
Synonyms: EDTA acetoxymethyl ester; Ethylenediaminetetraacetic acid acetoxymethyl ester
EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation .
1
Obeldesivir
Obeldesivir
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1 Cited Publications
Cat. No.: HY-145994
CAS No.: 2647441-36-7
Purity:  99.53%
Synonyms: ATV006
Target:  

SARS-CoV

Research Areas:  

Infection

Obeldesivir (ATV006) is a potent, orally active antiviral agent and ester proagents of GS-441524. Obeldesivir inhibits the replication of SARS-CoV-2 and its variants. Obeldesivir can be used for SARS-CoV-2 research .
1
Imdevimab
Imdevimab
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1 Cited Publications
Cat. No.: HY-P99342
CAS No.: 2415933-40-1
Synonyms: REGN10987

Target:  

SARS-CoV

Research Areas:  

Infection

Imdevimab (REGN10987) is a human monoclonal antibody that targets SARS-CoV-2 virus. Imdevimab can be used in combination with Casirivimab (HY-P99341) to reduce viral load and transiently increases anti-receptor-binding domain IgG titers. Imdevimab maintains most of its neutralization activity against viruses with B.1.1.7, B.1.351 and mink cluster 5 spike proteins .
1
β-catenin-IN-3
β-catenin-IN-3
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1 Cited Publications
Cat. No.: HY-147007
CAS No.: 1005288-15-2
Purity:  96.58%
Target:  

β-catenin Wnt CDK

Research Areas:  

Cancer

β-catenin-IN-3 (Compound C2) is a selective β-catenin inhibitor. β-catenin-IN-3 binds to allosteric site on the surface of β-catenin with K D calculated at 54.96 nM. β-catenin-IN-3 selectively inhibits β-catenin via targeting a cryptic allosteric modulation site, lowers its cellular load. β-catenin-IN-3 significantly reduces viability of β-catenin driven cancer cells, and triggers β-catenin degradation via proteasome system in β-catenin-overexpressing cancer cells .
1
Licoflavone C
Licoflavone C
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1 Cited Publications
Cat. No.: HY-N4183
CAS No.: 72357-31-4
Category:  

Flavonoids Leguminosae Flavones Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer

Target:  

Apoptosis Caspase Estrogen Receptor/ERR

Licoflavone C is a broad-spectrum antiviral inhibitor with estrogen-like properties. Licoflavone C binds to viral endonuclease (CEN) and inhibits the replication of various bunyaviruses including severe fever with thrombocytopenia syndrome virus (SFTSV) and lymphocytic choriomeningitis virus in a non-substrate competitive manner. The IC50 values of Licoflavone C against SFTSV CEN and SFTSV CEN are 35.5 μM and 135.8 μM, respectively, and its Kd value against SFTSV CEN is 9.53 μM. After viral entry into cells, Licoflavone C reduces viral loads in mouse tissues in a dose-dependent manner, and exhibits extremely low cytotoxicity and genotoxicity. Licoflavone C induces apoptosis by increasing caspase 3/7 activity, blocks the cell cycle, and alleviates chemotherapy-induced chromosomal damage. Licoflavone C is applicable to the research on severe fever with thrombocytopenia syndrome and related viral infection mechanisms .
Hydrogenated soya phosphatidylcholine
Hydrogenated soya phosphatidylcholine
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Cat. No.: HY-42990
CAS No.: 97281-48-6
Synonyms: HSPC; Hydrogenated soybean phosphatidylcholine
Hydrogenated soya phosphatidylcholine (hydrogenated soybean phosphatidylcholine) is a natural product. Hydrogenated soya phosphatidylcholine can extend drug release in regard to drug loading and solubility for oral drug delivery of watersoluble drugs .
DMPG sodium
DMPG sodium
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Cat. No.: HY-22274
CAS No.: 200880-40-6
DMPG sodium is a biochemical reagent. DMPG sodium is used as a liposome carrier to load 6-shogaol (HY-14616) with anticancer activity .
Fmoc-Trp(Boc)-OH
Fmoc-Trp(Boc)-OH
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Cat. No.: HY-W008034
CAS No.: 143824-78-6
Synonyms: Fmoc-L-Trp(Boc)-OH
Fmoc-Trp(Boc)-OH (Fmoc-L-Trp(Boc)-OH) is an amino acid derivative with protective groups. Fmoc-Trp(Boc)-OH can self-assemble into stable and pH-responsive spherical nanoparticles, which can load and release bioactive molecules, with good biocompatibility and high cell uptake rate. Fmoc-Trp(Boc)-OH can be used in research on drug delivery .
Gontivimab
Gontivimab
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Cat. No.: HY-P99647
CAS No.: 1257358-38-5
Synonyms: ALX-0171; VR-465

Target:  

RSV

Research Areas:  

Infection

Gontivimab (ALX-0171; VR-465) is a poent anti-RSV prefusion F protein nanobody with a KD value of 0.113 nM. Gontivimab shows antiviral activity. Gontivimab reduces the RSV load in the nose and lung .
Gellan gum, for cell culture
Gellan gum, for cell culture
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Cat. No.: HY-125870
CAS No.: 71010-52-1
Synonyms: Agar substitute gelling agent, for cell culture
Gellan gum is a linear microbial exopolysaccharide that can be used as a cell scaffold for both soft tissue and load bearing applications. Gellan gum has many advantages such as biocompatibility, biodegradability, nontoxic in nature, and physical stability in the presence of cations .
GS-621763
GS-621763
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Cat. No.: HY-145119
CAS No.: 2647442-13-3
Purity:  99.72%
Target:  

SARS-CoV

Research Areas:  

Infection

GS-621763 is an orally available precursor to GS-441524 that exhibits anti-SARS-CoV-2 viral activity in mice. GS-621763 reduces viral load to undetectable levels in ferrets infected with SARS-CoV-2 .
Tetracaine
Tetracaine
0 Images
Cat. No.: HY-A0079
CAS No.: 94-24-6
Synonyms: Amethocaine
Target:  

Sodium Channel Calcium Channel

Research Areas:  

Neurological Disease

Tetracaine (Amethocaine) is a sodium channel inhibitor and ryanodine receptor (RyR) inhibitor. Tetracaine blocks sodium conduction across nerve cell membranes, preventing rapid sodium ion influx and depolarization. Tetracaine exhibits biphasic effects on spontaneous sarcoplasmic reticulum Ca 2+ release in Ca 2+-overloaded ventricular myocytes, and increases sarcoplasmic reticulum Ca 2+ load. Tetracaine can be used in research related to eye diseases .
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