94-24-6
Chemical Structure
Tetracaine
Synonym(s): Amethocaine
- CAS No.: 94-24-6
- Formula:C15H24N2O2
- Molecular Weight:264.36
IUPAC Name: 2-(dimethylamino)ethyl 4-(butylamino)benzoate
InChIKey: GKCBAIGFKIBETG-UHFFFAOYSA-N
SMILES: O=C(OCCN(C)C)C1=CC=C(NCCCC)C=C1
Biological Activity:
Tetracaine (Amethocaine) is a sodium channel inhibitor and ryanodine receptor (RyR) inhibitor. Tetracaine blocks sodium conduction across nerve cell membranes, preventing rapid sodium ion influx and depolarization. Tetracaine exhibits biphasic effects on spontaneous sarcoplasmic reticulum Ca2+ release in Ca2+-overloaded ventricular myocytes, and increases sarcoplasmic reticulum Ca2+ load. Tetracaine can be used in research related to eye diseases[1][2][3].
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Tetracaine | 99.87% | Tetracaine (Amethocaine) is a sodium channel inhibitor and ryanodine receptor (RyR) inhibitor. Tetracaine blocks sodium conduction across nerve cell membranes, preventing rapid sodium ion influx and depolarization. Tetracaine exhibits biphasic effects on spontaneous sarcoplasmic reticulum Ca2+ release in Ca2+-overloaded ventricular myocytes, and increases sarcoplasmic reticulum Ca2+ load. Tetracaine can be used in research related to eye diseases. |
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Tetracaine (Standard) | ≥98% | Tetracaine (Standard) is the analytical standard of Tetracaine. This product is intended for research and analytical applications. 0 | ||||||||||||||||||||
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- [1]. Macsari I, et al. 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. J Med Chem. 2012;55(15):6866-6880. [Content Brief]
- [2]. Bartfield JM, et al. A comparison of proparacaine and tetracaine eye anesthetics. Acad Emerg Med. 1994;1(4):364-367. [Content Brief]
- [3]. Györke S, et al. Dual effects of tetracaine on spontaneous calcium release in rat ventricular myocytes. J Physiol. 1997;500 ( Pt 2)(Pt 2):297-309. [Content Brief]
Keywords
