1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
    Anti-infection
  2. Dopamine Receptor
    Histamine Receptor
    Bacterial
  3. Thiethylperazine dimaleate

Thiethylperazine dimaleate 

Cat. No.: HY-B1794A
Handling Instructions

Thiethylperazine dimaleate is a phenothiazine derivate, and an orally active dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine dimaleate is also a slective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine dimaleate has anti-emetic, antipsychotic and antimicrobial effects.

For research use only. We do not sell to patients.

Thiethylperazine dimaleate Chemical Structure

Thiethylperazine dimaleate Chemical Structure

CAS No. : 1179-69-7

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Description

Thiethylperazine dimaleate is a phenothiazine derivate, and an orally active dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine dimaleate is also a slective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine dimaleate has anti-emetic, antipsychotic and antimicrobial effects[1][2][3].

IC50 & Target

Dopamine D2-receptor[1]
Histamine H1-receptor[1]
ABCC1[2]
Enterococcus faecalis[3]

In Vitro

Thiethylperazine could enhance the antibiotic (Vancomycin) activity at a concentration as low as 2 μg/mL. Thiethylperazine inhibits Vancomycin-sensitive E. faecalis ATCC 29212, Vancomycin-resistant E. faecalis ATCC 51299 and vancomycin-resistant E. faecalis (VREF) isolates with MIC values of 8 μg/mL, 16 μg/mL and 8 μg/mL, respectively[3].

In Vivo

Thiethylperazine (3 mg/kg; intramuscular injection; twice daily; for 30 days; young APP/PS1 mice) treatment significantly reduces Aβ42 levels in APP/PS1 mice[2].

Animal Model: Young Aβ precursor protein (APPswe) and mutant presenilin-1 (PS1) (APP/PS1) mice[2]
Dosage: 3 mg/kg
Administration: Intramuscular injection; twice daily; for 30 days
Result: Significantly reduced Aβ42 levels in APP/PS1 mice.
Molecular Weight

631.76

Formula

C₃₀H₃₇N₃O₈S₂

CAS No.

1179-69-7

SMILES

CN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(SCC)C=C24)CC1.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Thiethylperazine dimaleateDopamine ReceptorHistamine ReceptorBacterialAnti-emeticphenothiazineD2-receptorH1-receptorpregnancycleftAlzheimerdiseaseAβ42ABCC1antipsychoticInhibitorinhibitorinhibit

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Thiethylperazine dimaleate
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HY-B1794A
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