Thiethylperazine dimaleate
Based on 3 publication(s) in Google Scholar
Thiethylperazine dimaleate, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine dimaleate is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine dimaleate has anti-emetic, antipsychotic and antimicrobial effects.
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- Pureté : 99.99%
- CAS No.: 1179-69-7
- Formule: C30H37N3O8S2
- Masse moléculaire:631.76
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Stockage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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HY-123205
OxatomideH1-histamine/P2X7 Receptor Antagonist -
HY-B1794
ThiethylperazineD2/H1 Antagonist -
HY-N3187
NimbinTau Aggregation Inhibitor -
HY-B1794R
Thiethylperazine (Standard)D2/H1 Antagonist -
HY-123205R
Oxatomide (Standard)Standard of Oxatomide -
HY-B1794AR
Thiethylperazine dimaleate (Standard)Anti-emetic Agent
Publications Citing Use of MedChemExpress (MCE) Thiethylperazine dimaleate
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Activité biologique
Description
IC50 & Target
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D2 Receptor |
H1 Receptor |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | CC50 |
18.37 μM
Compound: Thiethylperazine Maleate
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CC50 determination at MOI 0.004 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in Vero E6 cells
CC50 determination at MOI 0.004 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in Vero E6 cells
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10.1101/2020.03.25.008482 |
| Vero C1008 | CC50 |
18.37 μM
Compound: Thiethylperazine Maleate
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CC50 determination at MOI 0.01 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in Vero E6 cells
CC50 determination at MOI 0.01 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in Vero E6 cells
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10.1101/2020.03.25.008482 |
| Vero C1008 | IC50 |
7.09 μM
Compound: Thiethylperazine Maleate
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IC50 determination at MOI 0.004 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in SARS-CoV-2 infected Vero E6 cells
IC50 determination at MOI 0.004 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in SARS-CoV-2 infected Vero E6 cells
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10.1101/2020.03.25.008482 |
| Vero C1008 | IC50 |
8.02 μM
Compound: Thiethylperazine Maleate
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IC50 determination at MOI 0.01 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in SARS-CoV-2 infected Vero E6 cells
IC50 determination at MOI 0.01 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in SARS-CoV-2 infected Vero E6 cells
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10.1101/2020.03.25.008482 |
In Vitro
Thiethylperazine could enhance the antibiotic (Vancomycin) activity at a concentration as low as 2 μg/mL. Thiethylperazine inhibits Vancomycin-sensitive E. faecalis ATCC 29212, Vancomycin-resistant E. faecalis ATCC 51299 and vancomycin-resistant E. faecalis (VREF) isolates with MIC values of 8 μg/mL, 16 μg/mL and 8 μg/mL, respectively[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Young Aβ precursor protein (APPswe) and mutant presenilin-1 (PS1) (APP/PS1) mice[2]
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Dosage:3 mg/kg
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Administration:Intramuscular injection; twice daily; for 30 days
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Result:Significantly reduced Aβ42 levels in APP/PS1 mice.
Chemical Information
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CAS No. 1179-69-7
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Appearance Solid
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Masse moléculaire 631.76
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Formule C30H37N3O8S2
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Color White to off-white
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SMILES
CN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(SCC)C=C24)CC1.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (3)
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Journal Impact Factor
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Most Recent
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J Adv Res
The gut microbiotas with metabolites regulate the protective role of miR-30a-5p in myocardial infarction. [Abstract]2024 Oct 21:S2090-1232(24)00472-7. PMID: 39442873 -
ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576
Solvant et solubilité
In Vitro:
DMSO : 125 mg/mL (197.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (278 KB)
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SDS (398 KB)
- English - EN (398 KB)
- Français - FR (398 KB)
- Deutsch - DE (398 KB)
- Norwegian - NO (398 KB)
- Español - ES (398 KB)
- Swedish - SV (398 KB)
- Italian - IT (398 KB)
- Korean - KR (398 KB)
- Portuguese - PT (398 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Czeizel AE, et al. Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drug. BJOG. 2003 May;110(5):497-9. [Content Brief]
[2]. Krohn M, et al. Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice. J Clin Invest. 2011 Oct;121(10):3924-31. [Content Brief]
[3]. Rahbar M, et al. Enhancement of vancomycin activity by phenothiazines against vancomycin-resistant Enterococcus faecium in vitro. Basic Clin Pharmacol Toxicol. 2010 Aug;107(2):676-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5829 mL | 7.9144 mL | 15.8288 mL | 39.5720 mL |
| 5 mM | 0.3166 mL | 1.5829 mL | 3.1658 mL | 7.9144 mL | |
| 10 mM | 0.1583 mL | 0.7914 mL | 1.5829 mL | 3.9572 mL | |
| 15 mM | 0.1055 mL | 0.5276 mL | 1.0553 mL | 2.6381 mL | |
| 20 mM | 0.0791 mL | 0.3957 mL | 0.7914 mL | 1.9786 mL | |
| 25 mM | 0.0633 mL | 0.3166 mL | 0.6332 mL | 1.5829 mL | |
| 30 mM | 0.0528 mL | 0.2638 mL | 0.5276 mL | 1.3191 mL | |
| 40 mM | 0.0396 mL | 0.1979 mL | 0.3957 mL | 0.9893 mL | |
| 50 mM | 0.0317 mL | 0.1583 mL | 0.3166 mL | 0.7914 mL | |
| 60 mM | 0.0264 mL | 0.1319 mL | 0.2638 mL | 0.6595 mL | |
| 80 mM | 0.0198 mL | 0.0989 mL | 0.1979 mL | 0.4946 mL | |
| 100 mM | 0.0158 mL | 0.0791 mL | 0.1583 mL | 0.3957 mL |
Thiethylperazine dimaleate Related Classifications
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