Thiethylperazine

Cat. No.: HY-B1794 Purity: 99.41%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Thiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects.

For research use only. We do not sell to patients.

Thiethylperazine Chemical Structure

CAS No. : 1420-55-9

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 690	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Other Forms of Thiethylperazine:

Thiethylperazine dimaleate In-stock

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Biological Activity
Purity & Documentation
Customer Review

Description

In Vitro

Thiethylperazine can enhance the antibiotic (Vancomycin) activity at a concentration as low as 2 μg/mL. Thiethylperazine inhibits Vancomycin-sensitive E. faecalis ATCC 29212, Vancomycin-resistant E. faecalis ATCC 51299 and vancomycin-resistant E. faecalis (VREF) isolates with MIC values of 8 μg/mL, 16 μg/mL and 8 μg/mL, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Thiethylperazine (3 mg/kg; intramuscular injection; twice daily; for 30 days) significantly reduces Aβ42 levels in young APP/PS1 mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Young Aβ precursor protein (APPswe) and mutant presenilin-1 (PS1) (APP/PS1) mice^[2]
Dosage:	3 mg/kg
Administration:	Intramuscular injection; twice daily; for 30 days
Result:	Significantly reduced Aβ42 levels in APP/PS1 mice.

Molecular Weight

399.62

Formula

C₂₂H₂₉N₃S₂

CAS No.

1420-55-9

Appearance

Solid

Color

Light brown to gray

SMILES

CN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(SCC)C=C24)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (250.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5024 mL	12.5119 mL	25.0238 mL
5 mM	0.5005 mL	2.5024 mL	5.0048 mL
10 mM	0.2502 mL	1.2512 mL	2.5024 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.41%

Select Batch:

Data Sheet (285 KB) SDS (251 KB)

COA (247 KB) HNMR (275 KB) LCMS (270 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5024 mL	12.5119 mL	25.0238 mL	62.5594 mL
	5 mM	0.5005 mL	2.5024 mL	5.0048 mL	12.5119 mL
	10 mM	0.2502 mL	1.2512 mL	2.5024 mL	6.2559 mL
	15 mM	0.1668 mL	0.8341 mL	1.6683 mL	4.1706 mL
	20 mM	0.1251 mL	0.6256 mL	1.2512 mL	3.1280 mL
	25 mM	0.1001 mL	0.5005 mL	1.0010 mL	2.5024 mL
	30 mM	0.0834 mL	0.4171 mL	0.8341 mL	2.0853 mL
	40 mM	0.0626 mL	0.3128 mL	0.6256 mL	1.5640 mL
	50 mM	0.0500 mL	0.2502 mL	0.5005 mL	1.2512 mL
	60 mM	0.0417 mL	0.2085 mL	0.4171 mL	1.0427 mL
	80 mM	0.0313 mL	0.1564 mL	0.3128 mL	0.7820 mL
	100 mM	0.0250 mL	0.1251 mL	0.2502 mL	0.6256 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thiethylperazine1420-55-9Inhibitorinhibitorinhibit

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Thiethylperazine

Other Forms of Thiethylperazine: