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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
m-calpain
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "m-calpain" in MCE Product Catalog:
14
14 Publications Verification
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Research Areas:
PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor with Ki values of 0.21 μM and 0.37 μM for μ- and m-calpains respectively, which is neuroprotective .
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7 Cited Publications
Cat. No.: HY-19749
CAS No.: 181765-30-0
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PD 151746 is a selective calpain-1 inhibitor with an IC50 of 260 nM. PD 151746 binds μ-calpain Ca 2+-binding sites, and shows selectivity over cathepsin B, papain, trypsin, thermolysin, and basal calcineurin. PD 151746 reduces Oxidized low-density lipoprotein (oxLDL)-induced cytotoxicity, apoptotic DNA fragmentation, and blocks IL-1α maturation. PD 151746 can be used for the research of atherosclerosis and psoriasis .
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Calpain Inhibitor VI (SJA6017) is a synthesized peptide aldehyde inhibitor of calpain. Calpain Inhibitor VI inhibits purified m-calpain with the IC50 of 80 nM. Calpain Inhibitor VI can be used for the research of cataract .
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Pirenoxine (Catalin K) is an antioxidant with lens-protective activity. Pirenoxine inhibits lens sclerosis, prevents lipid peroxidation and suppresses lens protein opacification. Pirenoxine blocks benzoquinone acetic acid-induced cataract progression. Pirenoxine can be used in research related to presbyopia and cataracts .
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(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki=19 nM). (Rac)-Calpain Inhibitor XII has lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM). (Rac)-Calpain Inhibitor XII has the potential for studying the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury .
Cat. No.: HY-W409181
CAS No.: 179461-52-0
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Research Areas:
(Rac)-PD 151746 is the optically inactive racemate of PD 151746 (HY-19749). PD 151746 is a neuroprotective calpain inhibitor with Ki values of 0.26 μM (u-calpain) and 5.33 μM (m-calpain), respectively .
Cat. No.: HY-P72115
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CAPN2; calpain M-Type; calpain 2; M-calpain; CANPL2; CANP 2; CANPml; calpain 2, Large [Catalytic] Subunit; MCANP; calpain, Large Polypeptide L2; Calcium-Activated Neutral Proteinase 2; calpain Large Polypeptide L2; calpain 2, (M/II) Large Subunit; calpain
Species:
Human
Source:
E. coli
Cat. No.: HY-100529R
CAS No.: 179528-45-1
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Research Areas:
PD150606 (Standard) is the analytical standard of PD150606 (HY-100529). This product is intended for research and analytical applications. PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor with Ki values of 0.21 μM and 0.37 μM for μ- and m-calpains respectively, which is neuroprotective .
Cat. No.: HY-RS18379
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Capn2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Capn2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-108296A
CAS No.: 51410-30-1
Synonyms: Catalin K sodium
Research Areas:
Pirenoxine sodium (Catalin K sodium) is an antioxidant with lens-protective activity. Pirenoxine sodium inhibits lens sclerosis, prevents lipid peroxidation and suppresses lens protein opacification. Pirenoxine sodium blocks benzoquinone acetic acid-induced cataract progression. Pirenoxine sodium can be used in research related to presbyopia and cataracts .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
