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Cat. No.: HY-P80444

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Calpain 2 Antibody (YA572)

Name: Calpain 2 Antibody (YA572)
Brand: MedChemExpress
SKU: HY-P80444
Price: 146.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 publication(s) in Google Scholar

Calpain 2 Antibody (YA572) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to Calpain 2.

For research use only. We do not sell to patients.

Host:
Rabbit
Isotype:
IgG
Application:
WB, IHC-P, ICC/IF, FC
Reactivity :
Human

Formulation:
Supplied in10mM TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Conjugation:
Non-conjugated

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications
Product Details
Product Properties
- Appearance
- Formulation
- Storage & Stability
- Shipping
Publications (1)
Background
Documentation
Help & FAQs
Classifications
Bioz

Applications

Application	WB WB: Western Blot	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	IHC-P IHC-P: Immunohistochemistry-Paraffin	FC FC: Flow Cytometry
Dilution Ratio	1:500-2000	1:50-200	1:50-200	1:50

Product Details

Description

Calpain 2 Antibody (YA572) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to Calpain 2.

Host Rabbit
Clonality Monoclonal,Recombinant
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 80kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 80kDa

Species Reactivity Database

Entrez Gene: 824 Human ; 29154 Rat

SwissProt: P17655 Human ; Q07009 Rat

OMIM: 114230 Human

Immunogen

A synthesized peptide derived from human CAPN2. The exact sequence is proprietary to MCE.

Sensitivity

Endogenous

Purification

affinity purified by Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

Appearance

Liquid
Formulation

Supplied in10mM TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Publications (1)

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Journal Impact Factor

Adv Sci (Weinh)

Calpain-2-Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection. [Abstract]

2025 Jul;12(25):e2501112. PMID: 40171827

Background

Function

Calpain 2 is a Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs^[1].
Subcellular Localization

Cytoplasm; Cell membrane
Expression

Tissue_specificity:Ubiquitous
Subunit

Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Interacts with PIDD1 alternative open reading frame protein altPIDD1 (PubMed:39532532)
SwissProt ID

P17655
Gene ID

824 [NCBI]