CAPN2 - calpain 2 Gene

Also Known as CANP2; mCANP; CANPL2; CANPml

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 824

About CAPN2

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:223,701,597-223,776,018 (from NCBI)

This gene has 12 transcripts (splice variants), 246 orthologues and 20 paralogues. Ubiquitous expression in lung (RPKM 90.0), gall bladder (RPKM 66.0) and 25 other tissues.

Summary

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous Enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

CAPN2 Products (2)

mRNA	Protein	Name
NM_001146068.2	NP_001139540.1	calpain-2 catalytic subunit isoform 2
NM_001748.5	NP_001739.3	calpain-2 catalytic subunit isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium-dependent cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	12150984	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10639123	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in proteolysis involved in protein catabolic process	IDA IDA: Inferred from direct assay	12150984	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	14559243	GOA
part of calpain complex	IPI IPI: Inferred from physical interaction	10639123	GOA
located in cytosol	IDA IDA: Inferred from direct assay	12150984	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	14559243	GOA
colocalizes with membrane raft	IDA IDA: Inferred from direct assay	12150984	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	14559243	GOA
located in perinuclear endoplasmic reticulum	IDA IDA: Inferred from direct assay	14559243	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12150984	GOA
located in pseudopodium	IDA IDA: Inferred from direct assay	14559243	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAPN2 Protein Structure

Peptidase_C2

Calpain_III

EF-hand_8

0
200
400
600
700 a.a.

Protein Preferred Names	Protein Names
calpain-2 catalytic subunit	CANP 2

CAPN2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CAPN2	P17655	ZDHHC17	Homo sapiens	Q8IUH5	Y2H Array	24705354
Intra	CAPN2	P17655	CAPNS1	Homo sapiens	P04632	Anti Tag CoIP	33961781
Intra	CAPN2	P17655	CAPNS1	Homo sapiens	P04632	Chromatography	28319173
Intra	CAPN2	P17655	CAPNS1	Homo sapiens	P04632	NMR	18519038
Intra	CAPN2	P17655	LOXL2	Homo sapiens	Q9Y4K0	Anti Bait CoIP	31911079
Intra	CAPN2	P17655	LOXL2	Homo sapiens	Q9Y4K0	Anti Tag CoIP	31911079

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CAPN2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72115	CAPN2 Protein, Human (His)	P17655 (S20-L700)	≥ 90%, as determined by reducing SDS-PAGE.

CAPN2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80444	Calpain 2 Antibody (YA572)	WB, IHC-P, ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Nuclear Senile Cataract	Senile Nuclear Cataract Senile Nuclear Sclerosis
Inflammatory Bowel Disease 15	IBD15
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Spinocerebellar Atrophy Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar
Limb-Girdle Muscular Dystrophy	Lgmd Limb Girdle Muscular Dystrophy Muscular Dystrophies, Limb-Girdle Erb'S Muscular Dystrophy Leyden-Mbius Muscular Dystrophy Limb-Girdle Syndrome Myopathic Limb-Girdle Syndrome Limb Girdle Muscular Dystrophy Limb-Girdle Dystrophy, Muscular, Limb-Girdle Lgmd - [Limb-Girdle Muscular Dystrophy] Limb Girdle Muscle Dystrophy Limb-Girdle Myopathy
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Female Stress Incontinence	Female Urinary Stress Incontinence Stress Incontinence - Female
Marfan Syndrome	MFS Mfs1 Marfan'S Syndrome Marfan Syndrome Type 1 Marfan Syndrome, Type I Mass Phenotype Contractural Arachnodactyly Mass Syndrome Octd Overlap Connective Tissue Disease Marfanoid Hypermobility Syndrome Marfan Disease
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2a	Leyden-Moebius Muscular Dystrophy Lgmd2a Limb-Girdle Muscular Dystrophy Due To Calpain Deficiency Muscular Dystrophy, Limb-Girdle, Type 2a Pelvofemoral Muscular Dystrophy Primary Calpainopathy
Wolfram Syndrome 2	WFS2
Diabetic Cataract	Cataract - Diabetic
Muscular Dystrophy, Duchenne Type	Duchenne Muscular Dystrophy DMD Muscular Dystrophy, Duchenne Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type Severe Dystrophinopathy, Duchenne Type Muscular Dystrophy Duchenne Dystrophy, Muscular, Duchenne Type Benign Duchenne Muscular Dystrophy Duchenne Motor Neuron Disease Duchenne Type Dystrophy Duchenne-Griesinger Disease
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Autosomal Recessive Limb-Girdle Muscular Dystrophy	Muscular Dystrophy, Limb-Girdle, Autosomal Recessive
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01889	CAPN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01896	CAPNS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18379	Capn2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24859	Capn2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CAPN2	VGNC	VGNC:60354
Macaca mulatta	CAPN2	VGNC	VGNC:70532
Mus musculus	CAPN2	MGD	MGI:88264
Canis familiaris	CAPN2	VGNC	VGNC:53334
Bos taurus	CAPN2	VGNC	VGNC:55037
Rattus norvegicus	CAPN2	RGD	RGD:2268
Others	CAPN2	NCBI