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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
34 Results for "
macrocyclic compounds
" in MedChemExpress (MCE) Product Catalog:
Products (34)
34 Results for "macrocyclic compounds" in MCE Product Catalog:
Cat. No.: HY-W034566
CAS No.: 296-35-5
Synonyms: Hexaaza-18-crown-6; 1,4,7,10,13,16-Hexaazacyclooctadecane
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Milbemycin A3 is a 16-membered macrocyclic lactone compound found in the soil bacterium Saccharopolyspora hygroscopicus subsp. aureolacrimosus. Milbemycin A3 enhances the opening of glutamate- and GABA-gated chloride channels and exhibits insecticidal activity. Milbemycin A3 can be used in insect resistance-related research .
Cat. No.: HY-103048A
Purity: 99.34%
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Cat. No.: HY-N12730
CAS No.: 81557-52-0
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Cat. No.: HY-173076A
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Cat. No.: HY-103048
CAS No.: 1629654-95-0
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Cat. No.: HY-162234
CAS No.: 2948289-20-9
PKCTheta-IN-1 (Compound 19) is a selective macrocyclic PKCTheta inhibitor with IC50 value of 0.1 nM .
Cat. No.: HY-178936
CAS No.: 3094174-82-7
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JAK2-IN-15 is an orally active, potent, selective JAK2 inhibitor (IC50 = 1.17 nM). JAK2-IN-15 can inhibit the AK2-STAT signaling pathway. JAK2-IN-15 significantly improves key pathological indicators such as hematocrit and splenomegaly in an Epoetin beta (HY-114134) (rhEPO)-induced mouse model. JAK2-IN-15 can be used for the study of Polycythemia Vera (PV) .
Cat. No.: HY-161096
CAS No.: 3034861-58-7
Cat. No.: HY-P10767
CAS No.: 2468971-42-6
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Cat. No.: HY-W127809
CAS No.: 550-52-7
Cat. No.: HY-133015
CAS No.: 2376774-73-9
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Mcl-1 inhibitor 3 (compound 1) is a highly potent and orally activate macrocyclic Mcl-1 inhibitor (Ki= 0.061 nM; IC50=19 nM in an OPM-2 cell viability assay). Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity ..
Cat. No.: HY-161370
CAS No.: 2574390-19-3
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VD4162 (Compound 8b) is a macrocyclic inhibitor of serine proteases. VD4162 can significantly improve potency for all four target enzymes TMPRSS2 (IC50 = 3.7 nM), HGFA(IC50 = 3.3 nM), matriptase (IC50 = 2.9 nM), and hepsin (IC50 = 0.54 nM). VD4162 can be used for the research of cancer .
Cat. No.: HY-P3347
CAS No.: 2891469-81-9
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Cat. No.: HY-158150
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Cat. No.: HY-N13181
CAS No.: 213903-67-4
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Cat. No.: HY-173076
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Cat. No.: HY-168902
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Proteasome-IN-7 (Compound 6f) is an epoxyketone macrocyclic peptidyl proteasome inhibitor (IC50 value of 37.92 nM for 20S proteasome ChT-L subunit). Proteasome-IN-7 displays robust antiproliferative effects against multiple myeloma, acute lymphoblastic leukemia and non-small cell lung cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
