2376774-73-9
2376774-73-9
Chemical Structure
Mcl-1 inhibitor 3
- CAS No.: 2376774-73-9
- Formula:C40H52ClF2N5O7S
- Molecular Weight:820.38
InChIKey: OCZBGAPIVMKKDK-HBUYLHAMSA-N
SMILES: ClC1=CC(CCC2)=C(C=C1)[C@]2(CO3)CN(C[C@H]4[C@@H](CC4)[C@@H](OCCN5CC(F)(F)C5)/C=C/CCN(C)C6=O)C7=C3C=CC([C@@](O)(C(NS(=O)(N(C)C)=O)=O)C6)=C7
Biological Activity: Mcl-1 inhibitor 3 (compound 1) is a highly potent and orally activate macrocyclic Mcl-1 inhibitor (Ki= 0.061 nM; IC50=19 nM in an OPM-2 cell viability assay). Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity[1]..
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Mcl-1 inhibitor 3 | Mcl-1 inhibitor 3 (compound 1) is a highly potent and orally activate macrocyclic Mcl-1 inhibitor (Ki= 0.061 nM; IC50=19 nM in an OPM-2 cell viability assay). Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.. | |||||||||||||||||||||
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References
Keywords
