2891469-81-9
![NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-p3347.gif "NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) Chemical Structure")
2891469-81-9
Chemical Structure
NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)
- CAS No.: 2891469-81-9
- Formula:C49H73N13O11
- Molecular Weight:1020.18
InChIKey: IIVCDBIBOGOXBU-NXDMJTDOSA-N
SMILES: N[C@@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N2CCC[C@H]2C(N[C@H](CC3=CC=C4C=CC=CC4=C3)C(O)=O)=O)=O)=O)CCCCN)=O)C/C=C\C1)=O)CO)=O)CC(C)C)=O)CCCNC(N)=N)=O
Biological Activity: NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) (compound 40), a macrocyclic analogue of Ape13, is a potent APJ agonist (Ki=5.7 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) exhibits a favorable Gα12-biased signaling and an increased in vivo half-life[1].
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NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) | NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) (compound 40), a macrocyclic analogue of Ape13, is a potent APJ agonist (Ki=5.7 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) exhibits a favorable Gα12-biased signaling and an increased in vivo half-life. | |||||||||||||||||||||
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