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Results for "

muscle fiber

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) AMPK (3) Bacterial (2) Calcium Channel (1) Ceramidase (1) Chloride Channel (1) Cholinesterase (ChE) (1) Endogenous Metabolite (1) Fungal (2) Gap Junction Protein (1) IGF-1R (1) Interleukin Related (1) mAChR (1) mTOR (3) Myosin (1) Nuclear Factor of activated T Cells (NFAT) (1) Parasite (1) PI3K (1) Reference Standards (1) Sodium Channel (2) TGF-β Receptor (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Infection (3) Inflammation/Immunology (4) Metabolic Disease (4) Neurological Disease (5)

Inhibitors & Agonists

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16690

BTS 3 Publications Verification N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine	Myosin	Others
BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of *skeletal muscle* myosin II subfragment 1 (S1) ATPase activity, with an IC₅₀*s of ~5 µM for actin- and Ca ²⁺-stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle* fibers .

HY-N1677

2,6-Dimethoxy-1,4-benzoquinone	Akt mTOR Bacterial Fungal AMPK	Infection Metabolic Disease Inflammation/Immunology Cancer
2,6-Dimethoxy-1,4-benzoquinone is a 1,4-benzoquinone derivative. 2,6-Dimethoxy-1,4-benzoquinone promotes phosphorylation of AKT, S6K, mTOR, 4E-BP1, and AMPK, and attenuates mTORC1 activity as part of the AKT/mTOR pathway. 2,6-Dimethoxy-1,4-benzoquinone stimulates myoblast differentiation, increases myotube size, elevates MHC protein expression, enhances mitochondrial biogenesis, respiration, and DNA content, and increases skeletal muscle weights, fiber size, grip strength, and treadmill performance. 2,6-Dimethoxy-1,4-benzoquinone exerts anti-cancer, anti-inflammatory, anti-adipogenic, antibacterial, and antimutagenic effects, inhibits adipogenic transcription factors, nitric oxide production, skin tumor development, Magnaporthe oryzae growth, spore germination, appressorium formation, and growth of select bacterial species, induces H₂O₂ generation and rice defense gene expression, and reduces rice blast lesion formation. 2,6-Dimethoxy-1,4-benzoquinone can be used for the research of obesity, skin tumorigenesis, rice blast disease, and food-borne illness .

HY-P99588

Stamulumab 1 Publications Verification MYO-029	TGF-β Receptor	Metabolic Disease
Stamulumab (MYO-029) is a recombinant human IgG1λ antibody that binds to myostatin and neutralizes its activity by preventing binding to its endogenous high-affinity receptor ActRIIB. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia in SCID mice. Stamulumab has the potential for Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) research .

HY-158183

NMD670	Chloride Channel	Neurological Disease
NMD670 is an orally active inhibitor of skeletal muscle specific chloride channel ClC-1 with an EC₅₀ of 1.6 μM. NMD670 enhances neuromuscular transmission and improves muscle contraction and strength. NMD670 can be used in the study of muscle weakness and muscle fatigue .

HY-130687A

Psicose DL-Psicose	PI3K mTOR Akt IGF-1R	Inflammation/Immunology
Psicose is a natural and low-calorie sweetener. Psicose can activate the PI3K/Akt/mTOR pathway to promote muscle synthesis. Psicose can upregulate IGF-1 and downregulate Myostatin. Psicose regulates mitochondrial function by increasing G6P activity. Psicose enhances antioxidant enzyme activity and reduces oxidative stress markers. Psicose reduces plasma triglycerides and total cholesterol. Psicose can improve muscle fiber size and reduce fibrosis. Psicose can be used for research on sarcopenia .

HY-N15841

C25 Ceramide (d18:1/25:0)	Ceramidase	Others
C25 Ceramide (d18:1/25:0) is an endogenous ultra-long-chain ceramide that antagonizes the detrimental effects of long-chain ceramides on insulin sensitivity. C25 Ceramide (d18:1/25:0) is specifically enriched in oxidative skeletal muscle fibers, where it serves dual roles in providing structural support to cell membranes and regulating cellular signaling. By participating in the regulation of lipid homeostasis within muscle fibers, C25 Ceramide (d18:1/25:0) helps maintain normal insulin signaling. C25 Ceramide (d18:1/25:0) is primarily utilized in research concerning metabolic diseases—particularly in mechanistic studies investigating the muscle fiber type-specific aspects of insulin resistance .

HY-100945

Nitrocaramiphen hydrochloride	mAChR	Neurological Disease
Nitrocaramiphen hydrochloride is a selective M1 receptor antagonist (K_i: 5.5 nM). Nitrocaramiphen Hydrochloride inhibits the hyperpolarizing effect of muscarine in the muscle fibers .

HY-106718

Barucainide	Sodium Channel	Cardiovascular Disease
Barucainide is an Ib-class anti-arrhythmic agent (moderately blocking sodium channel). Barucainide exhibits concentration-dependent inhibitory effects on the maximum upstroke velocity (V_max) of Purkinje fibers and ventricular muscle in dogs. Barucainide significantly shortens the action potential duration (APD). Barucainide significantly inhibits the pacemaker activity frequency of atrial tissue in rabbits and the enhanced automaticity of Purkinje fibers under normal resting potential in response to isoproterenol. Barucainide cannot inhibit the abnormal automaticity emission frequency of canine Purkinje fibers induced by barium. Barucainide can be used for research on arrhythmias .

HY-115839A

Detajmium L-tartrate Detajmium bitartrate; Tachmalcor	Sodium Channel	Cardiovascular Disease
Detajmium (L-tartrate) is an antiarrhythmic compound. Detajmium has effect on V_max in both dog ventricular muscle and Purkinje fibers was frequency dependent .

HY-100718

SCH00013	Calcium Channel	Cardiovascular Disease
SCH00013 is a cardiotonic that primarily increases the sensitivity of muscle fibers to Ca++.

HY-108381

Idrocilamide LCB29	Others	Others
Idrocilamide (LCB29) exhibits a muscle relaxing effect, that inhibits muscle twitch, tetanic tension, K ⁺-induced as well as voltage clamp-induced contraction of rat soleus muscle fibers. Idrocilamide is also a caffeine antagonist, inhibiting the breakdown and biotransformation of caffeine .

HY-137968

Avermectin B1a aglycon	Parasite	Infection
Avermectin B1a aglycon is an aglycone derivative of Avermectin B1a (HY-15308), an antiparasitic agent that paralyzes nematodes. Avermectin B1a aglycon hyperpolarizes P. crassipes muscle fibers, with a minimum effective concentration of 0.1 μM .

HY-N16431

NFAT-133	AMPK Nuclear Factor of activated T Cells (NFAT) Interleukin Related Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
NFAT-133 is an aromatic polyketide with immunosuppressive and antidiabetic activity. NFAT-133 activates the AMPK pathway, promoting glucose uptake in L6 muscle fibers, thereby resisting diabetes. NFAT-133 inhibits the transcriptional activity of activated T-cell nuclear factor (NFAT), thereby suppressing the expression of IL-2 and the proliferation of T cells, demonstrating an immunosuppressive effect. NFAT-133 does not exhibit antibacterial activity or cytotoxicity, but it can weaken the production of NO in RAW264.7 cells induced by Lipopolysaccharide (LPS) (HY-D1056) .

HY-121143

Bis-Q	Cholinesterase (ChE)	Neurological Disease
Bis-Q is an acetylcholine (ACh) agonist that targets voltage-clamped muscle fibers of the fish Xenomystus nigris. Bis-Q exists in two forms: cis-Bis-Q (non-agonist) and trans-Bis-Q (agonist). Photoisomerization converts cis-Bis-Q to trans-Bis-Q, which induces agonist-induced currents. Channels activated by trans-Bis-Q and ACh have similar conductances and open times. Flashes increase the ratio of trans-Bis-Q to cis-Bis-Q until light equilibrium is reached. Further flashes transiently increase agonist-induced currents, indicating binding of trans-Bis-Q to desensitized receptors. Higher concentrations of cis-Bis-Q produce larger agonist-induced currents that decay exponentially. .

HY-N1677R

2,6-Dimethoxy-1,4-benzoquinone (Standard)	Reference Standards Akt mTOR Bacterial Fungal AMPK	Infection Metabolic Disease Inflammation/Immunology Cancer
2,6-Dimethoxy-1,4-benzoquinone (Standard) is the analytical standard of 2,6-Dimethoxy-1,4-benzoquinone (HY-N1677). This product is intended for research and analytical applications. 2,6-Dimethoxy-1,4-benzoquinone is a 1,4-benzoquinone derivative. 2,6-Dimethoxy-1,4-benzoquinone promotes phosphorylation of AKT, S6K, mTOR, 4E-BP1, and AMPK, and attenuates mTORC1 activity as part of the AKT/mTOR pathway. 2,6-Dimethoxy-1,4-benzoquinone stimulates myoblast differentiation, increases myotube size, elevates MHC protein expression, enhances mitochondrial biogenesis, respiration, and DNA content, and increases skeletal muscle weights, fiber size, grip strength, and treadmill performance. 2,6-Dimethoxy-1,4-benzoquinone exerts anti-cancer, anti-inflammatory, anti-adipogenic, antibacterial, and antimutagenic effects, inhibits adipogenic transcription factors, nitric oxide production, skin tumor development, Magnaporthe oryzae growth, spore germination, appressorium formation, and growth of select bacterial species, induces H2O2 generation and rice defense gene expression, and reduces rice blast lesion formation. 2,6-Dimethoxy-1,4-benzoquinone can be used for the research of obesity, skin tumorigenesis, rice blast disease, and food-borne illness.

HY-167983

Cx43 HC-IN-1	Gap Junction Protein	Neurological Disease
Cx43 HC-IN-1 (Compound D4) is a selective and orally active inhibitor of connexin hemichannels (Cx43 HC). Cx43 HC-IN-1 effectively inhibits the hemichannel activity mediated by Cx43/Cx45 in denervated skeletal muscle fibers, significantly increasing the reinnervation rate of muscle fibers by neurons. Cx43 HC-IN-1 reduces neuroinflammation and neuronal overexcitation by inhibiting hemichannels in glial cells in the brain, and alleviates epilepsy in mice. Cx43 HC-IN-1 can be used for research on epilepsy and muscle diseases .

Cat. No.	Product Name	Target	Research Area

HY-P2152A

Antho-RPamide II hydrochloride	Peptides	Neurological Disease
Antho-RPamide II hydrochloride is a bioactive neuropeptide. Antho-RPamide II hydrochloride can be isolated for the sea anemone Anthopleura elegantissima. Antho-RPamide II hydrochloride inhibits the spontaneous, rhythmic contractions in tentacle longitudinal muscle fibers of sea anemones .

Cat. No.	Product Name

HY-K0608

Masson Staining Kit
MCE Masson Staining Kit can simultaneously stain various tissue components, such as cell nuclei, collagen fibers, and muscle fibers. It features low toxicity, environmental friendliness, simple operation, and stable performance. The staining results show clear coloration and high contrast. The stained sections can be stored for long periods with minimal fading, facilitating long-term preservation and image analysis. This kit is widely used in studies of connective tissue, muscle tissue, and collagen fibers, and is suitable for histological observation and related pathological analyses.

Masson Staining Kit

MCE Masson Staining Kit can simultaneously stain various tissue components, such as cell nuclei, collagen fibers, and muscle fibers. It features low toxicity, environmental friendliness, simple operation, and stable performance. The staining results show clear coloration and high contrast. The stained sections can be stored for long periods with minimal fading, facilitating long-term preservation and image analysis. This kit is widely used in studies of connective tissue, muscle tissue, and collagen fibers, and is suitable for histological observation and related pathological analyses.

HY-K0611

Modified Van Gieson Staining Kit
MCE Modified Van Gieson Staining Kit employs Celestine Blue and Mayer’s hematoxylin for nuclear staining, providing clearer and more stable nuclear visualization while facilitating longer preservation of stained sections. Ponceau S is used for collagen fiber staining, offering stable coloration and strong resistance to fading. This method enables effective differentiation between collagen fibers and muscle fibers, and can assist in distinguishing collagen fiber–derived tumors from myogenic tumors to a certain extent. It is also suitable for observing tissue or organ injury, repair processes, and the degree of fibrosis.

Modified Van Gieson Staining Kit

MCE Modified Van Gieson Staining Kit employs Celestine Blue and Mayer’s hematoxylin for nuclear staining, providing clearer and more stable nuclear visualization while facilitating longer preservation of stained sections. Ponceau S is used for collagen fiber staining, offering stable coloration and strong resistance to fading. This method enables effective differentiation between collagen fibers and muscle fibers, and can assist in distinguishing collagen fiber–derived tumors from myogenic tumors to a certain extent. It is also suitable for observing tissue or organ injury, repair processes, and the degree of fibrosis.

HY-K0612

Weigert Elastin Staining Kit
MCE Weigert Elastin Staining Kit combines Weigert Resorcinol Fuchsin Staining Solution with Van Gieson (VG) Staining Solution. Weigert Resorcinol Fuchsin Solution is mainly used for staining elastic fibers, Van Gieson (VG) Solution is used for collagen fiber staining. The principle of VG staining is based on differences in the size of anionic dye molecules and the permeability of tissues. Picric acid (PA) has the smallest molecular weight and preferentially enters dense structures. Ponceau Red or acid fuchsin has a relatively larger molecular weight and primarily binds to collagen fibers, while light green has the largest molecular weight and stains other tissue components. After VG staining, collagen fibers appear red, while muscle fibers and cytoplasm appear yellow, enabling a clear distinction between tissue components.

Weigert Elastin Staining Kit

MCE Weigert Elastin Staining Kit combines Weigert Resorcinol Fuchsin Staining Solution with Van Gieson (VG) Staining Solution. Weigert Resorcinol Fuchsin Solution is mainly used for staining elastic fibers, Van Gieson (VG) Solution is used for collagen fiber staining. The principle of VG staining is based on differences in the size of anionic dye molecules and the permeability of tissues. Picric acid (PA) has the smallest molecular weight and preferentially enters dense structures. Ponceau Red or acid fuchsin has a relatively larger molecular weight and primarily binds to collagen fibers, while light green has the largest molecular weight and stains other tissue components. After VG staining, collagen fibers appear red, while muscle fibers and cytoplasm appear yellow, enabling a clear distinction between tissue components.

HY-K0615

ATPase Staining Kit for Muscle Fibers (Calcium Activation Method)
MCE ATPase Staining Kit for Muscle Fibers (Calcium Activation Method) is based on the hydrolysis of ATP by ATPase, which generates ADP and inorganic phosphate. Phosphate combines with calcium ions to form colorless calcium phosphate precipitates. Calcium phosphate is then treated with cobalt chloride to form cobalt phosphate, which, after treatment with sulfide solution, results in the formation of brown-black cobalt sulfide precipitates at the enzyme activity sites.

ATPase Staining Kit for Muscle Fibers (Calcium Activation Method)

MCE ATPase Staining Kit for Muscle Fibers (Calcium Activation Method) is based on the hydrolysis of ATP by ATPase, which generates ADP and inorganic phosphate. Phosphate combines with calcium ions to form colorless calcium phosphate precipitates. Calcium phosphate is then treated with cobalt chloride to form cobalt phosphate, which, after treatment with sulfide solution, results in the formation of brown-black cobalt sulfide precipitates at the enzyme activity sites.

HY-K0609

Modified Masson Staining Kit
MCE Modified Masson Staining Kit employs Celestine Blue hematoxylin for light nuclear staining, offering shorter differentiation time compared to conventional methods. It features low toxicity, environmental friendliness, simple operation, and stable performance. The staining results show clear coloration and high contrast. The stained sections can be stored for long periods with minimal fading, facilitating long-term preservation and image analysis. This kit is widely used in studies of connective tissue, muscle tissue, and collagen fibers, and is suitable for histological observation and related pathological analyses.

Modified Masson Staining Kit

MCE Modified Masson Staining Kit employs Celestine Blue hematoxylin for light nuclear staining, offering shorter differentiation time compared to conventional methods. It features low toxicity, environmental friendliness, simple operation, and stable performance. The staining results show clear coloration and high contrast. The stained sections can be stored for long periods with minimal fading, facilitating long-term preservation and image analysis. This kit is widely used in studies of connective tissue, muscle tissue, and collagen fibers, and is suitable for histological observation and related pathological analyses.

Cat. No.	Product Name	Target	Research Area	Image