100684-32-0
Chemical Structure
Biological Activity: Myoglobin is an oxygen-binding heme protein. Myoglobin scavenges ROS via its peroxidase activity, and binds to and inactivates NO in the heart and oxidative skeletal muscle. Myoglobin stores, buffers and facilitates intracellular oxygen diffusion, maintains aerobic metabolism under hypoxic/anoxic conditions, and provides oxygen supply support for mitochondria. Myoglobin alleviates oxidative stress, protects cardiac function and affects cardiac redox pathways. Myoglobin can be used in studies related to ischemia-reperfusion injury, oxidative stress-induced cardiac dysfunction and acute myocardial infarction[1][2][3][4][5].
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Myoglobin | 99.00% | Myoglobin is an oxygen-binding heme protein. Myoglobin scavenges ROS via its peroxidase activity, and binds to and inactivates NO in the heart and oxidative skeletal muscle. Myoglobin stores, buffers and facilitates intracellular oxygen diffusion, maintains aerobic metabolism under hypoxic/anoxic conditions, and provides oxygen supply support for mitochondria. Myoglobin alleviates oxidative stress, protects cardiac function and affects cardiac redox pathways. Myoglobin can be used in studies related to ischemia-reperfusion injury, oxidative stress-induced cardiac dysfunction and acute myocardial infarction. | ||||||||||||||||||||
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- [1]. Ordway GA, et al. Myoglobin: an essential hemoprotein in striated muscle. The Journal of experimental biology. 2004 Sep;207(Pt 20):3441-6. [Content Brief]
- [2]. Baron CP, et al. Myoglobin-induced lipid oxidation. A review. Journal of agricultural and food chemistry. 2002 Jul 03;50(14):3887-97. [Content Brief]
- [3]. Flögel U, et al. Role of myoglobin in the antioxidant defense of the heart. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2004 Jul;18(10):1156-8. [Content Brief]
- [4]. Flögel U, et al. Myoglobin: A scavenger of bioactive NO. Proceedings of the National Academy of Sciences of the United States of America. 2001 Jan 16;98(2):735-40. [Content Brief]
- [5]. Gibler WB, et al. Myoglobin as an early indicator of acute myocardial infarction. Annals of emergency medicine. 1987 Aug;16(8):851-6. [Content Brief]
Keywords
