74752-07-1
74752-07-1
Chemical Structure
Recainam hydrochloride
Synonym(s): Wy-42362 hydrochloride
- CAS No.: 74752-07-1
- Formula:C15H26ClN3O
- Molecular Weight:299.84
InChIKey: AICVYMBHECMYRL-UHFFFAOYSA-N
SMILES: CC(C)NCCCNC(NC1=C(C=CC=C1C)C)=O.[H]Cl
Biological Activity: Recainam (Wy-42362) hydrochloride is a potent orally active antiarrhythmic agent and a sodium channel inhibitor. Recainam hydrochloride elevates ventricular fibrillation threshold, suppresses induced cardiac dysrhythmias, and may accentuate cardiac tissue refractoriness heterogeneity. Recainam hydrochloride can be used for the research of arrhythmias[1][2][3][4].
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Recainam hydrochloride | Recainam (Wy-42362) hydrochloride is a potent orally active antiarrhythmic agent and a sodium channel inhibitor. Recainam hydrochloride elevates ventricular fibrillation threshold, suppresses induced cardiac dysrhythmias, and may accentuate cardiac tissue refractoriness heterogeneity. Recainam hydrochloride can be used for the research of arrhythmias. | |||||||||||||||||||||
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References
- [1]. Frame LH, et al. Effect of recainam on the energy required for ventricular defibrillation in dogs as assessed with implanted electrodes. J Am Coll Cardiol. 1988 Sep;12(3):746-52. [Content Brief]
- [2]. Takikawa R, et al. Electrophysiologic effects of a new antiarrhythmic agent, recainam, on isolated canine and rabbit myocardial fibers. J Am Coll Cardiol. 1988 Apr;11(4):875-81. [Content Brief]
- [3]. Scatina JA, et al. Species differences in the pharmacokinetics of recainam, a new anti-arrhythmic drug. Biopharm Drug Dispos. 1990 Jul;11(5):445-61. [Content Brief]
- [4]. Anastasiou-Nana MI, et al., Recainam, a potent new antiarrhythmic agent: effects on complex ventricular arrhythmias. J Am Coll Cardiol. 1986 Aug;8(2):427-35. [Content Brief]
Keywords
