79784-22-8
Chemical Structure
Barucainide
- CAS. Nr.: 79784-22-8
- Formula:C22H30N2O2
- Molecular Weight:354.49
IUPAC Name: 4-((4-benzyl-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-yl)oxy)-N-isopropylbutan-1-amine
InChIKey: KXSKBNFNSAMNEZ-UHFFFAOYSA-N
SMILES: CC(C)NCCCCOC1=C(C)N=C(CC2=CC=CC=C2)C3=C1COC3
Biological Activity: Barucainide is an Ib-class anti-arrhythmic agent (moderately blocking sodium channel). Barucainide exhibits concentration-dependent inhibitory effects on the maximum upstroke velocity (Vmax) of Purkinje fibers and ventricular muscle in dogs. Barucainide significantly shortens the action potential duration (APD). Barucainide significantly inhibits the pacemaker activity frequency of atrial tissue in rabbits and the enhanced automaticity of Purkinje fibers under normal resting potential in response to isoproterenol. Barucainide cannot inhibit the abnormal automaticity emission frequency of canine Purkinje fibers induced by barium. Barucainide can be used for research on arrhythmias[1][2].
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Barucainide | Barucainide is an Ib-class anti-arrhythmic agent (moderately blocking sodium channel). Barucainide exhibits concentration-dependent inhibitory effects on the maximum upstroke velocity (Vmax) of Purkinje fibers and ventricular muscle in dogs. Barucainide significantly shortens the action potential duration (APD). Barucainide significantly inhibits the pacemaker activity frequency of atrial tissue in rabbits and the enhanced automaticity of Purkinje fibers under normal resting potential in response to isoproterenol. Barucainide cannot inhibit the abnormal automaticity emission frequency of canine Purkinje fibers induced by barium. Barucainide can be used for research on arrhythmias. | |||||||||||||||||||||
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- [1]. Zehender M, et al. Efficacy and tolerance of the new class IB antiarrhythmic barucainide: an intravenous dose-finding study. Clin Pharmacol Ther. 1991 Jan;49(1):78-85. [Content Brief]
- [2]. Takanaka C, Singh BN. Barucainide, a novel class Ib antiarrhythmic agent with a slow kinetic property: electrophysiologic observations in isolated canine and rabbit cardiac muscle. Am Heart J. 1990 May;119(5):1050-60. [Content Brief]
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