48 Results for "

oedema

" in MedChemExpress (MCE) Product Catalog:
Products (48)

48 Results for "oedema" in MCE Product Catalog:

23
23 Publications Verification
Cat. No.: HY-N0171A
CAS No.: 83-46-5
Synonyms: β-Sitosterol (purity>98%); 22,23-Dihydrostigmasterol (purity>98%)
Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-103025
CAS No.: 86401-95-8
Purity:  99.82%
Synonyms: ZK 91588; MPA
Research Areas:  

Inflammation/Immunology

Methylprednisolone aceponate (ZK 91588) is a glucocorticoid and anti-inflammatory agent with weak systemic effects. Methylprednisolone aceponate is a selective glucocorticoid receptor Ligand.Methylprednisolone aceponate can be used for research of eczema and other inflammatory skin disorders .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-N6028
CAS No.: 59219-65-7
Darutoside is an orally effective diterpene compound with significant anti-inflammatory, analgesic, wound healing promotion, and immunomodulatory activities. Darutoside reduces edema and pain responses by inhibiting the expression of COX-2 and the migration of inflammatory cells. It regulates macrophage polarization towards the M2 type by inhibiting the NF-κB pathway, alleviating inflammation and promoting wound healing. Through multi-target regulation of metabolic networks, Darutoside significantly alleviates acute gouty arthritis .
loading...
    loading...
Cat. No.: HY-150069
CAS No.: 2271269-01-1
Purity:  99.16%
Target:  

Bcl-2 Family Apoptosis

Research Areas:  

Metabolic Disease

UBX1325 is an Bcl-xL inhibitor that promotes apoptosis in senescent cells. UBX1325 is a potent anti-aging agent that can be used in studies of age-related eye diseases such as diabetic macular oedema (DME), age-related macular degeneration (AMD) and diabetic retinopathy (DR) .
loading...
    loading...
Cat. No.: HY-101432
CAS No.: 17969-20-9
Purity:  99.52%
Synonyms: ICI-54450; Acidum fenclozicum; Mialex
Target:  

COX

Research Areas:  

Inflammation/Immunology

Fenclozic acid (ICI-54450) is an orally active anti-inflammatory, analgesic, and antipyretic agent. Fenclozic acid exhibits anti-inflammatory activity in Edadjuvant-induced arthritis and Carrageenin-induced oedema in rats. Fenclozic acid can be used for the research of arthritis .
loading...
    loading...
Cat. No.: HY-100845
CAS No.: 83729-01-5
Synonyms: Divinorin A
Salvinorin A is a potent, unique and short-acting high efficacy kappa-opioid receptor (KOPr) agonist with Ki value of 4.3 nm. Salvinorin A is a non-nitrogenous neoclerodane isolated from Salvia divinorum.
loading...
    loading...
Cat. No.: HY-N1205
CAS No.: 6750-60-3
Spathulenol is isolated from Aristolochia yunnanensis, and has antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities. Spathulenol shows a high antioxidant activity with an IC50 of 85.60 μg/mL in the DPPH system .
loading...
    loading...
Cat. No.: HY-U00153
CAS No.: 2470-73-7
Target:  

Drug Derivative

Research Areas:  

Neurological Disease

Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate.
loading...
    loading...
Cat. No.: HY-W050088
CAS No.: 55453-87-7
Synonyms: HP 549
Isoxepac (HP 549) is an orally active non-steroidal anti-inflammatory agent. Isoxepac can inhibit Carrageenan (HY-125474) paw oedema, adjuvant-induced polyarthritis, and prostaglandin synthesis. Isoxepac (200 mg) has an analgesic effect after meniscectomy with a low incidence of side effects. Isoxepac can be used in the research of inflammatory (rheumatoid arthritis) and pain-related diseases .
loading...
    loading...
Cat. No.: HY-110036
CAS No.: 180002-83-9
Purity:  99.12%
Synonyms: L768242
GW-405833 (L768242) is a potent, selective cannabinoid receptor 2 (CB2) agonist. GW405833 has EC50 and Ki values ​​of 0.65 nM and 3.92 nM for CB2, and EC50 and Ki values ​​of 16.1 μM and 4772 nM for CB1. GW-405833 also exhibits non-competitive CB1 antagonist, exerting its analgesic and and anti-inflammatory effect through a CB1 receptor (rather than CB2) dependent mechanism. GW-405833 can significantly inhibit the production of cAMP stimulated by Forskolin (HY-15371). GW405833 inhibits glycolysis by down-regulating HIF-1α, thereby alleviating acute liver failure (ALF) .
loading...
    loading...
Cat. No.: HY-W009706
CAS No.: 22131-79-9
Synonyms: Allopydin; W-7320
Alclofenac (Allopydin) is an orally active prostaglandin synthase inhibitor with anti-inflammatory, analgesic and antipyretic activities. Alclofenac irreversibly inhibits platelet aggregation. Alclofenac can be used in research related to rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, low back pain and sciatica .
loading...
    loading...
Cat. No.: HY-105172
CAS No.: 147159-51-1
Purity:  98.27%
Synonyms: CAP-232; TLN-232
Target:  

Somatostatin Receptor

Research Areas:  

Inflammation/Immunology Cancer

TT-232 (CAP-232), a somatostatin derivative, is a peptide SSTR1/SSTR4 agonist. TT-232 inhibits cancer cell proliferation and induces apoptosis. TT-232 is also a broad-spectrum anti-inflammatory and analgesic agent .
loading...
    loading...
Cat. No.: HY-B1254
CAS No.: 5588-16-9
Synonyms: Althiazide
Target:  

Others

Research Areas:  

Cardiovascular Disease

Altizide (Althiazide) is an orally active diuretic. Altizide can be used in studies of oedema and hypertension .
loading...
    loading...
Cat. No.: HY-A0235
CAS No.: 55300-29-3
Synonyms: Stakane
Antrafenine (Stakane) is a derivative of 2-(quinolin-4-ylamino) benzoate, and is an orally active anti-inflammatory and analgesic agent. Antrafenine protects mammalian epithelial cells from cell death upon exposure to influenza A virus A/WSN/33 (H1N1). Antrafenine inhibits carrageenan-induced paw swelling in rats, and reduces exudate volume and total leukocyte infiltration in carrageenan- and calcium pyrophosphate dihydrate crystal-induced pleurisy in rats. Antrafenine can be used in studies related to influenza and pseudogout .
loading...
    loading...
Cat. No.: HY-123179
CAS No.: 7195-27-9
Purity:  ≥99.0%
Target:  

Carbonic Anhydrase

Research Areas:  

Cardiovascular Disease

Mefruside is an orally active diuretic and has a mild hypotensive effect. Mefruside inhibits the synthesis of urea in an isolated rat liver perfusion model. Mefruside can be used in studies of oedema and hypertension .
loading...
    loading...
Cat. No.: HY-14840A
CAS No.: 949925-07-9
Synonyms: MRZ 9547
(R)-Phenylpiracetam (MRZ 9547) is a dopamine transporter (DAT) inhibitor (Ki: 14.8 μM; IC50: 65.5 μM). (R)-Phenylpiracetam can be used for the research of the neurological or neuropsychiatric disorders .
loading...
    loading...
Cat. No.: HY-P5875A
P4pal10 TFA is the TFA salt form of P4pal10 (HY-P5875). P4pal10 TFA is an antagonist for protease-activated receptor 4 (PAR4). P4pal10 TFA inhibits the platelet aggregation, inhibits tissue factor (TF)-induced thrombin generation, and exhibits anticoagulant and antithrombotic activities. P4pal10 TFA reduces the oedema and the granulocyte infiltration induced by Carrageenan (HY-125474). P4pal10 TFA ameliorates the injury in rats myocardial ischemia/reperfusion (I/R) models .
loading...
    loading...
Cat. No.: HY-Y0537J
CAS No.: 7447-40-7
Potassium chloride, meets analytical specification of Ph. Eur., BP, USP, FCC, E508, ≤0.0001% Al is a neutral potassium salt that can be used for buffer preparation, and can be used in biochemical research .
loading...
    loading...
Cat. No.: HY-404056
CAS No.: 2151021-59-7
(R)-AZ8838 is a competitive PAR2 antagonist with a pKi of  5.2 for human PAR2. (R)-AZ8838 exert anti-inflammatory effects in a rat model of PAR2 agonist-induced paw oedema .
loading...
    loading...
Cat. No.: HY-P991415
Synonyms: AM712

Target:  

VEGFR Tie

Research Areas:  

Others

ASKG-712 (AM712) is a recombinant anti-VEGF humanized monoclonal antibody and Ang-2 antagonist peptide fusion protein. ASKG-712 can be used in Wet age-related macular degeneration and Diabetic macular oedema research .
loading...
    loading...