55300-29-3
Chemical Structure
Antrafenine
Synonym(s): Stakane
- No. CAS: 55300-29-3
- Formula:C30H26F6N4O2
- Molecular Weight:588.54
IUPAC Name: 2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl 2-((7-(trifluoromethyl)quinolin-4-yl)amino)benzoate
InChIKey: NWGGKKGAFZIVBJ-UHFFFAOYSA-N
SMILES: O=C(OCCN1CCN(C2=CC=CC(C(F)(F)F)=C2)CC1)C3=CC=CC=C3NC4=CC=NC5=CC(C(F)(F)F)=CC=C45
Biological Activity: Antrafenine (Stakane) is a derivative of 2-(quinolin-4-ylamino) benzoate, and is an orally active anti-inflammatory and analgesic agent. Antrafenine protects mammalian epithelial cells from cell death upon exposure to influenza A virus A/WSN/33 (H1N1). Antrafenine inhibits carrageenan-induced paw swelling in rats, and reduces exudate volume and total leukocyte infiltration in carrageenan- and calcium pyrophosphate dihydrate crystal-induced pleurisy in rats. Antrafenine can be used in studies related to influenza and pseudogout[1][2].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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Antrafenine | 99.76% | Antrafenine (Stakane) is a derivative of 2-(quinolin-4-ylamino) benzoate, and is an orally active anti-inflammatory and analgesic agent. Antrafenine protects mammalian epithelial cells from cell death upon exposure to influenza A virus A/WSN/33 (H1N1). Antrafenine inhibits carrageenan-induced paw swelling in rats, and reduces exudate volume and total leukocyte infiltration in carrageenan- and calcium pyrophosphate dihydrate crystal-induced pleurisy in rats. Antrafenine can be used in studies related to influenza and pseudogout. | ||||||||||||||||||||
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References
- [1]. Tang YS, et al. Anti-influenza virus activities and mechanism of antrafenine analogs. Eur J Med Chem. 2023 Nov 15;260:115775. [Content Brief]
- [2]. Dunn CJ, et al. Antrafenine: anti-inflammatory activity with respect to oedema and leucocyte infiltration in the rat. Agents Actions. 1984 Feb;14(2):296-9. [Content Brief]
