55453-87-7
Chemical Structure
Isoxepac
Synonym(s): HP 549
- CAS No.: 55453-87-7
- Formula:C16H12O4
- Molecular Weight:268.27
IUPAC Name: 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid
InChIKey: QFGMXJOBTNZHEL-UHFFFAOYSA-N
SMILES: O=C(O)CC1=CC=C(C2=C1)OCC3=CC=CC=C3C2=O
Biological Activity: Isoxepac (HP 549) is an orally active non-steroidal anti-inflammatory agent. Isoxepac can inhibit Carrageenan (HY-125474) paw oedema, adjuvant-induced polyarthritis, and prostaglandin synthesis. Isoxepac (200 mg) has an analgesic effect after meniscectomy with a low incidence of side effects. Isoxepac can be used in the research of inflammatory (rheumatoid arthritis) and pain-related diseases[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Isoxepac | 99.97% | Isoxepac (HP 549) is an orally active non-steroidal anti-inflammatory agent. Isoxepac can inhibit Carrageenan (HY-125474) paw oedema, adjuvant-induced polyarthritis, and prostaglandin synthesis. Isoxepac (200 mg) has an analgesic effect after meniscectomy with a low incidence of side effects. Isoxepac can be used in the research of inflammatory (rheumatoid arthritis) and pain-related diseases. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Isoxepac (Standard) | ≥98% | Isoxepac (Standard) (HP 549 (Standard)) is the analytical standard of Isoxepac (HY-W050088). This product is intended for research and analytical applications. Isoxepac (HP 549) is an orally active non-steroidal anti-inflammatory agent. Isoxepac can inhibit Carrageenan (HY-125474) paw oedema, adjuvant-induced polyarthritis, and prostaglandin synthesis. Isoxepac (200 mg) has an analgesic effect after meniscectomy with a low incidence of side effects. Isoxepac can be used in the research of inflammatory (rheumatoid arthritis) and pain-related diseases. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.81
HY-108109P-8977 -
Similarity Score 0.79
HY-131416DD-3305 -
Similarity Score 0.75
![Dibenzo[b,e]oxepin-11(6H)-one Chemical Structure](//file.medchemexpress.com/product_pic/hy-w006672.gif)
HY-W006672Dibenzo[b,e]oxepin-11(6H)-one -
Similarity Score 0.70
HY-W062109Olopatadine -
Similarity Score 0.69
HY-B0426AROlopatadine hydrochloride (Standard) -
Similarity Score 0.65
HY-N7502R2-(Hydroxymethyl)anthraquinone (Standard) -
Similarity Score 0.64
HY-W031757Anthraquinone-2-carboxylic acid -
Similarity Score 0.62
HY-131118Desmethyl Ketoprofen -
Similarity Score 0.62
HY-N51252-Hydroxy-1-methoxyanthraquinone -
Explore the MedChemAI to find more analogs
![Dibenzo[b,e]oxepin-11(6H)-one Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w006672.gif)
References
- [1]. L S Gerlis, et al. Isoxepac in rheumatoid arthritis: a double-blind comparison with aspirin. Rheumatol Rehabil. 1981 Feb 1;20(1):50-3. [Content Brief]
- [2]. W J Honig, et al. Analgesic effect of isoxepac on postmeniscectomy pain: a controlled trial. J Clin Pharmacol. Feb-Mar 1982;22(2-3):82-8. [Content Brief]
- [3]. H P Illing, et al. Species differences in the disposition and metabolism of 6,11-dihydro-11-oxodibenz[be]oxepin-2-acetic acid (isoxepac) in rat, rabbit, dog, rhesus monkey, and man. Drug Metab Dispos. Sep-Oct 1978;6(5):510-7. [Content Brief]
