2 Results for "

p27 ubiquitylation

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "p27 ubiquitylation" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-123578
CAS No.: 241127-79-7
Purity:  99.65%
Target:  

EGFR E1/E2/E3 Enzyme

Research Areas:  

Cancer

NSC689857 is a potent EGFR and SCF SKP2 inhibitor with an IC50 value of 36 μM for Skp2-Cks1. NSC689857 can inhibit p27 ubiquitylation (IC50=30 μM). NSC689857 has varied activity across cancer types, with more activity against leukemia cell lines than others .
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Cat. No.: HY-P11020
Target:  

E1/E2/E3 Enzyme

Research Areas:  

Cancer

p27 Analogue CP2 is a macrocyclic peptide inhibitor targeting the Cks1-Skp2-Skp1 complex (Kd = 32 nM). p27 Analogue CP2 blocks SCFSkp2/Cks1-mediated ubiquitylation and degradation of p27, restoring p27 levels and inhibiting cell proliferation. p27 Analogue CP2 is promising for research of cancers dependent on Skp2 overexpression such as breast cancer .
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