241127-79-7
241127-79-7
Chemical Structure
NSC689857
- CAS No.: 241127-79-7
- Formula:C25H29NO4
- Molecular Weight:407.50
IUPAC Name: adamantan-1-ylmethyl 4-((2,5-dihydroxybenzyl)amino)benzoate
InChIKey: MXKHJVTZHIIIMQ-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C=C1)NCC2=CC(O)=CC=C2O)OCC34CC5CC(CC(C4)C5)C3
Biological Activity: NSC689857 is a potent EGFR and SCFSKP2 inhibitor with an IC50 value of 36 μM for Skp2-Cks1. NSC689857 can inhibit p27 ubiquitylation (IC50=30 μM). NSC689857 has varied activity across cancer types, with more activity against leukemia cell lines than others[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NSC689857 | 99.49% | NSC689857 is a potent EGFR and SCFSKP2 inhibitor with an IC50 value of 36 μM for Skp2-Cks1. NSC689857 can inhibit p27 ubiquitylation (IC50=30 μM). NSC689857 has varied activity across cancer types, with more activity against leukemia cell lines than others. | ||||||||||||||||||||
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References
- [1]. Vuong W, et al. High-Throughput Screen for Inhibitors of Androgen Receptor-RUNX2 Transcriptional Regulation in Prostate Cancer. J Pharmacol Exp Ther. 2016 Nov;359(2):256-261. [Content Brief]
- [2]. Lough L, et al. Chemical probes of Skp2-mediated p27 ubiquitylation and degradation. Medchemcomm. 2018 Jun 11;9(7):1093-1104. [Content Brief]
