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Results for "

phorbol ester

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (3) Bacterial (1) Biochemical Assay Reagents (1) CCR (2) CHIKV (1) Collagen (1) COX (2) Drug Derivative (2) EBV (2) Endogenous Metabolite (1) Fungal (1) HIV (2) Interleukin Related (2) Liposome (1) NF-κB (5) NO Synthase (1) Nuclear Factor of activated T Cells (NFAT) (1) Parasite (1) Phosphatase (1) Phospholipase (2) PKC (11) Reactive Oxygen Species (ROS) (2) Reference Standards (3) SphK (2) TNF Receptor (1) TRP Channel (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (2) Endocrinology (2) Infection (6) Inflammation/Immunology (15) Metabolic Disease (3) Neurological Disease (3)

By Targets:

Akt (1)

Apoptosis (3)

Bacterial (1)

Biochemical Assay Reagents (1)

CCR (2)

CHIKV (1)

Collagen (1)

COX (2)

Drug Derivative (2)

EBV (2)

Endogenous Metabolite (1)

Fungal (1)

HIV (2)

Interleukin Related (2)

Liposome (1)

NF-κB (5)

NO Synthase (1)

Nuclear Factor of activated T Cells (NFAT) (1)

Parasite (1)

Phosphatase (1)

Phospholipase (2)

PKC (11)

Reactive Oxygen Species (ROS) (2)

Reference Standards (3)

SphK (2)

TNF Receptor (1)

TRP Channel (1)

By Research Areas:

Cancer (16)

Cardiovascular Disease (2)

Endocrinology (2)

Infection (6)

Inflammation/Immunology (15)

Metabolic Disease (3)

Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Antibodies

GMP Molecules

Targets Recommended: CETP Carboxylesterase (CES) Hormone-Sensitive Lipase (HSL)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18739

Phorbol 12-myristate 13-acetate 725+ Cited Publications PMA; TPA; phorbol myristate acetate	PKC SphK NF-κB	Neurological Disease Inflammation/Immunology Cancer
Phorbol 12-myristate 13-acetate (PMA; TPA; Phorbol myristate acetate), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator . Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells (Validated by MedChemExpress (MCE)) .

HY-18985

Phorbol 12,13-dibutyrate 3 Publications Verification phorbol dibutyrate; PDBu	PKC	Cancer
Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter .

HY-116291

*4α-Phorbol* 12,13-didecanoate** 4αPDD	TRP Channel CHIKV	Infection Inflammation/Immunology
4α-Phorbol 12,13-didecanoate (4αPDD) is a transient receptor potential vanilloid 4 (TRPV4) agonist. 4α-Phorbol 12,13-didecanoate can promote Ca ²⁺ influx, induce ATP release and function as an osmoreceptor. 4α-Phorbol 12,13-didecanoate can inhibit water intake and increase maximal micturition pressure in rats. 4α-Phorbol 12,13-didecanoate can be used for the researches of inflammation and infection, such as chikungunya virus (CHIKV) .

HY-N2609

7,4'-Dihydroxyflavone 4 Publications Verification	COX CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

HY-18739R

Phorbol 12-myristate 13-acetate (Standard) PMA (Standard); TPA (Standard); phorbol myristate acetate (Standard)	PKC SphK NF-κB Reference Standards	Inflammation/Immunology
Phorbol 12-myristate 13-acetate (PMA; TPA; Phorbol myristate acetate) (Standard) is the analytical standard of Phorbol 12-myristate 13-acetate. This product is intended for research and analytical applications.

HY-N2147

*Phorbol* 4β-phorbol	Others	Cancer
Phorbol is the flagship member of the tigliane diterpene family. Phorbol can be isolated from natural sources and through semisynthesis. Phorbol can form esters that have a wide array of biological properties, which includes the induction of angiogenesis in vitro and promoting tumor in vivo .

HY-136427

KRM-III	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
KRM-III is a potent and orally active T-cell antigen receptor (TCR) inhibitor. KRM-III inhibits TCR- and phorbol myristate acetate/ionomycin-induced activation of nuclear factor of activated T cells (NFAT) and T-cell proliferation with an IC₅₀ of ~5 μM. Anti-inflammatory activity .

HY-W743654

Capsorubin	Apoptosis	Cancer
Capsorubin is a carotenoid found in peppers with multiple biological activities. Capsorubin (167 μM) inhibits lipid peroxidation induced by 2,2'-azobis(2,4-dimethylvaleronitrile) (AMVN) in vitro. Capsorubin (1 μM) reduces UVB-induced DNA strand breaks and apoptosis in human dermal fibroblasts. Capsorubin also inhibits Epstein-Barr virus early antigen (EBV-EA) activation induced by phorbol 12-myristate 13-acetate in Raji cells, a marker of tumorigenesis.

HY-160070

Phorbol-12,13-didecanoate	HIV	Cancer
Phorbol-12,13-didecanoate is an anti-viral TPA compound and a tumor promoter. It can cause changes in actin-containing structures ^{[1] ^.}

HY-114095

BML-280 VU0285655-1	Phospholipase TNF Receptor Interleukin Related	Metabolic Disease Inflammation/Immunology Cancer
BML-280 (VU0285655-1) is a potent and selective phospholipase D2 (PLD2) inhibitor. BML-280 has the ability to prevent caspase-3 cleavage and reduction in cell viability induced by high glucose. BML-280 can be used for rheumatoid arthritis research .

HY-18985G

Phorbol 12,13-dibutyrate phorbol dibutyrate; PDBu	PKC	Cancer
Phorbol 12,13-dibutyrate (Phorbol dibutyrate) (GMP) is Phorbol 12,13-dibutyrate (HY-18985) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Phorbol 12,13-dibutyrate is a PKC activator and a potent skin tumor promoter .

HY-W743654R

Capsorubin (Standard)	Apoptosis Reference Standards	Cancer
Capsorubin (Standard) is the analytical standard of Capsorubin. This product is intended for research and analytical applications. Capsorubin is a carotenoid found in peppers with multiple biological activities. Capsorubin (167 μM) inhibits lipid peroxidation induced by 2,2'-azobis(2,4-dimethylvaleronitrile) (AMVN) in vitro. Capsorubin (1 μM) reduces UVB-induced DNA strand breaks and apoptosis in human dermal fibroblasts. Capsorubin also inhibits Epstein-Barr virus early antigen (EBV-EA) activation induced by phorbol 12-myristate 13-acetate in Raji cells, a marker of tumorigenesis.

HY-118442

Sphingosine (d14:1) Tetradecasphing-4-enine	PKC	Cancer
Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent Protein kinase C (PKC) inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG)/Phorbol esters .

HY-N10866

Phorbol 12-tiglate	Others	Cancer
Phorbol 12-tiglate is a derivative of Phorbol (HY-N2147). Phorbol, a hydrolyzed product of Croton oil, promotes tumor development by activating protein kinase C. Phorbol and its derivatives can be used to construct carcinogenic models in biomedical research .

HY-129330

Sapintoxin D	PKC	Others
Sapintoxin D is a fluorescent phorbol ester that can be used to study the activation of protein kinase C (PKC). Sapintoxin D is a calcium-dependent PKC activator .

HY-118725

Luffariellolide	Phospholipase	Inflammation/Immunology
Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 (HSF-PLA2) (IC₅₀=5 μM). Luffariellolide effectively inhibits phorbol ester (PMA)-induced ear edema (ED₅₀=50 μg/ear) .

HY-123487

Sapintoxin A	PKC	Others
Sapintoxin A is a phorbol ester that can be isolated from the unripe fruits of Sapium indicum .

HY-P5452

PKCd (8-17)	PKC	Others
PKCd (8-17) is a biological active peptide. (This peptide is derived from the V1 domain of protein kinase C (PKC)d. It inhibits phorbol 12-myristate 13-acetate (PMA)-induced PKCd translocation and activation. Inhibition of PKCd reduces ischemia damage in cardiac and cerebral cells, induces proliferation of fibroblasts, and inhibits graft coronary artery disease in mice.)

HY-172546

Lyso-monosialoganglioside GM2 ammonium LysoGM2 ammonium	PKC	Metabolic Disease
Lyso-monosialoganglioside GM2 (LysoGM2) ammonium is a lysosphingolipid and protein kinase C inhibitor (IC₅₀: 50 μM). Lyso-monosialoganglioside GM2 ammonium can inhibit the binding of protein kinase C to Phorbol 12,13-dibutyrate (HY-18985). Lyso-monosialoganglioside GM2 ammonium is a specific biomarker for GM2 gangliosidosis. Lyso-monosialoganglioside GM2 ammonium can be used in the research of sphingolipidoses .

HY-N10872

Phorbol-12-(2-methylbutyrate)	Others	Others
Phorbol-12-(2-methylbutyrate) is a nature product that could be isolated form croton oil .

HY-N2408

4α-Phorbol Isophorbol; α-phorbol	Others	Others
4α-Phorbol is a compound that can be isolated from croton oil .

HY-124273

C2 L-threo Ceramide (d18:1/2:0) L-threo Cer(d18:1/2:0); L-threo Ceramide (d18:1/2:0); N-acetyl-L-threo-Sphingosine	Endogenous Metabolite	Cardiovascular Disease
C2 L-threo Ceramide (d18:1/2:0) (L-threo Cer(d18:1/2:0); L-threo Ceramide (d18:1/2:0)) is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is 50% less than that stimulated by C2 ceramide. C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. It also induces cell cycle arrest in the G0/G1 phase and a 7-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells.

HY-N2609R

7,4'-Dihydroxyflavone (Standard)	COX Reference Standards CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM .

HY-N7823

Phorbol 13-acetate	Others	Others
Phorbol 13-acetate is a Diterpenoids product that can be isolated from the roots of Euphorbia pekinensis Rupr. .

HY-137309

4-Deoxy-4α-phorbol	HIV	Others
4-Deoxy-4α-phorbol is a tetracyclic diterpene found in E. desmondi. It has been used in the semisynthesis of inhibitors of the HIV-1-induced cytopathic effect on MT-4 cells and 4α-phorbol esters .

HY-165362

AO-1535	Reactive Oxygen Species (ROS)	Inflammation/Immunology
AO-1535 is a semisynthetic monoglycosylceramide that inhibits the production of reactive oxygen intermediates in human monocytes and macrophages stimulated by phorbol ester and chemotactic tetrapeptide. AO-1535 can be used for the research of inflammatory dermatoses .

HY-107227

12-O-Tiglylphorbol-13-isobutyrate	Others	Others
12-O-Tiglylphorbol-13-isobutyrate is a phorbol diester constituent of Croton tiglium L. seed oil (croton oil) .

HY-N1143

Tomentin	Others	Inflammation/Immunology
Tomentin is a compound isolated from Sphaeralcea angustifolia. Tomentin inhibits the formation of λ-carrageenan footpad edema at 58 %. Tomentin inhibits the phorbol ester-induced auricular edema formation by 57 % .

HY-N5051

25(S)-Ruscogenin-1-O-α-L-rhamnopyranosyl (1→2)-β-D-xylopyranoside	Others	Inflammation/Immunology
25(S)-Ruscogenin-1-O-α-L-rhamnopyranosyl (1→2)-β-D-xylopyranoside shows inhibitory activity of neutrophil respiratory burst stimulated by PMA(phorbol myristate acetate) .

HY-116730

CHS-111	Reactive Oxygen Species (ROS)	Others
CHS-111 is a benzyl indazole inhibitor of superoxide anion O ^2- generation. CHS-111 inhibits the cell migration, and reduces the formyl-Met-Leu-Phe- but not phorbol ester-stimulated phospholipase D activity, with the IC₅₀ of 3.9 μM .

HY-100702

SH-5	Akt Apoptosis	Cancer
SH-5 is a potent AKT inhibitor. SH-5 potentiates the apoptosis induced by tumor necrosis factor. SH-5 blocks NF-kB activation induced by TNF-a, lipopolysaccharide (HY-D1056), phorbol ester (HY-18739), and cigarette smoke .

HY-N14549

Cycloepoxydon	Phosphatase	Inflammation/Immunology
Cycloepoxydon inhibits the Phorbol 12-myristate 13-acetate (HY-18739) (PMA)-induced NF-KB and AP-1 mediated secreted alkaline phosphatase (SEAP) expression with IC₅₀s of 1-2 μg/mL (4.2-8.4 μM) and 3-5 μg/mL (12.6-21 μM), respectively .

HY-116585

C6 D-Threo Ceramide (d18:1/6:0)	Liposome Interleukin Related	Neurological Disease
C6 D-Threo Ceramide (d18:1/6:0) is a bioactive sphingolipid and cell-permeable analog of ceramides. C6 D-Threo Ceramide (d18:1/6:0) enhances IL-4 production induced by Phorbol 12-myristate 13-acetate (HY-18739) in EL4 T cells .

HY-N9475

Betulonaldehyde	Parasite	Infection Inflammation/Immunology Cancer
Betulonaldehyde is a pentacyclic triterpenoid that can be isolated from Diospyros filipendula. Betulonaldehyde has antiplasmodial activity (IC₅₀: 3.36 µg/mL). Betulonaldehyde has cytotoxic to NCI H187 lung cancer cells and non-cancerous Vero cells (IC₅₀s: 19.23 and 17.09 µg/mL, respectively). Betulonaldehyde inhibits Phorbol 12-myristate 13-acetate (HY-18739) induced inflammation in mice .

HY-N11736

*12-O-Tiglyl-phorbol* 13-dodecanoate**	Collagen	Metabolic Disease
12-O-Tiglyl-phorbol 13-dodecanoate (TD13) is a potential inhibitor with anti-hepatic fibrosis activity, and it belongs to a series of derivatives of oral APOL2 inhibitors and anti-hepatic fibrosis agents. It shows no obvious toxicity in preclinical models. Compounds of the 12-O-Tiglyl-phorbol 13-dodecanoate series inhibit the expression of fibronectin, type I collagen and α-smooth muscle actin in hepatic stellate cells. 12-O-Tiglyl-phorbol 13-dodecanoate can be isolated from the Euphorbiaceae plant Euphorbia fischeriana, and it is applicable to the research of hepatic fibrosis .

HY-N9752

Mogroside II B	EBV	Infection
Mogroside II B is a cucurbitane-type glycoside with a sweet taste in water. Mogroside II B inhibits the activation of Epstein Barr virus early antigen (EBV-EA) induced by Phorbol 12-myristate 13-acetate (TPA) (HY-18739). Mogroside II B exerts weak inhibitory effects on the activation of the nitric oxide (NO) donor (NOR1) .

HY-134107

Azido-erythro-sphingosine	Biochemical Assay Reagents	Others
Azido-erythro-sphingosines is an intermidate for synthesis of lipid molecules with two hydroxyl groups and a terminal azide group. Azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry. The hydroxyl groups enable further derivatization or replacement with other reactive functional groups. Azido-erythro-sphingosine is a derivative of Sphingosine, which is a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets.

HY-E70853

PKCδ Recombinant Human Active Protein Kinase	PKC	Cancer
PKCδ is a PKC isoform. PKCδ is expressed ubiquitously among cells and tissues. It is activated by diacylglycerol produced by receptor-mediated hydrolysis of membrane inositol phospholipids as well as by tumor-promoting phorbol ester through the binding of these compounds to the C1 region in its regulatory domain. PKCδ Recombinant Human Active Protein Kinase is a recombinant PKCδ protein that can be used to study PKCδ-related functions .

HY-N8818

3-Acetoxytirucalla-7,24-dien-21-oic acid	Others	Inflammation/Immunology
3-Acetoxytirucalla-7,24-dien-21-oic acid, derived from Boswellia carteri, exhibits anti-inflammatory activity. Its ID₅₀ for Phorbol 12-myristate 13-acetate (HY-18739)-induced ear swelling in mice is 0.06 mg per ear. 3-Acetoxytirucalla-7,24-dien-21-oic acid holds potential for research in the field of inflammation .

HY-N18053

Anabsinthin	Drug Derivative Bacterial NF-κB NO Synthase	Infection
Anabsinthin is a dimeric sesquiterpene lactone. Anabsinthin can be found in Artemisia absinthium L. (wormwood). Anabsinthin modulates intracellular calcium levels, mediates anti-inflammatory and antioxidant effects. Anabsinthin inhibits Phorbol 12-myristate 13-acetate (HY-18739)-induced superoxide anion production, increased iNOS and MUC5AC protein expression, and IL-1β transcription upregulation. Anabsinthin can be used for the research of citrus canker .

HY-N18117

21-Hydroxyisoohchininolide	EBV	Infection Cancer
21-Hydroxyisoohchininolide is a salannin-type limonoid. 21-Hydroxyisoohchininolide inhibits lipopolysaccharide (LPS, HY-D1056)-induced nitric oxide production in mouse macrophages. 21-Hydroxyisoohchininolide exhibits cytotoxic activity against leukemia cells and breast cancer cells. 21-Hydroxyisoohchininolide suppresses phorbol 12-myristate 13-acetate (PMA) (HY-18739)-induced activation of Epstein-Barr virus early antigen in lymphocytes. 21-Hydroxyisoohchininolide can be used for the research of leukemia, breast cancer and inflammatory diseases .

HY-129980A

NPC-15437		Neurological Disease Cancer
NPC-15437 is a selective PKC inhibitor with an IC₅₀ of 19 µM. NPC-15437 competitively inhibits phorbol ester- (K_i of 5 µM) and phosphatidylserine-induced (K_i of 12 µM) PKC activity. NPC-15437 does not inhibits cAMP-dependent or calcium/calmodulin-dependent protein kinases. NPC-15437 augments TRAIL-induced cell death in non-small cell lung cancer and medulloblastoma cells. NPC-15437 can be used for the research of non-small cell lung cancer, medulloblastoma, and neurological disease .

HY-N18070

12-Deoxyphorbol-13-isobutyrate-20-acetate	Drug Derivative PKC Fungal	Cardiovascular Disease Infection Inflammation/Immunology Cancer
12-Deoxyphorbol-13-isobutyrate-20-acetate is a 12-deoxy-phorbol diterpene ester. 12-Deoxyphorbol-13-isobutyrate-20-acetate is a protein kinase C (PKC) agonist that activates protein kinase C to phosphorylate troponin I and troponin T. 12-Deoxyphorbol-13-isobutyrate-20-acetate induces skin irritation and necrosis in mice without cocarcinogenic activity. 12-Deoxyphorbol-13-isobutyrate-20-acetate inhibits Aspergillus carbonarius growth. 12-Deoxyphorbol-13-isobutyrate-20-acetate supports research on heart failure, cardiomyopathies and fungal infection .

Phorbol 12,13-dibutyrate phorbol dibutyrate; PDBu	Fluorescent Dye
Phorbol 12,13-dibutyrate (Phorbol dibutyrate) (GMP) is Phorbol 12,13-dibutyrate (HY-18985) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Phorbol 12,13-dibutyrate is a PKC activator and a potent skin tumor promoter .

Cat. No.	Product Name	Target	Research Area