17673-25-5
Chemical Structure
Phorbol
Synonym(s): 4β-Phorbol
- CAS No.: 17673-25-5
- Formula:C20H28O6
- Molecular Weight:364.43
IUPAC Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b,9,9a-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-5H-cyclopropa[3,4]benzo[1,2-e]azulen-5-one
InChIKey: QGVLYPPODPLXMB-UBTYZVCOSA-N
SMILES: O=C1C(C)=C[C@@]2([H])[C@]3(O)[C@@]([C@@](C4(C)C)([H])[C@@]4(O)[C@H](O)[C@H]3C)([H])C=C(CO)C[C@]12O
Biological Activity: Phorbol is the flagship member of the tigliane diterpene family. Phorbol can be isolated from natural sources and through semisynthesis. Phorbol can form esters that have a wide array of biological properties, which includes the induction of angiogenesis in vitro and promoting tumor in vivo[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Phorbol | 98.17% | Phorbol is the flagship member of the tigliane diterpene family. Phorbol can be isolated from natural sources and through semisynthesis. Phorbol can form esters that have a wide array of biological properties, which includes the induction of angiogenesis in vitro and promoting tumor in vivo. | ||||||||||||||||||||
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References
- [1]. Kawamura, S., et al., (2016). Nineteen-step total synthesis of (+)-phorbol. Nature, 532(7597), 90–93. [Content Brief]
- [2]. Montesano, R., & Orci, L. (1985). Tumor-promoting phorbol esters induce angiogenesis in vitro. Cell, 42(2), 469–477. [Content Brief]
- [3]. Blumberg P. M. (1980). In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1. Critical reviews in toxicology, 8(2), 153–197. [Content Brief]
