Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
ps210 030s
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "ps210 030s" in MCE Product Catalog:
PS210 is a potent and selective PDK1 activator with a Kd of 3 μM and targets the PIF-binding pocket of PDK1. PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt or GSK3. In cells, the prodrug of PS210 (PS423) acts as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K .
(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of?PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment .
PS423 is a prodrug of PS210, acting as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K. PS210 is a potent and selective PDK1 activator targeting the PIF binding pocket of PDK1 .
Cat. No.: HY-L030
774 compounds
The composition of endogenous metabolite compounds is affected by the upstream influence of the proteome and genome as well as environmental factors, lifestyle factors, medication, and underlying disease. Therefore, metabolites have been described as proximal reporters of disease because their abundances in biological specimens are often directly related to pathogenic mechanisms. In more recent years, metabolomics approach has been adopted or suggested to be used in various research areas including drug discovery, neurosciences, agriculture, food and nutrition, and environmental sciences.
MCE owns a unique collection of 774 human endogenous metabolites, all of which are derived from human issues. This library is a powerful tool for metabonomics research and metabolism-related drug discovery.
Cat. No.: HY-P8F030A
Synonyms: CD80,CD80-FITC,2D10
Cat. No.: HY-P8F030B
Synonyms: CD80,CD80-AF488,2D10
Cat. No.: HY-P8F030C
Synonyms: CD80,CD80-PE,2D10
Cat. No.: HY-P8F030D
Synonyms: CD80,CD80-PE-Cy7,2D10
Cat. No.: HY-P8F030E
Synonyms: CD80,CD80-PE-CF596,2D10
Cat. No.: HY-P8F030F
Synonyms: CD80,CD80-PerCP,2D10
Cat. No.: HY-P8F030G
Synonyms: CD80,CD80-PerCP-Cy5.5,2D10
Cat. No.: HY-P8F030H
Synonyms: CD80,CD80-AF647,2D10
Cat. No.: HY-P8F030I
Synonyms: CD80,CD80-APC,2D10
Cat. No.: HY-P8F030J
Synonyms: CD80,CD80-APC-Cy7,2D10
Cat. No.: HY-P8F030K
Synonyms: CD80,CD80-AF700,2D10
Cat. No.: HY-P8F030L
Synonyms: CD80,CD80-PC Blue,2D10
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
