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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
rabbit arteriovenous shunt model
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "rabbit arteriovenous shunt model" in MCE Product Catalog:
Cat. No.: HY-175735
CAS No.: 2563884-39-7
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Factor XI-IN-2 is a Factor XI activation inhibitor with an IC50 of 20 nM. Factor XI-IN-2 does not directly inhibit the enzymatic activity of FXIa, but specifically binds to the FXI enzyme precursor and allosterically inhibits the process by which it is activated by FXIIa. Factor XI-IN-2 inhibits thrombosis in the rabbit arteriovenous (AV) shunt thrombosis model. Factor XI-IN-2 can be used for the study of antithrombus .
Cat. No.: HY-165437
CAS No.: 135124-72-0
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AY 31390 is a potent PDE III inhibitor. AY 31390 increases intracellular cAMP levels by selectively inhibiting the low-Km cAMP-specific PDE III, thereby stabilizing platelets and exerting antithrombotic effects independently of plasma adenosine concentrations. AY 31390 can be used in the study of thrombosis, angina pectoris, cerebral ischemia, and peripheral vascular diseases .
Cat. No.: HY-106830
CAS No.: 94386-65-9
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Pelrinone is an orally active cardiotonic agent and PDE III inhibitor with an IC50 of 36 μM. Pelrinone elevates intracellular cAMP levels. The action of Pelrinone is independent of β-adrenergic receptors, and it does not inhibit Na +/K +-ATPase. Pelrinone exerts positive inotropic and vasodilatory effects. Pelrinone inhibits platelet aggregation, reduces thrombus formation, and exerts weak anticoagulant activity without altering hematocrit or circulating platelet counts. Pelrinone can be used in research related to congestive heart failure and coronary thrombosis .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
