94386-65-9
Chemical Structure
Pelrinone
- CAS No.: 94386-65-9
- Formula:C12H11N5O
- Molecular Weight:241.25
IUPAC Name: 2-methyl-4-oxo-6-((pyridin-3-ylmethyl)amino)-1,4-dihydropyrimidine-5-carbonitrile
InChIKey: NZXHFDXOCVIYLO-UHFFFAOYSA-N
SMILES: N#CC=1C(=O)N=C(NC1NCC=2C=NC=CC2)C
Biological Activity: Pelrinone is an orally active cardiotonic agent and PDE III inhibitor with an IC50 of 36 μM. Pelrinone elevates intracellular cAMP levels. The action of Pelrinone is independent of β-adrenergic receptors, and it does not inhibit Na+/K+-ATPase. Pelrinone exerts positive inotropic and vasodilatory effects. Pelrinone inhibits platelet aggregation, reduces thrombus formation, and exerts weak anticoagulant activity without altering hematocrit or circulating platelet counts. Pelrinone can be used in research related to congestive heart failure and coronary thrombosis[1][2][3].
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Pelrinone | Pelrinone is an orally active cardiotonic agent and PDE III inhibitor with an IC50 of 36 μM. Pelrinone elevates intracellular cAMP levels. The action of Pelrinone is independent of β-adrenergic receptors, and it does not inhibit Na+/K+-ATPase. Pelrinone exerts positive inotropic and vasodilatory effects. Pelrinone inhibits platelet aggregation, reduces thrombus formation, and exerts weak anticoagulant activity without altering hematocrit or circulating platelet counts. Pelrinone can be used in research related to congestive heart failure and coronary thrombosis. | |||||||||||||||||||||
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- [1]. Bagli J, et al. Chemistry and positive inotropic effect of pelrinone and related derivatives. A novel class of 2-methylpyrimidones as inotropic agents. J Med Chem. 1988 Apr;31(4):814-23. [Content Brief]
- [2]. Patelunas DM, et al. Comparative antithrombotic activities of the phosphodiesterase inhibitors pelrinone (AY-26,768), AY-31,390 and milrinone. Thromb Res. 1991;62(5):389-400. [Content Brief]
- [3]. Kitzen JM, et al. Antithrombotic activity of the phosphodiesterase III inhibitor pelrinone in a canine model of coronary artery thrombosis: enhancement of efficacy with concurrent alpha 2-adrenergic antagonism. J Cardiovasc Pharmacol. 1991;18(6):777-790. [Content Brief]
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